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Protein

Protein BEX1

Gene

BEX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).By similarity

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1
Gene namesi
Name:BEX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1036. BEX1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Shuttles between the cytoplasm and the nucleus.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55859.
OpenTargetsiENSG00000133169.
PharmGKBiPA25340.

Polymorphism and mutation databases

BioMutaiBEX1.
DMDMi91208332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297721 – 125Protein BEX1Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).By similarity
Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9HBH7.
PRIDEiQ9HBH7.

PTM databases

iPTMnetiQ9HBH7.
PhosphoSitePlusiQ9HBH7.

Expressioni

Tissue specificityi

Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.3 Publications

Gene expression databases

BgeeiENSG00000133169.
CleanExiHS_BEX1.
GenevisibleiQ9HBH7. HS.

Organism-specific databases

HPAiHPA045384.

Interactioni

Subunit structurei

Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997505EBI-7162175,EBI-724076
TEX11Q8IYF33EBI-7162175,EBI-742397

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120961. 15 interactors.
IntActiQ9HBH7. 21 interactors.
MINTiMINT-8247480.
STRINGi9606.ENSP00000361813.

Structurei

3D structure databases

ProteinModelPortaliQ9HBH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9HBH7.
OMAiEAGEYCV.
OrthoDBiEOG091G0ZN3.
PhylomeDBiQ9HBH7.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HBH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKEKRAVN SLSMENANQE NEEKEQVANK GEPLALPLDA GEYCVPRGNR
60 70 80 90 100
RRFRVRQPIL QYRWDMMHRL GEPQARMREE NMERIGEEVR QLMEKLREKQ
110 120
LSHSLRAVST DPPHHDHHDE FCLMP
Length:125
Mass (Da):14,860
Last modified:April 4, 2006 - v2
Checksum:i2406DD71F7E663D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → L in AAG09752 (PubMed:11989783).Curated1
Sequence conflicti88E → G in AAG09752 (PubMed:11989783).Curated1
Sequence conflicti100Q → R in BAF83647 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0426679V → L.Corresponds to variant rs3174500dbSNPEnsembl.1
Natural variantiVAR_04266811S → N.Corresponds to variant rs1045058dbSNPEnsembl.1
Natural variantiVAR_04266913S → I.Corresponds to variant rs1045061dbSNPEnsembl.1
Natural variantiVAR_04267014M → V.Corresponds to variant rs1045063dbSNPEnsembl.1
Natural variantiVAR_04267117A → V.Corresponds to variant rs1045065dbSNPEnsembl.1
Natural variantiVAR_02575640A → V.Corresponds to variant rs709036dbSNPEnsembl.1
Natural variantiVAR_02575766M → I.Corresponds to variant rs1045082dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237783 mRNA. Translation: AAG09752.1.
AY833561 mRNA. Translation: AAX40679.1.
AF183416 mRNA. Translation: AAG09685.1.
AF220189 mRNA. Translation: AAF67654.1.
AK290958 mRNA. Translation: BAF83647.1.
AL008708 Genomic DNA. Translation: CAI42418.1.
BC126427 mRNA. Translation: AAI26428.1.
BC126429 mRNA. Translation: AAI26430.1.
CCDSiCCDS35354.1.
RefSeqiNP_060946.3. NM_018476.3.
UniGeneiHs.334370.

Genome annotation databases

EnsembliENST00000372728; ENSP00000361813; ENSG00000133169.
GeneIDi55859.
KEGGihsa:55859.
UCSCiuc004ejt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237783 mRNA. Translation: AAG09752.1.
AY833561 mRNA. Translation: AAX40679.1.
AF183416 mRNA. Translation: AAG09685.1.
AF220189 mRNA. Translation: AAF67654.1.
AK290958 mRNA. Translation: BAF83647.1.
AL008708 Genomic DNA. Translation: CAI42418.1.
BC126427 mRNA. Translation: AAI26428.1.
BC126429 mRNA. Translation: AAI26430.1.
CCDSiCCDS35354.1.
RefSeqiNP_060946.3. NM_018476.3.
UniGeneiHs.334370.

3D structure databases

ProteinModelPortaliQ9HBH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120961. 15 interactors.
IntActiQ9HBH7. 21 interactors.
MINTiMINT-8247480.
STRINGi9606.ENSP00000361813.

PTM databases

iPTMnetiQ9HBH7.
PhosphoSitePlusiQ9HBH7.

Polymorphism and mutation databases

BioMutaiBEX1.
DMDMi91208332.

Proteomic databases

PaxDbiQ9HBH7.
PRIDEiQ9HBH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372728; ENSP00000361813; ENSG00000133169.
GeneIDi55859.
KEGGihsa:55859.
UCSCiuc004ejt.2. human.

Organism-specific databases

CTDi55859.
DisGeNETi55859.
GeneCardsiBEX1.
HGNCiHGNC:1036. BEX1.
HPAiHPA045384.
MIMi300690. gene.
neXtProtiNX_Q9HBH7.
OpenTargetsiENSG00000133169.
PharmGKBiPA25340.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9HBH7.
OMAiEAGEYCV.
OrthoDBiEOG091G0ZN3.
PhylomeDBiQ9HBH7.
TreeFamiTF337909.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133169-MONOMER.

Miscellaneous databases

GeneWikiiBEX1.
GenomeRNAii55859.
PROiQ9HBH7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133169.
CleanExiHS_BEX1.
GenevisibleiQ9HBH7. HS.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBEX1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBH7
Secondary accession number(s): A0AVN1, A8K4J3, Q9NZ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was named BEX2 by some authors.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.