Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol dehydrogenase 14

Gene

RDH14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192SubstrateBy similarity1
Active sitei217Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 56NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.300 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway

Chemistry databases

SwissLipidsiSLP:000001788

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 14 (EC:1.1.1.-)
Alternative name(s):
Alcohol dehydrogenase PAN2
Short chain dehydrogenase/reductase family 7C member 4
Gene namesi
Name:RDH14
Synonyms:PAN2, SDR7C4
ORF Names:UNQ529/PRO1072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000240857.1
HGNCiHGNC:19979 RDH14
neXtProtiNX_Q9HBH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi57665
OpenTargetsiENSG00000240857
PharmGKBiPA134872714

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRDH14
DMDMi34395826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547701 – 336Retinol dehydrogenase 14Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HBH5
MaxQBiQ9HBH5
PaxDbiQ9HBH5
PeptideAtlasiQ9HBH5
PRIDEiQ9HBH5

PTM databases

iPTMnetiQ9HBH5
PhosphoSitePlusiQ9HBH5

Expressioni

Tissue specificityi

Expressed in brain, kidney, pancreas and placenta.

Gene expression databases

BgeeiENSG00000240857
CleanExiHS_PAN2
HS_RDH14
ExpressionAtlasiQ9HBH5 baseline and differential
GenevisibleiQ9HBH5 HS

Organism-specific databases

HPAiHPA056686

Interactioni

Protein-protein interaction databases

BioGridi121698, 14 interactors
IntActiQ9HBH5, 3 interactors
MINTiQ9HBH5
STRINGi9606.ENSP00000370648

Structurei

3D structure databases

ProteinModelPortaliQ9HBH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ9HBH5
KOiK11162
OMAiIMGCRDR
OrthoDBiEOG091G0FGA
PhylomeDBiQ9HBH5
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG
60 70 80 90 100
ANSGLGRATA AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE
110 120 130 140 150
PGVSGVGELI VRELDLASLR SVRAFCQEML QEEPRLDVLI NNAGIFQCPY
160 170 180 190 200
MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK SSAPSRIVVV SSKLYKYGDI
210 220 230 240 250
NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV TVNVLHPGIV
260 270 280 290 300
RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG
310 320 330
RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK
Length:336
Mass (Da):36,865
Last modified:March 1, 2001 - v1
Checksum:iBCC17B3CD6B70DED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237952 mRNA Translation: AAG12190.1
AY358511 mRNA Translation: AAQ88875.1
BC009830 mRNA Translation: AAH09830.1
CCDSiCCDS1693.1
RefSeqiNP_065956.1, NM_020905.3
UniGeneiHs.120319

Genome annotation databases

EnsembliENST00000381249; ENSP00000370648; ENSG00000240857
GeneIDi57665
KEGGihsa:57665
UCSCiuc002rcx.5 human

Similar proteinsi

Entry informationi

Entry nameiRDH14_HUMAN
AccessioniPrimary (citable) accession number: Q9HBH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health