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Protein

Retinol dehydrogenase 14

Gene

RDH14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192SubstrateBy similarity1
Active sitei217Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 56NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • osteoblast differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.300. 2681.
ReactomeiR-HSA-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 14 (EC:1.1.1.-)
Alternative name(s):
Alcohol dehydrogenase PAN2
Short chain dehydrogenase/reductase family 7C member 4
Gene namesi
Name:RDH14
Synonyms:PAN2, SDR7C4
ORF Names:UNQ529/PRO1072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19979. RDH14.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • endoplasmic reticulum membrane Source: Reactome
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi57665.
OpenTargetsiENSG00000240857.
PharmGKBiPA134872714.

Chemistry databases

DrugBankiDB00162. Vitamin A.

Polymorphism and mutation databases

BioMutaiRDH14.
DMDMi34395826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547701 – 336Retinol dehydrogenase 14Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HBH5.
MaxQBiQ9HBH5.
PaxDbiQ9HBH5.
PeptideAtlasiQ9HBH5.
PRIDEiQ9HBH5.

PTM databases

iPTMnetiQ9HBH5.
PhosphoSitePlusiQ9HBH5.

Expressioni

Tissue specificityi

Expressed in brain, kidney, pancreas and placenta.

Gene expression databases

BgeeiENSG00000240857.
CleanExiHS_PAN2.
HS_RDH14.
ExpressionAtlasiQ9HBH5. baseline and differential.
GenevisibleiQ9HBH5. HS.

Organism-specific databases

HPAiHPA056686.

Interactioni

Protein-protein interaction databases

BioGridi121698. 9 interactors.
IntActiQ9HBH5. 3 interactors.
MINTiMINT-4723605.
STRINGi9606.ENSP00000370648.

Structurei

3D structure databases

ProteinModelPortaliQ9HBH5.
SMRiQ9HBH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9HBH5.
KOiK11162.
OMAiGDPGLMH.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ9HBH5.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HBH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG
60 70 80 90 100
ANSGLGRATA AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE
110 120 130 140 150
PGVSGVGELI VRELDLASLR SVRAFCQEML QEEPRLDVLI NNAGIFQCPY
160 170 180 190 200
MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK SSAPSRIVVV SSKLYKYGDI
210 220 230 240 250
NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV TVNVLHPGIV
260 270 280 290 300
RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG
310 320 330
RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK
Length:336
Mass (Da):36,865
Last modified:March 1, 2001 - v1
Checksum:iBCC17B3CD6B70DED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237952 mRNA. Translation: AAG12190.1.
AY358511 mRNA. Translation: AAQ88875.1.
BC009830 mRNA. Translation: AAH09830.1.
CCDSiCCDS1693.1.
RefSeqiNP_065956.1. NM_020905.3.
UniGeneiHs.120319.

Genome annotation databases

EnsembliENST00000381249; ENSP00000370648; ENSG00000240857.
GeneIDi57665.
KEGGihsa:57665.
UCSCiuc002rcx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237952 mRNA. Translation: AAG12190.1.
AY358511 mRNA. Translation: AAQ88875.1.
BC009830 mRNA. Translation: AAH09830.1.
CCDSiCCDS1693.1.
RefSeqiNP_065956.1. NM_020905.3.
UniGeneiHs.120319.

3D structure databases

ProteinModelPortaliQ9HBH5.
SMRiQ9HBH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121698. 9 interactors.
IntActiQ9HBH5. 3 interactors.
MINTiMINT-4723605.
STRINGi9606.ENSP00000370648.

Chemistry databases

DrugBankiDB00162. Vitamin A.

PTM databases

iPTMnetiQ9HBH5.
PhosphoSitePlusiQ9HBH5.

Polymorphism and mutation databases

BioMutaiRDH14.
DMDMi34395826.

Proteomic databases

EPDiQ9HBH5.
MaxQBiQ9HBH5.
PaxDbiQ9HBH5.
PeptideAtlasiQ9HBH5.
PRIDEiQ9HBH5.

Protocols and materials databases

DNASUi57665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381249; ENSP00000370648; ENSG00000240857.
GeneIDi57665.
KEGGihsa:57665.
UCSCiuc002rcx.5. human.

Organism-specific databases

CTDi57665.
DisGeNETi57665.
GeneCardsiRDH14.
HGNCiHGNC:19979. RDH14.
HPAiHPA056686.
neXtProtiNX_Q9HBH5.
OpenTargetsiENSG00000240857.
PharmGKBiPA134872714.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ9HBH5.
KOiK11162.
OMAiGDPGLMH.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ9HBH5.
TreeFamiTF105429.

Enzyme and pathway databases

BRENDAi1.1.1.300. 2681.
ReactomeiR-HSA-5365859. RA biosynthesis pathway.

Miscellaneous databases

ChiTaRSiRDH14. human.
GeneWikiiRDH14.
GenomeRNAii57665.
PROiQ9HBH5.

Gene expression databases

BgeeiENSG00000240857.
CleanExiHS_PAN2.
HS_RDH14.
ExpressionAtlasiQ9HBH5. baseline and differential.
GenevisibleiQ9HBH5. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRDH14_HUMAN
AccessioniPrimary (citable) accession number: Q9HBH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.