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Q9HBG4

- VPP4_HUMAN

UniProt

Q9HBG4 - VPP4_HUMAN

Protein

V-type proton ATPase 116 kDa subunit a isoform 4

Gene

ATP6V0A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.By similarity

    GO - Molecular functioni

    1. ATPase binding Source: UniProtKB
    2. hydrogen ion transmembrane transporter activity Source: InterPro
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: Ensembl
    2. cellular iron ion homeostasis Source: Reactome
    3. excretion Source: HGNC
    4. insulin receptor signaling pathway Source: Reactome
    5. interaction with host Source: Reactome
    6. ossification Source: HGNC
    7. phagosome maturation Source: Reactome
    8. proton transport Source: HGNC
    9. regulation of pH Source: HGNC
    10. sensory perception of sound Source: HGNC
    11. transferrin transport Source: Reactome
    12. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000105929-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase 116 kDa subunit a isoform 4
    Short name:
    V-ATPase 116 kDa isoform a4
    Alternative name(s):
    Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4
    Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform
    Gene namesi
    Name:ATP6V0A4
    Synonyms:ATP6N1B, ATP6N2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:866. ATP6V0A4.

    Subcellular locationi

    Apical cell membrane; Multi-pass membrane protein
    Note: Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.

    GO - Cellular componenti

    1. apical part of cell Source: UniProtKB
    2. apical plasma membrane Source: UniProtKB
    3. brush border membrane Source: HGNC
    4. endosome Source: UniProtKB
    5. endosome membrane Source: Reactome
    6. extracellular vesicular exosome Source: UniProt
    7. integral component of membrane Source: UniProtKB-KW
    8. lysosomal membrane Source: UniProtKB
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: UniProtKB
    11. vacuolar proton-transporting V-type ATPase, V0 domain Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Renal tubular acidosis, distal, autosomal recessive (RTADR) [MIM:602722]: An autosomal recessive disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti175 – 1751G → D in RTADR. 1 Publication
    VAR_020993
    Natural varianti237 – 2371Missing in RTADR. 1 Publication
    VAR_020994
    Natural varianti449 – 4491R → H in RTADR. 1 Publication
    VAR_020995
    Natural varianti524 – 5241P → L in RTADR. 1 Publication
    VAR_017255
    Natural varianti580 – 5801M → T in RTADR. 1 Publication
    Corresponds to variant rs3807153 [ dbSNP | Ensembl ].
    VAR_017256
    Natural varianti807 – 8071R → Q in RTADR. 1 Publication
    Corresponds to variant rs28939081 [ dbSNP | Ensembl ].
    VAR_020996
    Natural varianti820 – 8201G → R in RTADR. 1 Publication
    VAR_017257

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi602722. phenotype.
    Orphaneti93609. Autosomal recessive distal renal tubular acidosis without deafness.
    PharmGKBiPA25147.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 840840V-type proton ATPase 116 kDa subunit a isoform 4PRO_0000119219Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBG4.
    PaxDbiQ9HBG4.
    PRIDEiQ9HBG4.

    PTM databases

    PhosphoSiteiQ9HBG4.

    Expressioni

    Tissue specificityi

    Expressed in adult and fetal kidney. Found in the inner ear.1 Publication

    Gene expression databases

    BgeeiQ9HBG4.
    CleanExiHS_ATP6V0A4.
    GenevestigatoriQ9HBG4.

    Organism-specific databases

    HPAiHPA018029.

    Interactioni

    Subunit structurei

    The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''.

    Protein-protein interaction databases

    BioGridi119097. 2 interactions.
    STRINGi9606.ENSP00000253856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 390390CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini410 – 4112VacuolarSequence Analysis
    Topological domaini429 – 44315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini474 – 53865VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini559 – 57618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini598 – 64245VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini663 – 72765CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini753 – 77321VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini813 – 84028CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei391 – 40919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 42817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 47330HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei577 – 59721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei643 – 66220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei728 – 75225HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 81239HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase 116 kDa subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1269.
    HOGENOMiHOG000037059.
    HOVERGENiHBG014606.
    InParanoidiQ9HBG4.
    KOiK02154.
    OMAiHRAVSYL.
    OrthoDBiEOG74FF04.
    PhylomeDBiQ9HBG4.
    TreeFamiTF300346.

    Family and domain databases

    InterProiIPR002490. V-ATPase_116kDa_su.
    IPR026028. V-type_ATPase_116kDa_su_euka.
    [Graphical view]
    PANTHERiPTHR11629. PTHR11629. 1 hit.
    PfamiPF01496. V_ATPase_I. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001293. ATP6V0A1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HBG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK    50
    FVNEVRRCES LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL 100
    EKLEGELQEA NQNQQALKQS FLELTELKYL LKKTQDFFET ETNLADDFFT 150
    EDTSGLLELK AVPAYMTGKL GFIAGVINRE RMASFERLLW RICRGNVYLK 200
    FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD GFRATVYPCP 250
    EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ 300
    KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM 350
    APIMTTVQSK TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT 400
    FPFLFAVMFG DCGHGTVMLL AALWMILNER RLLSQKTDNE IWNTFFHGRY 450
    LILLMGIFSI YTGLIYNDCF SKSLNIFGSS WSVQPMFRNG TWNTHVMEES 500
    LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK MKMSVILGIV 550
    QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC 600
    FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS 650
    VPWMLLIKPF ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS 700
    ADTHGALDDH GEEFNFGDVF VHQAIHTIEY CLGCISNTAS YLRLWALSLA 750
    HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI IFAVFAVLTV AILLIMEGLS 800
    AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE 840
    Length:840
    Mass (Da):96,386
    Last modified:October 5, 2010 - v2
    Checksum:i449964EBC01D4649
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521P → R in AAI09305. (PubMed:15489334)Curated
    Sequence conflicti252 – 2521P → R in AAI09306. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21V → A.2 Publications
    Corresponds to variant rs10258719 [ dbSNP | Ensembl ].
    VAR_020992
    Natural varianti175 – 1751G → D in RTADR. 1 Publication
    VAR_020993
    Natural varianti237 – 2371Missing in RTADR. 1 Publication
    VAR_020994
    Natural varianti449 – 4491R → H in RTADR. 1 Publication
    VAR_020995
    Natural varianti524 – 5241P → L in RTADR. 1 Publication
    VAR_017255
    Natural varianti554 – 5541F → L.
    Corresponds to variant rs1026435 [ dbSNP | Ensembl ].
    VAR_066612
    Natural varianti580 – 5801M → T in RTADR. 1 Publication
    Corresponds to variant rs3807153 [ dbSNP | Ensembl ].
    VAR_017256
    Natural varianti604 – 6041H → Q.
    Corresponds to variant rs3807154 [ dbSNP | Ensembl ].
    VAR_066613
    Natural varianti807 – 8071R → Q in RTADR. 1 Publication
    Corresponds to variant rs28939081 [ dbSNP | Ensembl ].
    VAR_020996
    Natural varianti820 – 8201G → R in RTADR. 1 Publication
    VAR_017257

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245517 mRNA. Translation: AAG11415.1.
    AK292945 mRNA. Translation: BAF85634.1.
    AC018663 Genomic DNA. No translation available.
    AC020983 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24043.1.
    CH471070 Genomic DNA. Translation: EAW83892.1.
    BC109304 mRNA. Translation: AAI09305.1.
    BC109305 mRNA. Translation: AAI09306.1.
    CCDSiCCDS5849.1.
    RefSeqiNP_065683.2. NM_020632.2.
    NP_570855.2. NM_130840.2.
    NP_570856.2. NM_130841.2.
    XP_005250450.1. XM_005250393.1.
    XP_005250451.1. XM_005250394.1.
    UniGeneiHs.98967.

    Genome annotation databases

    EnsembliENST00000310018; ENSP00000308122; ENSG00000105929.
    ENST00000353492; ENSP00000253856; ENSG00000105929.
    ENST00000393054; ENSP00000376774; ENSG00000105929.
    GeneIDi50617.
    KEGGihsa:50617.
    UCSCiuc003vuf.3. human.

    Polymorphism databases

    DMDMi308153516.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245517 mRNA. Translation: AAG11415.1 .
    AK292945 mRNA. Translation: BAF85634.1 .
    AC018663 Genomic DNA. No translation available.
    AC020983 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24043.1 .
    CH471070 Genomic DNA. Translation: EAW83892.1 .
    BC109304 mRNA. Translation: AAI09305.1 .
    BC109305 mRNA. Translation: AAI09306.1 .
    CCDSi CCDS5849.1.
    RefSeqi NP_065683.2. NM_020632.2.
    NP_570855.2. NM_130840.2.
    NP_570856.2. NM_130841.2.
    XP_005250450.1. XM_005250393.1.
    XP_005250451.1. XM_005250394.1.
    UniGenei Hs.98967.

    3D structure databases

    ProteinModelPortali Q9HBG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119097. 2 interactions.
    STRINGi 9606.ENSP00000253856.

    Protein family/group databases

    TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q9HBG4.

    Polymorphism databases

    DMDMi 308153516.

    Proteomic databases

    MaxQBi Q9HBG4.
    PaxDbi Q9HBG4.
    PRIDEi Q9HBG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310018 ; ENSP00000308122 ; ENSG00000105929 .
    ENST00000353492 ; ENSP00000253856 ; ENSG00000105929 .
    ENST00000393054 ; ENSP00000376774 ; ENSG00000105929 .
    GeneIDi 50617.
    KEGGi hsa:50617.
    UCSCi uc003vuf.3. human.

    Organism-specific databases

    CTDi 50617.
    GeneCardsi GC07M138391.
    H-InvDB HIX0007123.
    HGNCi HGNC:866. ATP6V0A4.
    HPAi HPA018029.
    MIMi 602722. phenotype.
    605239. gene.
    neXtProti NX_Q9HBG4.
    Orphaneti 93609. Autosomal recessive distal renal tubular acidosis without deafness.
    PharmGKBi PA25147.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1269.
    HOGENOMi HOG000037059.
    HOVERGENi HBG014606.
    InParanoidi Q9HBG4.
    KOi K02154.
    OMAi HRAVSYL.
    OrthoDBi EOG74FF04.
    PhylomeDBi Q9HBG4.
    TreeFami TF300346.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000105929-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    GeneWikii ATP6V0A4.
    GenomeRNAii 50617.
    NextBioi 53132.
    PROi Q9HBG4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HBG4.
    CleanExi HS_ATP6V0A4.
    Genevestigatori Q9HBG4.

    Family and domain databases

    InterProi IPR002490. V-ATPase_116kDa_su.
    IPR026028. V-type_ATPase_116kDa_su_euka.
    [Graphical view ]
    PANTHERi PTHR11629. PTHR11629. 1 hit.
    Pfami PF01496. V_ATPase_I. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001293. ATP6V0A1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing."
      Smith A.N., Skaug J., Choate K.A., Nayir A., Bakkaloglu A., Ozen S., Hulton S.A., Sanjad S.A., Al-Sabban E.A., Lifton R.P., Scherer S.W., Karet F.E.
      Nat. Genet. 26:71-75(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS RTADR LEU-524; THR-580 AND ARG-820, VARIANT ALA-2.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-2.
      Tissue: Trachea.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. Cited for: TISSUE SPECIFICITY, VARIANTS RTADR ASP-175; LYS-237 DEL; HIS-449 AND GLN-807.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiVPP4_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBG4
    Secondary accession number(s): A4D1R4, A8KA80, Q32M47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3