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Q9HBF4

- ZFYV1_HUMAN

UniProt

Q9HBF4 - ZFYV1_HUMAN

Protein

Zinc finger FYVE domain-containing protein 1

Gene

ZFYVE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    3. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger FYVE domain-containing protein 1
    Alternative name(s):
    Double FYVE-containing protein 1
    SR3
    Tandem FYVE fingers-1
    Gene namesi
    Name:ZFYVE1
    Synonyms:DFCP1, KIAA1589, TAFF1, ZNFN2A1
    ORF Names:PP10436
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:13180. ZFYVE1.

    Subcellular locationi

    Golgi apparatusGolgi stack. Endoplasmic reticulum
    Note: Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. Golgi stack Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi616 – 6161T → R: Partially restore PtdIns3P binding; when associated with R-733. 1 Publication
    Mutagenesisi617 – 6171K → A: Drastically reduce PtdIns3P binding; when associated with A-619 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication
    Mutagenesisi619 – 6191H → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication
    Mutagenesisi621 – 6211R → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-619. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication
    Mutagenesisi654 – 6541C → S: Abolishes PtdIns3P binding; when associated with S-770. 1 Publication
    Mutagenesisi733 – 7331S → R: Partially restored PtdIns3P binding; when associated with R-616. 1 Publication
    Mutagenesisi734 – 7341K → A: Drastically reduce PtdIns3P binding; when associated with A-736 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication
    Mutagenesisi736 – 7361H → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication
    Mutagenesisi738 – 7381R → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-736. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication
    Mutagenesisi770 – 7701C → S: Abolishes PtdIns3P binding; when associated with S-654. 2 Publications

    Organism-specific databases

    PharmGKBiPA37752.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 777777Zinc finger FYVE domain-containing protein 1PRO_0000098713Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBF4.
    PaxDbiQ9HBF4.
    PRIDEiQ9HBF4.

    PTM databases

    PhosphoSiteiQ9HBF4.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis.

    Gene expression databases

    ArrayExpressiQ9HBF4.
    BgeeiQ9HBF4.
    CleanExiHS_ZFYVE1.
    GenevestigatoriQ9HBF4.

    Organism-specific databases

    HPAiHPA002898.

    Interactioni

    Subunit structurei

    Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CAP621362EBI-4401611,EBI-357253

    Protein-protein interaction databases

    BioGridi119749. 4 interactions.
    IntActiQ9HBF4. 2 interactions.
    MINTiMINT-8247369.
    STRINGi9606.ENSP00000326921.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBF4.
    SMRiQ9HBF4. Positions 604-659, 715-771.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 FYVE-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG303950.
    HOGENOMiHOG000044357.
    HOVERGENiHBG057679.
    InParanoidiQ9HBF4.
    KOiK17603.
    PhylomeDBiQ9HBF4.
    TreeFamiTF323237.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 2 hits.
    [Graphical view]
    SMARTiSM00064. FYVE. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEiPS50178. ZF_FYVE. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBF4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH    50
    RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINLC 100
    LECQKRTHSG GNKRRHPVTV YNVSNLQESL EAEEMDEETK RKKMTEKVVS 150
    FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT 200
    FFYGREVFKT SPTQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT 250
    RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA 300
    RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEVPEKLI QDRFRKLGRF 350
    PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL 400
    KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGVGC KKSMNHGKEG 450
    VPHEAKSRCR YSHQYDNRVY TCKACYERGE EVSVVPKTSA STDSPWMGLA 500
    KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDGFL 550
    KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ 600
    ILSCNKCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV 650
    CDNCYEARNV QLAVTEAQVD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL 700
    GLVKDAARPA YWVPDHEILH CHNCRKEFSI KLSKHHCRAC GQGFCDECSH 750
    DRRAVPSRGW DHPVRVCFNC NKKPGDL 777
    Length:777
    Mass (Da):87,176
    Last modified:March 1, 2001 - v1
    Checksum:i11B5E561066CBCD5
    GO
    Isoform 2 (identifier: Q9HBF4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-415: Missing.

    Show »
    Length:362
    Mass (Da):40,260
    Checksum:i70B405CA16F3EE9D
    GO
    Isoform 3 (identifier: Q9HBF4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         507-520: Missing.

    Show »
    Length:763
    Mass (Da):85,592
    Checksum:i17702137AF3EFED7
    GO

    Sequence cautioni

    The sequence AAL55826.1 differs from that shown. Reason: Frameshift at position 480.
    The sequence BAB13415.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55085.1 differs from that shown. Reason: Erroneous termination at position 760. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201V → M in BC014902. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 415415Missing in isoform 2. 1 PublicationVSP_008007Add
    BLAST
    Alternative sequencei507 – 52014Missing in isoform 3. 1 PublicationVSP_056770Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251025 mRNA. Translation: AAG23748.1.
    AJ310569 mRNA. Translation: CAC83950.1.
    AF311602 mRNA. Translation: AAK27339.1.
    AB046809 mRNA. Translation: BAB13415.1. Different initiation.
    AK027399 mRNA. Translation: BAB55085.1. Different termination.
    AL442663 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81084.1.
    BC053520 mRNA. Translation: AAH53520.1.
    BC014902 mRNA. No translation available.
    AF318319 mRNA. Translation: AAL55826.1. Frameshift.
    CCDSiCCDS41969.1. [Q9HBF4-2]
    CCDS9811.1. [Q9HBF4-1]
    RefSeqiNP_001268663.1. NM_001281734.1.
    NP_001268664.1. NM_001281735.1. [Q9HBF4-2]
    NP_067083.1. NM_021260.3. [Q9HBF4-1]
    NP_848535.1. NM_178441.2. [Q9HBF4-2]
    UniGeneiHs.335106.

    Genome annotation databases

    EnsembliENST00000318876; ENSP00000326921; ENSG00000165861.
    ENST00000394207; ENSP00000377757; ENSG00000165861. [Q9HBF4-2]
    ENST00000555072; ENSP00000452232; ENSG00000165861. [Q9HBF4-2]
    ENST00000556143; ENSP00000450742; ENSG00000165861. [Q9HBF4-1]
    GeneIDi53349.
    KEGGihsa:53349.
    UCSCiuc001xnl.3. human. [Q9HBF4-2]
    uc001xnm.3. human. [Q9HBF4-1]
    uc010arj.3. human.

    Polymorphism databases

    DMDMi34098716.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251025 mRNA. Translation: AAG23748.1 .
    AJ310569 mRNA. Translation: CAC83950.1 .
    AF311602 mRNA. Translation: AAK27339.1 .
    AB046809 mRNA. Translation: BAB13415.1 . Different initiation.
    AK027399 mRNA. Translation: BAB55085.1 . Different termination.
    AL442663 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81084.1 .
    BC053520 mRNA. Translation: AAH53520.1 .
    BC014902 mRNA. No translation available.
    AF318319 mRNA. Translation: AAL55826.1 . Frameshift.
    CCDSi CCDS41969.1. [Q9HBF4-2 ]
    CCDS9811.1. [Q9HBF4-1 ]
    RefSeqi NP_001268663.1. NM_001281734.1.
    NP_001268664.1. NM_001281735.1. [Q9HBF4-2 ]
    NP_067083.1. NM_021260.3. [Q9HBF4-1 ]
    NP_848535.1. NM_178441.2. [Q9HBF4-2 ]
    UniGenei Hs.335106.

    3D structure databases

    ProteinModelPortali Q9HBF4.
    SMRi Q9HBF4. Positions 604-659, 715-771.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119749. 4 interactions.
    IntActi Q9HBF4. 2 interactions.
    MINTi MINT-8247369.
    STRINGi 9606.ENSP00000326921.

    PTM databases

    PhosphoSitei Q9HBF4.

    Polymorphism databases

    DMDMi 34098716.

    Proteomic databases

    MaxQBi Q9HBF4.
    PaxDbi Q9HBF4.
    PRIDEi Q9HBF4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318876 ; ENSP00000326921 ; ENSG00000165861 .
    ENST00000394207 ; ENSP00000377757 ; ENSG00000165861 . [Q9HBF4-2 ]
    ENST00000555072 ; ENSP00000452232 ; ENSG00000165861 . [Q9HBF4-2 ]
    ENST00000556143 ; ENSP00000450742 ; ENSG00000165861 . [Q9HBF4-1 ]
    GeneIDi 53349.
    KEGGi hsa:53349.
    UCSCi uc001xnl.3. human. [Q9HBF4-2 ]
    uc001xnm.3. human. [Q9HBF4-1 ]
    uc010arj.3. human.

    Organism-specific databases

    CTDi 53349.
    GeneCardsi GC14M073436.
    HGNCi HGNC:13180. ZFYVE1.
    HPAi HPA002898.
    MIMi 605471. gene.
    neXtProti NX_Q9HBF4.
    PharmGKBi PA37752.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303950.
    HOGENOMi HOG000044357.
    HOVERGENi HBG057679.
    InParanoidi Q9HBF4.
    KOi K17603.
    PhylomeDBi Q9HBF4.
    TreeFami TF323237.

    Miscellaneous databases

    ChiTaRSi ZFYVE1. human.
    GeneWikii ZFYVE1.
    GenomeRNAii 53349.
    NextBioi 56004.
    PROi Q9HBF4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HBF4.
    Bgeei Q9HBF4.
    CleanExi HS_ZFYVE1.
    Genevestigatori Q9HBF4.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 2 hits.
    [Graphical view ]
    SMARTi SM00064. FYVE. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEi PS50178. ZF_FYVE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library."
      Derubeis A.R., Young M.F., Jia L., Robey P.G., Fisher L.W.
      Gene 255:195-203(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Bone marrow stroma.
    2. "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments."
      Ridley S.H., Ktistakis N., Davidson K., Anderson K.E., Manifava M., Ellson C.D., Lipp P., Bootman M., Coadwell J., Nazarian A., Erdjument-Bromage H., Tempst P., Cooper M.A., Thuring J.W.J.F., Lim Z.-Y., Holmes A.B., Stephens L.R., Hawkins P.T.
      J. Cell Sci. 114:3991-4000(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH PTDINS3P, MUTAGENESIS OF CYS-770.
    3. "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi."
      Cheung P.C.F., Trinkle-Mulcahy L., Cohen P., Lucocq J.M.
      Biochem. J. 355:113-121(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION, INTERACTION WITH PTDINS3P, MUTAGENESIS OF THR-616; LYS-617; HIS-619; ARG-621; CYS-654; SER-733; LYS-734; HIS-736; ARG-738 AND CYS-770.
    4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    6. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Eye and Melanoma.
    9. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 372-777 (ISOFORM 1).
    10. "TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells."
      Tomar D., Singh R., Singh A.K., Pandya C.D., Singh R.
      Biochim. Biophys. Acta 1823:316-326(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRIM13, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiZFYV1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBF4
    Secondary accession number(s): J3KNL9
    , Q8WYX7, Q96K57, Q9BXP9, Q9HCI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3