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Protein

Zinc finger FYVE domain-containing protein 1

Gene

ZFYVE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular response to starvation Source: ParkinsonsUK-UCL
  • macroautophagy Source: ParkinsonsUK-UCL
  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9HBF4.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 1
Alternative name(s):
Double FYVE-containing protein 1
SR3
Tandem FYVE fingers-1
Gene namesi
Name:ZFYVE1
Synonyms:DFCP1, KIAA1589, TAFF1, ZNFN2A1
ORF Names:PP10436
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:13180. ZFYVE1.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: MGI
  • endoplasmic reticulum Source: UniProtKB
  • ER-mitochondrion membrane contact site Source: MGI
  • extrinsic component of omegasome membrane Source: UniProtKB
  • Golgi stack Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • pre-autophagosomal structure Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi616T → R: Partially restore PtdIns3P binding; when associated with R-733. 1 Publication1
Mutagenesisi617K → A: Drastically reduce PtdIns3P binding; when associated with A-619 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi619H → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi621R → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-619. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi654C → S: Abolishes PtdIns3P binding; when associated with S-770. 1 Publication1
Mutagenesisi733S → R: Partially restored PtdIns3P binding; when associated with R-616. 1 Publication1
Mutagenesisi734K → A: Drastically reduce PtdIns3P binding; when associated with A-736 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi736H → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi738R → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-736. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi770C → S: Abolishes PtdIns3P binding; when associated with S-654. 2 Publications1

Organism-specific databases

OpenTargetsiENSG00000165861.
PharmGKBiPA37752.

Polymorphism and mutation databases

BioMutaiZFYVE1.
DMDMi34098716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000987131 – 777Zinc finger FYVE domain-containing protein 1Add BLAST777

Proteomic databases

EPDiQ9HBF4.
MaxQBiQ9HBF4.
PaxDbiQ9HBF4.
PeptideAtlasiQ9HBF4.
PRIDEiQ9HBF4.

PTM databases

iPTMnetiQ9HBF4.
PhosphoSitePlusiQ9HBF4.

Expressioni

Tissue specificityi

Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis.

Gene expression databases

BgeeiENSG00000165861.
CleanExiHS_ZFYVE1.
ExpressionAtlasiQ9HBF4. baseline and differential.
GenevisibleiQ9HBF4. HS.

Organism-specific databases

HPAiHPA002898.

Interactioni

Subunit structurei

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-4401611,EBI-357253

Protein-protein interaction databases

BioGridi119749. 9 interactors.
IntActiQ9HBF4. 5 interactors.
MINTiMINT-8247369.
STRINGi9606.ENSP00000450742.

Structurei

3D structure databases

ProteinModelPortaliQ9HBF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 FYVE-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1818. Eukaryota.
ENOG410XNRF. LUCA.
GeneTreeiENSGT00390000016097.
HOGENOMiHOG000044357.
HOVERGENiHBG057679.
InParanoidiQ9HBF4.
KOiK17603.
PhylomeDBiQ9HBF4.
TreeFamiTF323237.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 2 hits.
[Graphical view]
SMARTiSM00064. FYVE. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50178. ZF_FYVE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH
60 70 80 90 100
RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINLC
110 120 130 140 150
LECQKRTHSG GNKRRHPVTV YNVSNLQESL EAEEMDEETK RKKMTEKVVS
160 170 180 190 200
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT
210 220 230 240 250
FFYGREVFKT SPTQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT
260 270 280 290 300
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA
310 320 330 340 350
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEVPEKLI QDRFRKLGRF
360 370 380 390 400
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL
410 420 430 440 450
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGVGC KKSMNHGKEG
460 470 480 490 500
VPHEAKSRCR YSHQYDNRVY TCKACYERGE EVSVVPKTSA STDSPWMGLA
510 520 530 540 550
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDGFL
560 570 580 590 600
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ
610 620 630 640 650
ILSCNKCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV
660 670 680 690 700
CDNCYEARNV QLAVTEAQVD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL
710 720 730 740 750
GLVKDAARPA YWVPDHEILH CHNCRKEFSI KLSKHHCRAC GQGFCDECSH
760 770
DRRAVPSRGW DHPVRVCFNC NKKPGDL
Length:777
Mass (Da):87,176
Last modified:March 1, 2001 - v1
Checksum:i11B5E561066CBCD5
GO
Isoform 2 (identifier: Q9HBF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-415: Missing.

Show »
Length:362
Mass (Da):40,260
Checksum:i70B405CA16F3EE9D
GO
Isoform 3 (identifier: Q9HBF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     507-520: Missing.

Show »
Length:763
Mass (Da):85,592
Checksum:i17702137AF3EFED7
GO

Sequence cautioni

The sequence AAL55826 differs from that shown. Reason: Frameshift at position 480.Curated
The sequence BAB13415 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55085 differs from that shown. Reason: Erroneous termination at position 760. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120V → M in BC014902 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080071 – 415Missing in isoform 2. 1 PublicationAdd BLAST415
Alternative sequenceiVSP_056770507 – 520Missing in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251025 mRNA. Translation: AAG23748.1.
AJ310569 mRNA. Translation: CAC83950.1.
AF311602 mRNA. Translation: AAK27339.1.
AB046809 mRNA. Translation: BAB13415.1. Different initiation.
AK027399 mRNA. Translation: BAB55085.1. Different termination.
AL442663 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81084.1.
BC053520 mRNA. Translation: AAH53520.1.
BC014902 mRNA. No translation available.
AF318319 mRNA. Translation: AAL55826.1. Frameshift.
CCDSiCCDS41969.1. [Q9HBF4-2]
CCDS61498.1. [Q9HBF4-3]
CCDS9811.1. [Q9HBF4-1]
RefSeqiNP_001268663.1. NM_001281734.1. [Q9HBF4-3]
NP_001268664.1. NM_001281735.1. [Q9HBF4-2]
NP_067083.1. NM_021260.3. [Q9HBF4-1]
NP_848535.1. NM_178441.2. [Q9HBF4-2]
XP_016876862.1. XM_017021373.1. [Q9HBF4-2]
UniGeneiHs.335106.

Genome annotation databases

EnsembliENST00000318876; ENSP00000326921; ENSG00000165861. [Q9HBF4-3]
ENST00000394207; ENSP00000377757; ENSG00000165861. [Q9HBF4-2]
ENST00000555072; ENSP00000452232; ENSG00000165861. [Q9HBF4-2]
ENST00000556143; ENSP00000450742; ENSG00000165861. [Q9HBF4-1]
GeneIDi53349.
KEGGihsa:53349.
UCSCiuc001xnl.5. human. [Q9HBF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251025 mRNA. Translation: AAG23748.1.
AJ310569 mRNA. Translation: CAC83950.1.
AF311602 mRNA. Translation: AAK27339.1.
AB046809 mRNA. Translation: BAB13415.1. Different initiation.
AK027399 mRNA. Translation: BAB55085.1. Different termination.
AL442663 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81084.1.
BC053520 mRNA. Translation: AAH53520.1.
BC014902 mRNA. No translation available.
AF318319 mRNA. Translation: AAL55826.1. Frameshift.
CCDSiCCDS41969.1. [Q9HBF4-2]
CCDS61498.1. [Q9HBF4-3]
CCDS9811.1. [Q9HBF4-1]
RefSeqiNP_001268663.1. NM_001281734.1. [Q9HBF4-3]
NP_001268664.1. NM_001281735.1. [Q9HBF4-2]
NP_067083.1. NM_021260.3. [Q9HBF4-1]
NP_848535.1. NM_178441.2. [Q9HBF4-2]
XP_016876862.1. XM_017021373.1. [Q9HBF4-2]
UniGeneiHs.335106.

3D structure databases

ProteinModelPortaliQ9HBF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119749. 9 interactors.
IntActiQ9HBF4. 5 interactors.
MINTiMINT-8247369.
STRINGi9606.ENSP00000450742.

PTM databases

iPTMnetiQ9HBF4.
PhosphoSitePlusiQ9HBF4.

Polymorphism and mutation databases

BioMutaiZFYVE1.
DMDMi34098716.

Proteomic databases

EPDiQ9HBF4.
MaxQBiQ9HBF4.
PaxDbiQ9HBF4.
PeptideAtlasiQ9HBF4.
PRIDEiQ9HBF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318876; ENSP00000326921; ENSG00000165861. [Q9HBF4-3]
ENST00000394207; ENSP00000377757; ENSG00000165861. [Q9HBF4-2]
ENST00000555072; ENSP00000452232; ENSG00000165861. [Q9HBF4-2]
ENST00000556143; ENSP00000450742; ENSG00000165861. [Q9HBF4-1]
GeneIDi53349.
KEGGihsa:53349.
UCSCiuc001xnl.5. human. [Q9HBF4-1]

Organism-specific databases

CTDi53349.
GeneCardsiZFYVE1.
HGNCiHGNC:13180. ZFYVE1.
HPAiHPA002898.
MIMi605471. gene.
neXtProtiNX_Q9HBF4.
OpenTargetsiENSG00000165861.
PharmGKBiPA37752.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1818. Eukaryota.
ENOG410XNRF. LUCA.
GeneTreeiENSGT00390000016097.
HOGENOMiHOG000044357.
HOVERGENiHBG057679.
InParanoidiQ9HBF4.
KOiK17603.
PhylomeDBiQ9HBF4.
TreeFamiTF323237.

Enzyme and pathway databases

SIGNORiQ9HBF4.

Miscellaneous databases

ChiTaRSiZFYVE1. human.
GeneWikiiZFYVE1.
GenomeRNAii53349.
PROiQ9HBF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165861.
CleanExiHS_ZFYVE1.
ExpressionAtlasiQ9HBF4. baseline and differential.
GenevisibleiQ9HBF4. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 2 hits.
[Graphical view]
SMARTiSM00064. FYVE. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50178. ZF_FYVE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFYV1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBF4
Secondary accession number(s): J3KNL9
, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.