Interleukin-21 receptor precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9HBE5 (IL21R_HUMAN)

Last modified June 16, 2009. Version 80. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Interleukin-21 receptor
      Short name=IL-21R
Alternative name(s):
    Novel interleukin receptor

Gene names

Name:	IL21R
Synonyms:	NILR
ORF Names:	UNQ3121/PRO10273

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is a receptor for interleukin-21.
Subunit structure	Heterodimer with the common gamma chain. Associates with JAK1.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	natural killer cell activation Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	interleukin-21 receptor activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

19

Chain

519

Interleukin-21 receptor

PRO_0000010881

Regions

Topological domain

213

Extracellular Potential

Transmembrane

21

Potential

Topological domain

285

Cytoplasmic Potential

Domain

90

Fibronectin type-III

Motif

5

WSXWS motif

Motif

9

Box 1 motif

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

Potential

Natural variations

Natural variant

1

R → C: dbSNP rs3093370. Ref.4

VAR_014360

Natural variant

1

S → R: dbSNP rs3093385. Ref.4

VAR_014361

Natural variant

1

G → S: dbSNP rs3093386. Ref.4

VAR_014362

Experimental info

Sequence conflict

1

G → R in AAG23419. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9HBE5-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 414079CCB974850A
Show »

538

59,130

        10         20         30         40         50         60 
MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT WQDQYEELKD 

        70         80         90        100        110        120 
EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD QSGNYSQECG SFLLAESIKP 

       130        140        150        160        170        180 
APPFNVTVTF SGQYNISWRS DYEDPAFYML KGKLQYELQY RNRGDPWAVS PRRKLISVDS 

       190        200        210        220        230        240 
RSVSLLPLEF RKDSSYELQV RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL 

       250        260        270        280        290        300 
LLLLVIVFIP AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS 

       310        320        330        340        350        360 
LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS FWPTAQNSGG 

       370        380        390        400        410        420 
SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP ALDLDAGLEP SPGLEDPLLD 

       430        440        450        460        470        480 
AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK PPLADGEDWA GGLPWGGRSP GGVSESEAGS 

       490        500        510        520        530 
PLAGLDMDTF DSGFVGSDCS SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function." Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R. Foster D. Nature 408:57-63(2000) [PubMed: 11081504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J. Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed: 11016959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	SeattleSNPs variation discovery resource Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-191; ARG-318 AND SER-484.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Lymph.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
	AF254067 mRNA. Translation: AAG29346.1. AF269133 mRNA. Translation: AAG23419.1. AY358826 mRNA. Translation: AAQ89185.1. AY064474 Genomic DNA. Translation: AAL39168.1. BC004348 mRNA. Translation: AAH04348.1. BC007946 mRNA. Translation: AAH07946.2.
IPI	IPI00034249.
RefSeq	NP_068570.1. NP_851564.1. NP_851565.1.
UniGene	Hs.210546
3D structure databases
HSSP	HSSP built from PDB template 1EBA based on UniProtKB P19235.
ModBase	Search...
PTM databases
PhosphoSite	Q9HBE5.
Proteomic databases
PRIDE	Q9HBE5.
Genome annotation databases
Ensembl	ENSG00000103522. Homo sapiens. [Contig view]
GeneID	50615.
KEGG	hsa:50615.
Organism-specific databases
GeneCards	GC16P027321.
H-InvDB	HIX0012913. HIX0012914.
HGNC	HGNC:6006. IL21R.
MIM	605383. gene.
PharmGKB	PA29821.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9HBE5.
HOVERGEN	Q9HBE5.
OMA	Q9HBE5. SGDFKKW.
Gene expression databases
ArrayExpress	Q9HBE5.
Bgee	Q9HBE5.
CleanEx	HS_IL21R.
GermOnline	ENSG00000103522. Homo sapiens.
Family and domain databases
InterPro	IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003531. Hempt_rcpt_S_F1_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 1 hit.
SMART	SM00060. FN3. 1 hit. [Graphical view]
PROSITE	PS50853. FN3. False negative. PS01355. HEMATOPO_REC_S_F1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	53120.
SOURCE	Search...

Entry information

Entry name

IL21R_HUMAN

Accession

Primary (citable) accession number: Q9HBE5
Secondary accession number(s): Q96HZ1, Q9HB91

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents