Q9HBE5 (IL21R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-21 receptor
Short name=IL-21 receptor
Short name=IL-21R

Alternative name(s):
Novel interleukin receptor
CD_antigen=CD360

Gene names

Name:	IL21R
Synonyms:	NILR
ORF Names:	UNQ3121/PRO10273

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a receptor for interleukin-21.
Subunit structure	Heterodimer with the common gamma subunit. Associates with JAK1.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	natural killer cell activation Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	interleukin-21 receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.8
	Chain	20 – 538	519	Interleukin-21 receptor		PRO_0000010881
Regions
	Topological domain	20 – 232	213	Extracellular Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Topological domain	254 – 538	285	Cytoplasmic Potential
	Domain	120 – 209	90	Fibronectin type-III
	Motif	214 – 218	5	WSXWS motif
	Motif	266 – 274	9	Box 1 motif
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	135	1	N-linked (GlcNAc...) Potential
	Disulfide bond	25 ↔ 35		By similarity
	Disulfide bond	65 ↔ 81		Potential
Natural variations
	Natural variant	191	1	R → C. Ref.4 Corresponds to variant rs3093370 [ dbSNP | Ensembl ].		VAR_014360
	Natural variant	318	1	S → R. Ref.4 Corresponds to variant rs3093385 [ dbSNP | Ensembl ].		VAR_014361
	Natural variant	484	1	G → S. Ref.4 Corresponds to variant rs3093386 [ dbSNP | Ensembl ].		VAR_014362
Experimental info
	Sequence conflict	386	1	G → R in AAG23419. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9HBE5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 414079CCB974850A	FASTA	538	59,130
	10 20 30 40 50 60 MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT WQDQYEELKD 70 80 90 100 110 120 EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD QSGNYSQECG SFLLAESIKP 130 140 150 160 170 180 APPFNVTVTF SGQYNISWRS DYEDPAFYML KGKLQYELQY RNRGDPWAVS PRRKLISVDS 190 200 210 220 230 240 RSVSLLPLEF RKDSSYELQV RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL 250 260 270 280 290 300 LLLLVIVFIP AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS 310 320 330 340 350 360 LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS FWPTAQNSGG 370 380 390 400 410 420 SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP ALDLDAGLEP SPGLEDPLLD 430 440 450 460 470 480 AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK PPLADGEDWA GGLPWGGRSP GGVSESEAGS 490 500 510 520 530 PLAGLDMDTF DSGFVGSDCS SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function." Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R. , Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C., Moore M., Grant F.J., Lofton-Day C., Gilbert T., Raymond F., Ching A., Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K., Holly R.D., Foster D. Nature 408:57-63(2000) [PubMed: 11081504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J. Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed: 11016959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	SeattleSNPs variation discovery resource Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-191; ARG-318 AND SER-484.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Lymph.
[8]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF254067 mRNA. Translation: AAG29346.1. AF269133 mRNA. Translation: AAG23419.1. AY358826 mRNA. Translation: AAQ89185.1. AY064474 Genomic DNA. Translation: AAL39168.1. AK292663 mRNA. Translation: BAF85352.1. CH471145 Genomic DNA. Translation: EAW55746.1. CH471145 Genomic DNA. Translation: EAW55747.1. CH471145 Genomic DNA. Translation: EAW55748.1. BC004348 mRNA. Translation: AAH04348.1. BC007946 mRNA. Translation: AAH07946.2.
IPI	IPI00034249.
RefSeq	NP_068570.1. NM_021798.3. NP_851564.1. NM_181078.2. NP_851565.4. NM_181079.4.
UniGene	Hs.210546.
3D structure databases
ProteinModelPortal	Q9HBE5.
SMR	Q9HBE5. Positions 20-225.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HBE5.
PTM databases
PhosphoSite	Q9HBE5.
Polymorphism databases
DMDM	20454997.
Proteomic databases
PRIDE	Q9HBE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337929; ENSP00000338010; ENSG00000103522. ENST00000395754; ENSP00000379103; ENSG00000103522. ENST00000395755; ENSP00000379104; ENSG00000103522.
GeneID	50615.
KEGG	hsa:50615.
UCSC	uc002doq.1. human.
Organism-specific databases
CTD	50615.
GeneCards	GC16P027413.
H-InvDB	HIX0012913. HIX0012914.
HGNC	HGNC:6006. IL21R.
HPA	HPA042296.
MIM	605383. gene.
neXtProt	NX_Q9HBE5.
PharmGKB	PA29821.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14874.
GeneTree	ENSGT00510000048783.
HOGENOM	HBG126773.
HOVERGEN	HBG052105.
InParanoid	Q9HBE5.
OMA	SGDFKKW.
OrthoDB	EOG4NZTTW.
PhylomeDB	Q9HBE5.
Gene expression databases
ArrayExpress	Q9HBE5.
Bgee	Q9HBE5.
CleanEx	HS_IL21R.
Genevestigator	Q9HBE5.
GermOnline	ENSG00000103522. Homo sapiens.
Family and domain databases
InterPro	IPR003961. Fibronectin_type3. IPR003531. Hempt_rcpt_S_F1_CS. IPR013783. Ig-like_fold. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K05075.
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. False negative. PS01355. HEMATOPO_REC_S_F1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	53120.
SOURCE	Search...

Entry information

Entry name

IL21R_HUMAN

Accession

Primary (citable) accession number: Q9HBE5
Secondary accession number(s): A8K9E8 , D3DWF7, Q96HZ1, Q9HB91

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.