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Q9HBE5

- IL21R_HUMAN

UniProt

Q9HBE5 - IL21R_HUMAN

Protein

Interleukin-21 receptor

Gene

IL21R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    This is a receptor for interleukin-21.

    GO - Molecular functioni

    1. interleukin-21 receptor activity Source: UniProtKB

    GO - Biological processi

    1. interleukin-21-mediated signaling pathway Source: GOC
    2. natural killer cell activation Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ9HBE5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21 receptor
    Short name:
    IL-21 receptor
    Short name:
    IL-21R
    Alternative name(s):
    Novel interleukin receptor
    CD_antigen: CD360
    Gene namesi
    Name:IL21R
    Synonyms:NILR
    ORF Names:UNQ3121/PRO10273
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6006. IL21R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    IL21R immunodeficiency (IL21RID) [MIM:615207]: An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 822Missing in IL21RID; loss of function mutation.
    VAR_069898
    Natural varianti201 – 2011R → L in IL21RID; loss of function mutation; the mutation results in defective trafficking of the protein, with misfolding, impaired processing and abnormal subcellular distribution rather than proper expression at the plasma membrane. 1 Publication
    VAR_069899
    Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6.

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615207. phenotype.
    Orphaneti357329. Cryptosporidiosis - chronic cholangitis - liver disease.
    PharmGKBiPA29821.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 538519Interleukin-21 receptorPRO_0000010881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 1091 Publication
    Disulfide bondi25 ↔ 351 Publication
    Disulfide bondi65 ↔ 811 Publication
    Glycosylationi73 – 731N-linked (GlcNAc...)1 Publication
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141C-linked (Man)

    Post-translational modificationi

    C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9HBE5.
    PaxDbiQ9HBE5.
    PRIDEiQ9HBE5.

    Expressioni

    Tissue specificityi

    Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

    Gene expression databases

    BgeeiQ9HBE5.
    CleanExiHS_IL21R.
    GenevestigatoriQ9HBE5.

    Organism-specific databases

    HPAiHPA042296.

    Interactioni

    Subunit structurei

    Heterodimer with the common gamma subunit. Associates with JAK1.1 Publication

    Protein-protein interaction databases

    BioGridi119095. 4 interactions.
    STRINGi9606.ENSP00000338010.

    Structurei

    Secondary structure

    1
    538
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 275
    Beta strandi29 – 3810
    Beta strandi40 – 434
    Beta strandi46 – 516
    Beta strandi64 – 729
    Beta strandi74 – 829
    Helixi85 – 873
    Beta strandi93 – 997
    Beta strandi106 – 1138
    Helixi114 – 1163
    Beta strandi124 – 13916
    Helixi141 – 1433
    Helixi145 – 1506
    Beta strandi153 – 16210
    Beta strandi172 – 1765
    Beta strandi181 – 1855
    Beta strandi195 – 20410
    Beta strandi221 – 2244

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TGXX-ray2.80A/C/E/G/I/K/M/O20-232[»]
    ProteinModelPortaliQ9HBE5.
    SMRiQ9HBE5. Positions 20-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 232213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 538285CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 11898Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini119 – 228110Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi214 – 2185WSXWS motif
    Motifi266 – 2749Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.1 Publication
    The box 1 motif is required for JAK interaction and/or activation.1 Publication

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40447.
    HOGENOMiHOG000013192.
    HOVERGENiHBG052105.
    InParanoidiQ9HBE5.
    KOiK05075.
    OMAiRDRPYGL.
    OrthoDBiEOG767398.
    PhylomeDBiQ9HBE5.
    TreeFamiTF337874.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HBE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT    50
    WQDQYEELKD EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD 100
    QSGNYSQECG SFLLAESIKP APPFNVTVTF SGQYNISWRS DYEDPAFYML 150
    KGKLQYELQY RNRGDPWAVS PRRKLISVDS RSVSLLPLEF RKDSSYELQV 200
    RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL LLLLVIVFIP 250
    AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS 300
    LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS 350
    FWPTAQNSGG SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP 400
    ALDLDAGLEP SPGLEDPLLD AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK 450
    PPLADGEDWA GGLPWGGRSP GGVSESEAGS PLAGLDMDTF DSGFVGSDCS 500
    SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS 538
    Length:538
    Mass (Da):59,130
    Last modified:March 1, 2001 - v1
    Checksum:i414079CCB974850A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3861G → R in AAG23419. (PubMed:11016959)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 822Missing in IL21RID; loss of function mutation.
    VAR_069898
    Natural varianti191 – 1911R → C.1 Publication
    Corresponds to variant rs3093370 [ dbSNP | Ensembl ].
    VAR_014360
    Natural varianti201 – 2011R → L in IL21RID; loss of function mutation; the mutation results in defective trafficking of the protein, with misfolding, impaired processing and abnormal subcellular distribution rather than proper expression at the plasma membrane. 1 Publication
    VAR_069899
    Natural varianti318 – 3181S → R.1 Publication
    Corresponds to variant rs3093385 [ dbSNP | Ensembl ].
    VAR_014361
    Natural varianti484 – 4841G → S.1 Publication
    Corresponds to variant rs3093386 [ dbSNP | Ensembl ].
    VAR_014362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254067 mRNA. Translation: AAG29346.1.
    AF269133 mRNA. Translation: AAG23419.1.
    AY358826 mRNA. Translation: AAQ89185.1.
    AY064474 Genomic DNA. Translation: AAL39168.1.
    AK292663 mRNA. Translation: BAF85352.1.
    CH471145 Genomic DNA. Translation: EAW55746.1.
    CH471145 Genomic DNA. Translation: EAW55747.1.
    CH471145 Genomic DNA. Translation: EAW55748.1.
    BC004348 mRNA. Translation: AAH04348.1.
    BC007946 mRNA. Translation: AAH07946.2.
    CCDSiCCDS10630.1.
    RefSeqiNP_068570.1. NM_021798.3.
    NP_851564.1. NM_181078.2.
    NP_851565.4. NM_181079.4.
    UniGeneiHs.210546.

    Genome annotation databases

    EnsembliENST00000337929; ENSP00000338010; ENSG00000103522.
    ENST00000395754; ENSP00000379103; ENSG00000103522.
    ENST00000564089; ENSP00000456707; ENSG00000103522.
    GeneIDi50615.
    KEGGihsa:50615.
    UCSCiuc002doq.2. human.

    Polymorphism databases

    DMDMi20454997.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254067 mRNA. Translation: AAG29346.1 .
    AF269133 mRNA. Translation: AAG23419.1 .
    AY358826 mRNA. Translation: AAQ89185.1 .
    AY064474 Genomic DNA. Translation: AAL39168.1 .
    AK292663 mRNA. Translation: BAF85352.1 .
    CH471145 Genomic DNA. Translation: EAW55746.1 .
    CH471145 Genomic DNA. Translation: EAW55747.1 .
    CH471145 Genomic DNA. Translation: EAW55748.1 .
    BC004348 mRNA. Translation: AAH04348.1 .
    BC007946 mRNA. Translation: AAH07946.2 .
    CCDSi CCDS10630.1.
    RefSeqi NP_068570.1. NM_021798.3.
    NP_851564.1. NM_181078.2.
    NP_851565.4. NM_181079.4.
    UniGenei Hs.210546.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TGX X-ray 2.80 A/C/E/G/I/K/M/O 20-232 [» ]
    ProteinModelPortali Q9HBE5.
    SMRi Q9HBE5. Positions 20-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119095. 4 interactions.
    STRINGi 9606.ENSP00000338010.

    Polymorphism databases

    DMDMi 20454997.

    Proteomic databases

    MaxQBi Q9HBE5.
    PaxDbi Q9HBE5.
    PRIDEi Q9HBE5.

    Protocols and materials databases

    DNASUi 50615.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337929 ; ENSP00000338010 ; ENSG00000103522 .
    ENST00000395754 ; ENSP00000379103 ; ENSG00000103522 .
    ENST00000564089 ; ENSP00000456707 ; ENSG00000103522 .
    GeneIDi 50615.
    KEGGi hsa:50615.
    UCSCi uc002doq.2. human.

    Organism-specific databases

    CTDi 50615.
    GeneCardsi GC16P027413.
    H-InvDB HIX0012914.
    HGNCi HGNC:6006. IL21R.
    HPAi HPA042296.
    MIMi 605383. gene.
    615207. phenotype.
    neXtProti NX_Q9HBE5.
    Orphaneti 357329. Cryptosporidiosis - chronic cholangitis - liver disease.
    PharmGKBi PA29821.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40447.
    HOGENOMi HOG000013192.
    HOVERGENi HBG052105.
    InParanoidi Q9HBE5.
    KOi K05075.
    OMAi RDRPYGL.
    OrthoDBi EOG767398.
    PhylomeDBi Q9HBE5.
    TreeFami TF337874.

    Enzyme and pathway databases

    SignaLinki Q9HBE5.

    Miscellaneous databases

    GeneWikii Interleukin-21_receptor.
    GenomeRNAii 50615.
    NextBioi 53120.
    PROi Q9HBE5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HBE5.
    CleanExi HS_IL21R.
    Genevestigatori Q9HBE5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain."
      Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J.
      Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. SeattleSNPs variation discovery resource
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-191; ARG-318 AND SER-484.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell and Lymph.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    9. "The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma."
      Ueda C., Akasaka T., Kurata M., Maesako Y., Nishikori M., Ichinohasama R., Imada K., Uchiyama T., Ohno H.
      Oncogene 21:368-376(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN B-CELL NON-HODGKIN LYMPHOMA, CHROMOSOMAL TRANSLOCATION WITH BCL6.
    10. "Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R."
      Hamming O.J., Kang L., Svensson A., Karlsen J.L., Rahbek-Nielsen H., Paludan S.R., Hjorth S.A., Bondensgaard K., Hartmann R.
      J. Biol. Chem. 287:9454-9460(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 20-232 IN COMPLEX WITH IL21, DOMAIN WSXWS MOTIF, GLYCOSYLATION AT ASN-73 AND TRP-214, DOMAINS FIBRONECTIN, DISULFIDE BONDS.
    11. Cited for: VARIANTS IL21RID 81-CYS-HIS-82 DEL AND LEU-201, CHARACTERIZATION VARIANT IL21RID LEU-201.

    Entry informationi

    Entry nameiIL21R_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBE5
    Secondary accession number(s): A8K9E8
    , D3DWF7, Q96HZ1, Q9HB91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3