Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HBE4

- IL21_HUMAN

UniProt

Q9HBE4 - IL21_HUMAN

Protein

Interleukin-21

Gene

IL21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.By similarity2 Publications

    GO - Molecular functioni

    1. cytokine receptor binding Source: UniProtKB
    2. interleukin-2 receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell maturation Source: UniProtKB
    2. immune response Source: InterPro
    3. positive regulation of B cell proliferation Source: MGI
    4. positive regulation of cell proliferation Source: MGI
    5. positive regulation of inflammatory response Source: BHF-UCL
    6. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    7. positive regulation of interleukin-10 production Source: Ensembl
    8. positive regulation of interleukin-17 production Source: BHF-UCL
    9. positive regulation of natural killer cell cytokine production Source: Ensembl
    10. positive regulation of natural killer cell differentiation Source: Ensembl
    11. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
    12. positive regulation of T cell proliferation Source: UniProtKB
    13. positive regulation of tissue remodeling Source: BHF-UCL
    14. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
    15. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
    16. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiQ9HBE4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21
    Short name:
    IL-21
    Alternative name(s):
    Za11
    Gene namesi
    Name:IL21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:6005. IL21.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29820.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 155133Interleukin-21PRO_0000015505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 115
    Disulfide bondi71 ↔ 118
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9HBE4.
    PRIDEiQ9HBE4.

    Expressioni

    Tissue specificityi

    Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.1 Publication

    Gene expression databases

    BgeeiQ9HBE4.
    CleanExiHS_IL21.
    GenevestigatoriQ9HBE4.

    Interactioni

    Protein-protein interaction databases

    BioGridi121857. 2 interactions.
    IntActiQ9HBE4. 2 interactions.
    MINTiMINT-8201759.
    STRINGi9606.ENSP00000264497.

    Structurei

    Secondary structure

    1
    155
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi25 – 4218
    Helixi43 – 486
    Helixi62 – 643
    Helixi65 – 7410
    Helixi85 – 9612
    Beta strandi101 – 1055
    Beta strandi107 – 1093
    Beta strandi113 – 1153
    Turni118 – 1203
    Helixi126 – 14217

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OQPNMR-A23-155[»]
    3TGXX-ray2.80B/D/F/H/J/L/N/P23-155[»]
    ProteinModelPortaliQ9HBE4.
    SMRiQ9HBE4. Positions 23-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HBE4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40525.
    HOGENOMiHOG000113039.
    HOVERGENiHBG052106.
    InParanoidiQ9HBE4.
    KOiK05434.
    OrthoDBiEOG7M98JN.
    PhylomeDBiQ9HBE4.
    TreeFamiTF336380.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view]
    PANTHERiPTHR14356. PTHR14356. 1 hit.
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBE4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERIVICLMV IFLGTLVHKS SSQGQDRHMI RMRQLIDIVD QLKNYVNDLV    50
    PEFLPAPEDV ETNCEWSAFS CFQKAQLKSA NTGNNERIIN VSIKKLKRKP 100
    PSTNAGRRQK HRLTCPSCDS YEKKPPKEFL ERFKSLLQKM IHQHLSSRTH 150
    GSEDS 155
    Length:155
    Mass (Da):17,923
    Last modified:November 23, 2004 - v2
    Checksum:iE994A3D19029B914
    GO
    Isoform 2 (identifier: Q9HBE4-2) [UniParc]FASTAAdd to Basket

    Also known as: IL-21iso

    The sequence of this isoform differs from the canonical sequence as follows:
         140-155: MIHQHLSSRTHGSEDS → VSTLSFI

    Show »
    Length:146
    Mass (Da):16,867
    Checksum:iCCC4D7F9602AD06A
    GO

    Sequence cautioni

    The sequence AAG29348.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH66258.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH66259.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH66260.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH66261.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH66262.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH69124.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAU88182.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ABG36529.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei140 – 15516MIHQH…GSEDS → VSTLSFI in isoform 2. 1 PublicationVSP_030129Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254069 mRNA. Translation: AAG29348.1. Different initiation.
    DQ645417 mRNA. Translation: ABG36529.1. Different initiation.
    AY763518 Genomic DNA. Translation: AAU88182.1. Different initiation.
    AC053545 Genomic DNA. No translation available.
    BC066258 mRNA. Translation: AAH66258.1. Different initiation.
    BC066259 mRNA. Translation: AAH66259.1. Different initiation.
    BC066260 mRNA. Translation: AAH66260.1. Different initiation.
    BC066261 mRNA. Translation: AAH66261.1. Different initiation.
    BC066262 mRNA. Translation: AAH66262.1. Different initiation.
    BC069124 mRNA. Translation: AAH69124.1. Different initiation.
    RefSeqiNP_001193935.1. NM_001207006.2.
    NP_068575.1. NM_021803.3.
    UniGeneiHs.567559.

    Genome annotation databases

    EnsembliENST00000264497; ENSP00000264497; ENSG00000138684.
    GeneIDi59067.
    KEGGihsa:59067.
    UCSCiuc003ies.3. human. [Q9HBE4-1]
    uc010int.4. human. [Q9HBE4-2]

    Polymorphism databases

    DMDMi55976599.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254069 mRNA. Translation: AAG29348.1 . Different initiation.
    DQ645417 mRNA. Translation: ABG36529.1 . Different initiation.
    AY763518 Genomic DNA. Translation: AAU88182.1 . Different initiation.
    AC053545 Genomic DNA. No translation available.
    BC066258 mRNA. Translation: AAH66258.1 . Different initiation.
    BC066259 mRNA. Translation: AAH66259.1 . Different initiation.
    BC066260 mRNA. Translation: AAH66260.1 . Different initiation.
    BC066261 mRNA. Translation: AAH66261.1 . Different initiation.
    BC066262 mRNA. Translation: AAH66262.1 . Different initiation.
    BC069124 mRNA. Translation: AAH69124.1 . Different initiation.
    RefSeqi NP_001193935.1. NM_001207006.2.
    NP_068575.1. NM_021803.3.
    UniGenei Hs.567559.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OQP NMR - A 23-155 [» ]
    3TGX X-ray 2.80 B/D/F/H/J/L/N/P 23-155 [» ]
    ProteinModelPortali Q9HBE4.
    SMRi Q9HBE4. Positions 23-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121857. 2 interactions.
    IntActi Q9HBE4. 2 interactions.
    MINTi MINT-8201759.
    STRINGi 9606.ENSP00000264497.

    Polymorphism databases

    DMDMi 55976599.

    Proteomic databases

    PaxDbi Q9HBE4.
    PRIDEi Q9HBE4.

    Protocols and materials databases

    DNASUi 59067.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264497 ; ENSP00000264497 ; ENSG00000138684 .
    GeneIDi 59067.
    KEGGi hsa:59067.
    UCSCi uc003ies.3. human. [Q9HBE4-1 ]
    uc010int.4. human. [Q9HBE4-2 ]

    Organism-specific databases

    CTDi 59067.
    GeneCardsi GC04M123534.
    H-InvDB HIX0031753.
    HGNCi HGNC:6005. IL21.
    MIMi 605384. gene.
    neXtProti NX_Q9HBE4.
    PharmGKBi PA29820.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40525.
    HOGENOMi HOG000113039.
    HOVERGENi HBG052106.
    InParanoidi Q9HBE4.
    KOi K05434.
    OrthoDBi EOG7M98JN.
    PhylomeDBi Q9HBE4.
    TreeFami TF336380.

    Enzyme and pathway databases

    SignaLinki Q9HBE4.

    Miscellaneous databases

    EvolutionaryTracei Q9HBE4.
    GeneWikii Interleukin_21.
    GenomeRNAii 59067.
    NextBioi 65134.
    PROi Q9HBE4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HBE4.
    CleanExi HS_IL21.
    Genevestigatori Q9HBE4.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view ]
    PANTHERi PTHR14356. PTHR14356. 1 hit.
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Cloning and characterization of an isoform of interleukin-21."
      Rahman M., Nara H., Onoda T., Araki A., Li J., Hoshino T., Asao H.
      FEBS Lett. 581:4001-4009(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. SeattleSNPs variation discovery resource
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells."
      Strengell M., Julkunen I., Matikainen S.
      J. Leukoc. Biol. 76:416-422(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses."
      Sivakumar P.V., Foster D.C., Clegg C.H.
      Immunology 112:177-182(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue."
      Bondensgaard K., Breinholt J., Madsen D., Omkvist D.H., Kang L., Worsaae A., Becker P., Schioedt C.B., Hjorth S.A.
      J. Biol. Chem. 282:23326-23336(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 23-155, DISULFIDE BONDS.
    9. "Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R."
      Hamming O.J., Kang L., Svensson A., Karlsen J.L., Rahbek-Nielsen H., Paludan S.R., Hjorth S.A., Bondensgaard K., Hartmann R.
      J. Biol. Chem. 287:9454-9460(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 23-155 IN COMPLEX WITH IL21R, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL21_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBE4
    Secondary accession number(s): A5J0L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3