PATZ1

Functionⁱ

Transcriptional repressor.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	264 – 276	A.T hookAdd BLAST	13
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	413 – 436	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	442 – 464	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	495 – 518	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	605 – 628	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10949935
metal ion binding Source: UniProtKB-KW
RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

male gonad development Source: Ensembl
negative regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 10713105
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 10713105
spermatogenesis Source: Ensembl
T cell differentiation Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q9HBE1.

SIGNORⁱ

Q9HBE1.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POZ-, AT hook-, and zinc finger-containing protein 1 Alternative name(s): BTB/POZ domain zinc finger transcription factor Protein kinase A RI subunit alpha-associated protein Zinc finger and BTB domain-containing protein 19 Zinc finger protein 278 Zinc finger sarcoma gene protein
Gene namesⁱ	Name:PATZ1 Synonyms:PATZ, RIAZ, ZBTB19, ZNF278, ZSG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13071. PATZ1.

HGNCⁱ

HGNC:13071. PATZ1.

Subcellular locationⁱ

Nucleus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor."
  Fedele M., Benvenuto G., Pero R., Majello B., Battista S., Lembo F., Vollono E., Day P.M., Santoro M., Lania L., Bruni C.B., Fusco A., Chiatiotti L.
  J. Biol. Chem. 275:7894-7901(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH RNF4.

GO - Cellular componentⁱ

nucleoplasm Source: HPA
nucleus
Source: UniProtKB
Traceable author statementⁱ
- 10713105

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.1 Publication

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23598.
Open Targets More...OpenTargetsⁱ	ENSG00000100105.
PharmGKBⁱ	PA162398806.

Polymorphism and mutation databases

BioMutaⁱ	PATZ1.
DMDMⁱ	38258840.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047504	1 – 687	POZ-, AT hook-, and zinc finger-containing protein 1Add BLAST		687

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	112	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	272	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	282	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9HBE1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HBE1.
PaxDbⁱ	Q9HBE1.
PeptideAtlas More...PeptideAtlasⁱ	Q9HBE1.
PRIDEⁱ	Q9HBE1.

PTM databases

iPTMnetⁱ	Q9HBE1.
PhosphoSitePlusⁱ	Q9HBE1.

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000100105.
CleanExⁱ	HS_PATZ1.
ExpressionAtlasⁱ	Q9HBE1. baseline and differential.
Genevisibleⁱ	Q9HBE1. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047893. HPA048315.

HPAⁱ

HPA047893.
HPA048315.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HNRNPF	P52597	4	EBI-11022007,EBI-352986
HNRNPH1	P31943	4	EBI-11022007,EBI-351590
LURAP1L	Q8IV03	4	EBI-11022007,EBI-12898559
NHLRC4	P0CG21	4	EBI-11022007,EBI-12868744
PPP1R37	O75864	4	EBI-11022007,EBI-5235692
RBPMS	Q93062-3	5	EBI-11022007,EBI-740343
TRAF1	Q13077	4	EBI-11022007,EBI-359224

Show more details

Protein-protein interaction databases

BioGridⁱ	117133. 38 interactors.
IntActⁱ	Q9HBE1. 74 interactors.
STRINGⁱ	9606.ENSP00000266269.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	295 – 297	Combined sources	3
Helixⁱ	304 – 314	Combined sources	11
Turnⁱ	315 – 317	Combined sources	3
Beta strandⁱ	354 – 357	Combined sources	4
Turnⁱ	358 – 361	Combined sources	4
Beta strandⁱ	362 – 366	Combined sources	5
Helixⁱ	367 – 373	Combined sources	7
Helixⁱ	374 – 376	Combined sources	3
Beta strandⁱ	382 – 385	Combined sources	4
Turnⁱ	386 – 389	Combined sources	4
Beta strandⁱ	391 – 393	Combined sources	3
Helixⁱ	395 – 405	Combined sources	11
Beta strandⁱ	411 – 413	Combined sources	3
Beta strandⁱ	416 – 418	Combined sources	3
Beta strandⁱ	421 – 424	Combined sources	4
Helixⁱ	425 – 434	Combined sources	10

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EPP	NMR	-	A	286-338	[»]
	2EPQ	NMR	-	A	380-411	[»]
	2EPR	NMR	-	A	350-384	[»]
	2EPS	NMR	-	A	408-445	[»]
	2YT9	NMR	-	A	355-436	[»]
ProteinModelPortalⁱ	Q9HBE1.
SMRⁱ	Q9HBE1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9HBE1.

EvolutionaryTraceⁱ

Q9HBE1.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 130	BTBPROSITE-ProRule annotationAdd BLAST		90

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	413 – 436	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	442 – 464	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	495 – 518	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	605 – 628	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063522.
HOGENOMⁱ	HOG000037943.
HOVERGENⁱ	HBG056645.
InParanoidⁱ	Q9HBE1.
OMAⁱ	LDSMMFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04OT.
PhylomeDBⁱ	Q9HBE1.
TreeFamⁱ	TF331686.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR000637. HMGI/Y_DNA-bd_CS. IPR011333. SKP1/BTB/POZ. IPR013087. Znf_C2H2_type. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651. BTB. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 8 hits.
SUPFAMⁱ	SSF54695. SSF54695. 2 hits. SSF57667. SSF57667. 4 hits.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit. PS00354. HMGI_Y. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9HBE1-1) [UniParc]FASTA Add to basket

Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE 
        60         70         80         90        100
SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG 
       110        120        130        140        150
SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE 
       160        170        180        190        200
ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN 
       210        220        230        240        250
GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP 
       260        270        280        290        300
FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 
       310        320        330        340        350
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR 
       360        370        380        390        400
TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY 
       410        420        430        440        450
HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQTCNAS 
       460        470        480        490        500
FATRDRLRSH LACHEDKVPC QVCGKYLRAA YMADHLKKHS EGPSNFCSIC 
       510        520        530        540        550
NRGFSSASYL KVHVKTHHGV PLPQVSRHQE PILNGGAAFH CARTYGNKEG 
       560        570        580        590        600
QKCSHQDPIE SSDSYGDLSD ASDLKTPEKQ SANGSFSCDM AVPKNKMESD 
       610        620        630        640        650
GEKKYPCPEC GSFFRSKSYL NKHIQKVHVR ALGGPLGDLG PALGSPFSPQ 
       660        670        680 
QNMSLLESFG FQIVQSAFAS SLVDPEVDQQ PMGPEGK

Length:687

Mass (Da):74,060

Last modified:March 1, 2001 - v1

Checksum:ⁱ0F1C59A78C6D110A

GO

Isoform 2 (identifier: Q9HBE1-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
504-537: FSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGA → LQAPGAHPEWGSSVPLRQDLWQQRRPEMLTSGSD
538-687: Missing.

« Hide

        10         20         30         40         50
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE 
        60         70         80         90        100
SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG 
       110        120        130        140        150
SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE 
       160        170        180        190        200
ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN 
       210        220        230        240        250
GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP 
       260        270        280        290        300
FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 
       310        320        330        340        350
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR 
       360        370        380        390        400
TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY 
       410        420        430        440        450
HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQTCNAS 
       460        470        480        490        500
FATRDRLRSH LACHEDKVPC QVCGKYLRAA YMADHLKKHS EGPSNFCSIC 
       510        520        530 
NRGLQAPGAH PEWGSSVPLR QDLWQQRRPE MLTSGSD

Show »

Length:537

Mass (Da):57,995

Checksum:ⁱ950792413BF1F5DB

GO

Isoform 3 (identifier: Q9HBE1-3) [UniParc]FASTA Add to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
503-548: Missing.

« Hide

        10         20         30         40         50
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE 
        60         70         80         90        100
SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG 
       110        120        130        140        150
SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE 
       160        170        180        190        200
ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN 
       210        220        230        240        250
GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP 
       260        270        280        290        300
FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 
       310        320        330        340        350
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR 
       360        370        380        390        400
TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY 
       410        420        430        440        450
HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQTCNAS 
       460        470        480        490        500
FATRDRLRSH LACHEDKVPC QVCGKYLRAA YMADHLKKHS EGPSNFCSIC 
       510        520        530        540        550
NREGQKCSHQ DPIESSDSYG DLSDASDLKT PEKQSANGSF SCDMAVPKNK 
       560        570        580        590        600
MESDGEKKYP CPECGSFFRS KSYLNKHIQK VHVRALGGPL GDLGPALGSP 
       610        620        630        640 
FSPQQNMSLL ESFGFQIVQS AFASSLVDPE VDQQPMGPEG K

Show »

Length:641

Mass (Da):69,079

Checksum:ⁱ29515535E380F0CE

GO

Isoform 4 (identifier: Q9HBE1-4) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
446-537: TCNASFATRD...HQEPILNGGA → VWVGSSSGLP...SRAFTQWPVG
538-687: Missing.

« Hide

        10         20         30         40         50
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE 
        60         70         80         90        100
SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG 
       110        120        130        140        150
SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE 
       160        170        180        190        200
ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN 
       210        220        230        240        250
GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP 
       260        270        280        290        300
FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 
       310        320        330        340        350
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR 
       360        370        380        390        400
TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY 
       410        420        430        440        450
HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQVWVGS 
       460        470        480        490        500
SSGLPPLEPL PSDLPSWDFA QPALWRSSHS VPDTAFSLSL KKSFPALENL 
       510        520        530 
GPAHSSNTLF CPAPPGYLRQ GWTTPEGSRA FTQWPVG

Show »

Length:537

Mass (Da):57,601

Checksum:ⁱBA4A909E24800F13

GO

Sequence cautionⁱ

The sequence CAB51404 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	S → N in AAF32518 (PubMed:10713105).Curated	1
Sequence conflictⁱ	259	P → L in AAF32518 (PubMed:10713105).Curated	1
Sequence conflictⁱ	394	R → K in AAF32518 (PubMed:10713105).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052724	685	E → D. Corresponds to variant dbSNP:rs2240424Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_008802	446 – 537	TCNAS…LNGGA → VWVGSSSGLPPLEPLPSDLP SWDFAQPALWRSSHSVPDTA FSLSLKKSFPALENLGPAHS SNTLFCPAPPGYLRQGWTTP EGSRAFTQWPVG in isoform 4. 3 PublicationsAdd BLAST	92
Alternative sequenceⁱVSP_008801	503 – 548	Missing in isoform 3. 3 PublicationsAdd BLAST	46
Alternative sequenceⁱVSP_008799	504 – 537	FSSAS…LNGGA → LQAPGAHPEWGSSVPLRQDL WQQRRPEMLTSGSD in isoform 2. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_008800	538 – 687	Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST	150

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119256 mRNA. Translation: AAF32518.1. AF254082 mRNA. Translation: AAG09031.1. AF254083 mRNA. Translation: AAG09032.1. AF254084 mRNA. Translation: AAG09033.1. AF254085 mRNA. Translation: AAG09034.1. AY028384 mRNA. Translation: AAK19024.1. AL096880 mRNA. Translation: CAB51404.1. Different initiation. CR456613 mRNA. Translation: CAG30499.1. AC005003 Genomic DNA. Translation: AAF01349.1. BC021091 mRNA. Translation: AAH21091.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13894.1. [Q9HBE1-1] CCDS13895.1. [Q9HBE1-3] CCDS13896.1. [Q9HBE1-4] CCDS46691.1. [Q9HBE1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055138.2. NM_014323.2. [Q9HBE1-1] NP_114439.1. NM_032050.1. [Q9HBE1-3] NP_114440.1. NM_032051.1. [Q9HBE1-4] NP_114441.1. NM_032052.1. [Q9HBE1-2]
UniGeneⁱ	Hs.731398.

Genome annotation databases

Ensemblⁱ	ENST00000215919; ENSP00000215919; ENSG00000100105. [Q9HBE1-4] ENST00000266269; ENSP00000266269; ENSG00000100105. [Q9HBE1-1] ENST00000351933; ENSP00000337520; ENSG00000100105. [Q9HBE1-3] ENST00000405309; ENSP00000384173; ENSG00000100105. [Q9HBE1-2]
GeneIDⁱ	23598.
KEGGⁱ	hsa:23598.
UCSC genome browser More...UCSCⁱ	uc003akp.4. human. [Q9HBE1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9HBE1	A0A024R1M5 B0KWS7 Q9HD72	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset)	687	UniRef100_Q9HBE1	Cluster: POZ-, AT hook-, and zinc finger-containing protein 1	4
Q9HBE1-2	A0A024R1H7 U3CBQ4	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset)	537	UniRef100_A0A024R1H7	Cluster: Zinc finger protein 278, isoform CRA_b	3
Q9HBE1-3	A0A024R1F8 U3CA44	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset)	641	UniRef100_A0A024R1F8	Cluster: Zinc finger protein 278, isoform CRA_d	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9HBE1	A0A024R1M5 B0KWS7 Q9HD72 UPI000A28029C UPI0003330EAA UPI000395A36B UPI00071A6D51 UPI000B4D9DD2 F7H721 E1C1B9 +95	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Phascolarctos cinereus (Koala) Jaculus jaculus (Lesser Egyptian jerboa) Pseudopodoces humilis (Tibetan ground jay) (Podoces humilis) Sturnus vulgaris (Starling) Lonchura striata domestica (Bengalese finch) Gallus gallus (Chicken) Coturnix japonica (Japanese quail) (Coturnix coturnix japonica) Numida meleagris (Helmeted guineafowl) (Phasianus meleagris) And more	687	UniRef90_Q9HBE1	Cluster: POZ-, AT hook-, and zinc finger-containing protein 1	106
Q9HBE1-2	Q5NBZ1 UPI000333236E UPI000947E805 UPI0005776C9E UPI000653E64C A0A1A6HGE6 UPI00042C8948 S9WY89 UPI000332F7D7 UPI0005AC43A1 +51	Mus musculus (Mouse) Jaculus jaculus (Lesser Egyptian jerboa) Ailuropoda melanoleuca (Giant panda) Bison bison bison Mustela putorius furo (European domestic ferret) (Mustela furo) Neotoma lepida (Desert woodrat) Physeter catodon (Sperm whale) (Physeter macrocephalus) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Felis catus (Cat) (Felis silvestris catus) Dasypus novemcinctus (Nine-banded armadillo) And more	537	UniRef90_Q5NBZ1	Cluster: POZ (BTB) and AT hook-containing zinc finger 1	62
Q9HBE1-3	Q9JMG9 Q78I23 F1RPB9 I3L5L6 Q59HH1 F1P9P3 U6DRS0 M3X6P9 F6QU89 UPI000155ED29 +59	Mus musculus (Mouse) Sus scrofa (Pig) Homo sapiens (Human) Canis lupus familiaris (Dog) (Canis familiaris) Neovison vison (American mink) (Mustela vison) Felis catus (Cat) (Felis silvestris catus) Equus caballus (Horse) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) And more	641	UniRef90_Q9JMG9	Cluster: POZ (BTB) and AT hook-containing zinc finger 1	70
Q9HBE1-4	UPI000333357D UPI00032ADBCB A8K6Y8 H9FS92 K7B838 U3BQF6 F7E180 L5L5Y8 A0A1U7T9A9 Q5NBZ2 +62	Jaculus jaculus (Lesser Egyptian jerboa) Ochotona princeps (Southern American pika) Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset) Pteropus alecto (Black flying fox) Tarsius syrichta (Philippine tarsier) Mus musculus (Mouse) Dipodomys ordii (Ord's kangaroo rat) And more	537	UniRef90_Q9HBE1-4	Cluster: Isoform 4 of POZ-, AT hook-, and zinc finger-containing protein 1	73

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9HBE1	A0A024R1M5 B0KWS7 Q9HD72 UPI000A28029C UPI0003330EAA UPI000395A36B UPI000B4D9DD2 UPI00071A6D51 UPI000B3DD853 F7H721 +255	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Phascolarctos cinereus (Koala) Jaculus jaculus (Lesser Egyptian jerboa) Pseudopodoces humilis (Tibetan ground jay) (Podoces humilis) Lonchura striata domestica (Bengalese finch) Sturnus vulgaris (Starling) Numida meleagris (Helmeted guineafowl) (Phasianus meleagris) Coturnix japonica (Japanese quail) (Coturnix coturnix japonica) Gallus gallus (Chicken) And more	687	UniRef50_Q9HBE1	Cluster: POZ-, AT hook-, and zinc finger-containing protein 1	266
Q9HBE1-2	Q9HBE1-4 UPI000333357D UPI00032ADBCB UPI00005A497A UPI0003F06D62 UPI0005331EAF UPI000B4F7D4A UPI0004D06984 UPI000642E052 UPI000980A027 +142	Jaculus jaculus (Lesser Egyptian jerboa) Ochotona princeps (Southern American pika) Odobenus rosmarus divergens (Pacific walrus) Elephantulus edwardii (Cape long-eared elephant shrew) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Castor canadensis (Beaver) Sus scrofa (Pig) And more	537	UniRef50_Q9HBE1-4	Cluster: Isoform 4 of POZ-, AT hook-, and zinc finger-containing protein 1	153
Q9HBE1-4	UPI000333357D UPI00032ADBCB UPI00005A497A UPI0003F06D62 UPI0005331EAF UPI000B4F7D4A UPI0004D06984 UPI000642E052 UPI000980A027 UPI00022CEC37 +142	Jaculus jaculus (Lesser Egyptian jerboa) Ochotona princeps (Southern American pika) Odobenus rosmarus divergens (Pacific walrus) Elephantulus edwardii (Cape long-eared elephant shrew) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Castor canadensis (Beaver) Sus scrofa (Pig) And more	537	UniRef50_Q9HBE1-4	Cluster: Isoform 4 of POZ-, AT hook-, and zinc finger-containing protein 1	153

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119256 mRNA. Translation: AAF32518.1. AF254082 mRNA. Translation: AAG09031.1. AF254083 mRNA. Translation: AAG09032.1. AF254084 mRNA. Translation: AAG09033.1. AF254085 mRNA. Translation: AAG09034.1. AY028384 mRNA. Translation: AAK19024.1. AL096880 mRNA. Translation: CAB51404.1. Different initiation. CR456613 mRNA. Translation: CAG30499.1. AC005003 Genomic DNA. Translation: AAF01349.1. BC021091 mRNA. Translation: AAH21091.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13894.1. [Q9HBE1-1] CCDS13895.1. [Q9HBE1-3] CCDS13896.1. [Q9HBE1-4] CCDS46691.1. [Q9HBE1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055138.2. NM_014323.2. [Q9HBE1-1] NP_114439.1. NM_032050.1. [Q9HBE1-3] NP_114440.1. NM_032051.1. [Q9HBE1-4] NP_114441.1. NM_032052.1. [Q9HBE1-2]
UniGeneⁱ	Hs.731398.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EPP	NMR	-	A	286-338	[»]
	2EPQ	NMR	-	A	380-411	[»]
	2EPR	NMR	-	A	350-384	[»]
	2EPS	NMR	-	A	408-445	[»]
	2YT9	NMR	-	A	355-436	[»]
ProteinModelPortalⁱ	Q9HBE1.
SMRⁱ	Q9HBE1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117133. 38 interactors.
IntActⁱ	Q9HBE1. 74 interactors.
STRINGⁱ	9606.ENSP00000266269.

PTM databases

iPTMnetⁱ	Q9HBE1.
PhosphoSitePlusⁱ	Q9HBE1.

Polymorphism and mutation databases

BioMutaⁱ	PATZ1.
DMDMⁱ	38258840.

Proteomic databases

EPDⁱ	Q9HBE1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HBE1.
PaxDbⁱ	Q9HBE1.
PeptideAtlas More...PeptideAtlasⁱ	Q9HBE1.
PRIDEⁱ	Q9HBE1.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23598.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000215919; ENSP00000215919; ENSG00000100105. [Q9HBE1-4] ENST00000266269; ENSP00000266269; ENSG00000100105. [Q9HBE1-1] ENST00000351933; ENSP00000337520; ENSG00000100105. [Q9HBE1-3] ENST00000405309; ENSP00000384173; ENSG00000100105. [Q9HBE1-2]
GeneIDⁱ	23598.
KEGGⁱ	hsa:23598.
UCSC genome browser More...UCSCⁱ	uc003akp.4. human. [Q9HBE1-1]

Organism-specific databases

CTDⁱ	23598.
DisGeNET More...DisGeNETⁱ	23598.
GeneCardsⁱ	PATZ1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13071. PATZ1.
Human Protein Atlas More...HPAⁱ	HPA047893. HPA048315.
MIMⁱ	605165. gene.
neXtProtⁱ	NX_Q9HBE1.
Open Targets More...OpenTargetsⁱ	ENSG00000100105.
PharmGKBⁱ	PA162398806.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063522.
HOGENOMⁱ	HOG000037943.
HOVERGENⁱ	HBG056645.
InParanoidⁱ	Q9HBE1.
OMAⁱ	LDSMMFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04OT.
PhylomeDBⁱ	Q9HBE1.
TreeFamⁱ	TF331686.

Enzyme and pathway databases

SIGNORⁱ	Q9HBE1.

SIGNORⁱ

Q9HBE1.

Miscellaneous databases

ChiTaRSⁱ	PATZ1. human.
EvolutionaryTraceⁱ	Q9HBE1.
GeneWikiⁱ	PATZ1.
GenomeRNAiⁱ	23598.
Protein Ontology More...PROⁱ	PR:Q9HBE1.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100105.
CleanExⁱ	HS_PATZ1.
ExpressionAtlasⁱ	Q9HBE1. baseline and differential.
Genevisibleⁱ	Q9HBE1. HS.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR000637. HMGI/Y_DNA-bd_CS. IPR011333. SKP1/BTB/POZ. IPR013087. Znf_C2H2_type. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651. BTB. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 8 hits.
SUPFAMⁱ	SSF54695. SSF54695. 2 hits. SSF57667. SSF57667. 4 hits.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit. PS00354. HMGI_Y. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PATZ1_HUMAN
Accessionⁱ	Q9HBE1Primary (citable) accession number: Q9HBE1 Secondary accession number(s): Q9HBE2 , Q9HBE3, Q9P1A9, Q9UDU0, Q9Y529
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
	Last sequence update:	March 1, 2001
	Last modified:	August 30, 2017
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9HBE1 (PATZ1_HUMAN)

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POZ-, AT hook-, and zinc finger-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ