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Q9HBD1 (RC3H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Roquin-2
Alternative name(s):
Membrane-associated nucleic acid-binding protein
RING finger and CCCH-type zinc finger domain-containing protein 2
RING finger protein 164
Gene names
Name:RC3H2
Synonyms:MNAB, RNF164
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1191 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs By similarity. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs By similarity. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity By similarity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression By similarity. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation By similarity.

Subunit structure

Interacts with EDC4 By similarity. Interacts with CCR4-NOT deadenylase complex By similarity.

Subcellular location

CytoplasmP-body By similarity. Note: During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger. Ref.8

Tissue specificity

Expressed in spleen, testis, ovary and small intestine. Ref.1

Domain

The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies By similarity.

The ROQ region is required for CDE RNA-binding By similarity. It may also be involved in localization to stress granules By similarity.

Miscellaneous

The RING finger is highly conserved among the paralogs and among species, suggesting it may possess E3 ubiquitin ligase activity. A C. elegans homolog, rle-1, is involved in daf-16 ubiquitin-dependent degradation. Although such an activity has not be observed in mammalian cells so far, it is conceivable that RC3H2 may utilize E3 ubiquitin ligase activity in the promotion of mRNA decay (Ref.10).

Sequence similarities

Contains 1 C3H1-type zinc finger.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence BAA91340.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB15634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HBD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HBD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     454-478: VRTFPLLNKVGVNNTVTTTAGNVIS → EVLKQQGKLFQVQTEFQMQKTVFPS
     479-1191: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9HBD1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     443-506: YRLRNKKINA...SNAENSVSQL → CNPRGLYLHC...SPLEEPREED
     507-1191: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9HBD1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY
Isoform 5 (identifier: Q9HBD1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: AMQEEALKLVLLALEDGSALSRKV → GKIGYYLTFFISYWGLRMPISGAR
     219-1191: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q9HBD1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11911191Roquin-2
PRO_0000055968

Regions

Zinc finger14 – 5441RING-type; degenerate
Zinc finger410 – 43829C3H1-type
Region178 – 22952ROQ
Compositional bias576 – 704129Pro-rich

Amino acid modifications

Modified residue5491Phosphoserine Ref.7
Modified residue8081Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 195195Missing in isoform 6.
VSP_015017
Alternative sequence195 – 21824AMQEE…LSRKV → GKIGYYLTFFISYWGLRMPI SGAR in isoform 5.
VSP_015018
Alternative sequence219 – 1191973Missing in isoform 5.
VSP_015019
Alternative sequence443 – 50664YRLRN…SVSQL → CNPRGLYLHCCLLSSVASLG TVHNELYKQQHCDREKISVC AVKRAETCFSSQFFSPLEEP REED in isoform 3.
VSP_015020
Alternative sequence454 – 47825VRTFP…GNVIS → EVLKQQGKLFQVQTEFQMQK TVFPS in isoform 2.
VSP_015021
Alternative sequence479 – 1191713Missing in isoform 2.
VSP_015022
Alternative sequence507 – 1191685Missing in isoform 3.
VSP_015023
Alternative sequence1040 – 1191152LQSDY…KMVNS → VKKLNLSASCLMYLFSAAAS WLYHY in isoform 4 and isoform 6.
VSP_015024

Experimental info

Sequence conflict6501A → G in BAA91073. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 93633D8D83DC7409

FASTA1,191131,669
        10         20         30         40         50         60 
MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 

        70         80         90        100        110        120 
IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 

       130        140        150        160        170        180 
LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 

       190        200        210        220        230        240 
WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG 

       250        260        270        280        290        300 
HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW 

       310        320        330        340        350        360 
SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI 

       370        380        390        400        410        420 
DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR 

       430        440        450        460        470        480 
QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATVRTFPLL NKVGVNNTVT TTAGNVISVI 

       490        500        510        520        530        540 
GSTETTGKIV PSTNGISNAE NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD 

       550        560        570        580        590        600 
SVTENKIGSP PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ 

       610        620        630        640        650        660 
DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA SMPYADHYST 

       670        680        690        700        710        720 
FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI WRPPMYQRDD IIRSNSLPPM 

       730        740        750        760        770        780 
DVMHSSVYQT SLRERYNSLD GYYSVACQPP SEPRTTVPLP REPCGHLKTS CEEQIRRKPD 

       790        800        810        820        830        840 
QWAQYHTQKA PLVSSTLPVA TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS 

       850        860        870        880        890        900 
CGTIGSCINA IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP 

       910        920        930        940        950        960 
IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR WSSYGNEATS 

       970        980        990       1000       1010       1020 
SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL LLQREANALA MQQKWNSLDE 

      1030       1040       1050       1060       1070       1080 
GRHLTLNLLS KEIELRNGEL QSDYTEDATD TKPDRDIELE LSALDTDEPD GQSEPIEEIL 

      1090       1100       1110       1120       1130       1140 
DIQLGISSQN DQLLNGMAVE NGHPVQQHQK EPPKQKKQSL GEDHVILEEQ KTILPVTSCF 

      1150       1160       1170       1180       1190 
SQPLPVSISN ASCLPITTSV SAGNLILKTH VMSEDKNDFL KPVANGKMVN S 

« Hide

Isoform 2 [UniParc].

Checksum: D6233E801430829F
Show »

FASTA47853,877
Isoform 3 [UniParc].

Checksum: F2915DA0B8D0AC9E
Show »

FASTA50656,853
Isoform 4 [UniParc].

Checksum: 090E3F438698A35B
Show »

FASTA1,064117,917
Isoform 5 [UniParc].

Checksum: 91A1FAB4AAE5D91B
Show »

FASTA21824,282
Isoform 6 [UniParc].

Checksum: 56BCB1D341B35899
Show »

FASTA86996,362

References

« Hide 'large scale' references
[1]"A human gene coding for a membrane-associated nucleic acid-binding protein."
Siess D.C., Vedder C.T., Merkens L.S., Tanaka T., Freed A.C., McCoy S.L., Heinrich M.C., Deffebach M.E., Bennett R.M., Hefeneider S.H.
J. Biol. Chem. 275:33655-33662(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEIC ACID-BINDING, TISSUE SPECIFICITY.
Tissue: Monocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1191.
Tissue: Hepatoma.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1191 (ISOFORM 4).
Tissue: Lymph node and Melanoma.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-1191 (ISOFORM 5).
Tissue: Brain and Uterus.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs."
Athanasopoulos V., Barker A., Yu D., Tan A.H., Srivastava M., Contreras N., Wang J., Lam K.P., Brown S.H., Goodnow C.C., Dixon N.E., Leedman P.J., Saint R., Vinuesa C.G.
FEBS J. 277:2109-2127(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Molecular control of Tfh-cell differentiation by Roquin family proteins."
Heissmeyer V., Vogel K.U.
Immunol. Rev. 253:273-289(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW, MISCELLANEOUS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255303 mRNA. Translation: AAG00432.1.
AF255304 mRNA. Translation: AAG00433.1.
AK000308 mRNA. Translation: BAA91073.1.
AK000720 mRNA. Translation: BAA91340.1. Different initiation.
AK027042 mRNA. Translation: BAB15634.1. Different initiation.
AL833177 mRNA. Translation: CAI46182.1.
AL834431 mRNA. Translation: CAD39091.1.
AL359512, AC007066 Genomic DNA. Translation: CAI94964.1.
CH471090 Genomic DNA. Translation: EAW87547.1.
BC011688 mRNA. Translation: AAH11688.2.
BC044642 mRNA. Translation: AAH44642.1.
CCDSCCDS43874.1. [Q9HBD1-1]
CCDS48014.1. [Q9HBD1-4]
RefSeqNP_001094058.1. NM_001100588.1. [Q9HBD1-1]
NP_061323.2. NM_018835.2. [Q9HBD1-4]
UniGeneHs.533499.
Hs.709775.

3D structure databases

ProteinModelPortalQ9HBD1.
SMRQ9HBD1. Positions 12-59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120029. 4 interactions.
IntActQ9HBD1. 6 interactions.
MINTMINT-3052676.

PTM databases

PhosphoSiteQ9HBD1.

Polymorphism databases

DMDM73621223.

Proteomic databases

MaxQBQ9HBD1.
PaxDbQ9HBD1.
PRIDEQ9HBD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357244; ENSP00000349783; ENSG00000056586. [Q9HBD1-1]
ENST00000373665; ENSP00000362769; ENSG00000056586. [Q9HBD1-2]
ENST00000373670; ENSP00000362774; ENSG00000056586. [Q9HBD1-1]
ENST00000423239; ENSP00000411767; ENSG00000056586. [Q9HBD1-4]
ENST00000471874; ENSP00000474148; ENSG00000056586. [Q9HBD1-5]
ENST00000498479; ENSP00000474709; ENSG00000056586. [Q9HBD1-2]
GeneID54542.
KEGGhsa:54542.
UCSCuc004bnd.1. human. [Q9HBD1-1]
uc004bne.4. human. [Q9HBD1-4]
uc004bng.1. human. [Q9HBD1-5]
uc011lzg.2. human. [Q9HBD1-2]

Organism-specific databases

CTD54542.
GeneCardsGC09M125606.
HGNCHGNC:21461. RC3H2.
HPAHPA042863.
MIM615231. gene.
neXtProtNX_Q9HBD1.
PharmGKBPA162400905.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320727.
HOVERGENHBG080524.
InParanoidQ9HBD1.
KOK15690.
OMACFSQPLP.
OrthoDBEOG7QNVKM.
PhylomeDBQ9HBD1.
TreeFamTF317698.

Gene expression databases

ArrayExpressQ9HBD1.
BgeeQ9HBD1.
CleanExHS_RC3H2.
GenevestigatorQ9HBD1.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRC3H2. human.
GenomeRNAi54542.
NextBio56985.
PROQ9HBD1.
SOURCESearch...

Entry information

Entry nameRC3H2_HUMAN
AccessionPrimary (citable) accession number: Q9HBD1
Secondary accession number(s): Q4VXB1 expand/collapse secondary AC list , Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM