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Protein

Roquin-2

Gene

RC3H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 54RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri410 – 438C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • ligase activity Source: UniProtKB-KW
  • mRNA binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • ubiquitin-protein transferase activity Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Repressor

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Roquin-2 (EC:6.3.2.-1 Publication)
Alternative name(s):
Membrane-associated nucleic acid-binding protein
RING finger and CCCH-type zinc finger domain-containing protein 2
RING finger protein 164
Gene namesi
Name:RC3H2
Synonyms:MNAB, RNF164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21461. RC3H2.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: HPA
  • cytoplasmic mRNA processing body Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33C → S: Loss of activity. Loss of MAP3K5 ubiquitination. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000056586.
PharmGKBiPA162400905.

Polymorphism and mutation databases

BioMutaiRC3H2.
DMDMi73621223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559681 – 1191Roquin-2Add BLAST1191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei549PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1119PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HBD1.
MaxQBiQ9HBD1.
PaxDbiQ9HBD1.
PeptideAtlasiQ9HBD1.
PRIDEiQ9HBD1.
TopDownProteomicsiQ9HBD1-3. [Q9HBD1-3]

PTM databases

iPTMnetiQ9HBD1.
PhosphoSitePlusiQ9HBD1.

Expressioni

Tissue specificityi

Expressed in spleen, testis, ovary and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000056586.
CleanExiHS_RC3H2.
ExpressionAtlasiQ9HBD1. baseline and differential.
GenevisibleiQ9HBD1. HS.

Organism-specific databases

HPAiHPA042863.

Interactioni

Subunit structurei

Interacts with EDC4. Interacts with CCR4-NOT deadenylase complex (By similarity). Interacts with MAP3K5; the interaction is probably stimulus-dependent (PubMed:24448648).By similarity1 Publication

Protein-protein interaction databases

BioGridi120029. 21 interactors.
IntActiQ9HBD1. 9 interactors.
MINTiMINT-3052676.
STRINGi9606.ENSP00000349783.

Structurei

Secondary structure

11191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi93 – 106Combined sources14
Helixi107 – 109Combined sources3
Helixi128 – 138Combined sources11
Helixi145 – 169Combined sources25
Helixi173 – 186Combined sources14
Helixi194 – 208Combined sources15
Helixi216 – 227Combined sources12
Turni228 – 230Combined sources3
Helixi236 – 248Combined sources13
Beta strandi252 – 257Combined sources6
Beta strandi260 – 266Combined sources7
Helixi268 – 270Combined sources3
Helixi273 – 290Combined sources18
Helixi297 – 305Combined sources9
Beta strandi306 – 308Combined sources3
Helixi311 – 320Combined sources10
Helixi326 – 341Combined sources16
Helixi347 – 350Combined sources4
Helixi351 – 358Combined sources8
Helixi371 – 394Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z30X-ray2.71A86-404[»]
4Z31X-ray2.50A/B87-404[»]
4ZLCX-ray2.70A/B/C/D171-325[»]
4ZLDX-ray1.60A171-325[»]
ProteinModelPortaliQ9HBD1.
SMRiQ9HBD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 229ROQAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 704Pro-richAdd BLAST129

Domaini

The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies.By similarity
The ROQ region is required for CDE RNA-binding. It may also be involved in localization to stress granules.By similarity

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 54RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri410 – 438C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3161. Eukaryota.
ENOG410YWQD. LUCA.
GeneTreeiENSGT00390000004311.
HOVERGENiHBG080524.
InParanoidiQ9HBD1.
KOiK15690.
OMAiSCFSQPL.
OrthoDBiEOG091G02I2.
PhylomeDBiQ9HBD1.
TreeFamiTF317698.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR032670. RC3H2.
IPR027370. Znf-RING_LisH.
IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR13139:SF2. PTHR13139:SF2. 1 hit.
PfamiPF00642. zf-CCCH. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC
60 70 80 90 100
PFDQTAINTD IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK
110 120 130 140 150
CVEDLALYLK PLSGGKGVAS LNQSALSRPM QRKLVTLVNC QLVEEEGRVR
160 170 180 190 200
AMRAARSLGE RTVTELILQH QNPQQLSANL WAAVRARGCQ FLGPAMQEEA
210 220 230 240 250
LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG HVVQLLYRAS
260 270 280 290 300
CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW
310 320 330 340 350
SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL
360 370 380 390 400
RPHLELLANI DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH
410 420 430 440 450
ETPQPQPNSK YKTSMCRDLR QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI
460 470 480 490 500
NATVRTFPLL NKVGVNNTVT TTAGNVISVI GSTETTGKIV PSTNGISNAE
510 520 530 540 550
NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD SVTENKIGSP
560 570 580 590 600
PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ
610 620 630 640 650
DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA
660 670 680 690 700
SMPYADHYST FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI
710 720 730 740 750
WRPPMYQRDD IIRSNSLPPM DVMHSSVYQT SLRERYNSLD GYYSVACQPP
760 770 780 790 800
SEPRTTVPLP REPCGHLKTS CEEQIRRKPD QWAQYHTQKA PLVSSTLPVA
810 820 830 840 850
TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS CGTIGSCINA
860 870 880 890 900
IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP
910 920 930 940 950
IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR
960 970 980 990 1000
WSSYGNEATS SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL
1010 1020 1030 1040 1050
LLQREANALA MQQKWNSLDE GRHLTLNLLS KEIELRNGEL QSDYTEDATD
1060 1070 1080 1090 1100
TKPDRDIELE LSALDTDEPD GQSEPIEEIL DIQLGISSQN DQLLNGMAVE
1110 1120 1130 1140 1150
NGHPVQQHQK EPPKQKKQSL GEDHVILEEQ KTILPVTSCF SQPLPVSISN
1160 1170 1180 1190
ASCLPITTSV SAGNLILKTH VMSEDKNDFL KPVANGKMVN S
Length:1,191
Mass (Da):131,669
Last modified:August 16, 2005 - v2
Checksum:i93633D8D83DC7409
GO
Isoform 2 (identifier: Q9HBD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-478: VRTFPLLNKVGVNNTVTTTAGNVIS → EVLKQQGKLFQVQTEFQMQKTVFPS
     479-1191: Missing.

Note: No experimental confirmation available.
Show »
Length:478
Mass (Da):53,877
Checksum:iD6233E801430829F
GO
Isoform 3 (identifier: Q9HBD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-506: YRLRNKKINA...SNAENSVSQL → CNPRGLYLHC...SPLEEPREED
     507-1191: Missing.

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):56,853
Checksum:iF2915DA0B8D0AC9E
GO
Isoform 4 (identifier: Q9HBD1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY

Show »
Length:1,064
Mass (Da):117,917
Checksum:i090E3F438698A35B
GO
Isoform 5 (identifier: Q9HBD1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: AMQEEALKLVLLALEDGSALSRKV → GKIGYYLTFFISYWGLRMPISGAR
     219-1191: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,282
Checksum:i91A1FAB4AAE5D91B
GO
Isoform 6 (identifier: Q9HBD1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY

Note: No experimental confirmation available.
Show »
Length:869
Mass (Da):96,362
Checksum:i56BCB1D341B35899
GO

Sequence cautioni

The sequence BAA91340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15634 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti650A → G in BAA91073 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0150171 – 195Missing in isoform 6. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_015018195 – 218AMQEE…LSRKV → GKIGYYLTFFISYWGLRMPI SGAR in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_015019219 – 1191Missing in isoform 5. 1 PublicationAdd BLAST973
Alternative sequenceiVSP_015020443 – 506YRLRN…SVSQL → CNPRGLYLHCCLLSSVASLG TVHNELYKQQHCDREKISVC AVKRAETCFSSQFFSPLEEP REED in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_015021454 – 478VRTFP…GNVIS → EVLKQQGKLFQVQTEFQMQK TVFPS in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_015022479 – 1191Missing in isoform 2. 1 PublicationAdd BLAST713
Alternative sequenceiVSP_015023507 – 1191Missing in isoform 3. 1 PublicationAdd BLAST685
Alternative sequenceiVSP_0150241040 – 1191LQSDY…KMVNS → VKKLNLSASCLMYLFSAAAS WLYHY in isoform 4 and isoform 6. 2 PublicationsAdd BLAST152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255303 mRNA. Translation: AAG00432.1.
AF255304 mRNA. Translation: AAG00433.1.
AK000308 mRNA. Translation: BAA91073.1.
AK000720 mRNA. Translation: BAA91340.1. Different initiation.
AK027042 mRNA. Translation: BAB15634.1. Different initiation.
AL833177 mRNA. Translation: CAI46182.1.
AL834431 mRNA. Translation: CAD39091.1.
AL359512, AC007066 Genomic DNA. Translation: CAI94964.1.
CH471090 Genomic DNA. Translation: EAW87547.1.
BC011688 mRNA. Translation: AAH11688.2.
BC044642 mRNA. Translation: AAH44642.1.
CCDSiCCDS43874.1. [Q9HBD1-1]
CCDS48014.1. [Q9HBD1-4]
RefSeqiNP_001094058.1. NM_001100588.1. [Q9HBD1-1]
NP_061323.2. NM_018835.2. [Q9HBD1-4]
UniGeneiHs.533499.
Hs.709775.

Genome annotation databases

EnsembliENST00000357244; ENSP00000349783; ENSG00000056586. [Q9HBD1-1]
ENST00000373670; ENSP00000362774; ENSG00000056586. [Q9HBD1-1]
ENST00000423239; ENSP00000411767; ENSG00000056586. [Q9HBD1-4]
ENST00000471874; ENSP00000474148; ENSG00000056586. [Q9HBD1-5]
ENST00000498479; ENSP00000474709; ENSG00000056586. [Q9HBD1-2]
GeneIDi54542.
KEGGihsa:54542.
UCSCiuc004bnb.2. human. [Q9HBD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255303 mRNA. Translation: AAG00432.1.
AF255304 mRNA. Translation: AAG00433.1.
AK000308 mRNA. Translation: BAA91073.1.
AK000720 mRNA. Translation: BAA91340.1. Different initiation.
AK027042 mRNA. Translation: BAB15634.1. Different initiation.
AL833177 mRNA. Translation: CAI46182.1.
AL834431 mRNA. Translation: CAD39091.1.
AL359512, AC007066 Genomic DNA. Translation: CAI94964.1.
CH471090 Genomic DNA. Translation: EAW87547.1.
BC011688 mRNA. Translation: AAH11688.2.
BC044642 mRNA. Translation: AAH44642.1.
CCDSiCCDS43874.1. [Q9HBD1-1]
CCDS48014.1. [Q9HBD1-4]
RefSeqiNP_001094058.1. NM_001100588.1. [Q9HBD1-1]
NP_061323.2. NM_018835.2. [Q9HBD1-4]
UniGeneiHs.533499.
Hs.709775.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z30X-ray2.71A86-404[»]
4Z31X-ray2.50A/B87-404[»]
4ZLCX-ray2.70A/B/C/D171-325[»]
4ZLDX-ray1.60A171-325[»]
ProteinModelPortaliQ9HBD1.
SMRiQ9HBD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120029. 21 interactors.
IntActiQ9HBD1. 9 interactors.
MINTiMINT-3052676.
STRINGi9606.ENSP00000349783.

PTM databases

iPTMnetiQ9HBD1.
PhosphoSitePlusiQ9HBD1.

Polymorphism and mutation databases

BioMutaiRC3H2.
DMDMi73621223.

Proteomic databases

EPDiQ9HBD1.
MaxQBiQ9HBD1.
PaxDbiQ9HBD1.
PeptideAtlasiQ9HBD1.
PRIDEiQ9HBD1.
TopDownProteomicsiQ9HBD1-3. [Q9HBD1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357244; ENSP00000349783; ENSG00000056586. [Q9HBD1-1]
ENST00000373670; ENSP00000362774; ENSG00000056586. [Q9HBD1-1]
ENST00000423239; ENSP00000411767; ENSG00000056586. [Q9HBD1-4]
ENST00000471874; ENSP00000474148; ENSG00000056586. [Q9HBD1-5]
ENST00000498479; ENSP00000474709; ENSG00000056586. [Q9HBD1-2]
GeneIDi54542.
KEGGihsa:54542.
UCSCiuc004bnb.2. human. [Q9HBD1-1]

Organism-specific databases

CTDi54542.
GeneCardsiRC3H2.
HGNCiHGNC:21461. RC3H2.
HPAiHPA042863.
MIMi615231. gene.
neXtProtiNX_Q9HBD1.
OpenTargetsiENSG00000056586.
PharmGKBiPA162400905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3161. Eukaryota.
ENOG410YWQD. LUCA.
GeneTreeiENSGT00390000004311.
HOVERGENiHBG080524.
InParanoidiQ9HBD1.
KOiK15690.
OMAiSCFSQPL.
OrthoDBiEOG091G02I2.
PhylomeDBiQ9HBD1.
TreeFamiTF317698.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiRC3H2. human.
GenomeRNAii54542.
PROiQ9HBD1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000056586.
CleanExiHS_RC3H2.
ExpressionAtlasiQ9HBD1. baseline and differential.
GenevisibleiQ9HBD1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR032670. RC3H2.
IPR027370. Znf-RING_LisH.
IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR13139:SF2. PTHR13139:SF2. 1 hit.
PfamiPF00642. zf-CCCH. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRC3H2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBD1
Secondary accession number(s): Q4VXB1
, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.