Q9HBD1 (RC3H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger and CCCH-type zinc finger domain-containing protein 2

Alternative name(s):
Membrane-associated nucleic acid-binding protein
RING finger protein 164

Gene names

Name:	RC3H2
Synonyms:	MNAB, RNF164

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds DNA.
Subcellular location	Cytoplasm › perinuclear region. Endomembrane system. Note: Membrane-associated. Primarily localizes to the perinuclear space, probably to the endoplasmic reticulum or trans-Golgi network. Ref.1
Tissue specificity	Expressed in spleen, testis, ovary and small intestine. Ref.1
Sequence similarities	Contains 1 C3H1-type zinc finger. Contains 1 RING-type zinc finger.
Sequence caution	The sequence BAA91340.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15634.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell surface Inferred from direct assay Ref.1. Source: UniProtKB endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from direct assay Ref.1. Source: UniProtKB perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from direct assay Ref.1. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HBD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HBD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     454-478: VRTFPLLNKVGVNNTVTTTAGNVIS → EVLKQQGKLFQVQTEFQMQKTVFPS
     479-1191: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9HBD1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     443-506: YRLRNKKINA...SNAENSVSQL → CNPRGLYLHC...SPLEEPREED
     507-1191: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9HBD1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY

Isoform 5 (identifier: Q9HBD1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: AMQEEALKLVLLALEDGSALSRKV → GKIGYYLTFFISYWGLRMPISGAR
     219-1191: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9HBD1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.
     1040-1191: LQSDYTEDAT...PVANGKMVNS → VKKLNLSASCLMYLFSAAASWLYHY

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1191	1191	RING finger and CCCH-type zinc finger domain-containing protein 2		PRO_0000055968
Regions
	Zinc finger	14 – 54	41	RING-type; degenerate
	Zinc finger	410 – 438	29	C3H1-type
	Compositional bias	576 – 704	129	Pro-rich
Amino acid modifications
	Modified residue	549	1	Phosphoserine Ref.7
	Modified residue	808	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 195	195	Missing in isoform 6.		VSP_015017
	Alternative sequence	195 – 218	24	AMQEE…LSRKV → GKIGYYLTFFISYWGLRMPI SGAR in isoform 5.		VSP_015018
	Alternative sequence	219 – 1191	973	Missing in isoform 5.		VSP_015019
	Alternative sequence	443 – 506	64	YRLRN…SVSQL → CNPRGLYLHCCLLSSVASLG TVHNELYKQQHCDREKISVC AVKRAETCFSSQFFSPLEEP REED in isoform 3.		VSP_015020
	Alternative sequence	454 – 478	25	VRTFP…GNVIS → EVLKQQGKLFQVQTEFQMQK TVFPS in isoform 2.		VSP_015021
	Alternative sequence	479 – 1191	713	Missing in isoform 2.		VSP_015022
	Alternative sequence	507 – 1191	685	Missing in isoform 3.		VSP_015023
	Alternative sequence	1040 – 1191	152	LQSDY…KMVNS → VKKLNLSASCLMYLFSAAAS WLYHY in isoform 4 and isoform 6.		VSP_015024
Experimental info
	Sequence conflict	650	1	A → G in BAA91073. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 93633D8D83DC7409	FASTA	1,191	131,669
	10 20 30 40 50 60 MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 70 80 90 100 110 120 IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 130 140 150 160 170 180 LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 190 200 210 220 230 240 WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG 250 260 270 280 290 300 HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW 310 320 330 340 350 360 SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI 370 380 390 400 410 420 DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR 430 440 450 460 470 480 QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATVRTFPLL NKVGVNNTVT TTAGNVISVI 490 500 510 520 530 540 GSTETTGKIV PSTNGISNAE NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD 550 560 570 580 590 600 SVTENKIGSP PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ 610 620 630 640 650 660 DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA SMPYADHYST 670 680 690 700 710 720 FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI WRPPMYQRDD IIRSNSLPPM 730 740 750 760 770 780 DVMHSSVYQT SLRERYNSLD GYYSVACQPP SEPRTTVPLP REPCGHLKTS CEEQIRRKPD 790 800 810 820 830 840 QWAQYHTQKA PLVSSTLPVA TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS 850 860 870 880 890 900 CGTIGSCINA IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP 910 920 930 940 950 960 IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR WSSYGNEATS 970 980 990 1000 1010 1020 SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL LLQREANALA MQQKWNSLDE 1030 1040 1050 1060 1070 1080 GRHLTLNLLS KEIELRNGEL QSDYTEDATD TKPDRDIELE LSALDTDEPD GQSEPIEEIL 1090 1100 1110 1120 1130 1140 DIQLGISSQN DQLLNGMAVE NGHPVQQHQK EPPKQKKQSL GEDHVILEEQ KTILPVTSCF 1150 1160 1170 1180 1190 SQPLPVSISN ASCLPITTSV SAGNLILKTH VMSEDKNDFL KPVANGKMVN S
	Isoform 2 [UniParc]. Checksum: D6233E801430829F	FASTA	478	53,877
	10 20 30 40 50 60 MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 70 80 90 100 110 120 IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 130 140 150 160 170 180 LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 190 200 210 220 230 240 WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG 250 260 270 280 290 300 HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW 310 320 330 340 350 360 SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI 370 380 390 400 410 420 DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR 430 440 450 460 470 QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATEVLKQQG KLFQVQTEFQ MQKTVFPS
	Isoform 3 [UniParc]. Checksum: F2915DA0B8D0AC9E	FASTA	506	56,853
	10 20 30 40 50 60 MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 70 80 90 100 110 120 IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 130 140 150 160 170 180 LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 190 200 210 220 230 240 WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG 250 260 270 280 290 300 HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW 310 320 330 340 350 360 SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI 370 380 390 400 410 420 DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR 430 440 450 460 470 480 QQGGCPRGTN CTFAHSQEEL EKCNPRGLYL HCCLLSSVAS LGTVHNELYK QQHCDREKIS 490 500 VCAVKRAETC FSSQFFSPLE EPREED
	Isoform 4 [UniParc]. Checksum: 090E3F438698A35B	FASTA	1,064	117,917
	10 20 30 40 50 60 MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 70 80 90 100 110 120 IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 130 140 150 160 170 180 LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 190 200 210 220 230 240 WAAVRARGCQ FLGPAMQEEA LKLVLLALED GSALSRKVLV LFVVQRLEPR FPQASKTSIG 250 260 270 280 290 300 HVVQLLYRAS CFKVTKRDED SSLMQLKEEF RSYEALRREH DAQIVHIAME AGLRISPEQW 310 320 330 340 350 360 SSLLYGDLAH KSHMQSIIDK LQSPESFAKS VQELTIVLQR TGDPANLNRL RPHLELLANI 370 380 390 400 410 420 DPNPDAVSPT WEQLENAMVA VKTVVHGLVD FIQNYSRKGH ETPQPQPNSK YKTSMCRDLR 430 440 450 460 470 480 QQGGCPRGTN CTFAHSQEEL EKYRLRNKKI NATVRTFPLL NKVGVNNTVT TTAGNVISVI 490 500 510 520 530 540 GSTETTGKIV PSTNGISNAE NSVSQLISRS TDSTLRALET VKKVGKVGAN GQNAAGPSAD 550 560 570 580 590 600 SVTENKIGSP PKTPVSNVAA TSAGPSNVGT ELNSVPQKSS PFLTRVPVYP PHSENIQYFQ 610 620 630 640 650 660 DPRTQIPFEV PQYPQTGYYP PPPTVPAGVA PCVPRFVRSN NVPESSLPPA SMPYADHYST 670 680 690 700 710 720 FSPRDRMNSS PYQPPPPQPY GPVPPVPSGM YAPVYDSRRI WRPPMYQRDD IIRSNSLPPM 730 740 750 760 770 780 DVMHSSVYQT SLRERYNSLD GYYSVACQPP SEPRTTVPLP REPCGHLKTS CEEQIRRKPD 790 800 810 820 830 840 QWAQYHTQKA PLVSSTLPVA TQSPTPPSPL FSVDFRADFS ESVSGTKFEE DHLSHYSPWS 850 860 870 880 890 900 CGTIGSCINA IDSEPKDVIA NSNAVLMDLD SGDVKRRVHL FETQRRTKEE DPIIPFSDGP 910 920 930 940 950 960 IISKWGAISR SSRTGYHTTD PVQATASQGS ATKPISVSDY VPYVNAVDSR WSSYGNEATS 970 980 990 1000 1010 1020 SAHYVERDRF IVTDLSGHRK HSSTGDLLSL ELQQAKSNSL LLQREANALA MQQKWNSLDE 1030 1040 1050 1060 GRHLTLNLLS KEIELRNGEV KKLNLSASCL MYLFSAAASW LYHY
	Isoform 5 [UniParc]. Checksum: 91A1FAB4AAE5D91B	FASTA	218	24,282
	10 20 30 40 50 60 MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 70 80 90 100 110 120 IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 130 140 150 160 170 180 LNQSALSRPM QRKLVTLVNC QLVEEEGRVR AMRAARSLGE RTVTELILQH QNPQQLSANL 190 200 210 WAAVRARGCQ FLGPGKIGYY LTFFISYWGL RMPISGAR
	Isoform 6 [UniParc]. Checksum: 56BCB1D341B35899	FASTA	869	96,362
	10 20 30 40 50 60 MQEEALKLVL LALEDGSALS RKVLVLFVVQ RLEPRFPQAS KTSIGHVVQL LYRASCFKVT 70 80 90 100 110 120 KRDEDSSLMQ LKEEFRSYEA LRREHDAQIV HIAMEAGLRI SPEQWSSLLY GDLAHKSHMQ 130 140 150 160 170 180 SIIDKLQSPE SFAKSVQELT IVLQRTGDPA NLNRLRPHLE LLANIDPNPD AVSPTWEQLE 190 200 210 220 230 240 NAMVAVKTVV HGLVDFIQNY SRKGHETPQP QPNSKYKTSM CRDLRQQGGC PRGTNCTFAH 250 260 270 280 290 300 SQEELEKYRL RNKKINATVR TFPLLNKVGV NNTVTTTAGN VISVIGSTET TGKIVPSTNG 310 320 330 340 350 360 ISNAENSVSQ LISRSTDSTL RALETVKKVG KVGANGQNAA GPSADSVTEN KIGSPPKTPV 370 380 390 400 410 420 SNVAATSAGP SNVGTELNSV PQKSSPFLTR VPVYPPHSEN IQYFQDPRTQ IPFEVPQYPQ 430 440 450 460 470 480 TGYYPPPPTV PAGVAPCVPR FVRSNNVPES SLPPASMPYA DHYSTFSPRD RMNSSPYQPP 490 500 510 520 530 540 PPQPYGPVPP VPSGMYAPVY DSRRIWRPPM YQRDDIIRSN SLPPMDVMHS SVYQTSLRER 550 560 570 580 590 600 YNSLDGYYSV ACQPPSEPRT TVPLPREPCG HLKTSCEEQI RRKPDQWAQY HTQKAPLVSS 610 620 630 640 650 660 TLPVATQSPT PPSPLFSVDF RADFSESVSG TKFEEDHLSH YSPWSCGTIG SCINAIDSEP 670 680 690 700 710 720 KDVIANSNAV LMDLDSGDVK RRVHLFETQR RTKEEDPIIP FSDGPIISKW GAISRSSRTG 730 740 750 760 770 780 YHTTDPVQAT ASQGSATKPI SVSDYVPYVN AVDSRWSSYG NEATSSAHYV ERDRFIVTDL 790 800 810 820 830 840 SGHRKHSSTG DLLSLELQQA KSNSLLLQRE ANALAMQQKW NSLDEGRHLT LNLLSKEIEL 850 860 RNGEVKKLNL SASCLMYLFS AAASWLYHY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human gene coding for a membrane-associated nucleic acid-binding protein." Siess D.C., Vedder C.T., Merkens L.S., Tanaka T., Freed A.C., McCoy S.L., Heinrich M.C., Deffebach M.E., Bennett R.M., Hefeneider S.H. J. Biol. Chem. 275:33655-33662(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY. Tissue: Monocyte.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1191. Tissue: Hepatoma.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1191 (ISOFORM 4). Tissue: Lymph node and Melanoma.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-1191 (ISOFORM 5). Tissue: Brain and Uterus.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF255303 mRNA. Translation: AAG00432.1. AF255304 mRNA. Translation: AAG00433.1. AK000308 mRNA. Translation: BAA91073.1. AK000720 mRNA. Translation: BAA91340.1. Different initiation. AK027042 mRNA. Translation: BAB15634.1. Different initiation. AL833177 mRNA. Translation: CAI46182.1. AL834431 mRNA. Translation: CAD39091.1. AL359512, AC007066 Genomic DNA. Translation: CAI94964.1. CH471090 Genomic DNA. Translation: EAW87547.1. BC011688 mRNA. Translation: AAH11688.2. BC044642 mRNA. Translation: AAH44642.1.
IPI	IPI00177819. IPI00386606. IPI00552838. IPI00643035. IPI00643666. IPI00873992.
RefSeq	NP_001094058.1. NM_001100588.1. NP_061323.2. NM_018835.2.
UniGene	Hs.533499.
3D structure databases
ProteinModelPortal	Q9HBD1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HBD1. 3 interactions.
PTM databases
PhosphoSite	Q9HBD1.
Polymorphism databases
DMDM	73621223.
Proteomic databases
PaxDb	Q9HBD1.
PRIDE	Q9HBD1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357244; ENSP00000349783; ENSG00000056586. ENST00000373665; ENSP00000362769; ENSG00000056586. ENST00000373670; ENSP00000362774; ENSG00000056586. ENST00000423239; ENSP00000411767; ENSG00000056586.
GeneID	54542.
KEGG	hsa:54542.
UCSC	uc004bnd.1. human. uc004bne.4. human. uc004bng.1. human. uc011lzg.2. human.
Organism-specific databases
CTD	54542.
GeneCards	GC09M125606.
HGNC	HGNC:21461. RC3H2.
HPA	HPA042863.
neXtProt	NX_Q9HBD1.
PharmGKB	PA162400905.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320727.
HOVERGEN	HBG080524.
InParanoid	Q9HBD1.
KO	K15690.
OMA	CFSQPLP.
OrthoDB	EOG4BG8V7.
Gene expression databases
ArrayExpress	Q9HBD1.
Bgee	Q9HBD1.
CleanEx	HS_RC3H2.
Genevestigator	Q9HBD1.
GermOnline	ENSG00000056586. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR000571. Znf_CCCH. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00642. zf-CCCH. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. SM00356. ZnF_C3H1. 1 hit. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RC3H2. human.
GenomeRNAi	54542.
NextBio	56985.

Entry information

Entry name

RC3H2_HUMAN

Accession

Primary (citable) accession number: Q9HBD1
Secondary accession number(s): Q4VXB1 , Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.