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Protein

Aconitate hydratase

Gene

IRP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.UniRule annotation

Catalytic activityi

Citrate = isocitrate.UniRule annotation

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydrataseUniRule annotation (EC:4.2.1.3UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Name:IRP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ9HBB2.
PaxDbiQ9HBB2.
PeptideAtlasiQ9HBB2.
PRIDEiQ9HBB2.

Expressioni

Gene expression databases

BgeeiQ9HBB2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309477.

Structurei

3D structure databases

ProteinModelPortaliQ9HBB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 465465AconitaseInterPro annotationAdd
BLAST
Domaini594 – 719126Aconitase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0452. Eukaryota.
COG1048. LUCA.
HOVERGENiHBG052147.
KOiK01681.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR029784. IRE-BP1.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 4 hits.
PTHR11670:SF32. PTHR11670:SF32. 4 hits.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDAVKKLGG DPEKINPVCP ADLVIDHSIQ VDFNRRADSL QKNQDLEFER
60 70 80 90 100
NRERFEFLKW GSQAFHNMRI IPPGSGIIHQ VNLEYLARVV FDQDGYYYPD
110 120 130 140 150
SLVGTDSHTT MIDGLGILGW GVGGIEAEAV MLGQPISMVL PQVIGYRLMG
160 170 180 190 200
KPHPLVTSTD IVLTITKHLR QVGVVGKFVE FFGPGVAQLS IADRATIANM
210 220 230 240 250
CPEYGATAAF FPVDEVSITY LVQTGRDEEK LKYIKKYLQA VGMFRDFNDP
260 270 280 290 300
SQDPDFTQVV ELDLKTVVPC CSGPKRPQDK VAVSDMKKDF ESCLGAKQGF
310 320 330 340 350
KGFQVAPEHH NDHKTFIYDN TEFTLAHGSV VIAAITSCTN TSNPSVMLGA
360 370 380 390 400
GLLAKKAVDA GLNVMPYIKT SLSPGSGVVT YYLQESGVMP YLSQLGFDVV
410 420 430 440 450
GYGCMTCIGN SGPLPEPVVE AITQGDLVAV GVLSGNRNFE GRVHPNTRAN
460 470 480 490 500
YLASPPLVIA YAIAGTIRID FEKEPLGVNA KGQQVFLKDI WPTRDEIQAV
510 520 530 540 550
ERQYVIPGMF KEVYQKIETV NESWNALATP SDKLFFWNSK STYIKSPPFF
560 570 580 590 600
ENLTLDLQPP KSIVDAYVLL NLGDSVTTDH ISPAGNIARN SPAARYLTNR
610 620 630 640 650
GLTPREFNSY GSRRGNDAVM ARGTFANIRL LNRFLNKQAP QTIHLPSGEI
660 670 680 690 700
LDVFDAAERY QQAGLPLIVL AGKEYGAGSS RDWAAKGPFL LGIKAVLAES
710 720 730 740 750
YERIHRSNLV GMGVIPLEYL PGENADALGL TGQERYTIII PENLKPQMKV
760 770 780 790
QVKLDTGKTF QAVMRFDTDV ELTYFLNGGI LNYMIRKMAK
Length:790
Mass (Da):87,089
Last modified:March 1, 2001 - v1
Checksum:i4DEE8385DCA07C77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261088 mRNA. Translation: AAF99681.1.
RefSeqiNP_001265281.1. NM_001278352.1.
UniGeneiHs.567229.

Genome annotation databases

GeneIDi48.
KEGGihsa:48.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261088 mRNA. Translation: AAF99681.1.
RefSeqiNP_001265281.1. NM_001278352.1.
UniGeneiHs.567229.

3D structure databases

ProteinModelPortaliQ9HBB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309477.

Proteomic databases

EPDiQ9HBB2.
PaxDbiQ9HBB2.
PeptideAtlasiQ9HBB2.
PRIDEiQ9HBB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi48.
KEGGihsa:48.

Organism-specific databases

CTDi48.

Phylogenomic databases

eggNOGiKOG0452. Eukaryota.
COG1048. LUCA.
HOVERGENiHBG052147.
KOiK01681.

Miscellaneous databases

ChiTaRSiACO1. human.
GenomeRNAii48.

Gene expression databases

BgeeiQ9HBB2.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR029784. IRE-BP1.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 4 hits.
PTHR11670:SF32. PTHR11670:SF32. 4 hits.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
    Ye Z., Connor J.R.
    Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain astrocytomaImported.

Entry informationi

Entry nameiQ9HBB2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBB2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.