Q9HBA9 (FOH1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylated-alpha-linked acidic dipeptidase
Short name=NAALADase
EC=3.4.-.-

Alternative name(s):
Cell growth-inhibiting gene 26 protein
Prostate-specific membrane antigen-like protein
Putative folate hydrolase 1B

Gene names

Name:	FOLH1B
Synonyms:	PSMAL
ORF Names:	GIG26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity By similarity. Exhibits a dipeptidyl-peptidase IV type activity By similarity.
Cofactor	Binds 2 zinc ions per subunit By similarity. Required for NAALADase activity By similarity.
Subcellular location	Cytoplasm Probable Ref.1.
Tissue specificity	Kidney and liver. Not expressed in the prostate. Ref.1
Sequence similarities	Belongs to the peptidase M28 family. M28B subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Dipeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	dipeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Putative N-acetylated-alpha-linked acidic dipeptidase		PRO_0000256137
Sites
	Active site	116	1	For NAALADase activity By similarity
	Active site	320	1	Charge relay system By similarity
	Active site	358	1	Charge relay system By similarity
	Active site	381	1	Charge relay system By similarity
	Metal binding	69	1	Zinc 2 By similarity
	Metal binding	79	1	Zinc 1 By similarity
	Metal binding	79	1	Zinc 2 By similarity
	Metal binding	117	1	Zinc 1 By similarity
	Metal binding	145	1	Zinc 2 By similarity
	Metal binding	245	1	Zinc 1 By similarity
Natural variations
	Natural variant	151	1	N → K. Corresponds to variant rs10830339 [ dbSNP | Ensembl ].		VAR_059782

Sequences

	Sequence		Length	Mass (Da)
	Q9HBA9 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 26CD6E082AC1E8D3	FASTA	442	50,045
	10 20 30 40 50 60 MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV IGTLRGAVEP 70 80 90 100 110 120 DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE GWRPRRTILF ASWDAEEFGL 130 140 150 160 170 180 LGSTEWAEDN SRLLQERGVA YINADSSIEG NYTLRVDCTP LMYSLVYNLT KELKSPDEGF 190 200 210 220 230 240 EGKSLYESWT KKSPSPEFSG MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG 250 260 270 280 290 300 YPLYHSVYET YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA 310 320 330 340 350 360 DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP ILLRMMNDQL 370 380 390 400 410 420 MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI YDALFDIESK VDPSKAWGDV 430 440 KRQISVAAFT VQAAAETLSE VA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene." O'Keefe D.S., Bacich D.J., Heston W.D.W. Prostate 58:200-210(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Liver.
[2]	"Identification of a human cell growth inhibition gene." Kim J.W. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF261715 mRNA. Translation: AAG29102.1. AY544126 mRNA. Translation: AAT11157.1.
IPI	IPI00176923.
RefSeq	NP_710163.1. NM_153696.2.
UniGene	Hs.645352.
3D structure databases
HSSP	HSSP built from PDB template 2C6C based on UniProtKB Q04609.
ProteinModelPortal	Q9HBA9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000257034.
PTM databases
PhosphoSite	Q9HBA9.
Polymorphism databases
DMDM	74718738.
Proteomic databases
PaxDb	Q9HBA9.
PRIDE	Q9HBA9.
Protocols and materials databases
DNASU	219595.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	219595.
KEGG	hsa:219595.
UCSC	uc001pda.3. human.
Organism-specific databases
CTD	219595.
GeneCards	GC11P089371.
HGNC	HGNC:13636. FOLH1B.
MIM	609020. gene.
neXtProt	NX_Q9HBA9.
PharmGKB	PA165543408.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74799.
HOGENOM	HOG000211921.
InParanoid	Q9HBA9.
OrthoDB	EOG48GW2N.
PhylomeDB	Q9HBA9.
Gene expression databases
Genevestigator	Q9HBA9.
GermOnline	ENSG00000134612. Homo sapiens.
Family and domain databases
Gene3D	1.20.930.40. 1 hit.
InterPro	IPR007484. Peptidase_M28. IPR007365. TFR-like_dimer_dom. [Graphical view]
Pfam	PF04389. Peptidase_M28. 1 hit. PF04253. TFR_dimer. 1 hit. [Graphical view]
SUPFAM	SSF47672. Transferrin_rcpt-like_dimerise. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	219595.
NextBio	90696.
SOURCE	Search...

Entry information

Entry name

FOH1B_HUMAN

Accession

Primary (citable) accession number: Q9HBA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.