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Q9HBA9 (FOH1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative N-acetylated-alpha-linked acidic dipeptidase

Short name=NAALADase
EC=3.4.-.-
Alternative name(s):
Cell growth-inhibiting gene 26 protein
Prostate-specific membrane antigen-like protein
Putative folate hydrolase 1B
Gene names
Name:FOLH1B
Synonyms:PSMAL
ORF Names:GIG26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity By similarity.

Exhibits a dipeptidyl-peptidase IV type activity By similarity.

Cofactor

Binds 2 zinc ions per subunit By similarity. Required for NAALADase activity By similarity.

Subcellular location

Cytoplasm Probable Ref.1.

Tissue specificity

Kidney and liver. Not expressed in the prostate. Ref.1

Sequence similarities

Belongs to the peptidase M28 family. M28B subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   LigandMetal-binding
Zinc
   Molecular functionDipeptidase
Hydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Multifunctional enzyme
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondipeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metallopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Putative N-acetylated-alpha-linked acidic dipeptidase
PRO_0000256137

Sites

Active site1161For NAALADase activity By similarity
Active site3201Charge relay system By similarity
Active site3581Charge relay system By similarity
Active site3811Charge relay system By similarity
Metal binding691Zinc 1 By similarity
Metal binding791Zinc 1 By similarity
Metal binding791Zinc 2 By similarity
Metal binding1171Zinc 2 By similarity
Metal binding1451Zinc 1 By similarity
Metal binding2451Zinc 2 By similarity

Natural variations

Natural variant1511N → K.
Corresponds to variant rs10830339 [ dbSNP | Ensembl ].
VAR_059782

Sequences

Sequence LengthMass (Da)Tools
Q9HBA9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 26CD6E082AC1E8D3

FASTA44250,045
        10         20         30         40         50         60 
MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV IGTLRGAVEP 

        70         80         90        100        110        120 
DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE GWRPRRTILF ASWDAEEFGL 

       130        140        150        160        170        180 
LGSTEWAEDN SRLLQERGVA YINADSSIEG NYTLRVDCTP LMYSLVYNLT KELKSPDEGF 

       190        200        210        220        230        240 
EGKSLYESWT KKSPSPEFSG MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG 

       250        260        270        280        290        300 
YPLYHSVYET YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA 

       310        320        330        340        350        360 
DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP ILLRMMNDQL 

       370        380        390        400        410        420 
MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI YDALFDIESK VDPSKAWGDV 

       430        440 
KRQISVAAFT VQAAAETLSE VA 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene."
O'Keefe D.S., Bacich D.J., Heston W.D.W.
Prostate 58:200-210(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Identification of a human cell growth inhibition gene."
Kim J.W.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF261715 mRNA. Translation: AAG29102.1.
AY544126 mRNA. Translation: AAT11157.1.
RefSeqNP_710163.1. NM_153696.2.
UniGeneHs.645352.

3D structure databases

ProteinModelPortalQ9HBA9.
SMRQ9HBA9. Positions 1-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000257034.

PTM databases

PhosphoSiteQ9HBA9.

Polymorphism databases

DMDM74718738.

Proteomic databases

PaxDbQ9HBA9.
PRIDEQ9HBA9.

Protocols and materials databases

DNASU219595.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID219595.
KEGGhsa:219595.
UCSCuc001pda.3. human.

Organism-specific databases

CTD219595.
GeneCardsGC11P089371.
HGNCHGNC:13636. FOLH1B.
MIM609020. gene.
neXtProtNX_Q9HBA9.
PharmGKBPA165543408.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74799.
HOGENOMHOG000211921.
InParanoidQ9HBA9.
PhylomeDBQ9HBA9.

Gene expression databases

GenevestigatorQ9HBA9.

Family and domain databases

Gene3D1.20.930.40. 1 hit.
InterProIPR007484. Peptidase_M28.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamPF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMSSF47672. SSF47672. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi219595.
NextBio90696.
PROQ9HBA9.
SOURCESearch...

Entry information

Entry nameFOH1B_HUMAN
AccessionPrimary (citable) accession number: Q9HBA9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM