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Q9HBA9

- FOH1B_HUMAN

UniProt

Q9HBA9 - FOH1B_HUMAN

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Protein
Putative N-acetylated-alpha-linked acidic dipeptidase
Gene
FOLH1B, PSMAL, GIG26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity By similarity.
Exhibits a dipeptidyl-peptidase IV type activity By similarity.

Cofactori

Binds 2 zinc ions per subunit By similarity. Required for NAALADase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Zinc 1 By similarity
Metal bindingi79 – 791Zinc 1 By similarity
Metal bindingi79 – 791Zinc 2 By similarity
Active sitei116 – 1161For NAALADase activity By similarity
Metal bindingi117 – 1171Zinc 2 By similarity
Metal bindingi145 – 1451Zinc 1 By similarity
Metal bindingi245 – 2451Zinc 2 By similarity
Active sitei320 – 3201Charge relay system By similarity
Active sitei358 – 3581Charge relay system By similarity
Active sitei381 – 3811Charge relay system By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative N-acetylated-alpha-linked acidic dipeptidase (EC:3.4.-.-)
    Short name:
    NAALADase
    Alternative name(s):
    Cell growth-inhibiting gene 26 protein
    Prostate-specific membrane antigen-like protein
    Putative folate hydrolase 1B
    Gene namesi
    Name:FOLH1B
    Synonyms:PSMAL
    ORF Names:GIG26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:13636. FOLH1B.

    Subcellular locationi

    Cytoplasm Inferred 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165543408.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Putative N-acetylated-alpha-linked acidic dipeptidase
    PRO_0000256137Add
    BLAST

    Proteomic databases

    PaxDbiQ9HBA9.
    PRIDEiQ9HBA9.

    PTM databases

    PhosphoSiteiQ9HBA9.

    Expressioni

    Tissue specificityi

    Kidney and liver. Not expressed in the prostate.1 Publication

    Gene expression databases

    GenevestigatoriQ9HBA9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000257034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBA9.
    SMRiQ9HBA9. Positions 1-442.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG74799.
    HOGENOMiHOG000211921.
    InParanoidiQ9HBA9.
    PhylomeDBiQ9HBA9.

    Family and domain databases

    Gene3Di1.20.930.40. 1 hit.
    InterProiIPR007484. Peptidase_M28.
    IPR007365. TFR-like_dimer_dom.
    [Graphical view]
    PfamiPF04389. Peptidase_M28. 1 hit.
    PF04253. TFR_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF47672. SSF47672. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HBA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV    50
    IGTLRGAVEP DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE 100
    GWRPRRTILF ASWDAEEFGL LGSTEWAEDN SRLLQERGVA YINADSSIEG 150
    NYTLRVDCTP LMYSLVYNLT KELKSPDEGF EGKSLYESWT KKSPSPEFSG 200
    MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG YPLYHSVYET 250
    YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA 300
    DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP 350
    ILLRMMNDQL MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI 400
    YDALFDIESK VDPSKAWGDV KRQISVAAFT VQAAAETLSE VA 442
    Length:442
    Mass (Da):50,045
    Last modified:March 1, 2001 - v1
    Checksum:i26CD6E082AC1E8D3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511N → K.
    Corresponds to variant rs10830339 [ dbSNP | Ensembl ].
    VAR_059782

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261715 mRNA. Translation: AAG29102.1.
    AY544126 mRNA. Translation: AAT11157.1.
    RefSeqiNP_710163.1. NM_153696.2.
    UniGeneiHs.645352.

    Genome annotation databases

    GeneIDi219595.
    KEGGihsa:219595.
    UCSCiuc001pda.3. human.

    Polymorphism databases

    DMDMi74718738.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261715 mRNA. Translation: AAG29102.1 .
    AY544126 mRNA. Translation: AAT11157.1 .
    RefSeqi NP_710163.1. NM_153696.2.
    UniGenei Hs.645352.

    3D structure databases

    ProteinModelPortali Q9HBA9.
    SMRi Q9HBA9. Positions 1-442.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000257034.

    PTM databases

    PhosphoSitei Q9HBA9.

    Polymorphism databases

    DMDMi 74718738.

    Proteomic databases

    PaxDbi Q9HBA9.
    PRIDEi Q9HBA9.

    Protocols and materials databases

    DNASUi 219595.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 219595.
    KEGGi hsa:219595.
    UCSCi uc001pda.3. human.

    Organism-specific databases

    CTDi 219595.
    GeneCardsi GC11P089371.
    HGNCi HGNC:13636. FOLH1B.
    MIMi 609020. gene.
    neXtProti NX_Q9HBA9.
    PharmGKBi PA165543408.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74799.
    HOGENOMi HOG000211921.
    InParanoidi Q9HBA9.
    PhylomeDBi Q9HBA9.

    Miscellaneous databases

    GenomeRNAii 219595.
    NextBioi 90696.
    PROi Q9HBA9.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9HBA9.

    Family and domain databases

    Gene3Di 1.20.930.40. 1 hit.
    InterProi IPR007484. Peptidase_M28.
    IPR007365. TFR-like_dimer_dom.
    [Graphical view ]
    Pfami PF04389. Peptidase_M28. 1 hit.
    PF04253. TFR_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47672. SSF47672. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene."
      O'Keefe D.S., Bacich D.J., Heston W.D.W.
      Prostate 58:200-210(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Identification of a human cell growth inhibition gene."
      Kim J.W.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFOH1B_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 1, 2001
    Last modified: June 11, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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