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Protein

Putative N-acetylated-alpha-linked acidic dipeptidase

Gene

FOLH1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.By similarity
Exhibits a dipeptidyl-peptidase IV type activity.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. Required for NAALADase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Zinc 1By similarity1
Metal bindingi69Zinc 1; via tele nitrogen; catalyticBy similarity1
Metal bindingi79Zinc 1; catalyticBy similarity1
Metal bindingi79Zinc 2By similarity1
Active sitei116For NAALADase activityBy similarity1
Binding sitei116SubstrateBy similarity1
Metal bindingi117Zinc 2By similarity1
Metal bindingi125CalciumBy similarity1
Metal bindingi128CalciumBy similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1
Binding sitei211SubstrateBy similarity1
Binding sitei244SubstrateBy similarity1
Metal bindingi245Zinc 2; via tele nitrogenBy similarity1
Active sitei320Charge relay systemBy similarity1
Active sitei358Charge relay systemBy similarity1
Active sitei381Charge relay systemBy similarity1

GO - Molecular functioni

  • dipeptidase activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW
  • metallocarboxypeptidase activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134612-MONOMER.
ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative N-acetylated-alpha-linked acidic dipeptidase (EC:3.4.-.-)
Short name:
NAALADase
Alternative name(s):
Cell growth-inhibiting gene 26 protein
Prostate-specific membrane antigen-like protein
Putative folate hydrolase 1B
Gene namesi
Name:FOLH1B
Synonyms:PSMAL
ORF Names:GIG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13636. FOLH1B.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi219595.
PharmGKBiPA165543408.

Polymorphism and mutation databases

BioMutaiFOLH1B.
DMDMi74718738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561371 – 442Putative N-acetylated-alpha-linked acidic dipeptidaseAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)By similarity1
Glycosylationi151N-linked (GlcNAc...)By similarity1
Glycosylationi168N-linked (GlcNAc...)By similarity1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)By similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HBA9.
PaxDbiQ9HBA9.
PeptideAtlasiQ9HBA9.
PRIDEiQ9HBA9.

PTM databases

iPTMnetiQ9HBA9.
PhosphoSitePlusiQ9HBA9.

Expressioni

Tissue specificityi

Kidney and liver. Not expressed in the prostate.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256999.

Structurei

3D structure databases

ProteinModelPortaliQ9HBA9.
SMRiQ9HBA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 210Substrate bindingBy similarity2
Regioni226 – 228Substrate bindingBy similarity3
Regioni244 – 245Substrate bindingBy similarity2
Regioni391 – 392Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000211921.
InParanoidiQ9HBA9.
PhylomeDBiQ9HBA9.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR007484. Peptidase_M28.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HBA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV
60 70 80 90 100
IGTLRGAVEP DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE
110 120 130 140 150
GWRPRRTILF ASWDAEEFGL LGSTEWAEDN SRLLQERGVA YINADSSIEG
160 170 180 190 200
NYTLRVDCTP LMYSLVYNLT KELKSPDEGF EGKSLYESWT KKSPSPEFSG
210 220 230 240 250
MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG YPLYHSVYET
260 270 280 290 300
YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA
310 320 330 340 350
DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP
360 370 380 390 400
ILLRMMNDQL MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI
410 420 430 440
YDALFDIESK VDPSKAWGDV KRQISVAAFT VQAAAETLSE VA
Length:442
Mass (Da):50,045
Last modified:March 1, 2001 - v1
Checksum:i26CD6E082AC1E8D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059782151N → K.Corresponds to variant rs10830339dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261715 mRNA. Translation: AAG29102.1.
AY544126 mRNA. Translation: AAT11157.1.
RefSeqiNP_710163.1. NM_153696.2.
UniGeneiHs.645352.

Genome annotation databases

GeneIDi219595.
KEGGihsa:219595.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261715 mRNA. Translation: AAG29102.1.
AY544126 mRNA. Translation: AAT11157.1.
RefSeqiNP_710163.1. NM_153696.2.
UniGeneiHs.645352.

3D structure databases

ProteinModelPortaliQ9HBA9.
SMRiQ9HBA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256999.

PTM databases

iPTMnetiQ9HBA9.
PhosphoSitePlusiQ9HBA9.

Polymorphism and mutation databases

BioMutaiFOLH1B.
DMDMi74718738.

Proteomic databases

MaxQBiQ9HBA9.
PaxDbiQ9HBA9.
PeptideAtlasiQ9HBA9.
PRIDEiQ9HBA9.

Protocols and materials databases

DNASUi219595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi219595.
KEGGihsa:219595.

Organism-specific databases

CTDi219595.
DisGeNETi219595.
GeneCardsiFOLH1B.
HGNCiHGNC:13636. FOLH1B.
MIMi609020. gene.
neXtProtiNX_Q9HBA9.
PharmGKBiPA165543408.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000211921.
InParanoidiQ9HBA9.
PhylomeDBiQ9HBA9.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134612-MONOMER.
ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

GenomeRNAii219595.
PROiQ9HBA9.
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR007484. Peptidase_M28.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOH1B_HUMAN
AccessioniPrimary (citable) accession number: Q9HBA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.