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Protein

Alpha-parvin

Gene

Parva

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.By similarity1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion, Cell shape, Chemotaxis, Cilium biogenesis/degradation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-parvin
Alternative name(s):
Actopaxin
Gene namesi
Name:Parva
Synonyms:Actp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71021. Parva.

Subcellular locationi

  • Cell junctionfocal adhesion 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cytoplasmcytoskeleton 1 Publication
  • CytoplasmmyofibrilsarcomereZ line By similarity

  • Note: Constituent of focal adhesions.

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • protein complex Source: RGD
  • Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 372371Alpha-parvinPRO_0000121582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9HB97.
PRIDEiQ9HB97.

PTM databases

iPTMnetiQ9HB97.
PhosphoSiteiQ9HB97.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Interactioni

Subunit structurei

Interacts with ARHGAP31. Interacts with TGFB1I1. Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with the actin cytoskeleton.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi248617. 1 interaction.
IntActiQ9HB97. 2 interactions.
STRINGi10116.ENSRNOP00000021671.

Structurei

3D structure databases

ProteinModelPortaliQ9HB97.
SMRiQ9HB97. Positions 244-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 201107CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini262 – 369108CH 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 255Interaction with ARHGAP31By similarity

Sequence similaritiesi

Belongs to the parvin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9HB97.
KOiK06275.
PhylomeDBiQ9HB97.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HB97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSEFQ
60 70 80 90 100
EEGMNAINLP LSPISFELDP EDTMLEENEV RTMVDPNSRN DPKLQELMKV
110 120 130 140 150
LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE
160 170 180 190 200
IAQKQKLQTV LEKINEALKL PPRSIKWNVD SVHAKNLVAI LHLLVALSQY
210 220 230 240 250
FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF
260 270 280 290 300
DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
310 320 330 340 350
GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV
360 370
NCDLKSTLRV LYNLFTKYRN VE
Length:372
Mass (Da):42,292
Last modified:June 1, 2001 - v2
Checksum:i7AAD24EBC25D094C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264765 mRNA. Translation: AAG09802.2.
RefSeqiNP_065707.2. NM_020656.2.
UniGeneiRn.92564.

Genome annotation databases

GeneIDi57341.
KEGGirno:57341.
UCSCiRGD:71021. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264765 mRNA. Translation: AAG09802.2.
RefSeqiNP_065707.2. NM_020656.2.
UniGeneiRn.92564.

3D structure databases

ProteinModelPortaliQ9HB97.
SMRiQ9HB97. Positions 244-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248617. 1 interaction.
IntActiQ9HB97. 2 interactions.
STRINGi10116.ENSRNOP00000021671.

PTM databases

iPTMnetiQ9HB97.
PhosphoSiteiQ9HB97.

Proteomic databases

PaxDbiQ9HB97.
PRIDEiQ9HB97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57341.
KEGGirno:57341.
UCSCiRGD:71021. rat.

Organism-specific databases

CTDi55742.
RGDi71021. Parva.

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9HB97.
KOiK06275.
PhylomeDBiQ9HB97.

Miscellaneous databases

NextBioi611322.
PROiQ9HB97.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion."
    Nikolopoulos S.N., Turner C.E.
    J. Cell Biol. 151:1435-1448(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ACTIN; PXN AND TGFB1I1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPARVA_RAT
AccessioniPrimary (citable) accession number: Q9HB97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: January 20, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.