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Q9HB89

- NMUR1_HUMAN

UniProt

Q9HB89 - NMUR1_HUMAN

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Protein

Neuromedin-U receptor 1

Gene

NMUR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. neuromedin U receptor activity Source: UniProtKB
  3. neuropeptide receptor activity Source: ProtInc

GO - Biological processi

  1. activation of phospholipase C activity Source: UniProtKB
  2. calcium ion transport Source: UniProtKB
  3. calcium-mediated signaling Source: UniProtKB
  4. chloride transport Source: UniProtKB
  5. G-protein coupled receptor signaling pathway Source: ProtInc
  6. inositol phosphate-mediated signaling Source: UniProtKB
  7. neuropeptide signaling pathway Source: UniProtKB
  8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  9. smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:NMUR1
Synonyms:GPR66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4518. NMUR1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Neuromedin-U receptor 1PRO_0000069906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB89.
PRIDEiQ9HB89.

PTM databases

PhosphoSiteiQ9HB89.

Expressioni

Tissue specificityi

Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications

Gene expression databases

BgeeiQ9HB89.
CleanExiHS_NMUR1.
GenevestigatoriQ9HB89.

Organism-specific databases

HPAiHPA027895.

Interactioni

Protein-protein interaction databases

BioGridi115600. 2 interactions.
STRINGi9606.ENSP00000305877.

Structurei

3D structure databases

ProteinModelPortaliQ9HB89.
SMRiQ9HB89. Positions 24-371.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565ExtracellularSequence AnalysisAdd
BLAST
Topological domaini87 – 9711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini119 – 13820ExtracellularSequence AnalysisAdd
BLAST
Topological domaini162 – 18120CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini203 – 23533ExtracellularSequence AnalysisAdd
BLAST
Topological domaini257 – 29438CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini316 – 33823ExtracellularSequence AnalysisAdd
BLAST
Topological domaini360 – 42667CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei139 – 16123Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308321.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9HB89.
KOiK05052.
OMAiLVILRHK.
OrthoDBiEOG7T4MK9.
PhylomeDBiQ9HB89.
TreeFamiTF318522.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH
210 220 230 240 250
GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL
260 270 280 290 300
YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
310 320 330 340 350
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA
360 370 380 390 400
ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD
410 420
VGSLGSWVHP LAGNDGPEAQ QETDPS
Length:426
Mass (Da):47,351
Last modified:March 1, 2001 - v1
Checksum:iF8DD781C020F04AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031R → Q in AAH36543. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272362 mRNA. Translation: AAG24793.1.
AC017104 Genomic DNA. Translation: AAY24249.1.
BC036543 mRNA. Translation: AAH36543.1.
BC051914 mRNA. Translation: AAH51914.1.
AF044601, AF044600 Genomic DNA. Translation: AAC02680.1.
CCDSiCCDS2486.1.
RefSeqiNP_006047.3. NM_006056.4.
UniGeneiHs.471619.

Genome annotation databases

EnsembliENST00000305141; ENSP00000305877; ENSG00000171596.
GeneIDi10316.
KEGGihsa:10316.
UCSCiuc002vry.4. human.

Polymorphism databases

DMDMi74761608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272362 mRNA. Translation: AAG24793.1 .
AC017104 Genomic DNA. Translation: AAY24249.1 .
BC036543 mRNA. Translation: AAH36543.1 .
BC051914 mRNA. Translation: AAH51914.1 .
AF044601 , AF044600 Genomic DNA. Translation: AAC02680.1 .
CCDSi CCDS2486.1.
RefSeqi NP_006047.3. NM_006056.4.
UniGenei Hs.471619.

3D structure databases

ProteinModelPortali Q9HB89.
SMRi Q9HB89. Positions 24-371.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115600. 2 interactions.
STRINGi 9606.ENSP00000305877.

Chemistry

ChEMBLi CHEMBL1075178.
GuidetoPHARMACOLOGYi 298.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9HB89.

Polymorphism databases

DMDMi 74761608.

Proteomic databases

PaxDbi Q9HB89.
PRIDEi Q9HB89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305141 ; ENSP00000305877 ; ENSG00000171596 .
GeneIDi 10316.
KEGGi hsa:10316.
UCSCi uc002vry.4. human.

Organism-specific databases

CTDi 10316.
GeneCardsi GC02M232387.
HGNCi HGNC:4518. NMUR1.
HPAi HPA027895.
MIMi 604153. gene.
neXtProti NX_Q9HB89.
PharmGKBi PA28910.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308321.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000113804.
HOVERGENi HBG103506.
InParanoidi Q9HB89.
KOi K05052.
OMAi LVILRHK.
OrthoDBi EOG7T4MK9.
PhylomeDBi Q9HB89.
TreeFami TF318522.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuromedin_U_receptor_1.
GenomeRNAii 10316.
NextBioi 39099.
PROi Q9HB89.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB89.
CleanExi HS_NMUR1.
Genevestigatori Q9HB89.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
    Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
    J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS and Testis.
  4. "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors."
    Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D.
    Genomics 52:223-229(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNMUR1_HUMAN
AccessioniPrimary (citable) accession number: Q9HB89
Secondary accession number(s): O43664, Q7LDP6, Q8NE20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3