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Q9HB89

- NMUR1_HUMAN

UniProt

Q9HB89 - NMUR1_HUMAN

Protein

Neuromedin-U receptor 1

Gene

NMUR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB
    2. neuromedin U receptor activity Source: UniProtKB
    3. neuropeptide receptor activity Source: ProtInc

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. calcium ion transport Source: UniProtKB
    3. calcium-mediated signaling Source: UniProtKB
    4. chloride transport Source: UniProtKB
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. inositol phosphate-mediated signaling Source: UniProtKB
    7. neuropeptide signaling pathway Source: UniProtKB
    8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    9. smooth muscle contraction Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuromedin-U receptor 1
    Short name:
    NMU-R1
    Alternative name(s):
    G-protein coupled receptor 66
    G-protein coupled receptor FM-3
    Gene namesi
    Name:NMUR1
    Synonyms:GPR66
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4518. NMUR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28910.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Neuromedin-U receptor 1PRO_0000069906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9HB89.
    PRIDEiQ9HB89.

    PTM databases

    PhosphoSiteiQ9HB89.

    Expressioni

    Tissue specificityi

    Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications

    Gene expression databases

    BgeeiQ9HB89.
    CleanExiHS_NMUR1.
    GenevestigatoriQ9HB89.

    Organism-specific databases

    HPAiHPA027895.

    Interactioni

    Protein-protein interaction databases

    BioGridi115600. 2 interactions.
    STRINGi9606.ENSP00000305877.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB89.
    SMRiQ9HB89. Positions 24-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6565ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 9711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini203 – 23533ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 29438CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 33823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 42667CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 16123Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308321.
    HOGENOMiHOG000113804.
    HOVERGENiHBG103506.
    InParanoidiQ9HB89.
    KOiK05052.
    OMAiLVILRHK.
    OrthoDBiEOG7T4MK9.
    PhylomeDBiQ9HB89.
    TreeFamiTF318522.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005390. NeuromedU_rcpt.
    IPR005391. NeuromedU_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01565. NEUROMEDINUR.
    PR01566. NEUROMEDNU1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HB89-1 [UniParc]FASTAAdd to Basket

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    MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK    50
    YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF 100
    SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL 150
    NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH 200
    GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL 250
    YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF 300
    VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA 350
    ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD 400
    VGSLGSWVHP LAGNDGPEAQ QETDPS 426
    Length:426
    Mass (Da):47,351
    Last modified:March 1, 2001 - v1
    Checksum:iF8DD781C020F04AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031R → Q in AAH36543. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272362 mRNA. Translation: AAG24793.1.
    AC017104 Genomic DNA. Translation: AAY24249.1.
    BC036543 mRNA. Translation: AAH36543.1.
    BC051914 mRNA. Translation: AAH51914.1.
    AF044601, AF044600 Genomic DNA. Translation: AAC02680.1.
    CCDSiCCDS2486.1.
    RefSeqiNP_006047.3. NM_006056.4.
    UniGeneiHs.471619.

    Genome annotation databases

    EnsembliENST00000305141; ENSP00000305877; ENSG00000171596.
    GeneIDi10316.
    KEGGihsa:10316.
    UCSCiuc002vry.4. human.

    Polymorphism databases

    DMDMi74761608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272362 mRNA. Translation: AAG24793.1 .
    AC017104 Genomic DNA. Translation: AAY24249.1 .
    BC036543 mRNA. Translation: AAH36543.1 .
    BC051914 mRNA. Translation: AAH51914.1 .
    AF044601 , AF044600 Genomic DNA. Translation: AAC02680.1 .
    CCDSi CCDS2486.1.
    RefSeqi NP_006047.3. NM_006056.4.
    UniGenei Hs.471619.

    3D structure databases

    ProteinModelPortali Q9HB89.
    SMRi Q9HB89. Positions 24-371.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115600. 2 interactions.
    STRINGi 9606.ENSP00000305877.

    Chemistry

    ChEMBLi CHEMBL1075178.
    GuidetoPHARMACOLOGYi 298.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9HB89.

    Polymorphism databases

    DMDMi 74761608.

    Proteomic databases

    PaxDbi Q9HB89.
    PRIDEi Q9HB89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305141 ; ENSP00000305877 ; ENSG00000171596 .
    GeneIDi 10316.
    KEGGi hsa:10316.
    UCSCi uc002vry.4. human.

    Organism-specific databases

    CTDi 10316.
    GeneCardsi GC02M232387.
    HGNCi HGNC:4518. NMUR1.
    HPAi HPA027895.
    MIMi 604153. gene.
    neXtProti NX_Q9HB89.
    PharmGKBi PA28910.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308321.
    HOGENOMi HOG000113804.
    HOVERGENi HBG103506.
    InParanoidi Q9HB89.
    KOi K05052.
    OMAi LVILRHK.
    OrthoDBi EOG7T4MK9.
    PhylomeDBi Q9HB89.
    TreeFami TF318522.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuromedin_U_receptor_1.
    GenomeRNAii 10316.
    NextBioi 39099.
    PROi Q9HB89.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HB89.
    CleanExi HS_NMUR1.
    Genevestigatori Q9HB89.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005390. NeuromedU_rcpt.
    IPR005391. NeuromedU_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01565. NEUROMEDINUR.
    PR01566. NEUROMEDNU1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
      Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
      J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS and Testis.
    4. "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors."
      Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D.
      Genomics 52:223-229(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNMUR1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB89
    Secondary accession number(s): O43664, Q7LDP6, Q8NE20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-24 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3