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Protein

Neuromedin-U receptor 1

Gene

NMUR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB
  • neuromedin U receptor activity Source: UniProtKB
  • neuropeptide receptor activity Source: ProtInc

GO - Biological processi

  • activation of phospholipase C activity Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • calcium-mediated signaling Source: UniProtKB
  • chloride transport Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • inositol phosphate-mediated signaling Source: UniProtKB
  • neuropeptide signaling pathway Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:NMUR1
Synonyms:GPR66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4518. NMUR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565ExtracellularSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 9711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini119 – 13820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei139 – 16123Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini162 – 18120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini203 – 23533ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini257 – 29438CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini316 – 33823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini360 – 42667CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28910.

Polymorphism and mutation databases

BioMutaiNMUR1.
DMDMi74761608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Neuromedin-U receptor 1PRO_0000069906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB89.
PRIDEiQ9HB89.

PTM databases

PhosphoSiteiQ9HB89.

Expressioni

Tissue specificityi

Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications

Gene expression databases

BgeeiQ9HB89.
CleanExiHS_NMUR1.
GenevisibleiQ9HB89. HS.

Organism-specific databases

HPAiHPA027895.

Interactioni

Protein-protein interaction databases

BioGridi115600. 2 interactions.
STRINGi9606.ENSP00000305877.

Structurei

3D structure databases

ProteinModelPortaliQ9HB89.
SMRiQ9HB89. Positions 24-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308321.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9HB89.
KOiK05052.
OMAiLVILRHK.
OrthoDBiEOG7T4MK9.
PhylomeDBiQ9HB89.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH
210 220 230 240 250
GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL
260 270 280 290 300
YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
310 320 330 340 350
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA
360 370 380 390 400
ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD
410 420
VGSLGSWVHP LAGNDGPEAQ QETDPS
Length:426
Mass (Da):47,351
Last modified:March 1, 2001 - v1
Checksum:iF8DD781C020F04AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031R → Q in AAH36543 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272362 mRNA. Translation: AAG24793.1.
AC017104 Genomic DNA. Translation: AAY24249.1.
BC036543 mRNA. Translation: AAH36543.1.
BC051914 mRNA. Translation: AAH51914.1.
AF044601, AF044600 Genomic DNA. Translation: AAC02680.1.
CCDSiCCDS2486.1.
RefSeqiNP_006047.3. NM_006056.4.
XP_011508789.1. XM_011510487.1.
UniGeneiHs.471619.

Genome annotation databases

EnsembliENST00000305141; ENSP00000305877; ENSG00000171596.
GeneIDi10316.
KEGGihsa:10316.
UCSCiuc002vry.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272362 mRNA. Translation: AAG24793.1.
AC017104 Genomic DNA. Translation: AAY24249.1.
BC036543 mRNA. Translation: AAH36543.1.
BC051914 mRNA. Translation: AAH51914.1.
AF044601, AF044600 Genomic DNA. Translation: AAC02680.1.
CCDSiCCDS2486.1.
RefSeqiNP_006047.3. NM_006056.4.
XP_011508789.1. XM_011510487.1.
UniGeneiHs.471619.

3D structure databases

ProteinModelPortaliQ9HB89.
SMRiQ9HB89. Positions 24-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115600. 2 interactions.
STRINGi9606.ENSP00000305877.

Chemistry

ChEMBLiCHEMBL1075178.
GuidetoPHARMACOLOGYi298.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9HB89.

Polymorphism and mutation databases

BioMutaiNMUR1.
DMDMi74761608.

Proteomic databases

PaxDbiQ9HB89.
PRIDEiQ9HB89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305141; ENSP00000305877; ENSG00000171596.
GeneIDi10316.
KEGGihsa:10316.
UCSCiuc002vry.4. human.

Organism-specific databases

CTDi10316.
GeneCardsiGC02M232387.
HGNCiHGNC:4518. NMUR1.
HPAiHPA027895.
MIMi604153. gene.
neXtProtiNX_Q9HB89.
PharmGKBiPA28910.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG308321.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9HB89.
KOiK05052.
OMAiLVILRHK.
OrthoDBiEOG7T4MK9.
PhylomeDBiQ9HB89.
TreeFamiTF318522.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiNMUR1. human.
GeneWikiiNeuromedin_U_receptor_1.
GenomeRNAii10316.
NextBioi39099.
PROiQ9HB89.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HB89.
CleanExiHS_NMUR1.
GenevisibleiQ9HB89. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
    Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
    J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS and Testis.
  4. "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors."
    Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D.
    Genomics 52:223-229(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNMUR1_HUMAN
AccessioniPrimary (citable) accession number: Q9HB89
Secondary accession number(s): O43664, Q7LDP6, Q8NE20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.