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Q9HB89 (NMUR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-U receptor 1

Short name=NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene names
Name:NMUR1
Synonyms:GPR66
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides By similarity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord. Ref.1 Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.4. Source: ProtInc

activation of phospholipase C activity

Inferred from direct assay Ref.1. Source: UniProtKB

calcium ion transport

Inferred from direct assay Ref.1. Source: UniProtKB

calcium-mediated signaling

Inferred from direct assay Ref.1. Source: UniProtKB

chloride transport

Inferred from direct assay Ref.1. Source: UniProtKB

inositol phosphate-mediated signaling

Inferred from direct assay Ref.1. Source: UniProtKB

neuropeptide signaling pathway

Traceable author statement Ref.1. Source: UniProtKB

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay Ref.1. Source: UniProtKB

smooth muscle contraction

Inferred from expression pattern Ref.1. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from direct assay Ref.1. Source: UniProtKB

integral component of plasma membrane

Traceable author statement Ref.4. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.1. Source: UniProtKB

neuromedin U receptor activity

Inferred from direct assay Ref.1. Source: UniProtKB

neuropeptide receptor activity

Traceable author statement PubMed 10811630. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Neuromedin-U receptor 1
PRO_0000069906

Regions

Topological domain1 – 6565Extracellular Potential
Transmembrane66 – 8621Helical; Name=1; Potential
Topological domain87 – 9711Cytoplasmic Potential
Transmembrane98 – 11821Helical; Name=2; Potential
Topological domain119 – 13820Extracellular Potential
Transmembrane139 – 16123Helical; Name=3; Potential
Topological domain162 – 18120Cytoplasmic Potential
Transmembrane182 – 20221Helical; Name=4; Potential
Topological domain203 – 23533Extracellular Potential
Transmembrane236 – 25621Helical; Name=5; Potential
Topological domain257 – 29438Cytoplasmic Potential
Transmembrane295 – 31521Helical; Name=6; Potential
Topological domain316 – 33823Extracellular Potential
Transmembrane339 – 35921Helical; Name=7; Potential
Topological domain360 – 42667Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation411N-linked (GlcNAc...) Potential
Disulfide bond134 ↔ 219 By similarity

Experimental info

Sequence conflict2031R → Q in AAH36543. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9HB89 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F8DD781C020F04AA

FASTA42647,351
        10         20         30         40         50         60 
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK YLGPQQTELF 

        70         80         90        100        110        120 
MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF SLAVSDLLVL LVGLPLELYE 

       130        140        150        160        170        180 
MWHNYPFLLG VGGCYFRTLL FEMVCLASVL NVTALSVERY VAVVHPLQAR SMVTRAHVRR 

       190        200        210        220        230        240 
VLGAVWGLAM LCSLPNTSLH GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF 

       250        260        270        280        290        300 
CLPMAIMSVL YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF 

       310        320        330        340        350        360 
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA ANPVLYSLMS 

       370        380        390        400        410        420 
SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD VGSLGSWVHP LAGNDGPEAQ 


QETDPS 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS and Testis.
[4]"Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors."
Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D.
Genomics 52:223-229(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-426, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF272362 mRNA. Translation: AAG24793.1.
AC017104 Genomic DNA. Translation: AAY24249.1.
BC036543 mRNA. Translation: AAH36543.1.
BC051914 mRNA. Translation: AAH51914.1.
AF044601, AF044600 Genomic DNA. Translation: AAC02680.1.
CCDSCCDS2486.1.
RefSeqNP_006047.3. NM_006056.4.
UniGeneHs.471619.

3D structure databases

ProteinModelPortalQ9HB89.
SMRQ9HB89. Positions 24-371.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115600. 2 interactions.
STRING9606.ENSP00000305877.

Chemistry

ChEMBLCHEMBL1075178.
GuidetoPHARMACOLOGY298.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9HB89.

Polymorphism databases

DMDM74761608.

Proteomic databases

PaxDbQ9HB89.
PRIDEQ9HB89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305141; ENSP00000305877; ENSG00000171596.
GeneID10316.
KEGGhsa:10316.
UCSCuc002vry.4. human.

Organism-specific databases

CTD10316.
GeneCardsGC02M232387.
HGNCHGNC:4518. NMUR1.
HPAHPA027895.
MIM604153. gene.
neXtProtNX_Q9HB89.
PharmGKBPA28910.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308321.
HOGENOMHOG000113804.
HOVERGENHBG103506.
InParanoidQ9HB89.
KOK05052.
OMALVILRHK.
OrthoDBEOG7T4MK9.
PhylomeDBQ9HB89.
TreeFamTF318522.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9HB89.
CleanExHS_NMUR1.
GenevestigatorQ9HB89.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuromedin_U_receptor_1.
GenomeRNAi10316.
NextBio39099.
PROQ9HB89.
SOURCESearch...

Entry information

Entry nameNMUR1_HUMAN
AccessionPrimary (citable) accession number: Q9HB89
Secondary accession number(s): O43664, Q7LDP6, Q8NE20
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries