Reviewed, UniProtKB/Swiss-Prot Q9HB75 (PIDD_HUMAN)

Names and origin

Protein names

Recommended name:
    Leucine-rich repeat and death domain-containing protein
Alternative name(s):
    p53-induced protein with a death domain

Gene names

Name:	LRDD
Synonyms:	PIDD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. Ref.2 Ref.9 Ref.10
Subunit structure	Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with CASP2 and CRADD. Ref.9 Ref.10 Ref.1 Ref.11
Subcellular location	Cytoplasm. Nucleus. Ref.10
Tissue specificity	Ubiquitous. Ref.1
Induction	Induced by gamma-irradiation. Ref.2
Sequence similarities	Contains 1 death domain. Contains 7 LRR (leucine-rich) repeats. Contains 1 peptidase S68 domain. Contains 2 ZU5 domains.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	death receptor binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CRADD	P78560	1	EBI-520427,EBI-520375

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HB75-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HB75-2)

The sequence of this isoform differs from the canonical sequence as follows:
     704-720: Missing.

Isoform 3 (identifier: Q9HB75-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.
     579-589: Missing.

Isoform 4 (identifier: Q9HB75-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.

Isoform 5 (identifier: Q9HB75-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.
     589-589: W → WSVPPSFLSPPPPVCTALLTPSSPR
     759-815: RLRGSEGPRR...VALHLGVSYR → VGLRDSRGAG...GGGLASPWHP
     816-910: Missing.

Isoform 6 (identifier: Q9HB75-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-492: Missing.
     589-589: W → WSVPPSFLSPPPPVCTALLTPSSPR
     704-720: Missing.
     759-815: RLRGSEGPRR...VALHLGVSYR → VGLRDSRGAG...GGGLASPWHP
     816-910: Missing.

Isoform 7 (identifier: Q9HB75-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.
     585-621: THFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIAL → LALVHHQELCGRPGSEGLGAAAAAPCEPHRSAAAPGP
     622-910: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.8

Chain

2 – 910

909

Leucine-rich repeat and death domain-containing protein

PRO_0000245243

Regions

Repeat

124 – 147

24

LRR 1

Repeat

149 – 170

22

LRR 2

Repeat

171 – 193

23

LRR 3

Repeat

194 – 216

23

LRR 4

Repeat

218 – 239

22

LRR 5

Repeat

241 – 262

22

LRR 6

Repeat

263 – 285

23

LRR 7

Domain

315 – 422

108

ZU5 1

Domain

423 – 452

30

Peptidase S68

Domain

453 – 565

113

ZU5 2

Domain

788 – 873

86

Death

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.8

Modified residue

299

1

Phosphoserine Ref.8

Modified residue

305

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

1 – 492

492

Missing in isoform 6.

VSP_019664

Alternative sequence

1 – 313

313

Missing in isoform 4, isoform 5 and isoform 7.

VSP_019665

Alternative sequence

1 – 146

146

Missing in isoform 3.

VSP_019666

Alternative sequence

579 – 589

11

Missing in isoform 3.

VSP_019667

Alternative sequence

585 – 621

37

THFSW…NLIAL → LALVHHQELCGRPGSEGLGA AAAAPCEPHRSAAAPGP in isoform 7.

VSP_019668

Alternative sequence

589

1

W → WSVPPSFLSPPPPVCTALLT PSSPR in isoform 5 and isoform 6.

VSP_019669

Alternative sequence

622 – 910

289

Missing in isoform 7.

VSP_019670

Alternative sequence

704 – 720

17

Missing in isoform 2 and isoform 6.

VSP_019671

Alternative sequence

759 – 815

57

RLRGS…GVSYR → VGLRDSRGAGQDRGPGVTRV TWWSWGWSPGLNALFPSNRD FEGPRGHGGGLASPWHP in isoform 5 and isoform 6.

VSP_019672

Alternative sequence

816 – 910

95

Missing in isoform 5 and isoform 6.

VSP_019673

Natural variant

331

1

Q → R: dbSNP rs10902221. Ref.2 Ref.1 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7

VAR_028031

Experimental info

Sequence conflict

335

1

V → A in BAC11272. Ref.4

Sequence conflict

421

1

W → L in AAP97716. Ref.3

Sequence conflict

492

1

S → F in BAC11272. Ref.4

Sequence conflict

512

1

A → V in CAD38708. Ref.6

Sequence conflict

601

1

G → E in CAD38708. Ref.6

Sequence conflict

895

1

A → V in AAF69491. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

910

Helix Strand Turn

Details...

Turn

782 – 784

3

Helix

789 – 797

9

Helix

803 – 809

7

Helix

814 – 823

10

Turn

824 – 826

3

Helix

828 – 841

14

Helix

849 – 859

11

Helix

863 – 872

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 8C98FC64230B57F8	FASTA	910	99,712
	10 20 30 40 50 60 MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ 70 80 90 100 110 120 LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG 130 140 150 160 170 180 LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH 190 200 210 220 230 240 NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR 250 260 270 280 290 300 SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP 310 320 330 340 350 360 DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL 370 380 390 400 410 420 LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS 430 440 450 460 470 480 WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF 490 500 510 520 530 540 PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS 550 560 570 580 590 600 GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV 610 620 630 640 650 660 GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV 670 680 690 700 710 720 EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ 730 740 750 760 770 780 VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG 790 800 810 820 830 840 DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA 850 860 870 880 890 900 ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS 910 APQPPEPAQA
	Isoform 2. Checksum: 426694FB8EC10235	FASTA	893	97,823
	10 20 30 40 50 60 MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ 70 80 90 100 110 120 LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG 130 140 150 160 170 180 LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH 190 200 210 220 230 240 NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR 250 260 270 280 290 300 SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP 310 320 330 340 350 360 DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL 370 380 390 400 410 420 LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS 430 440 450 460 470 480 WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF 490 500 510 520 530 540 PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS 550 560 570 580 590 600 GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV 610 620 630 640 650 660 GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV 670 680 690 700 710 720 EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVSFYRGA VPVRVPEEAE 730 740 750 760 770 780 AARQRKGADA LWMATLPIKL PRLRGSEGPR RGAGLSLAPL NLGDAETGFL TQSNLLSVAG 790 800 810 820 830 840 RLGLDWPAVA LHLGVSYREV QRIRHEFRDD LDEQIRHMLF SWAERQAGQP GAVGLLVQAL 850 860 870 880 890 EQSDRQDVAE EVRAVLELGR RKYQDSIRRM GLAPKDPALP GSSAPQPPEP AQA
	Isoform 3. Checksum: 6BD2B00A12B574DC	FASTA	753	82,971
	10 20 30 40 50 60 MRGLGALLLS HNCLSELPEA LGALPALTFL TVTHNRLQTL PPALGALSTL QRLDLSQNLL 70 80 90 100 110 120 DTLPPEIGGL GSLLELNLAS NRLQSLPASL AGLRSLRLLV LHSNLLASVP ADLARLPLLT 130 140 150 160 170 180 RLDLRDNQLR DLPPELLDAP FVRLQGNPLG EASPDAPSSP VAALIPEMPR LFLTSDLDSF 190 200 210 220 230 240 PVTPQGCSVT LACGVRLQFP AGATATPITI RYRLLLPEPG LVPLGPHDAL LSHVLELQPH 250 260 270 280 290 300 GVAFQQDVGL WLLFTPPQAR RCREVVVRTR NDNSWGDLET YLEEEAPQRL WAHCQVPHFS 310 320 330 340 350 360 WFLVVSRPVS NACLVPPEGT LLCSSGHPGV KVIFPPGATE EPRRVSMQVV RMAGRELQAL 370 380 390 400 410 420 LGEPEAAVSP LLCLSQSGPP SFLQPVTVQL PLPSGITGLS LDRSRLHLLY WAPPAATWDD 430 440 450 460 470 480 ITAQVVLELT HLYWLWYTTK NCVGGLARKA WERLRLHRVN LIALQRRRDP EQVLLQCLPR 490 500 510 520 530 540 NKVDATLRRL LERYRGPEPS DTVEMFEGEE FFAAFERGID VDADRPDCVE GRICFVFYSH 550 560 570 580 590 600 LKNVKEVYVT TTLDREAQAV RGQVSFYRGA VPVRVPEEAE AARQRKGADA LWMATLPIKL 610 620 630 640 650 660 PRLRGSEGPR RGAGLSLAPL NLGDAETGFL TQSNLLSVAG RLGLDWPAVA LHLGVSYREV 670 680 690 700 710 720 QRIRHEFRDD LDEQIRHMLF SWAERQAGQP GAVGLLVQAL EQSDRQDVAE EVRAVLELGR 730 740 750 RKYQDSIRRM GLAPKDPALP GSSAPQPPEP AQA
	Isoform 4. Checksum: 2572BA6345C426AA	FASTA	597	66,720
	10 20 30 40 50 60 MPRLFLTSDL DSFPVTPQGC SVTLACGVRL QFPAGATATP ITIRYRLLLP EPGLVPLGPH 70 80 90 100 110 120 DALLSHVLEL QPHGVAFQQD VGLWLLFTPP QARRCREVVV RTRNDNSWGD LETYLEEEAP 130 140 150 160 170 180 QRLWAHCQVP HFSWFLVVSR PVSNACLVPP EGTLLCSSGH PGVKVIFPPG ATEEPRRVSM 190 200 210 220 230 240 QVVRMAGREL QALLGEPEAA VSPLLCLSQS GPPSFLQPVT VQLPLPSGIT GLSLDRSRLH 250 260 270 280 290 300 LLYWAPPAAT WDDITAQVVL ELTHLYARFQ VTHFSWYWLW YTTKNCVGGL ARKAWERLRL 310 320 330 340 350 360 HRVNLIALQR RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE 370 380 390 400 410 420 RGIDVDADRP DCVEGRICFV FYSHLKNVKE VYVTTTLDRE AQAVRGQVSF YRGAVPVRVP 430 440 450 460 470 480 EEAEAARQRK GADALWMATL PIKLPRLRGS EGPRRGAGLS LAPLNLGDAE TGFLTQSNLL 490 500 510 520 530 540 SVAGRLGLDW PAVALHLGVS YREVQRIRHE FRDDLDEQIR HMLFSWAERQ AGQPGAVGLL 550 560 570 580 590 VQALEQSDRQ DVAEEVRAVL ELGRRKYQDS IRRMGLAPKD PALPGSSAPQ PPEPAQA
	Isoform 5. Checksum: ACB01B6B05784BF1	FASTA	526	58,652
	10 20 30 40 50 60 MPRLFLTSDL DSFPVTPQGC SVTLACGVRL QFPAGATATP ITIRYRLLLP EPGLVPLGPH 70 80 90 100 110 120 DALLSHVLEL QPHGVAFQQD VGLWLLFTPP QARRCREVVV RTRNDNSWGD LETYLEEEAP 130 140 150 160 170 180 QRLWAHCQVP HFSWFLVVSR PVSNACLVPP EGTLLCSSGH PGVKVIFPPG ATEEPRRVSM 190 200 210 220 230 240 QVVRMAGREL QALLGEPEAA VSPLLCLSQS GPPSFLQPVT VQLPLPSGIT GLSLDRSRLH 250 260 270 280 290 300 LLYWAPPAAT WDDITAQVVL ELTHLYARFQ VTHFSWSVPP SFLSPPPPVC TALLTPSSPR 310 320 330 340 350 360 YWLWYTTKNC VGGLARKAWE RLRLHRVNLI ALQRRRDPEQ VLLQCLPRNK VDATLRRLLE 370 380 390 400 410 420 RYRGPEPSDT VEMFEGEEFF AAFERGIDVD ADRPDCVEGR ICFVFYSHLK NVKEVYVTTT 430 440 450 460 470 480 LDREAQAVRG QVSFYRGAVP VRVPEEAEAA RQRKGADALW MATLPIKLPV GLRDSRGAGQ 490 500 510 520 DRGPGVTRVT WWSWGWSPGL NALFPSNRDF EGPRGHGGGL ASPWHP
	Isoform 6. Checksum: 1A8F34F669B0F38A	FASTA	330	37,019
	10 20 30 40 50 60 MQVVRMAGRE LQALLGEPEA AVSPLLCLSQ SGPPSFLQPV TVQLPLPSGI TGLSLDRSRL 70 80 90 100 110 120 HLLYWAPPAA TWDDITAQVV LELTHLYARF QVTHFSWSVP PSFLSPPPPV CTALLTPSSP 130 140 150 160 170 180 RYWLWYTTKN CVGGLARKAW ERLRLHRVNL IALQRRRDPE QVLLQCLPRN KVDATLRRLL 190 200 210 220 230 240 ERYRGPEPSD TVEMFEGEEF FAAFERGIDV DADRPDCVEG RICFVFYSHL KNVKEVSFYR 250 260 270 280 290 300 GAVPVRVPEE AEAARQRKGA DALWMATLPI KLPVGLRDSR GAGQDRGPGV TRVTWWSWGW 310 320 330 SPGLNALFPS NRDFEGPRGH GGGLASPWHP
	Isoform 7. Checksum: 5E814E02D2E0E4CB	FASTA	308	33,375
	10 20 30 40 50 60 MPRLFLTSDL DSFPVTPQGC SVTLACGVRL QFPAGATATP ITIRYRLLLP EPGLVPLGPH 70 80 90 100 110 120 DALLSHVLEL QPHGVAFQQD VGLWLLFTPP QARRCREVVV RTRNDNSWGD LETYLEEEAP 130 140 150 160 170 180 QRLWAHCQVP HFSWFLVVSR PVSNACLVPP EGTLLCSSGH PGVKVIFPPG ATEEPRRVSM 190 200 210 220 230 240 QVVRMAGREL QALLGEPEAA VSPLLCLSQS GPPSFLQPVT VQLPLPSGIT GLSLDRSRLH 250 260 270 280 290 300 LLYWAPPAAT WDDITAQVVL ELTHLYARFQ VLALVHHQEL CGRPGSEGLG AAAAAPCEPH RSAAAPGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LRDD, a novel leucine rich repeat and death domain containing protein." Telliez J.-B., Bean K.M., Lin L.-L. Biochim. Biophys. Acta 1478:280-288(2000) [PubMed: 10825539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH FADD AND MADD, VARIANT ARG-331.
[2]	"Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis." Lin Y., Ma W., Benchimol S. Nat. Genet. 26:122-127(2000) [PubMed: 10973264] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION, VARIANT ARG-331.
[3]	Zan Q., Guo J.H., Yu L. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ARG-331. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ARG-331.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), VARIANT ARG-331. Tissue: Brain and Spleen.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ARG-331. Tissue: Testis.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-331. Tissue: Uterus.
[8]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-37; 69-93; 103-111; 183-316; 343-357; 415-435; 454-497; 552-581; 598-605; 613-623; 626-637; 651-740; 743-759; 768-798 AND 826-870, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-299 AND SER-305, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." Tinel A., Tschopp J. Science 304:843-846(2004) [PubMed: 15073321] [Abstract] Cited for: FUNCTION, DOMAIN, INTERACTION WITH CASP2 AND CRADD.
[10]	"PIDD mediates NF-kappaB activation in response to DNA damage." Janssens S., Tinel A., Lippens S., Tschopp J. Cell 123:1079-1092(2005) [PubMed: 16360037] [Abstract] Cited for: FUNCTION, INTERACTION WITH IKBKG AND RIP1, SUBCELLULAR LOCATION.
[11]	"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage." Vakifahmetoglu H., Olsson M., Orrenius S., Zhivotovsky B. Oncogene 25:5683-5692(2006) [PubMed: 16652156] [Abstract] Cited for: INTERACTION WITH CASP2 AND CRADD.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF229178 mRNA. Translation: AAF69491.1.
AF274972 mRNA. Translation: AAG13461.1.
AF465246 mRNA. Translation: AAP97716.1.
AK074893 mRNA. Translation: BAC11272.1.
AB208832 mRNA. Translation: BAD92069.1. Different initiation.
AB208949 mRNA. Translation: BAD92186.1. Different initiation.
AB209529 mRNA. Translation: BAD92766.1. Different initiation.
AL833849 mRNA. Translation: CAD38708.1. Different initiation.
BC014904 mRNA. Translation: AAH14904.1.

IPI

IPI00171737.
IPI00396438.
IPI00555732.
IPI00749289.
IPI00760720.
IPI00760854.
IPI00761169.

RefSeq

NP_060964.3.
NP_665893.2.
NP_665894.2.

UniGene

Hs.592290

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OF5	X-ray	3.20	H/I/J/K/L	778-883	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HB75. 5 interactions.

Protein family/group databases

MEROPS

S68.001.
S68.002.

Proteomic databases

PRIDE

Q9HB75.

Genome annotation databases

Ensembl

ENSG00000177595. Homo sapiens. [Contig view]

GeneID

55367.

KEGG

hsa:55367.

Organism-specific databases

GeneCards

GC11M000789.

H-InvDB

HIX0021767.

HGNC

HGNC:16491. LRDD.

HPA

CAB012647.

MIM

605247. gene.

PharmGKB

PA30445.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q9HB75.

OMA

Q9HB75. SHNCLSE.

Enzyme and pathway databases

Pathway_Interaction_DB

caspase_pathway. Caspase cascade in apoptosis.

Gene expression databases

ArrayExpress

Q9HB75.

Bgee

Q9HB75.

GermOnline

ENSG00000177595. Homo sapiens.

Family and domain databases

InterPro

IPR000488. Death.
IPR011029. DEATH-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR019502. Peptidase_S68_piddosome.
IPR000906. ZU5.
[Graphical view]

Gene3D

G3DSA:1.10.533.10. DEATH_like. 1 hit.

Pfam

PF00531. Death. 1 hit.
PF00560. LRR_1. 3 hits.
PF10461. Peptidase_S68. 1 hit.
[Graphical view]

SMART

SM00005. DEATH. 1 hit.
SM00369. LRR_TYP. 1 hit.
[Graphical view]

PROSITE

PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

59757.

SOURCE

Search...

Entry information

Entry name

PIDD_HUMAN

Accession

Primary (citable) accession number: Q9HB75
Secondary accession number(s): Q59FD1 , Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)