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Q9HB71

- CYBP_HUMAN

UniProt

Q9HB71 - CYBP_HUMAN

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Protein

Calcyclin-binding protein

Gene

CACYBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).1 Publication

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. cardiac muscle cell differentiation Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. negative regulation of cell death Source: Ensembl
  5. positive regulation of DNA replication Source: Ensembl
  6. response to growth hormone Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Short name:
hCacyBP
Alternative name(s):
S100A6-binding protein
Siah-interacting protein
Gene namesi
Name:CACYBP
Synonyms:S100A6BP, SIP
ORF Names:PNAS-107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30423. CACYBP.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication
Note: Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

GO - Cellular componenti

  1. beta-catenin destruction complex Source: UniProtKB
  2. cell body Source: Ensembl
  3. cytoplasm Source: HPA
  4. extracellular vesicular exosome Source: UniProt
  5. neuron projection Source: Ensembl
  6. nuclear envelope lumen Source: Ensembl
  7. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 264KRVR → AAVA: Abolishes interaction with SIAH1. 1 Publication
Mutagenesisi64 – 641V → N: Abolishes interaction with SIAH1; when associated with N-66. 1 Publication
Mutagenesisi66 – 661P → N: Abolishes interaction with SIAH1; when associated with N-64. 1 Publication

Organism-specific databases

PharmGKBiPA134894213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed6 Publications
Chaini2 – 228227Calcyclin-binding proteinPRO_0000185389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine6 Publications
Modified residuei8 – 81N6-acetyllysine1 Publication
Modified residuei19 – 191N6-acetyllysine1 Publication
Modified residuei85 – 851N6-acetyllysine1 Publication
Modified residuei118 – 1181N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9HB71.
PaxDbiQ9HB71.
PRIDEiQ9HB71.

2D gel databases

UCD-2DPAGEQ9HB71.

PTM databases

PhosphoSiteiQ9HB71.

Expressioni

Gene expression databases

BgeeiQ9HB71.
CleanExiHS_CACYBP.
ExpressionAtlasiQ9HB71. baseline and differential.
GenevestigatoriQ9HB71.

Organism-specific databases

HPAiHPA025753.
HPA057038.

Interactioni

Subunit structurei

Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.By similarity2 Publications

Protein-protein interaction databases

BioGridi118001. 41 interactions.
IntActiQ9HB71. 83 interactions.
MINTiMINT-200516.
STRINGi9606.ENSP00000356652.

Structurei

Secondary structure

1
228
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1917Combined sources
Helixi23 – 4624Combined sources
Beta strandi61 – 644Combined sources
Beta strandi79 – 835Combined sources
Beta strandi86 – 927Combined sources
Turni94 – 985Combined sources
Beta strandi103 – 1086Combined sources
Beta strandi110 – 1178Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi132 – 1343Combined sources
Turni138 – 1403Combined sources
Beta strandi142 – 1465Combined sources
Beta strandi149 – 1557Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi164 – 1674Combined sources
Helixi168 – 1747Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5MNMR-A63-176[»]
2A25X-ray2.20B58-70[»]
2A26X-ray1.20A/B/C1-47[»]
ProteinModelPortaliQ9HB71.
SMRiQ9HB71. Positions 1-47, 61-180, 188-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HB71.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 16795CSPROSITE-ProRule annotationAdd
BLAST
Domaini168 – 22861SGSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8079Interaction with SIAH1Add
BLAST
Regioni73 – 228156Interaction with SKP1Add
BLAST
Regioni154 – 22875Interaction with S100A6By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation
Contains 1 SGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG247905.
GeneTreeiENSGT00390000016470.
HOGENOMiHOG000238284.
HOVERGENiHBG003242.
InParanoidiQ9HB71.
KOiK04507.
OMAiVNFTERS.
OrthoDBiEOG7K9K4J.
PhylomeDBiQ9HB71.
TreeFamiTF323891.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS.
IPR015120. Siah-Interact_N.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HB71-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK
60 70 80 90 100
KAELLDNEKP AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP
110 120 130 140 150
TENVQVHFTE RSFDLLVKNL NGKSYSMIVN NLLKPISVEG SSKKVKTDTV
160 170 180 190 200
LILCRKKVEN TRWDYLTQVE KECKEKEKPS YDTETDPSEG LMNVLKKIYE
210 220
DGDDDMKRTI NKAWVESREK QAKGDTEF
Length:228
Mass (Da):26,210
Last modified:April 26, 2004 - v2
Checksum:i88C822FB14A7EF89
GO
Isoform 2 (identifier: Q9HB71-2) [UniParc]FASTAAdd to Basket

Also known as: SIP-S, S

The sequence of this isoform differs from the canonical sequence as follows:
     73-80: VKISNYGW → DGISQISL
     81-228: Missing.

Show »
Length:80
Mass (Da):8,956
Checksum:i13A2FAC2429FA9FD
GO
Isoform 3 (identifier: Q9HB71-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.

Show »
Length:185
Mass (Da):21,228
Checksum:i99286837B26B2395
GO

Sequence cautioni

The sequence AAG23817.1 differs from that shown. Reason: Frameshift at position 203. Curated
The sequence BAG52713.1 differs from that shown. Reason: Frameshift at position 3. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441M → V in AAG23817. 1 PublicationCurated
Sequence conflicti177 – 1771E → K in AAG23817. 1 PublicationCurated
Sequence conflicti183 – 1831T → P in AAG23817. 1 PublicationCurated
Sequence conflicti226 – 2261T → P in AAG23817. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 3. 1 PublicationVSP_046862Add
BLAST
Alternative sequencei73 – 808VKISNYGW → DGISQISL in isoform 2. CuratedVSP_010171
Alternative sequencei81 – 228148Missing in isoform 2. CuratedVSP_010172Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057356 mRNA. Translation: AAC21458.1.
AF314752 mRNA. Translation: AAG34170.1.
AL035305 mRNA. Translation: CAA22910.1.
AF275803 mRNA. Translation: AAG23817.1. Frameshift.
AY423723 mRNA. Translation: AAS00486.1.
AK093425 mRNA. Translation: BAG52713.1. Frameshift.
AK313278 mRNA. Translation: BAG36086.1.
Z99127 Genomic DNA. Translation: CAI18938.1.
Z99127 Genomic DNA. Translation: CAQ52581.1.
CH471067 Genomic DNA. Translation: EAW90982.1.
BC005975 mRNA. Translation: AAH05975.1.
BC022352 mRNA. Translation: AAH22352.1.
BC078151 mRNA. Translation: AAH78151.1.
CCDSiCCDS1315.1. [Q9HB71-1]
CCDS30942.1. [Q9HB71-3]
RefSeqiNP_001007215.1. NM_001007214.1. [Q9HB71-3]
NP_055227.1. NM_014412.2. [Q9HB71-1]
XP_005245149.1. XM_005245092.1. [Q9HB71-3]
UniGeneiHs.508524.

Genome annotation databases

EnsembliENST00000367679; ENSP00000356652; ENSG00000116161. [Q9HB71-1]
ENST00000405362; ENSP00000385771; ENSG00000116161. [Q9HB71-3]
ENST00000406752; ENSP00000384139; ENSG00000116161. [Q9HB71-2]
ENST00000613570; ENSP00000479414; ENSG00000116161. [Q9HB71-3]
GeneIDi27101.
KEGGihsa:27101.
UCSCiuc001gki.1. human. [Q9HB71-1]

Polymorphism databases

DMDMi46576651.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057356 mRNA. Translation: AAC21458.1 .
AF314752 mRNA. Translation: AAG34170.1 .
AL035305 mRNA. Translation: CAA22910.1 .
AF275803 mRNA. Translation: AAG23817.1 . Frameshift.
AY423723 mRNA. Translation: AAS00486.1 .
AK093425 mRNA. Translation: BAG52713.1 . Frameshift.
AK313278 mRNA. Translation: BAG36086.1 .
Z99127 Genomic DNA. Translation: CAI18938.1 .
Z99127 Genomic DNA. Translation: CAQ52581.1 .
CH471067 Genomic DNA. Translation: EAW90982.1 .
BC005975 mRNA. Translation: AAH05975.1 .
BC022352 mRNA. Translation: AAH22352.1 .
BC078151 mRNA. Translation: AAH78151.1 .
CCDSi CCDS1315.1. [Q9HB71-1 ]
CCDS30942.1. [Q9HB71-3 ]
RefSeqi NP_001007215.1. NM_001007214.1. [Q9HB71-3 ]
NP_055227.1. NM_014412.2. [Q9HB71-1 ]
XP_005245149.1. XM_005245092.1. [Q9HB71-3 ]
UniGenei Hs.508524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X5M NMR - A 63-176 [» ]
2A25 X-ray 2.20 B 58-70 [» ]
2A26 X-ray 1.20 A/B/C 1-47 [» ]
ProteinModelPortali Q9HB71.
SMRi Q9HB71. Positions 1-47, 61-180, 188-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118001. 41 interactions.
IntActi Q9HB71. 83 interactions.
MINTi MINT-200516.
STRINGi 9606.ENSP00000356652.

PTM databases

PhosphoSitei Q9HB71.

Polymorphism databases

DMDMi 46576651.

2D gel databases

UCD-2DPAGE Q9HB71.

Proteomic databases

MaxQBi Q9HB71.
PaxDbi Q9HB71.
PRIDEi Q9HB71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367679 ; ENSP00000356652 ; ENSG00000116161 . [Q9HB71-1 ]
ENST00000405362 ; ENSP00000385771 ; ENSG00000116161 . [Q9HB71-3 ]
ENST00000406752 ; ENSP00000384139 ; ENSG00000116161 . [Q9HB71-2 ]
ENST00000613570 ; ENSP00000479414 ; ENSG00000116161 . [Q9HB71-3 ]
GeneIDi 27101.
KEGGi hsa:27101.
UCSCi uc001gki.1. human. [Q9HB71-1 ]

Organism-specific databases

CTDi 27101.
GeneCardsi GC01P174968.
HGNCi HGNC:30423. CACYBP.
HPAi HPA025753.
HPA057038.
MIMi 606186. gene.
neXtProti NX_Q9HB71.
PharmGKBi PA134894213.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247905.
GeneTreei ENSGT00390000016470.
HOGENOMi HOG000238284.
HOVERGENi HBG003242.
InParanoidi Q9HB71.
KOi K04507.
OMAi VNFTERS.
OrthoDBi EOG7K9K4J.
PhylomeDBi Q9HB71.
TreeFami TF323891.

Miscellaneous databases

ChiTaRSi CACYBP. human.
EvolutionaryTracei Q9HB71.
GeneWikii CACYBP.
GenomeRNAii 27101.
NextBioi 49757.
PROi Q9HB71.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB71.
CleanExi HS_CACYBP.
ExpressionAtlasi Q9HB71. baseline and differential.
Genevestigatori Q9HB71.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS.
IPR015120. Siah-Interact_N.
[Graphical view ]
Pfami PF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human calcyclin binding protein (hCacyBP) gene."
    Liu W.X., Wu J., Zhao Z., Zhou Y., Peng X.Z., Yuan J.G., Qiang B.Q.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:181-186(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Amplification and overexpression of the gene encoding the human calcyclin binding protein on chromosome 1q24-q25 in advanced lung carcinomas."
    Petersen S., Schluens K., Dietel M., Petersen I.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Promyelocytic leukemia.
  5. "Identification of a human growth inhibition gene 5 (GIG5)."
    Kim J.W.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Skeletal muscle and Testis.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Skin.
  10. Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-14; 34-41; 112-118 AND 124-143, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.
  11. Bienvenut W.V., Heiserich L., Gottlieb E.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-19 AND 112-118, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  12. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."
    Matsuzawa S., Reed J.C.
    Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 2), SUBUNIT OF A COMPLEX WITH UBE2D1; SIAH1; SKP1; APC AND TBL1X, INTERACTION WITH SIAH1; SIAH2 AND SKP1.
  13. "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells."
    Wu J., Tan X., Peng X.Z., Yuan J.G., Qiang B.Q.
    J. Biochem. Mol. Biol. 36:354-358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-8; LYS-19; LYS-85 AND LYS-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex."
    Santelli E., Leone M., Li C., Fukushima T., Preece N.E., Olson A.J., Ely K.R., Reed J.C., Pellecchia M., Liddington R.C., Matsuzawa S.
    J. Biol. Chem. 280:34278-34287(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 1-70, SUBUNIT, MUTAGENESIS OF 23-LYS--ARG-26; VAL-64 AND PRO-66, FUNCTION, INTERACTION WITH SIAH1.
  21. "Solution structure of the core domain of calcyclin binding protein; SIAH-interacting protein (SIP)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 63-176.

Entry informationi

Entry nameiCYBP_HUMAN
AccessioniPrimary (citable) accession number: Q9HB71
Secondary accession number(s): B2ZWH2
, B3KSF1, O60666, Q5R370, Q5R371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3