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Q9HB58

- SP110_HUMAN

UniProt

Q9HB58 - SP110_HUMAN

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Protein

Sp110 nuclear body protein

Gene

SP110

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri534 – 58047PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. signal transducer activity Source: ProtInc
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. signal transduction Source: GOC
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Interferon-induced protein 41/75
Speckled 110 kDa
Transcriptional coactivator Sp110
Gene namesi
Name:SP110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5401. SP110.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation
Note: Found in the nuclear body.

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]: Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi235550. phenotype.
Orphaneti79124. Hepatic veno-occlusive disease - immunodeficiency.
PharmGKBiPA35104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Sp110 nuclear body proteinPRO_0000074101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphoserineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity
Modified residuei256 – 2561Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated (isoform 2).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HB58.
PaxDbiQ9HB58.
PRIDEiQ9HB58.

PTM databases

PhosphoSiteiQ9HB58.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Inductioni

By IFNG/IFN-gamma and all-trans retinoic acid (ATRA).

Gene expression databases

BgeeiQ9HB58.
CleanExiHS_SP110.
ExpressionAtlasiQ9HB58. baseline and differential.
GenevestigatoriQ9HB58.

Organism-specific databases

HPAiHPA047036.

Interactioni

Subunit structurei

Isoform 3 interacts with HCV core protein.1 Publication

Protein-protein interaction databases

BioGridi109657. 13 interactions.
IntActiQ9HB58. 9 interactions.
MINTiMINT-1401836.
STRINGi9606.ENSP00000258381.

Structurei

3D structure databases

ProteinModelPortaliQ9HB58.
SMRiQ9HB58. Positions 455-681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 108108HSRPROSITE-ProRule annotationAdd
BLAST
Domaini454 – 53582SANDPROSITE-ProRule annotationAdd
BLAST
Domaini581 – 67696BromoAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni525 – 5295Nuclear hormone receptor interactionSequence Analysis

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 29414Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi428 – 44417Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.Curated
Contains 1 HSR domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAND domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri534 – 58047PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Bromodomain, Zinc-finger

Phylogenomic databases

eggNOGiNOG306672.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
HOVERGENiHBG006294.
InParanoidiQ9HB58.
OMAiLITEMYT.
OrthoDBiEOG7SR4MV.
PhylomeDBiQ9HB58.
TreeFamiTF335091.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HB58-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME
60 70 80 90 100
SLEACRNLIP VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY
110 120 130 140 150
RSFKRVGASY EWQSRDTPIL LEAPTGLAEG SSLHTPLALP PPQPPQPSCS
160 170 180 190 200
PCAPRVSEPG TSSQQSDEIL SESPSPSDPV LPLPALIQEG RSTSVTNDKL
210 220 230 240 250
TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE MPHSPLGSMP
260 270 280 290 300
EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG
310 320 330 340 350
TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE
360 370 380 390 400
IIDGTSEMNE GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD
410 420 430 440 450
DSTWNSEVMM RVQKARTKCA RKSRLKEKKK EKDICSSSKR RFQKNIHRRG
460 470 480 490 500
KPKSDTVDFH CSKLPVTCGE AKGILYKKKM KHGSSVKCIR NEDGTWLTPN
510 520 530 540 550
EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC CQGGQLLCCG
560 570 580 590 600
TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ
610 620 630 640 650
PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF
660 670 680
YKASDFGQVG LDLEAEFEKD LKDVLGFHEA NDGGFWTLP
Length:689
Mass (Da):78,396
Last modified:November 30, 2010 - v5
Checksum:i31552E1A4C498EF7
GO
Isoform 2 (identifier: Q9HB58-2) [UniParc]FASTAAdd to Basket

Also known as: IFI75, 75

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     606-611: IRDYGE → NVSSSS
     612-689: Missing.

Show »
Length:408
Mass (Da):46,285
Checksum:iC9AFB49FD426F9F5
GO
Isoform 3 (identifier: Q9HB58-3) [UniParc]FASTAAdd to Basket

Also known as: Sp110b

The sequence of this isoform differs from the canonical sequence as follows:
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:549
Mass (Da):61,898
Checksum:iA074ED9825817FC3
GO
Isoform 4 (identifier: Q9HB58-4) [UniParc]FASTAAdd to Basket

Also known as: IFI41, 41

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-275: IRDNSPEPNDPEEPQEVSSTPSDK → MASSGVKNTPRWRRKAPHGRERKE
     300-349: Missing.
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:248
Mass (Da):28,510
Checksum:i54B0C13AA73E51E1
GO
Isoform 5 (identifier: Q9HB58-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-303: GTAS → AL
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:547
Mass (Da):61,766
Checksum:iFA0D7C52A2025D87
GO
Isoform 6 (identifier: Q9HB58-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     605-605: L → LKCEFLLLKAYCHPQSSFFTGIPFN

Show »
Length:713
Mass (Da):81,169
Checksum:i146D7A3D0EEB99EA
GO
Isoform 7 (identifier: Q9HB58-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRGFRM
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Note: No experimental confirmation available.

Show »
Length:555
Mass (Da):62,603
Checksum:i44866BA4C9BBA7D0
GO

Sequence cautioni

The sequence AAF99318.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAG09826.1 differs from that shown. Reason: Frameshift at positions 141 and 143.
The sequence AK026488 differs from that shown. Reason: Frameshift at positions 296, 542 and 567.
Isoform 3 : The sequence AAF99318.1 differs from that shown. Reason: Frameshift at position 534.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671D → T in AAF99318. (PubMed:10913195)Curated
Sequence conflicti167 – 1671D → T in AAG09826. (PubMed:10913195)Curated
Sequence conflicti464 – 4641L → S in AAA18806. (PubMed:7693701)Curated
Sequence conflicti570 – 5701M → I in AK026488. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81M → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036029
Natural varianti112 – 1121W → R.2 Publications
Corresponds to variant rs1129411 [ dbSNP | Ensembl ].
VAR_027170
Natural varianti128 – 1281A → V.1 Publication
Corresponds to variant rs11556887 [ dbSNP | Ensembl ].
VAR_027171
Natural varianti173 – 1731S → L.
Corresponds to variant rs41552315 [ dbSNP | Ensembl ].
VAR_047051
Natural varianti206 – 2061A → V.1 Publication
Corresponds to variant rs28930679 [ dbSNP | Ensembl ].
VAR_027172
Natural varianti207 – 2071E → K.3 Publications
Corresponds to variant rs9061 [ dbSNP | Ensembl ].
VAR_027173
Natural varianti210 – 2101S → A.
Corresponds to variant rs1063154 [ dbSNP | Ensembl ].
VAR_047052
Natural varianti212 – 2121E → G.1 Publication
Corresponds to variant rs1047254 [ dbSNP | Ensembl ].
VAR_027174
Natural varianti249 – 2491M → V.1 Publication
Corresponds to variant rs3769838 [ dbSNP | Ensembl ].
VAR_027175
Natural varianti267 – 2671E → G.1 Publication
Corresponds to variant rs1129425 [ dbSNP | Ensembl ].
VAR_027176
Natural varianti299 – 2991G → R.6 Publications
Corresponds to variant rs1365776 [ dbSNP | Ensembl ].
VAR_027177
Natural varianti367 – 3671T → M.1 Publication
Corresponds to variant rs59573011 [ dbSNP | Ensembl ].
VAR_027178
Natural varianti425 – 4251L → S Polymorphism; may be associated with increased susceptibility to tuberculosis. 3 Publications
Corresponds to variant rs3948464 [ dbSNP | Ensembl ].
VAR_027179
Natural varianti523 – 5231M → T.2 Publications
Corresponds to variant rs1135791 [ dbSNP | Ensembl ].
VAR_027180
Natural varianti579 – 5791M → I.1 Publication
Corresponds to variant rs3948463 [ dbSNP | Ensembl ].
VAR_027181
Natural varianti683 – 6831G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_036030

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform 4. 1 PublicationVSP_005991Add
BLAST
Alternative sequencei1 – 203203Missing in isoform 2. 1 PublicationVSP_005992Add
BLAST
Alternative sequencei1 – 11M → MGRGFRM in isoform 7. 1 PublicationVSP_046079
Alternative sequencei252 – 27524IRDNS…TPSDK → MASSGVKNTPRWRRKAPHGR ERKE in isoform 4. 1 PublicationVSP_005994Add
BLAST
Alternative sequencei300 – 34950Missing in isoform 4. 1 PublicationVSP_005995Add
BLAST
Alternative sequencei300 – 3034GTAS → AL in isoform 5. 1 PublicationVSP_005996
Alternative sequencei531 – 54919RKNSD…QLLCC → SGLLLCPPRINLKRELNSK in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsVSP_005997Add
BLAST
Alternative sequencei550 – 689140Missing in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsVSP_006000Add
BLAST
Alternative sequencei605 – 6051L → LKCEFLLLKAYCHPQSSFFT GIPFN in isoform 6. 1 PublicationVSP_035593
Alternative sequencei606 – 6116IRDYGE → NVSSSS in isoform 2. 1 PublicationVSP_006001
Alternative sequencei612 – 68978Missing in isoform 2. 1 PublicationVSP_006002Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22342 mRNA. Translation: AAA18806.1.
L22343 mRNA. Translation: AAD13402.1.
AF280094 mRNA. Translation: AAF99318.1. Frameshift.
AF280095 mRNA. Translation: AAG09826.1. Frameshift.
AK026488 mRNA. No translation available.
AK301097 mRNA. Translation: BAG62696.1.
AC009950 Genomic DNA. Translation: AAX93281.1.
CH471063 Genomic DNA. Translation: EAW70915.1.
BC019059 mRNA. Translation: AAH19059.1.
CCDSiCCDS2474.1. [Q9HB58-1]
CCDS2475.1. [Q9HB58-6]
CCDS2476.1. [Q9HB58-3]
CCDS54435.1. [Q9HB58-7]
PIRiA49515.
RefSeqiNP_001171944.1. NM_001185015.1. [Q9HB58-7]
NP_004500.3. NM_004509.3.
NP_536349.2. NM_080424.2.
XP_006712549.1. XM_006712486.1. [Q9HB58-6]
UniGeneiHs.145150.

Genome annotation databases

EnsembliENST00000258381; ENSP00000258381; ENSG00000135899. [Q9HB58-6]
ENST00000258382; ENSP00000258382; ENSG00000135899. [Q9HB58-3]
ENST00000358662; ENSP00000351488; ENSG00000135899. [Q9HB58-1]
ENST00000540870; ENSP00000439558; ENSG00000135899. [Q9HB58-7]
GeneIDi3431.
KEGGihsa:3431.
UCSCiuc002vqg.3. human. [Q9HB58-6]
uc002vqh.3. human. [Q9HB58-1]
uc010fxj.3. human. [Q9HB58-4]

Polymorphism databases

DMDMi313104323.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SP110base

SP110 mutation db

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22342 mRNA. Translation: AAA18806.1 .
L22343 mRNA. Translation: AAD13402.1 .
AF280094 mRNA. Translation: AAF99318.1 . Frameshift.
AF280095 mRNA. Translation: AAG09826.1 . Frameshift.
AK026488 mRNA. No translation available.
AK301097 mRNA. Translation: BAG62696.1 .
AC009950 Genomic DNA. Translation: AAX93281.1 .
CH471063 Genomic DNA. Translation: EAW70915.1 .
BC019059 mRNA. Translation: AAH19059.1 .
CCDSi CCDS2474.1. [Q9HB58-1 ]
CCDS2475.1. [Q9HB58-6 ]
CCDS2476.1. [Q9HB58-3 ]
CCDS54435.1. [Q9HB58-7 ]
PIRi A49515.
RefSeqi NP_001171944.1. NM_001185015.1. [Q9HB58-7 ]
NP_004500.3. NM_004509.3.
NP_536349.2. NM_080424.2.
XP_006712549.1. XM_006712486.1. [Q9HB58-6 ]
UniGenei Hs.145150.

3D structure databases

ProteinModelPortali Q9HB58.
SMRi Q9HB58. Positions 455-681.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109657. 13 interactions.
IntActi Q9HB58. 9 interactions.
MINTi MINT-1401836.
STRINGi 9606.ENSP00000258381.

PTM databases

PhosphoSitei Q9HB58.

Polymorphism databases

DMDMi 313104323.

Proteomic databases

MaxQBi Q9HB58.
PaxDbi Q9HB58.
PRIDEi Q9HB58.

Protocols and materials databases

DNASUi 3431.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258381 ; ENSP00000258381 ; ENSG00000135899 . [Q9HB58-6 ]
ENST00000258382 ; ENSP00000258382 ; ENSG00000135899 . [Q9HB58-3 ]
ENST00000358662 ; ENSP00000351488 ; ENSG00000135899 . [Q9HB58-1 ]
ENST00000540870 ; ENSP00000439558 ; ENSG00000135899 . [Q9HB58-7 ]
GeneIDi 3431.
KEGGi hsa:3431.
UCSCi uc002vqg.3. human. [Q9HB58-6 ]
uc002vqh.3. human. [Q9HB58-1 ]
uc010fxj.3. human. [Q9HB58-4 ]

Organism-specific databases

CTDi 3431.
GeneCardsi GC02M230997.
GeneReviewsi SP110.
HGNCi HGNC:5401. SP110.
HPAi HPA047036.
MIMi 235550. phenotype.
604457. gene.
neXtProti NX_Q9HB58.
Orphaneti 79124. Hepatic veno-occlusive disease - immunodeficiency.
PharmGKBi PA35104.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306672.
GeneTreei ENSGT00510000046835.
HOGENOMi HOG000089984.
HOVERGENi HBG006294.
InParanoidi Q9HB58.
OMAi LITEMYT.
OrthoDBi EOG7SR4MV.
PhylomeDBi Q9HB58.
TreeFami TF335091.

Miscellaneous databases

GeneWikii SP110.
GenomeRNAii 3431.
NextBioi 13528.
PROi Q9HB58.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB58.
CleanExi HS_SP110.
ExpressionAtlasi Q9HB58. baseline and differential.
Genevestigatori Q9HB58.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view ]
SMARTi SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEi PS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins."
    Kadereit S., Gewert D.R., Galabru J., Hovanessian A.G., Meurs E.F.
    J. Biol. Chem. 268:24432-24441(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), PHOSPHORYLATION (ISOFORM 2), VARIANT ARG-299.
    Tissue: Lymphoma.
  2. "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator."
    Bloch D.B., Nakajima A., Gulick T., Chiche J.-D., Orth D., de La Monte S.M., Bloch K.D.
    Mol. Cell. Biol. 20:6138-6146(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), SUBCELLULAR LOCATION, VARIANTS ARG-299 AND THR-523.
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANTS ARG-112; LYS-207; ARG-299 AND SER-425.
    Tissue: Ileal mucosa and Spleen.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ARG-299.
    Tissue: Lymph.
  7. "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus."
    Watashi K., Hijikata M., Tagawa A., Doi T., Marusawa H., Shimotohno K.
    Mol. Cell. Biol. 23:7498-7509(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV CORE PROTEIN.
  8. "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease."
    Roscioli T., Cliffe S.T., Bloch D.B., Bell C.G., Mullan G., Taylor P.J., Sarris M., Wang J., Donald J.A., Kirk E.P., Ziegler J.B., Salzer U., McDonald G.B., Wong M., Lindeman R., Buckley M.F.
    Nat. Genet. 38:620-622(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN VODI.
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: VARIANTS VAL-128; VAL-206; LYS-207; ARG-299; MET-367 AND SER-425.
  13. Cited for: VARIANTS ARG-112; LYS-207; GLY-212; VAL-249; GLY-267; ARG-299; SER-425; THR-523 AND ILE-579.
  14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-8 AND SER-683.

Entry informationi

Entry nameiSP110_HUMAN
AccessioniPrimary (citable) accession number: Q9HB58
Secondary accession number(s): B4DVI4
, F5H1M1, Q14976, Q14977, Q53TG2, Q8WUZ6, Q9HCT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 136 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3