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Q9HB58

- SP110_HUMAN

UniProt

Q9HB58 - SP110_HUMAN

Protein

Sp110 nuclear body protein

Gene

SP110

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 5 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri534 – 58047PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. signal transducer activity Source: ProtInc
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. signal transduction Source: GOC
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sp110 nuclear body protein
    Alternative name(s):
    Interferon-induced protein 41/75
    Speckled 110 kDa
    Transcriptional coactivator Sp110
    Gene namesi
    Name:SP110
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5401. SP110.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation
    Note: Found in the nuclear body.

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]: Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi235550. phenotype.
    Orphaneti79124. Hepatic veno-occlusive disease - immunodeficiency.
    PharmGKBiPA35104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Sp110 nuclear body proteinPRO_0000074101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751PhosphoserineBy similarity
    Modified residuei177 – 1771PhosphoserineBy similarity
    Modified residuei256 – 2561Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated (isoform 2).2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9HB58.
    PaxDbiQ9HB58.
    PRIDEiQ9HB58.

    PTM databases

    PhosphoSiteiQ9HB58.

    Expressioni

    Tissue specificityi

    Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

    Inductioni

    By IFNG/IFN-gamma and all-trans retinoic acid (ATRA).

    Gene expression databases

    ArrayExpressiQ9HB58.
    BgeeiQ9HB58.
    CleanExiHS_SP110.
    GenevestigatoriQ9HB58.

    Organism-specific databases

    HPAiHPA047036.

    Interactioni

    Subunit structurei

    Isoform 3 interacts with HCV core protein.1 Publication

    Protein-protein interaction databases

    BioGridi109657. 13 interactions.
    IntActiQ9HB58. 9 interactions.
    MINTiMINT-1401836.
    STRINGi9606.ENSP00000258381.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB58.
    SMRiQ9HB58. Positions 455-674.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 108108HSRPROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 53582SANDPROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 67696BromoAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni525 – 5295Nuclear hormone receptor interactionSequence Analysis

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi281 – 29414Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi428 – 44417Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.Curated
    Contains 1 HSR domain.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SAND domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri534 – 58047PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Bromodomain, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG306672.
    HOGENOMiHOG000089984.
    HOVERGENiHBG006294.
    OMAiLITEMYT.
    OrthoDBiEOG7SR4MV.
    PhylomeDBiQ9HB58.
    TreeFamiTF335091.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.10.390.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR001487. Bromodomain.
    IPR000770. SAND_dom.
    IPR010919. SAND_dom-like.
    IPR004865. Sp100.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01342. SAND. 1 hit.
    PF03172. Sp100. 1 hit.
    [Graphical view]
    SMARTiSM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00258. SAND. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    SSF63763. SSF63763. 1 hit.
    PROSITEiPS51414. HSR. 1 hit.
    PS50864. SAND. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HB58-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME    50
    SLEACRNLIP VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY 100
    RSFKRVGASY EWQSRDTPIL LEAPTGLAEG SSLHTPLALP PPQPPQPSCS 150
    PCAPRVSEPG TSSQQSDEIL SESPSPSDPV LPLPALIQEG RSTSVTNDKL 200
    TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE MPHSPLGSMP 250
    EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG 300
    TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE 350
    IIDGTSEMNE GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD 400
    DSTWNSEVMM RVQKARTKCA RKSRLKEKKK EKDICSSSKR RFQKNIHRRG 450
    KPKSDTVDFH CSKLPVTCGE AKGILYKKKM KHGSSVKCIR NEDGTWLTPN 500
    EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC CQGGQLLCCG 550
    TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ 600
    PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF 650
    YKASDFGQVG LDLEAEFEKD LKDVLGFHEA NDGGFWTLP 689
    Length:689
    Mass (Da):78,396
    Last modified:November 30, 2010 - v5
    Checksum:i31552E1A4C498EF7
    GO
    Isoform 2 (identifier: Q9HB58-2) [UniParc]FASTAAdd to Basket

    Also known as: IFI75, 75

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.
         606-611: IRDYGE → NVSSSS
         612-689: Missing.

    Show »
    Length:408
    Mass (Da):46,285
    Checksum:iC9AFB49FD426F9F5
    GO
    Isoform 3 (identifier: Q9HB58-3) [UniParc]FASTAAdd to Basket

    Also known as: Sp110b

    The sequence of this isoform differs from the canonical sequence as follows:
         531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
         550-689: Missing.

    Show »
    Length:549
    Mass (Da):61,898
    Checksum:iA074ED9825817FC3
    GO
    Isoform 4 (identifier: Q9HB58-4) [UniParc]FASTAAdd to Basket

    Also known as: IFI41, 41

    The sequence of this isoform differs from the canonical sequence as follows:
         1-251: Missing.
         252-275: IRDNSPEPNDPEEPQEVSSTPSDK → MASSGVKNTPRWRRKAPHGRERKE
         300-349: Missing.
         531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
         550-689: Missing.

    Show »
    Length:248
    Mass (Da):28,510
    Checksum:i54B0C13AA73E51E1
    GO
    Isoform 5 (identifier: Q9HB58-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         300-303: GTAS → AL
         531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
         550-689: Missing.

    Show »
    Length:547
    Mass (Da):61,766
    Checksum:iFA0D7C52A2025D87
    GO
    Isoform 6 (identifier: Q9HB58-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         605-605: L → LKCEFLLLKAYCHPQSSFFTGIPFN

    Show »
    Length:713
    Mass (Da):81,169
    Checksum:i146D7A3D0EEB99EA
    GO
    Isoform 7 (identifier: Q9HB58-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGRGFRM
         531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
         550-689: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:555
    Mass (Da):62,603
    Checksum:i44866BA4C9BBA7D0
    GO

    Sequence cautioni

    The sequence AAF99318.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAG09826.1 differs from that shown. Reason: Frameshift at positions 141 and 143.
    The sequence AK026488 differs from that shown. Reason: Frameshift at positions 296, 542 and 567.
    Isoform 3 : The sequence AAF99318.1 differs from that shown. Reason: Frameshift at position 534.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671D → T in AAF99318. (PubMed:10913195)Curated
    Sequence conflicti167 – 1671D → T in AAG09826. (PubMed:10913195)Curated
    Sequence conflicti464 – 4641L → S in AAA18806. (PubMed:7693701)Curated
    Sequence conflicti570 – 5701M → I in AK026488. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81M → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036029
    Natural varianti112 – 1121W → R.2 Publications
    Corresponds to variant rs1129411 [ dbSNP | Ensembl ].
    VAR_027170
    Natural varianti128 – 1281A → V.1 Publication
    Corresponds to variant rs11556887 [ dbSNP | Ensembl ].
    VAR_027171
    Natural varianti173 – 1731S → L.
    Corresponds to variant rs41552315 [ dbSNP | Ensembl ].
    VAR_047051
    Natural varianti206 – 2061A → V.1 Publication
    Corresponds to variant rs28930679 [ dbSNP | Ensembl ].
    VAR_027172
    Natural varianti207 – 2071E → K.3 Publications
    Corresponds to variant rs9061 [ dbSNP | Ensembl ].
    VAR_027173
    Natural varianti210 – 2101S → A.
    Corresponds to variant rs1063154 [ dbSNP | Ensembl ].
    VAR_047052
    Natural varianti212 – 2121E → G.1 Publication
    Corresponds to variant rs1047254 [ dbSNP | Ensembl ].
    VAR_027174
    Natural varianti249 – 2491M → V.1 Publication
    Corresponds to variant rs3769838 [ dbSNP | Ensembl ].
    VAR_027175
    Natural varianti267 – 2671E → G.1 Publication
    Corresponds to variant rs1129425 [ dbSNP | Ensembl ].
    VAR_027176
    Natural varianti299 – 2991G → R.6 Publications
    Corresponds to variant rs1365776 [ dbSNP | Ensembl ].
    VAR_027177
    Natural varianti367 – 3671T → M.1 Publication
    Corresponds to variant rs59573011 [ dbSNP | Ensembl ].
    VAR_027178
    Natural varianti425 – 4251L → S Polymorphism; may be associated with increased susceptibility to tuberculosis. 3 Publications
    Corresponds to variant rs3948464 [ dbSNP | Ensembl ].
    VAR_027179
    Natural varianti523 – 5231M → T.2 Publications
    Corresponds to variant rs1135791 [ dbSNP | Ensembl ].
    VAR_027180
    Natural varianti579 – 5791M → I.1 Publication
    Corresponds to variant rs3948463 [ dbSNP | Ensembl ].
    VAR_027181
    Natural varianti683 – 6831G → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036030

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 251251Missing in isoform 4. 1 PublicationVSP_005991Add
    BLAST
    Alternative sequencei1 – 203203Missing in isoform 2. 1 PublicationVSP_005992Add
    BLAST
    Alternative sequencei1 – 11M → MGRGFRM in isoform 7. 1 PublicationVSP_046079
    Alternative sequencei252 – 27524IRDNS…TPSDK → MASSGVKNTPRWRRKAPHGR ERKE in isoform 4. 1 PublicationVSP_005994Add
    BLAST
    Alternative sequencei300 – 34950Missing in isoform 4. 1 PublicationVSP_005995Add
    BLAST
    Alternative sequencei300 – 3034GTAS → AL in isoform 5. 1 PublicationVSP_005996
    Alternative sequencei531 – 54919RKNSD…QLLCC → SGLLLCPPRINLKRELNSK in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsVSP_005997Add
    BLAST
    Alternative sequencei550 – 689140Missing in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsVSP_006000Add
    BLAST
    Alternative sequencei605 – 6051L → LKCEFLLLKAYCHPQSSFFT GIPFN in isoform 6. 1 PublicationVSP_035593
    Alternative sequencei606 – 6116IRDYGE → NVSSSS in isoform 2. 1 PublicationVSP_006001
    Alternative sequencei612 – 68978Missing in isoform 2. 1 PublicationVSP_006002Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22342 mRNA. Translation: AAA18806.1.
    L22343 mRNA. Translation: AAD13402.1.
    AF280094 mRNA. Translation: AAF99318.1. Frameshift.
    AF280095 mRNA. Translation: AAG09826.1. Frameshift.
    AK026488 mRNA. No translation available.
    AK301097 mRNA. Translation: BAG62696.1.
    AC009950 Genomic DNA. Translation: AAX93281.1.
    CH471063 Genomic DNA. Translation: EAW70915.1.
    BC019059 mRNA. Translation: AAH19059.1.
    CCDSiCCDS2474.1. [Q9HB58-1]
    CCDS2475.1. [Q9HB58-6]
    CCDS2476.1. [Q9HB58-3]
    CCDS54435.1. [Q9HB58-7]
    PIRiA49515.
    RefSeqiNP_001171944.1. NM_001185015.1. [Q9HB58-7]
    NP_004500.3. NM_004509.3.
    NP_536349.2. NM_080424.2.
    XP_006712549.1. XM_006712486.1. [Q9HB58-6]
    UniGeneiHs.145150.

    Genome annotation databases

    EnsembliENST00000258381; ENSP00000258381; ENSG00000135899. [Q9HB58-6]
    ENST00000258382; ENSP00000258382; ENSG00000135899. [Q9HB58-3]
    ENST00000358662; ENSP00000351488; ENSG00000135899. [Q9HB58-1]
    ENST00000540870; ENSP00000439558; ENSG00000135899. [Q9HB58-7]
    GeneIDi3431.
    KEGGihsa:3431.
    UCSCiuc002vqg.3. human. [Q9HB58-6]
    uc002vqh.3. human. [Q9HB58-1]
    uc010fxj.3. human. [Q9HB58-4]

    Polymorphism databases

    DMDMi313104323.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SP110base

    SP110 mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22342 mRNA. Translation: AAA18806.1 .
    L22343 mRNA. Translation: AAD13402.1 .
    AF280094 mRNA. Translation: AAF99318.1 . Frameshift.
    AF280095 mRNA. Translation: AAG09826.1 . Frameshift.
    AK026488 mRNA. No translation available.
    AK301097 mRNA. Translation: BAG62696.1 .
    AC009950 Genomic DNA. Translation: AAX93281.1 .
    CH471063 Genomic DNA. Translation: EAW70915.1 .
    BC019059 mRNA. Translation: AAH19059.1 .
    CCDSi CCDS2474.1. [Q9HB58-1 ]
    CCDS2475.1. [Q9HB58-6 ]
    CCDS2476.1. [Q9HB58-3 ]
    CCDS54435.1. [Q9HB58-7 ]
    PIRi A49515.
    RefSeqi NP_001171944.1. NM_001185015.1. [Q9HB58-7 ]
    NP_004500.3. NM_004509.3.
    NP_536349.2. NM_080424.2.
    XP_006712549.1. XM_006712486.1. [Q9HB58-6 ]
    UniGenei Hs.145150.

    3D structure databases

    ProteinModelPortali Q9HB58.
    SMRi Q9HB58. Positions 455-674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109657. 13 interactions.
    IntActi Q9HB58. 9 interactions.
    MINTi MINT-1401836.
    STRINGi 9606.ENSP00000258381.

    PTM databases

    PhosphoSitei Q9HB58.

    Polymorphism databases

    DMDMi 313104323.

    Proteomic databases

    MaxQBi Q9HB58.
    PaxDbi Q9HB58.
    PRIDEi Q9HB58.

    Protocols and materials databases

    DNASUi 3431.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258381 ; ENSP00000258381 ; ENSG00000135899 . [Q9HB58-6 ]
    ENST00000258382 ; ENSP00000258382 ; ENSG00000135899 . [Q9HB58-3 ]
    ENST00000358662 ; ENSP00000351488 ; ENSG00000135899 . [Q9HB58-1 ]
    ENST00000540870 ; ENSP00000439558 ; ENSG00000135899 . [Q9HB58-7 ]
    GeneIDi 3431.
    KEGGi hsa:3431.
    UCSCi uc002vqg.3. human. [Q9HB58-6 ]
    uc002vqh.3. human. [Q9HB58-1 ]
    uc010fxj.3. human. [Q9HB58-4 ]

    Organism-specific databases

    CTDi 3431.
    GeneCardsi GC02M230997.
    GeneReviewsi SP110.
    HGNCi HGNC:5401. SP110.
    HPAi HPA047036.
    MIMi 235550. phenotype.
    604457. gene.
    neXtProti NX_Q9HB58.
    Orphaneti 79124. Hepatic veno-occlusive disease - immunodeficiency.
    PharmGKBi PA35104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306672.
    HOGENOMi HOG000089984.
    HOVERGENi HBG006294.
    OMAi LITEMYT.
    OrthoDBi EOG7SR4MV.
    PhylomeDBi Q9HB58.
    TreeFami TF335091.

    Miscellaneous databases

    GeneWikii SP110.
    GenomeRNAii 3431.
    NextBioi 13528.
    PROi Q9HB58.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HB58.
    Bgeei Q9HB58.
    CleanExi HS_SP110.
    Genevestigatori Q9HB58.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.10.390.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR001487. Bromodomain.
    IPR000770. SAND_dom.
    IPR010919. SAND_dom-like.
    IPR004865. Sp100.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01342. SAND. 1 hit.
    PF03172. Sp100. 1 hit.
    [Graphical view ]
    SMARTi SM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00258. SAND. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    SSF63763. SSF63763. 1 hit.
    PROSITEi PS51414. HSR. 1 hit.
    PS50864. SAND. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins."
      Kadereit S., Gewert D.R., Galabru J., Hovanessian A.G., Meurs E.F.
      J. Biol. Chem. 268:24432-24441(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), PHOSPHORYLATION (ISOFORM 2), VARIANT ARG-299.
      Tissue: Lymphoma.
    2. "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator."
      Bloch D.B., Nakajima A., Gulick T., Chiche J.-D., Orth D., de La Monte S.M., Bloch K.D.
      Mol. Cell. Biol. 20:6138-6146(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), SUBCELLULAR LOCATION, VARIANTS ARG-299 AND THR-523.
      Tissue: Spleen.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANTS ARG-112; LYS-207; ARG-299 AND SER-425.
      Tissue: Ileal mucosa and Spleen.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ARG-299.
      Tissue: Lymph.
    7. "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus."
      Watashi K., Hijikata M., Tagawa A., Doi T., Marusawa H., Shimotohno K.
      Mol. Cell. Biol. 23:7498-7509(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCV CORE PROTEIN.
    8. "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease."
      Roscioli T., Cliffe S.T., Bloch D.B., Bell C.G., Mullan G., Taylor P.J., Sarris M., Wang J., Donald J.A., Kirk E.P., Ziegler J.B., Salzer U., McDonald G.B., Wong M., Lindeman R., Buckley M.F.
      Nat. Genet. 38:620-622(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN VODI.
    9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: VARIANTS VAL-128; VAL-206; LYS-207; ARG-299; MET-367 AND SER-425.
    13. Cited for: VARIANTS ARG-112; LYS-207; GLY-212; VAL-249; GLY-267; ARG-299; SER-425; THR-523 AND ILE-579.
    14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-8 AND SER-683.

    Entry informationi

    Entry nameiSP110_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB58
    Secondary accession number(s): B4DVI4
    , F5H1M1, Q14976, Q14977, Q53TG2, Q8WUZ6, Q9HCT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3