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Protein

Cytochrome P450 3A43

Gene

CYP3A43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits low testosterone 6-beta-hydroxylase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A43 (EC:1.14.14.1)
Gene namesi
Name:CYP3A43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17450. CYP3A43.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A43PRO_0000051814Add
BLAST

Proteomic databases

PaxDbiQ9HB55.
PRIDEiQ9HB55.

PTM databases

PhosphoSiteiQ9HB55.

Expressioni

Tissue specificityi

Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.2 Publications

Inductioni

By rifampicin.

Gene expression databases

BgeeiQ9HB55.
CleanExiHS_CYP3A43.
ExpressionAtlasiQ9HB55. baseline and differential.
GenevestigatoriQ9HB55.

Interactioni

Protein-protein interaction databases

BioGridi122311. 1 interaction.
STRINGi9606.ENSP00000222382.

Structurei

3D structure databases

ProteinModelPortaliQ9HB55.
SMRiQ9HB55. Positions 28-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ9HB55.
KOiK17692.
OMAiCPESRFS.
OrthoDBiEOG744TBS.
PhylomeDBiQ9HB55.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9HB55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI
60 70 80 90 100
LFYLRGLWNF DRECNEKYGE MWGLYEGQQP MLVIMDPDMI KTVLVKECYS
110 120 130 140 150
VFTNQMPLGP MGFLKSALSF AEDEEWKRIR TLLSPAFTSV KFKEMVPIIS
160 170 180 190 200
QCGDMLVRSL RQEAENSKSI NLKDFFGAYT MDVITGTLFG VNLDSLNNPQ
210 220 230 240 250
DPFLKNMKKL LKLDFLDPFL LLISLFPFLT PVFEALNIGL FPKDVTHFLK
260 270 280 290 300
NSIERMKESR LKDKQKHRVD FFQQMIDSQN SKETKSHKAL SDLELVAQSI
310 320 330 340 350
IIIFAAYDTT STTLPFIMYE LATHPDVQQK LQEEIDAVLP NKAPVTYDAL
360 370 380 390 400
VQMEYLDMVV NETLRLFPVV SRVTRVCKKD IEINGVFIPK GLAVMVPIYA
410 420 430 440 450
LHHDPKYWTE PEKFCPERFS KKNKDSIDLY RYIPFGAGPR NCIGMRFALT
460 470 480 490 500
NIKLAVIRAL QNFSFKPCKE TQIPLKLDNL PILQPEKPIV LKVHLRDGIT

SGP
Length:503
Mass (Da):57,670
Last modified:March 1, 2001 - v1
Checksum:i2C585B9DC573F634
GO
Isoform 2 (identifier: Q9HB55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-417: E → ES

Show »
Length:504
Mass (Da):57,757
Checksum:iCB87C6873DAB7B0D
GO
Isoform 3 (identifier: Q9HB55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-420: FS → SH
     421-503: Missing.

Show »
Length:420
Mass (Da):48,304
Checksum:i60873437189BA207
GO
Isoform 4 (identifier: Q9HB55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-250: SLFPFLTPVFEALNIGLFPKDVTHFLK → YRVSLCCLGRSAWCDLGSLKPPPPGFE
     251-503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:250
Mass (Da):28,490
Checksum:i858527154F617A06
GO
Isoform 7 (identifier: Q9HB55-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-224: GLWNFDRECN...FLDPFLLLIS → RSLNKIPSWA...VMKNTEKCGA

Show »
Length:393
Mass (Da):44,808
Checksum:iA0D1F6642FC1D9E1
GO

Polymorphismi

At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 8864YGTHS…IMDPD → LGPIHINFLRSWEFLGQPLC LFWELFCSTLGVFGILTENV MKNTEKCGGCMRGNSPCWSS WIPT in allele CYP3A43*2.
VAR_018050Add
BLAST
Natural varianti27 – 271T → A.
Corresponds to variant rs45558032 [ dbSNP | Ensembl ].
VAR_048449
Natural varianti89 – 503415Missing in allele CYP3A43*2.
VAR_018051Add
BLAST
Natural varianti145 – 1451M → I.
Corresponds to variant rs45450092 [ dbSNP | Ensembl ].
VAR_048450
Natural varianti275 – 2751M → I.
Corresponds to variant rs45621431 [ dbSNP | Ensembl ].
VAR_048451
Natural varianti340 – 3401P → A in allele CYP3A43*3. 1 Publication
Corresponds to variant rs680055 [ dbSNP | Ensembl ].
VAR_018052

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 224169GLWNF…LLLIS → RSLNKIPSWAWWLTPVIPAL WEAEAGGSPKVRSSRPALPT WVFGILTENVMKNTEKCGA in isoform 7. 1 PublicationVSP_056736Add
BLAST
Alternative sequencei224 – 25027SLFPF…THFLK → YRVSLCCLGRSAWCDLGSLK PPPPGFE in isoform 4. CuratedVSP_000612Add
BLAST
Alternative sequencei251 – 503253Missing in isoform 4. CuratedVSP_000613Add
BLAST
Alternative sequencei417 – 4171E → ES in isoform 2. CuratedVSP_000609
Alternative sequencei419 – 4202FS → SH in isoform 3. CuratedVSP_000610
Alternative sequencei421 – 50383Missing in isoform 3. CuratedVSP_000611Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319634 mRNA. Translation: AAK00325.1.
AF337813 mRNA. Translation: AAK38841.1.
AF280107 Genomic DNA. Translation: AAG32291.1.
AF280108 mRNA. Translation: AAG33009.1.
AF280109 mRNA. Translation: AAG33010.1.
AF280110 mRNA. Translation: AAG33011.1.
AF280111 mRNA. Translation: AAG33012.1.
AY390423 mRNA. Translation: AAQ92351.1.
AY390424 mRNA. Translation: AAQ92352.1.
AY390425 mRNA. Translation: AAQ92353.1.
AY390426 mRNA. Translation: AAQ92354.1.
AC011904 Genomic DNA. Translation: AAS07394.1.
AC011904 Genomic DNA. Translation: AAS07395.1.
CH471091 Genomic DNA. Translation: EAW76632.1.
CH471091 Genomic DNA. Translation: EAW76634.1.
BC100981 mRNA. Translation: AAI00982.1.
CCDSiCCDS5675.1. [Q9HB55-2]
CCDS5676.1. [Q9HB55-1]
CCDS5677.1. [Q9HB55-3]
CCDS64723.1. [Q9HB55-6]
PIRiJC7627.
RefSeqiNP_001265850.1. NM_001278921.1. [Q9HB55-6]
NP_073731.1. NM_022820.4. [Q9HB55-2]
NP_476436.1. NM_057095.2. [Q9HB55-1]
NP_476437.1. NM_057096.3. [Q9HB55-3]
UniGeneiHs.306220.
Hs.571258.
Hs.728751.

Genome annotation databases

EnsembliENST00000222382; ENSP00000222382; ENSG00000021461. [Q9HB55-2]
ENST00000312017; ENSP00000312110; ENSG00000021461. [Q9HB55-3]
ENST00000354829; ENSP00000346887; ENSG00000021461. [Q9HB55-1]
ENST00000417625; ENSP00000416581; ENSG00000021461. [Q9HB55-6]
ENST00000434806; ENSP00000411653; ENSG00000021461. [Q9HB55-4]
GeneIDi64816.
KEGGihsa:64816.
UCSCiuc003urx.1. human. [Q9HB55-1]
uc003ury.1. human. [Q9HB55-2]
uc003urz.1. human. [Q9HB55-3]
uc010lgi.1. human.

Polymorphism databases

DMDMi20137481.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A43 alleles

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319634 mRNA. Translation: AAK00325.1.
AF337813 mRNA. Translation: AAK38841.1.
AF280107 Genomic DNA. Translation: AAG32291.1.
AF280108 mRNA. Translation: AAG33009.1.
AF280109 mRNA. Translation: AAG33010.1.
AF280110 mRNA. Translation: AAG33011.1.
AF280111 mRNA. Translation: AAG33012.1.
AY390423 mRNA. Translation: AAQ92351.1.
AY390424 mRNA. Translation: AAQ92352.1.
AY390425 mRNA. Translation: AAQ92353.1.
AY390426 mRNA. Translation: AAQ92354.1.
AC011904 Genomic DNA. Translation: AAS07394.1.
AC011904 Genomic DNA. Translation: AAS07395.1.
CH471091 Genomic DNA. Translation: EAW76632.1.
CH471091 Genomic DNA. Translation: EAW76634.1.
BC100981 mRNA. Translation: AAI00982.1.
CCDSiCCDS5675.1. [Q9HB55-2]
CCDS5676.1. [Q9HB55-1]
CCDS5677.1. [Q9HB55-3]
CCDS64723.1. [Q9HB55-6]
PIRiJC7627.
RefSeqiNP_001265850.1. NM_001278921.1. [Q9HB55-6]
NP_073731.1. NM_022820.4. [Q9HB55-2]
NP_476436.1. NM_057095.2. [Q9HB55-1]
NP_476437.1. NM_057096.3. [Q9HB55-3]
UniGeneiHs.306220.
Hs.571258.
Hs.728751.

3D structure databases

ProteinModelPortaliQ9HB55.
SMRiQ9HB55. Positions 28-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122311. 1 interaction.
STRINGi9606.ENSP00000222382.

Chemistry

BindingDBiQ9HB55.
ChEMBLiCHEMBL2364675.
DrugBankiDB01234. Dexamethasone.
DB08930. Dolutegravir.
DB00593. Ethosuximide.
DB00842. Oxazepam.
DB00780. Phenelzine.
DB01058. Praziquantel.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB00624. Testosterone.
DB01361. Troleandomycin.
DB00943. Zalcitabine.

PTM databases

PhosphoSiteiQ9HB55.

Polymorphism databases

DMDMi20137481.

Proteomic databases

PaxDbiQ9HB55.
PRIDEiQ9HB55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222382; ENSP00000222382; ENSG00000021461. [Q9HB55-2]
ENST00000312017; ENSP00000312110; ENSG00000021461. [Q9HB55-3]
ENST00000354829; ENSP00000346887; ENSG00000021461. [Q9HB55-1]
ENST00000417625; ENSP00000416581; ENSG00000021461. [Q9HB55-6]
ENST00000434806; ENSP00000411653; ENSG00000021461. [Q9HB55-4]
GeneIDi64816.
KEGGihsa:64816.
UCSCiuc003urx.1. human. [Q9HB55-1]
uc003ury.1. human. [Q9HB55-2]
uc003urz.1. human. [Q9HB55-3]
uc010lgi.1. human.

Organism-specific databases

CTDi64816.
GeneCardsiGC07P099426.
H-InvDBHIX0033547.
HGNCiHGNC:17450. CYP3A43.
MIMi606534. gene.
neXtProtiNX_Q9HB55.
PharmGKBiPA427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ9HB55.
KOiK17692.
OMAiCPESRFS.
OrthoDBiEOG744TBS.
PhylomeDBiQ9HB55.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.

Miscellaneous databases

GeneWikiiCYP3A43.
GenomeRNAii64816.
NextBioi66908.
PROiQ9HB55.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HB55.
CleanExiHS_CYP3A43.
ExpressionAtlasiQ9HB55. baseline and differential.
GenevestigatoriQ9HB55.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450."
    Domanski T.L., Finta C., Halpert J.R., Zaphiropoulos P.G.
    Mol. Pharmacol. 59:386-392(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHARACTERIZATION.
  2. "Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43."
    Westlind A., Malmebo S., Johansson I., Otter C., Andersson T.B., Ingelman-Sundberg M., Oscarson M.
    Biochem. Biophys. Res. Commun. 281:1349-1355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    Tissue: Liver.
  4. "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant."
    Cauffiez C., Lo-Guidice J.-M., Chevalier D., Allorge D., Hamdan R., Lhermitte M., Lafitte J.-J., Colombel J.-F., Libersa C., Broly F.
    Hum. Mutat. 23:101-101(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP3A43*2), VARIANT CYP3A43*3 ALA-340.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
  8. "Intergenic mRNA molecules resulting from trans-splicing."
    Finta C., Zaphiropoulos P.G.
    J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANS-SPLICING.
  9. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiCP343_HUMAN
AccessioniPrimary (citable) accession number: Q9HB55
Secondary accession number(s): Q495Y1
, Q75MK2, Q75MK3, Q9HB52, Q9HB53, Q9HB54, Q9HB57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.