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Q9HB55

- CP343_HUMAN

UniProt

Q9HB55 - CP343_HUMAN

Protein

Cytochrome P450 3A43

Gene

CYP3A43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Exhibits low testosterone 6-beta-hydroxylase activity.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A43 (EC:1.14.14.1)
    Gene namesi
    Name:CYP3A43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17450. CYP3A43.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A43PRO_0000051814Add
    BLAST

    Proteomic databases

    PaxDbiQ9HB55.
    PRIDEiQ9HB55.

    PTM databases

    PhosphoSiteiQ9HB55.

    Expressioni

    Tissue specificityi

    Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.2 Publications

    Inductioni

    By rifampicin.

    Gene expression databases

    ArrayExpressiQ9HB55.
    BgeeiQ9HB55.
    CleanExiHS_CYP3A43.
    GenevestigatoriQ9HB55.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000222382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB55.
    SMRiQ9HB55. Positions 28-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    KOiK17692.
    OMAiCPESRFS.
    OrthoDBiEOG744TBS.
    PhylomeDBiQ9HB55.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9HB55-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI    50
    LFYLRGLWNF DRECNEKYGE MWGLYEGQQP MLVIMDPDMI KTVLVKECYS 100
    VFTNQMPLGP MGFLKSALSF AEDEEWKRIR TLLSPAFTSV KFKEMVPIIS 150
    QCGDMLVRSL RQEAENSKSI NLKDFFGAYT MDVITGTLFG VNLDSLNNPQ 200
    DPFLKNMKKL LKLDFLDPFL LLISLFPFLT PVFEALNIGL FPKDVTHFLK 250
    NSIERMKESR LKDKQKHRVD FFQQMIDSQN SKETKSHKAL SDLELVAQSI 300
    IIIFAAYDTT STTLPFIMYE LATHPDVQQK LQEEIDAVLP NKAPVTYDAL 350
    VQMEYLDMVV NETLRLFPVV SRVTRVCKKD IEINGVFIPK GLAVMVPIYA 400
    LHHDPKYWTE PEKFCPERFS KKNKDSIDLY RYIPFGAGPR NCIGMRFALT 450
    NIKLAVIRAL QNFSFKPCKE TQIPLKLDNL PILQPEKPIV LKVHLRDGIT 500
    SGP 503
    Length:503
    Mass (Da):57,670
    Last modified:March 1, 2001 - v1
    Checksum:i2C585B9DC573F634
    GO
    Isoform 2 (identifier: Q9HB55-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         417-417: E → ES

    Show »
    Length:504
    Mass (Da):57,757
    Checksum:iCB87C6873DAB7B0D
    GO
    Isoform 3 (identifier: Q9HB55-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         419-420: FS → SH
         421-503: Missing.

    Show »
    Length:420
    Mass (Da):48,304
    Checksum:i60873437189BA207
    GO
    Isoform 4 (identifier: Q9HB55-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-250: SLFPFLTPVFEALNIGLFPKDVTHFLK → YRVSLCCLGRSAWCDLGSLKPPPPGFE
         251-503: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:250
    Mass (Da):28,490
    Checksum:i858527154F617A06
    GO
    Isoform 7 (identifier: Q9HB55-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-224: GLWNFDRECN...FLDPFLLLIS → RSLNKIPSWA...VMKNTEKCGA

    Show »
    Length:393
    Mass (Da):44,808
    Checksum:iA0D1F6642FC1D9E1
    GO

    Polymorphismi

    At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 8864YGTHS…IMDPD → LGPIHINFLRSWEFLGQPLC LFWELFCSTLGVFGILTENV MKNTEKCGGCMRGNSPCWSS WIPT in allele CYP3A43*2.
    VAR_018050Add
    BLAST
    Natural varianti27 – 271T → A.
    Corresponds to variant rs45558032 [ dbSNP | Ensembl ].
    VAR_048449
    Natural varianti89 – 503415Missing in allele CYP3A43*2.
    VAR_018051Add
    BLAST
    Natural varianti145 – 1451M → I.
    Corresponds to variant rs45450092 [ dbSNP | Ensembl ].
    VAR_048450
    Natural varianti275 – 2751M → I.
    Corresponds to variant rs45621431 [ dbSNP | Ensembl ].
    VAR_048451
    Natural varianti340 – 3401P → A in allele CYP3A43*3. 1 Publication
    Corresponds to variant rs680055 [ dbSNP | Ensembl ].
    VAR_018052

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 224169GLWNF…LLLIS → RSLNKIPSWAWWLTPVIPAL WEAEAGGSPKVRSSRPALPT WVFGILTENVMKNTEKCGA in isoform 7. 1 PublicationVSP_056736Add
    BLAST
    Alternative sequencei224 – 25027SLFPF…THFLK → YRVSLCCLGRSAWCDLGSLK PPPPGFE in isoform 4. CuratedVSP_000612Add
    BLAST
    Alternative sequencei251 – 503253Missing in isoform 4. CuratedVSP_000613Add
    BLAST
    Alternative sequencei417 – 4171E → ES in isoform 2. CuratedVSP_000609
    Alternative sequencei419 – 4202FS → SH in isoform 3. CuratedVSP_000610
    Alternative sequencei421 – 50383Missing in isoform 3. CuratedVSP_000611Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319634 mRNA. Translation: AAK00325.1.
    AF337813 mRNA. Translation: AAK38841.1.
    AF280107 Genomic DNA. Translation: AAG32291.1.
    AF280108 mRNA. Translation: AAG33009.1.
    AF280109 mRNA. Translation: AAG33010.1.
    AF280110 mRNA. Translation: AAG33011.1.
    AF280111 mRNA. Translation: AAG33012.1.
    AY390423 mRNA. Translation: AAQ92351.1.
    AY390424 mRNA. Translation: AAQ92352.1.
    AY390425 mRNA. Translation: AAQ92353.1.
    AY390426 mRNA. Translation: AAQ92354.1.
    AC011904 Genomic DNA. Translation: AAS07394.1.
    AC011904 Genomic DNA. Translation: AAS07395.1.
    CH471091 Genomic DNA. Translation: EAW76632.1.
    CH471091 Genomic DNA. Translation: EAW76634.1.
    BC100981 mRNA. Translation: AAI00982.1.
    CCDSiCCDS5675.1. [Q9HB55-2]
    CCDS5676.1. [Q9HB55-1]
    CCDS5677.1. [Q9HB55-3]
    PIRiJC7627.
    RefSeqiNP_001265850.1. NM_001278921.1.
    NP_073731.1. NM_022820.4. [Q9HB55-2]
    NP_476436.1. NM_057095.2. [Q9HB55-1]
    NP_476437.1. NM_057096.3. [Q9HB55-3]
    UniGeneiHs.306220.
    Hs.571258.
    Hs.728751.

    Genome annotation databases

    EnsembliENST00000222382; ENSP00000222382; ENSG00000021461. [Q9HB55-2]
    ENST00000312017; ENSP00000312110; ENSG00000021461. [Q9HB55-3]
    ENST00000354829; ENSP00000346887; ENSG00000021461. [Q9HB55-1]
    ENST00000417625; ENSP00000416581; ENSG00000021461.
    ENST00000434806; ENSP00000411653; ENSG00000021461. [Q9HB55-4]
    GeneIDi64816.
    KEGGihsa:64816.
    UCSCiuc003urx.1. human. [Q9HB55-1]
    uc003ury.1. human. [Q9HB55-2]
    uc003urz.1. human. [Q9HB55-3]
    uc010lgi.1. human.

    Polymorphism databases

    DMDMi20137481.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP3A43 alleles

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319634 mRNA. Translation: AAK00325.1 .
    AF337813 mRNA. Translation: AAK38841.1 .
    AF280107 Genomic DNA. Translation: AAG32291.1 .
    AF280108 mRNA. Translation: AAG33009.1 .
    AF280109 mRNA. Translation: AAG33010.1 .
    AF280110 mRNA. Translation: AAG33011.1 .
    AF280111 mRNA. Translation: AAG33012.1 .
    AY390423 mRNA. Translation: AAQ92351.1 .
    AY390424 mRNA. Translation: AAQ92352.1 .
    AY390425 mRNA. Translation: AAQ92353.1 .
    AY390426 mRNA. Translation: AAQ92354.1 .
    AC011904 Genomic DNA. Translation: AAS07394.1 .
    AC011904 Genomic DNA. Translation: AAS07395.1 .
    CH471091 Genomic DNA. Translation: EAW76632.1 .
    CH471091 Genomic DNA. Translation: EAW76634.1 .
    BC100981 mRNA. Translation: AAI00982.1 .
    CCDSi CCDS5675.1. [Q9HB55-2 ]
    CCDS5676.1. [Q9HB55-1 ]
    CCDS5677.1. [Q9HB55-3 ]
    PIRi JC7627.
    RefSeqi NP_001265850.1. NM_001278921.1.
    NP_073731.1. NM_022820.4. [Q9HB55-2 ]
    NP_476436.1. NM_057095.2. [Q9HB55-1 ]
    NP_476437.1. NM_057096.3. [Q9HB55-3 ]
    UniGenei Hs.306220.
    Hs.571258.
    Hs.728751.

    3D structure databases

    ProteinModelPortali Q9HB55.
    SMRi Q9HB55. Positions 28-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000222382.

    Chemistry

    BindingDBi Q9HB55.
    ChEMBLi CHEMBL2364675.
    DrugBanki DB00341. Cetirizine.
    DB00254. Doxycycline.

    PTM databases

    PhosphoSitei Q9HB55.

    Polymorphism databases

    DMDMi 20137481.

    Proteomic databases

    PaxDbi Q9HB55.
    PRIDEi Q9HB55.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222382 ; ENSP00000222382 ; ENSG00000021461 . [Q9HB55-2 ]
    ENST00000312017 ; ENSP00000312110 ; ENSG00000021461 . [Q9HB55-3 ]
    ENST00000354829 ; ENSP00000346887 ; ENSG00000021461 . [Q9HB55-1 ]
    ENST00000417625 ; ENSP00000416581 ; ENSG00000021461 .
    ENST00000434806 ; ENSP00000411653 ; ENSG00000021461 . [Q9HB55-4 ]
    GeneIDi 64816.
    KEGGi hsa:64816.
    UCSCi uc003urx.1. human. [Q9HB55-1 ]
    uc003ury.1. human. [Q9HB55-2 ]
    uc003urz.1. human. [Q9HB55-3 ]
    uc010lgi.1. human.

    Organism-specific databases

    CTDi 64816.
    GeneCardsi GC07P099426.
    H-InvDB HIX0033547.
    HGNCi HGNC:17450. CYP3A43.
    MIMi 606534. gene.
    neXtProti NX_Q9HB55.
    PharmGKBi PA427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    KOi K17692.
    OMAi CPESRFS.
    OrthoDBi EOG744TBS.
    PhylomeDBi Q9HB55.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.

    Miscellaneous databases

    GeneWikii CYP3A43.
    GenomeRNAii 64816.
    NextBioi 66908.
    PROi Q9HB55.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HB55.
    Bgeei Q9HB55.
    CleanExi HS_CYP3A43.
    Genevestigatori Q9HB55.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450."
      Domanski T.L., Finta C., Halpert J.R., Zaphiropoulos P.G.
      Mol. Pharmacol. 59:386-392(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHARACTERIZATION.
    2. "Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43."
      Westlind A., Malmebo S., Johansson I., Otter C., Andersson T.B., Ingelman-Sundberg M., Oscarson M.
      Biochem. Biophys. Res. Commun. 281:1349-1355(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
      Tissue: Liver.
    4. "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant."
      Cauffiez C., Lo-Guidice J.-M., Chevalier D., Allorge D., Hamdan R., Lhermitte M., Lafitte J.-J., Colombel J.-F., Libersa C., Broly F.
      Hum. Mutat. 23:101-101(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP3A43*2), VARIANT CYP3A43*3 ALA-340.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    8. "Intergenic mRNA molecules resulting from trans-splicing."
      Finta C., Zaphiropoulos P.G.
      J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TRANS-SPLICING.
    9. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

    Entry informationi

    Entry nameiCP343_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB55
    Secondary accession number(s): Q495Y1
    , Q75MK2, Q75MK3, Q9HB52, Q9HB53, Q9HB54, Q9HB57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3