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Q9HB40

- RISC_HUMAN

UniProt

Q9HB40 - RISC_HUMAN

Protein

Retinoid-inducible serine carboxypeptidase

Gene

SCPEP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be involved in vascular wall and kidney homeostasis.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671PROSITE-ProRule annotation
    Active sitei371 – 3711PROSITE-ProRule annotation
    Active sitei431 – 4311PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: UniProt

    GO - Biological processi

    1. negative regulation of blood pressure Source: UniProt
    2. positive regulation of vasodilation Source: UniProt
    3. retinoic acid metabolic process Source: UniProt

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinoid-inducible serine carboxypeptidase (EC:3.4.16.-)
    Alternative name(s):
    Serine carboxypeptidase 1
    Gene namesi
    Name:SCPEP1
    Synonyms:RISC, SCP1
    ORF Names:MSTP034, UNQ265/PRO302
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29507. SCPEP1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytosol Source: UniProt
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960711.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 452426Retinoid-inducible serine carboxypeptidasePRO_0000004284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)1 Publication
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9HB40.
    PaxDbiQ9HB40.
    PRIDEiQ9HB40.

    PTM databases

    PhosphoSiteiQ9HB40.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HB40.
    BgeeiQ9HB40.
    CleanExiHS_SCPEP1.
    GenevestigatoriQ9HB40.

    Organism-specific databases

    HPAiHPA039102.

    Interactioni

    Protein-protein interaction databases

    BioGridi121884. 12 interactions.
    STRINGi9606.ENSP00000262288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB40.
    SMRiQ9HB40. Positions 42-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000242971.
    HOVERGENiHBG002816.
    InParanoidiQ9HB40.
    KOiK09646.
    OMAiKFNQLKW.
    OrthoDBiEOG7DC245.
    PhylomeDBiQ9HB40.
    TreeFamiTF313740.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HB40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY    50
    MFWWLYYATN SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP 100
    RKTTWLQAAS LLFVDNPVGT GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF 150
    SCHKEFQTVP FYIFSESYGG KMAAGIGLEL YKAIQRGTIK CNFAGVALGD 200
    SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA VNKGLYREAT 250
    ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH 300
    VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI 350
    SIVDELLEAG INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK 400
    ALYSDPKSLE TSAFVKSYKN LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ 450
    QE 452
    Length:452
    Mass (Da):50,831
    Last modified:March 1, 2001 - v1
    Checksum:i40D8FB3CBC09E3DE
    GO
    Isoform 2 (identifier: Q9HB40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         295-296: CL → WF
         297-452: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:296
    Mass (Da):32,957
    Checksum:i883AD532A098E7D3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31L → V.
    Corresponds to variant rs34108204 [ dbSNP | Ensembl ].
    VAR_048684
    Natural varianti241 – 2411V → I.
    Corresponds to variant rs16957938 [ dbSNP | Ensembl ].
    VAR_048685

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei295 – 2962CL → WF in isoform 2. 1 PublicationVSP_008555
    Alternative sequencei297 – 452156Missing in isoform 2. 1 PublicationVSP_008556Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282618 mRNA. Translation: AAG16692.1.
    AY358559 mRNA. Translation: AAQ88923.1.
    AK027373 mRNA. Translation: BAB55069.1.
    BC010078 mRNA. No translation available.
    BC072405 mRNA. Translation: AAH72405.1.
    AF113214 mRNA. Translation: AAG39285.1.
    CCDSiCCDS11593.1. [Q9HB40-1]
    RefSeqiNP_067639.1. NM_021626.2. [Q9HB40-1]
    UniGeneiHs.514950.

    Genome annotation databases

    EnsembliENST00000262288; ENSP00000262288; ENSG00000121064. [Q9HB40-1]
    ENST00000576154; ENSP00000458587; ENSG00000121064. [Q9HB40-2]
    GeneIDi59342.
    KEGGihsa:59342.
    UCSCiuc002iuv.4. human. [Q9HB40-1]

    Polymorphism databases

    DMDMi41690765.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282618 mRNA. Translation: AAG16692.1 .
    AY358559 mRNA. Translation: AAQ88923.1 .
    AK027373 mRNA. Translation: BAB55069.1 .
    BC010078 mRNA. No translation available.
    BC072405 mRNA. Translation: AAH72405.1 .
    AF113214 mRNA. Translation: AAG39285.1 .
    CCDSi CCDS11593.1. [Q9HB40-1 ]
    RefSeqi NP_067639.1. NM_021626.2. [Q9HB40-1 ]
    UniGenei Hs.514950.

    3D structure databases

    ProteinModelPortali Q9HB40.
    SMRi Q9HB40. Positions 42-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121884. 12 interactions.
    STRINGi 9606.ENSP00000262288.

    Chemistry

    ChEMBLi CHEMBL2189131.

    Protein family/group databases

    MEROPSi S10.013.

    PTM databases

    PhosphoSitei Q9HB40.

    Polymorphism databases

    DMDMi 41690765.

    Proteomic databases

    MaxQBi Q9HB40.
    PaxDbi Q9HB40.
    PRIDEi Q9HB40.

    Protocols and materials databases

    DNASUi 59342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262288 ; ENSP00000262288 ; ENSG00000121064 . [Q9HB40-1 ]
    ENST00000576154 ; ENSP00000458587 ; ENSG00000121064 . [Q9HB40-2 ]
    GeneIDi 59342.
    KEGGi hsa:59342.
    UCSCi uc002iuv.4. human. [Q9HB40-1 ]

    Organism-specific databases

    CTDi 59342.
    GeneCardsi GC17P055055.
    HGNCi HGNC:29507. SCPEP1.
    HPAi HPA039102.
    neXtProti NX_Q9HB40.
    PharmGKBi PA134960711.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000242971.
    HOVERGENi HBG002816.
    InParanoidi Q9HB40.
    KOi K09646.
    OMAi KFNQLKW.
    OrthoDBi EOG7DC245.
    PhylomeDBi Q9HB40.
    TreeFami TF313740.

    Miscellaneous databases

    GeneWikii SCPEP1.
    GenomeRNAii 59342.
    NextBioi 65234.
    PROi Q9HB40.

    Gene expression databases

    ArrayExpressi Q9HB40.
    Bgeei Q9HB40.
    CleanExi HS_SCPEP1.
    Genevestigatori Q9HB40.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of novel serine carboxypeptidase precursor."
      Cho J.-J., Baik H.-H.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye and Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-452 (ISOFORM 1).
      Tissue: Aorta.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-41.
    7. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-126.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRISC_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB40
    Secondary accession number(s): Q96A94, Q9H3F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3