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Protein

Retinoid-inducible serine carboxypeptidase

Gene

SCPEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vascular wall and kidney homeostasis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671PROSITE-ProRule annotation
Active sitei371 – 3711PROSITE-ProRule annotation
Active sitei431 – 4311PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihuman-SCPEP1. Carboxypeptidase_S10.
MEROPSiS10.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoid-inducible serine carboxypeptidase (EC:3.4.16.-)
Alternative name(s):
Serine carboxypeptidase 1
Gene namesi
Name:SCPEP1
Synonyms:RISC, SCP1
ORF Names:MSTP034, UNQ265/PRO302
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29507. SCPEP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960711.

Polymorphism and mutation databases

BioMutaiSCPEP1.
DMDMi41690765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 452426Retinoid-inducible serine carboxypeptidasePRO_0000004284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)1 Publication
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HB40.
PaxDbiQ9HB40.
PRIDEiQ9HB40.

PTM databases

PhosphoSiteiQ9HB40.

Expressioni

Gene expression databases

BgeeiQ9HB40.
CleanExiHS_SCPEP1.
ExpressionAtlasiQ9HB40. baseline and differential.
GenevisibleiQ9HB40. HS.

Organism-specific databases

HPAiHPA039102.
HPA057200.

Interactioni

Protein-protein interaction databases

BioGridi121884. 11 interactions.
STRINGi9606.ENSP00000262288.

Structurei

3D structure databases

ProteinModelPortaliQ9HB40.
SMRiQ9HB40. Positions 42-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
GeneTreeiENSGT00790000123063.
HOGENOMiHOG000242971.
HOVERGENiHBG002816.
InParanoidiQ9HB40.
KOiK09646.
OMAiIILEQAN.
OrthoDBiEOG7DC245.
PhylomeDBiQ9HB40.
TreeFamiTF313740.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HB40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY
60 70 80 90 100
MFWWLYYATN SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP
110 120 130 140 150
RKTTWLQAAS LLFVDNPVGT GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF
160 170 180 190 200
SCHKEFQTVP FYIFSESYGG KMAAGIGLEL YKAIQRGTIK CNFAGVALGD
210 220 230 240 250
SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA VNKGLYREAT
260 270 280 290 300
ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH
310 320 330 340 350
VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI
360 370 380 390 400
SIVDELLEAG INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK
410 420 430 440 450
ALYSDPKSLE TSAFVKSYKN LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ

QE
Length:452
Mass (Da):50,831
Last modified:March 1, 2001 - v1
Checksum:i40D8FB3CBC09E3DE
GO
Isoform 2 (identifier: Q9HB40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-296: CL → WF
     297-452: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:296
Mass (Da):32,957
Checksum:i883AD532A098E7D3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31L → V.
Corresponds to variant rs34108204 [ dbSNP | Ensembl ].
VAR_048684
Natural varianti241 – 2411V → I.
Corresponds to variant rs16957938 [ dbSNP | Ensembl ].
VAR_048685

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 2962CL → WF in isoform 2. 1 PublicationVSP_008555
Alternative sequencei297 – 452156Missing in isoform 2. 1 PublicationVSP_008556Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282618 mRNA. Translation: AAG16692.1.
AY358559 mRNA. Translation: AAQ88923.1.
AK027373 mRNA. Translation: BAB55069.1.
BC010078 mRNA. No translation available.
BC072405 mRNA. Translation: AAH72405.1.
AF113214 mRNA. Translation: AAG39285.1.
CCDSiCCDS11593.1. [Q9HB40-1]
RefSeqiNP_067639.1. NM_021626.2. [Q9HB40-1]
UniGeneiHs.514950.

Genome annotation databases

EnsembliENST00000262288; ENSP00000262288; ENSG00000121064.
ENST00000576154; ENSP00000458587; ENSG00000121064. [Q9HB40-2]
GeneIDi59342.
KEGGihsa:59342.
UCSCiuc002iuv.4. human. [Q9HB40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282618 mRNA. Translation: AAG16692.1.
AY358559 mRNA. Translation: AAQ88923.1.
AK027373 mRNA. Translation: BAB55069.1.
BC010078 mRNA. No translation available.
BC072405 mRNA. Translation: AAH72405.1.
AF113214 mRNA. Translation: AAG39285.1.
CCDSiCCDS11593.1. [Q9HB40-1]
RefSeqiNP_067639.1. NM_021626.2. [Q9HB40-1]
UniGeneiHs.514950.

3D structure databases

ProteinModelPortaliQ9HB40.
SMRiQ9HB40. Positions 42-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121884. 11 interactions.
STRINGi9606.ENSP00000262288.

Chemistry

ChEMBLiCHEMBL2189131.

Protein family/group databases

ESTHERihuman-SCPEP1. Carboxypeptidase_S10.
MEROPSiS10.013.

PTM databases

PhosphoSiteiQ9HB40.

Polymorphism and mutation databases

BioMutaiSCPEP1.
DMDMi41690765.

Proteomic databases

MaxQBiQ9HB40.
PaxDbiQ9HB40.
PRIDEiQ9HB40.

Protocols and materials databases

DNASUi59342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262288; ENSP00000262288; ENSG00000121064.
ENST00000576154; ENSP00000458587; ENSG00000121064. [Q9HB40-2]
GeneIDi59342.
KEGGihsa:59342.
UCSCiuc002iuv.4. human. [Q9HB40-1]

Organism-specific databases

CTDi59342.
GeneCardsiGC17P055055.
HGNCiHGNC:29507. SCPEP1.
HPAiHPA039102.
HPA057200.
neXtProtiNX_Q9HB40.
PharmGKBiPA134960711.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2939.
GeneTreeiENSGT00790000123063.
HOGENOMiHOG000242971.
HOVERGENiHBG002816.
InParanoidiQ9HB40.
KOiK09646.
OMAiIILEQAN.
OrthoDBiEOG7DC245.
PhylomeDBiQ9HB40.
TreeFamiTF313740.

Miscellaneous databases

ChiTaRSiSCPEP1. human.
GeneWikiiSCPEP1.
GenomeRNAii59342.
NextBioi65234.
PROiQ9HB40.

Gene expression databases

BgeeiQ9HB40.
CleanExiHS_SCPEP1.
ExpressionAtlasiQ9HB40. baseline and differential.
GenevisibleiQ9HB40. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of novel serine carboxypeptidase precursor."
    Cho J.-J., Baik H.-H.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-452 (ISOFORM 1).
    Tissue: Aorta.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41.
  7. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-126.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRISC_HUMAN
AccessioniPrimary (citable) accession number: Q9HB40
Secondary accession number(s): Q96A94, Q9H3F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.