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Protein

Retinoid-inducible serine carboxypeptidase

Gene

SCPEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vascular wall and kidney homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167PROSITE-ProRule annotation1
Active sitei371PROSITE-ProRule annotation1
Active sitei431PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihuman-SCPEP1. Carboxypeptidase_S10.
MEROPSiS10.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoid-inducible serine carboxypeptidase (EC:3.4.16.-)
Alternative name(s):
Serine carboxypeptidase 1
Gene namesi
Name:SCPEP1
Synonyms:RISC, SCP1
ORF Names:MSTP034, UNQ265/PRO302
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29507. SCPEP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi59342.
OpenTargetsiENSG00000121064.
PharmGKBiPA134960711.

Chemistry databases

ChEMBLiCHEMBL2189131.
DrugBankiDB07506. L-BENZYLSUCCINIC ACID.

Polymorphism and mutation databases

BioMutaiSCPEP1.
DMDMi41690765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000428427 – 452Retinoid-inducible serine carboxypeptidaseAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9HB40.
MaxQBiQ9HB40.
PaxDbiQ9HB40.
PeptideAtlasiQ9HB40.
PRIDEiQ9HB40.
TopDownProteomicsiQ9HB40-1. [Q9HB40-1]

PTM databases

iPTMnetiQ9HB40.
PhosphoSitePlusiQ9HB40.
SwissPalmiQ9HB40.

Expressioni

Gene expression databases

BgeeiENSG00000121064.
CleanExiHS_SCPEP1.
ExpressionAtlasiQ9HB40. baseline and differential.
GenevisibleiQ9HB40. HS.

Organism-specific databases

HPAiHPA039102.
HPA057200.

Interactioni

Protein-protein interaction databases

BioGridi121884. 17 interactors.
IntActiQ9HB40. 1 interactor.
STRINGi9606.ENSP00000262288.

Structurei

3D structure databases

ProteinModelPortaliQ9HB40.
SMRiQ9HB40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1283. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00880000137977.
HOGENOMiHOG000242971.
HOVERGENiHBG002816.
InParanoidiQ9HB40.
KOiK09646.
OMAiTVASDMM.
OrthoDBiEOG091G0FY2.
PhylomeDBiQ9HB40.
TreeFamiTF313740.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00131. CARBOXYPEPT_SER_SER. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HB40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY
60 70 80 90 100
MFWWLYYATN SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP
110 120 130 140 150
RKTTWLQAAS LLFVDNPVGT GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF
160 170 180 190 200
SCHKEFQTVP FYIFSESYGG KMAAGIGLEL YKAIQRGTIK CNFAGVALGD
210 220 230 240 250
SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA VNKGLYREAT
260 270 280 290 300
ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH
310 320 330 340 350
VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI
360 370 380 390 400
SIVDELLEAG INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK
410 420 430 440 450
ALYSDPKSLE TSAFVKSYKN LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ

QE
Length:452
Mass (Da):50,831
Last modified:March 1, 2001 - v1
Checksum:i40D8FB3CBC09E3DE
GO
Isoform 2 (identifier: Q9HB40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-296: CL → WF
     297-452: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:296
Mass (Da):32,957
Checksum:i883AD532A098E7D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0486843L → V. Corresponds to variant dbSNP:rs34108204Ensembl.1
Natural variantiVAR_048685241V → I. Corresponds to variant dbSNP:rs16957938Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008555295 – 296CL → WF in isoform 2. 1 Publication2
Alternative sequenceiVSP_008556297 – 452Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282618 mRNA. Translation: AAG16692.1.
AY358559 mRNA. Translation: AAQ88923.1.
AK027373 mRNA. Translation: BAB55069.1.
BC010078 mRNA. No translation available.
BC072405 mRNA. Translation: AAH72405.1.
AF113214 mRNA. Translation: AAG39285.1.
CCDSiCCDS11593.1. [Q9HB40-1]
RefSeqiNP_067639.1. NM_021626.2. [Q9HB40-1]
UniGeneiHs.514950.

Genome annotation databases

EnsembliENST00000262288; ENSP00000262288; ENSG00000121064. [Q9HB40-1]
ENST00000576154; ENSP00000458587; ENSG00000121064. [Q9HB40-2]
GeneIDi59342.
KEGGihsa:59342.
UCSCiuc002iuv.5. human. [Q9HB40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRISC_HUMAN
AccessioniPrimary (citable) accession number: Q9HB40
Secondary accession number(s): Q96A94, Q9H3F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families