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Protein

Homeobox protein SEBOX

Gene

SEBOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable transcription factor involved in the control of specification of mesoderm and endoderm.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi45 – 10460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SEBOX
Alternative name(s):
Homeobox OG-9
Skin-, embryo-, brain- and oocyte-specific homeobox
Gene namesi
Name:SEBOX
Synonyms:OG9X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32942. SEBOX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSEBOX.
DMDMi322510071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Homeobox protein SEBOXPRO_0000311336Add
BLAST

Proteomic databases

PaxDbiQ9HB31.
PRIDEiQ9HB31.

Expressioni

Gene expression databases

ExpressionAtlasiQ9HB31. baseline.
GenevisibleiQ9HB31. HS.

Organism-specific databases

HPAiCAB016695.
CAB016765.
HPA045689.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000416240.

Structurei

3D structure databases

ProteinModelPortaliQ9HB31.
SMRiQ9HB31. Positions 45-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000231518.
HOVERGENiHBG098434.
InParanoidiQ9HB31.
OMAiDIGTREH.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSGVGTAW HGPLARPSGT LPFASSMPSP VDASSADGGS GLGSHRRKRT
60 70 80 90 100
TFSKGQLLEL ERAFAAWPYP NISTHEHLAW VTCLPEAKVQ VWFQKRWAKI
110 120 130 140 150
IKNRKSGILS PGSECPQSSC SLPDTLQQPW DPQMPGQPPP SSGTPQRTSV
160 170 180 190 200
CRHSSCPAPG LSPRQGWEGA KAVAPWGSAG ASEVHPSLER ATPQTSLGSL
210
SDLIYALAIV VNVDHS
Length:216
Mass (Da):22,879
Last modified:February 8, 2011 - v2
Checksum:i97FD1BC8BF8F716C
GO

Sequence cautioni

The sequence AAG14458.1 differs from that shown. Reason: Frameshift at position 9. Curated
The sequence EAW51081.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti207 – 2071L → S.2 Publications
Corresponds to variant rs9910163 [ dbSNP | Ensembl ].
VAR_037228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284337 Genomic DNA. Translation: AAG14458.1. Frameshift.
AC002094 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51081.1. Sequence problems.

Genome annotation databases

EnsembliENST00000438614; ENSP00000395142; ENSG00000274529.
UCSCiuc010wai.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284337 Genomic DNA. Translation: AAG14458.1. Frameshift.
AC002094 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51081.1. Sequence problems.

3D structure databases

ProteinModelPortaliQ9HB31.
SMRiQ9HB31. Positions 45-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000416240.

Polymorphism and mutation databases

BioMutaiSEBOX.
DMDMi322510071.

Proteomic databases

PaxDbiQ9HB31.
PRIDEiQ9HB31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438614; ENSP00000395142; ENSG00000274529.
UCSCiuc010wai.1. human.

Organism-specific databases

GeneCardsiSEBOX.
HGNCiHGNC:32942. SEBOX.
HPAiCAB016695.
CAB016765.
HPA045689.
MIMi610975. gene.
neXtProtiNX_Q9HB31.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000231518.
HOVERGENiHBG098434.
InParanoidiQ9HB31.
OMAiDIGTREH.
TreeFamiTF315976.

Miscellaneous databases

PROiQ9HB31.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9HB31. baseline.
GenevisibleiQ9HB31. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos."
    Cinquanta M., Rovescalli A.C., Kozak C.A., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 97:8904-8909(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-207.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-207.

Entry informationi

Entry nameiSEBOX_HUMAN
AccessioniPrimary (citable) accession number: Q9HB31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 8, 2011
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.