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Q9HB29

- ILRL2_HUMAN

UniProt

Q9HB29 - ILRL2_HUMAN

Protein

Interleukin-1 receptor-like 2

Gene

IL1RL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B.1 Publication

    GO - Molecular functioni

    1. interleukin-1, Type I, activating receptor activity Source: InterPro
    2. interleukin-1 receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. cytokine-mediated signaling pathway Source: GOC
    3. positive regulation of interleukin-6 production Source: Ensembl
    4. positive regulation of T cell differentiation Source: Ensembl
    5. regulation of inflammatory response Source: Ensembl
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor-like 2
    Alternative name(s):
    IL-36 receptor
    Short name:
    IL-36R
    Interleukin-1 receptor-related protein 2
    Short name:
    IL-1Rrp2
    Short name:
    IL1R-rp2
    Gene namesi
    Name:IL1RL2
    Synonyms:IL1RRP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5999. IL1RL2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29815.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 575556Interleukin-1 receptor-like 2PRO_0000015445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi42 ↔ 95PROSITE-ProRule annotation
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 195PROSITE-ProRule annotation
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 316PROSITE-ProRule annotation
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9HB29.
    PRIDEiQ9HB29.

    PTM databases

    PhosphoSiteiQ9HB29.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HB29.
    BgeeiQ9HB29.
    CleanExiHS_IL1RL2.
    GenevestigatoriQ9HB29.

    Organism-specific databases

    HPAiHPA015485.

    Interactioni

    Subunit structurei

    Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000264257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB29.
    SMRiQ9HB29. Positions 53-330, 381-537.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 335316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 575219CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11192Ig-like C2-type 1Add
    BLAST
    Domaini126 – 21186Ig-like C2-type 2Add
    BLAST
    Domaini222 – 31897Ig-like C2-type 3Add
    BLAST
    Domaini381 – 539159TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40914.
    HOGENOMiHOG000253916.
    HOVERGENiHBG052103.
    InParanoidiQ9HB29.
    KOiK05172.
    OMAiFTEQSQC.
    OrthoDBiEOG7H1JK3.
    PhylomeDBiQ9HB29.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HB29-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG    50
    EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR 100
    DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF 150
    PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT 200
    HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN 250
    VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI 300
    TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV 350
    SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA 400
    VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV 450
    IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES 500
    IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL 550
    QHTPCYRTAG PELGSRRKKC TLTTG 575
    Length:575
    Mass (Da):65,405
    Last modified:February 7, 2006 - v2
    Checksum:i7AC0FCAB43A2A6CD
    GO
    Isoform 2 (identifier: Q9HB29-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: MWSLLLCGLS...PFAFNCTFPP → MTGLVSLSYF...PSPFHCLSQQ
         47-163: Missing.
         217-218: TE → K

    Note: No experimental confirmation available.

    Show »
    Length:457
    Mass (Da):51,658
    Checksum:i573004E5D66E67BE
    GO

    Sequence cautioni

    The sequence AAB53237.1 differs from that shown. Reason: Frameshift at position 556.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861I → V in AAG21368. (PubMed:10882729)Curated
    Sequence conflicti545 – 55612PPVQL…HTPCY → LRSTCRSTHLCTA(PubMed:8898719)CuratedAdd
    BLAST
    Sequence conflicti556 – 5561Y → C in AAG21368. (PubMed:10882729)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti237 – 2371I → T.
    Corresponds to variant rs13405631 [ dbSNP | Ensembl ].
    VAR_053378
    Natural varianti352 – 3521V → I.1 Publication
    Corresponds to variant rs33946385 [ dbSNP | Ensembl ].
    VAR_025259
    Natural varianti550 – 5501L → P.1 Publication
    Corresponds to variant rs2302612 [ dbSNP | Ensembl ].
    VAR_025260

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4646MWSLL…CTFPP → MTGLVSLSYFPLSTRSCALQ SCSPVWGCGPCCSAGCPSPF HCLSQQ in isoform 2. 1 PublicationVSP_056292Add
    BLAST
    Alternative sequencei47 – 163117Missing in isoform 2. 1 PublicationVSP_056293Add
    BLAST
    Alternative sequencei217 – 2182TE → K in isoform 2. 1 PublicationVSP_056294

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284434 mRNA. Translation: AAG21368.1.
    U49065 mRNA. Translation: AAB53237.1. Frameshift.
    DQ131903 Genomic DNA. Translation: AAZ38712.1.
    AC007271 Genomic DNA. Translation: AAX81989.1.
    AC007248 Genomic DNA. Translation: AAY15046.1.
    BC107064 mRNA. Translation: AAI07065.1.
    CCDSiCCDS2056.1.
    PIRiG02426.
    RefSeqiNP_003845.2. NM_003854.2.
    XP_005264093.1. XM_005264036.1.
    UniGeneiHs.659863.

    Genome annotation databases

    EnsembliENST00000264257; ENSP00000264257; ENSG00000115598.
    ENST00000441515; ENSP00000413348; ENSG00000115598.
    ENST00000539491; ENSP00000442184; ENSG00000115598.
    GeneIDi8808.
    KEGGihsa:8808.
    UCSCiuc002tbs.3. human.

    Polymorphism databases

    DMDMi90110768.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284434 mRNA. Translation: AAG21368.1 .
    U49065 mRNA. Translation: AAB53237.1 . Frameshift.
    DQ131903 Genomic DNA. Translation: AAZ38712.1 .
    AC007271 Genomic DNA. Translation: AAX81989.1 .
    AC007248 Genomic DNA. Translation: AAY15046.1 .
    BC107064 mRNA. Translation: AAI07065.1 .
    CCDSi CCDS2056.1.
    PIRi G02426.
    RefSeqi NP_003845.2. NM_003854.2.
    XP_005264093.1. XM_005264036.1.
    UniGenei Hs.659863.

    3D structure databases

    ProteinModelPortali Q9HB29.
    SMRi Q9HB29. Positions 53-330, 381-537.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000264257.

    PTM databases

    PhosphoSitei Q9HB29.

    Polymorphism databases

    DMDMi 90110768.

    Proteomic databases

    PaxDbi Q9HB29.
    PRIDEi Q9HB29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264257 ; ENSP00000264257 ; ENSG00000115598 .
    ENST00000441515 ; ENSP00000413348 ; ENSG00000115598 .
    ENST00000539491 ; ENSP00000442184 ; ENSG00000115598 .
    GeneIDi 8808.
    KEGGi hsa:8808.
    UCSCi uc002tbs.3. human.

    Organism-specific databases

    CTDi 8808.
    GeneCardsi GC02P102803.
    H-InvDB HIX0029839.
    HGNCi HGNC:5999. IL1RL2.
    HPAi HPA015485.
    MIMi 604512. gene.
    neXtProti NX_Q9HB29.
    PharmGKBi PA29815.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40914.
    HOGENOMi HOG000253916.
    HOVERGENi HBG052103.
    InParanoidi Q9HB29.
    KOi K05172.
    OMAi FTEQSQC.
    OrthoDBi EOG7H1JK3.
    PhylomeDBi Q9HB29.
    TreeFami TF325519.

    Miscellaneous databases

    GeneWikii IL1RL2.
    GenomeRNAii 8808.
    NextBioi 33040.
    PROi Q9HB29.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HB29.
    Bgeei Q9HB29.
    CleanExi HS_IL1RL2.
    Genevestigatori Q9HB29.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
      Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
      J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)."
      Lovenberg T.W., Crowe P.D., Liu C., Chalmers D.T., Liu X.-J., Liaw C., Clevenger W., Oltersdorf T., De Souza E.B., Maki R.A.
      J. Neuroimmunol. 70:113-122(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. SeattleSNPs variation discovery resource
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-352 AND PRO-550.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
      Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
      J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS RECEPTOR FOR IL36G.

    Entry informationi

    Entry nameiILRL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB29
    Secondary accession number(s): A4FU63
    , Q13525, Q45H74, Q53TU8, Q587I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3