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Protein

Interleukin-1 receptor-like 2

Gene

IL1RL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.By similarity1 Publication

GO - Molecular functioni

  • interleukin-1, Type I, activating receptor activity Source: InterPro
  • interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Short name:
IL-36R
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:IL1RL2
Synonyms:IL1RRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115598.9.
HGNCiHGNC:5999. IL1RL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 335ExtracellularSequence analysisAdd BLAST316
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 575CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8808.
OpenTargetsiENSG00000115598.
PharmGKBiPA29815.

Polymorphism and mutation databases

BioMutaiIL1RL2.
DMDMi90110768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001544520 – 575Interleukin-1 receptor-like 2Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 95PROSITE-ProRule annotation
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 195PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 316PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB29.
PeptideAtlasiQ9HB29.
PRIDEiQ9HB29.

PTM databases

iPTMnetiQ9HB29.
PhosphoSitePlusiQ9HB29.

Expressioni

Tissue specificityi

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.2 Publications

Gene expression databases

BgeeiENSG00000115598.
CleanExiHS_IL1RL2.
ExpressionAtlasiQ9HB29. baseline and differential.
GenevisibleiQ9HB29. HS.

Organism-specific databases

HPAiHPA015485.

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).By similarity

Protein-protein interaction databases

BioGridi114336. 7 interactors.
STRINGi9606.ENSP00000264257.

Structurei

3D structure databases

ProteinModelPortaliQ9HB29.
SMRiQ9HB29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 111Ig-like C2-type 1Add BLAST92
Domaini126 – 211Ig-like C2-type 2Add BLAST86
Domaini222 – 318Ig-like C2-type 3Add BLAST97
Domaini381 – 539TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9HB29.
KOiK05172.
OMAiDNTNLRC.
OrthoDBiEOG091G03IT.
PhylomeDBiQ9HB29.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiView protein in Pfam
PF13895. Ig_2. 2 hits.
PF01582. TIR. 1 hit.
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HB29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG
60 70 80 90 100
EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR
110 120 130 140 150
DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF
160 170 180 190 200
PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT
210 220 230 240 250
HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN
260 270 280 290 300
VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI
310 320 330 340 350
TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV
360 370 380 390 400
SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA
410 420 430 440 450
VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV
460 470 480 490 500
IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES
510 520 530 540 550
IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL
560 570
QHTPCYRTAG PELGSRRKKC TLTTG
Length:575
Mass (Da):65,405
Last modified:February 7, 2006 - v2
Checksum:i7AC0FCAB43A2A6CD
GO
Isoform 2 (identifier: Q9HB29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MWSLLLCGLS...PFAFNCTFPP → MTGLVSLSYF...PSPFHCLSQQ
     47-163: Missing.
     217-218: TE → K

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):51,658
Checksum:i573004E5D66E67BE
GO

Sequence cautioni

The sequence AAB53237 differs from that shown. Reason: Frameshift at position 556.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486I → V in AAG21368 (PubMed:10882729).Curated1
Sequence conflicti545 – 556PPVQL…HTPCY → LRSTCRSTHLCTA (PubMed:8898719).CuratedAdd BLAST12
Sequence conflicti556Y → C in AAG21368 (PubMed:10882729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053378237I → T. Corresponds to variant dbSNP:rs13405631Ensembl.1
Natural variantiVAR_025259352V → I1 PublicationCorresponds to variant dbSNP:rs33946385Ensembl.1
Natural variantiVAR_025260550L → P1 PublicationCorresponds to variant dbSNP:rs2302612Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562921 – 46MWSLL…CTFPP → MTGLVSLSYFPLSTRSCALQ SCSPVWGCGPCCSAGCPSPF HCLSQQ in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_05629347 – 163Missing in isoform 2. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_056294217 – 218TE → K in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284434 mRNA. Translation: AAG21368.1.
U49065 mRNA. Translation: AAB53237.1. Frameshift.
DQ131903 Genomic DNA. Translation: AAZ38712.1.
AC007271 Genomic DNA. Translation: AAX81989.1.
AC007248 Genomic DNA. Translation: AAY15046.1.
BC107064 mRNA. Translation: AAI07065.1.
CCDSiCCDS2056.1. [Q9HB29-1]
PIRiG02426.
RefSeqiNP_003845.2. NM_003854.2. [Q9HB29-1]
XP_005264093.1. XM_005264036.1. [Q9HB29-1]
UniGeneiHs.659863.

Genome annotation databases

EnsembliENST00000264257; ENSP00000264257; ENSG00000115598. [Q9HB29-1]
ENST00000441515; ENSP00000413348; ENSG00000115598. [Q9HB29-2]
GeneIDi8808.
KEGGihsa:8808.
UCSCiuc002tbs.4. human. [Q9HB29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiILRL2_HUMAN
AccessioniPrimary (citable) accession number: Q9HB29
Secondary accession number(s): A4FU63
, Q13525, Q45H74, Q53TU8, Q587I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 7, 2006
Last modified: September 27, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families