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Q9HB29

- ILRL2_HUMAN

UniProt

Q9HB29 - ILRL2_HUMAN

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Protein

Interleukin-1 receptor-like 2

Gene
IL1RL2, IL1RRP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B.1 Publication

GO - Molecular functioni

  1. interleukin-1, Type I, activating receptor activity Source: InterPro
  2. interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. cytokine-mediated signaling pathway Source: GOC
  3. positive regulation of interleukin-6 production Source: Ensembl
  4. positive regulation of T cell differentiation Source: Ensembl
  5. regulation of inflammatory response Source: Ensembl
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Short name:
IL-36R
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:IL1RL2
Synonyms:IL1RRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5999. IL1RL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 335316Extracellular Reviewed predictionAdd
BLAST
Transmembranei336 – 35621Helical; Reviewed predictionAdd
BLAST
Topological domaini357 – 575219Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 575556Interleukin-1 receptor-like 2PRO_0000015445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi42 ↔ 95 By similarity
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi146 ↔ 195 By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi249 ↔ 316 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB29.
PRIDEiQ9HB29.

PTM databases

PhosphoSiteiQ9HB29.

Expressioni

Gene expression databases

ArrayExpressiQ9HB29.
BgeeiQ9HB29.
CleanExiHS_IL1RL2.
GenevestigatoriQ9HB29.

Organism-specific databases

HPAiHPA015485.

Interactioni

Subunit structurei

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Protein-protein interaction databases

STRINGi9606.ENSP00000264257.

Structurei

3D structure databases

ProteinModelPortaliQ9HB29.
SMRiQ9HB29. Positions 53-330, 381-537.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like C2-type 1Add
BLAST
Domaini126 – 21186Ig-like C2-type 2Add
BLAST
Domaini222 – 31897Ig-like C2-type 3Add
BLAST
Domaini381 – 539159TIRAdd
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40914.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9HB29.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG7H1JK3.
PhylomeDBiQ9HB29.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HB29-1 [UniParc]FASTAAdd to Basket

« Hide

MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG    50
EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR 100
DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF 150
PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT 200
HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN 250
VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI 300
TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV 350
SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA 400
VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV 450
IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES 500
IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL 550
QHTPCYRTAG PELGSRRKKC TLTTG 575
Length:575
Mass (Da):65,405
Last modified:February 7, 2006 - v2
Checksum:i7AC0FCAB43A2A6CD
GO

Sequence cautioni

The sequence AAB53237.1 differs from that shown. Reason: Frameshift at position 556.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371I → T.
Corresponds to variant rs13405631 [ dbSNP | Ensembl ].
VAR_053378
Natural varianti352 – 3521V → I.1 Publication
Corresponds to variant rs33946385 [ dbSNP | Ensembl ].
VAR_025259
Natural varianti550 – 5501L → P.1 Publication
Corresponds to variant rs2302612 [ dbSNP | Ensembl ].
VAR_025260

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861I → V in AAG21368. 1 Publication
Sequence conflicti545 – 55612PPVQL…HTPCY → LRSTCRSTHLCTA1 PublicationAdd
BLAST
Sequence conflicti556 – 5561Y → C in AAG21368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284434 mRNA. Translation: AAG21368.1.
U49065 mRNA. Translation: AAB53237.1. Frameshift.
DQ131903 Genomic DNA. Translation: AAZ38712.1.
AC007271 Genomic DNA. Translation: AAX81989.1.
AC007248 Genomic DNA. Translation: AAY15046.1.
CCDSiCCDS2056.1.
PIRiG02426.
RefSeqiNP_003845.2. NM_003854.2.
XP_005264093.1. XM_005264036.1.
UniGeneiHs.659863.

Genome annotation databases

EnsembliENST00000264257; ENSP00000264257; ENSG00000115598.
ENST00000539491; ENSP00000442184; ENSG00000115598.
GeneIDi8808.
KEGGihsa:8808.
UCSCiuc002tbs.3. human.

Polymorphism databases

DMDMi90110768.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284434 mRNA. Translation: AAG21368.1 .
U49065 mRNA. Translation: AAB53237.1 . Frameshift.
DQ131903 Genomic DNA. Translation: AAZ38712.1 .
AC007271 Genomic DNA. Translation: AAX81989.1 .
AC007248 Genomic DNA. Translation: AAY15046.1 .
CCDSi CCDS2056.1.
PIRi G02426.
RefSeqi NP_003845.2. NM_003854.2.
XP_005264093.1. XM_005264036.1.
UniGenei Hs.659863.

3D structure databases

ProteinModelPortali Q9HB29.
SMRi Q9HB29. Positions 53-330, 381-537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000264257.

PTM databases

PhosphoSitei Q9HB29.

Polymorphism databases

DMDMi 90110768.

Proteomic databases

PaxDbi Q9HB29.
PRIDEi Q9HB29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264257 ; ENSP00000264257 ; ENSG00000115598 .
ENST00000539491 ; ENSP00000442184 ; ENSG00000115598 .
GeneIDi 8808.
KEGGi hsa:8808.
UCSCi uc002tbs.3. human.

Organism-specific databases

CTDi 8808.
GeneCardsi GC02P102803.
H-InvDB HIX0029839.
HGNCi HGNC:5999. IL1RL2.
HPAi HPA015485.
MIMi 604512. gene.
neXtProti NX_Q9HB29.
PharmGKBi PA29815.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40914.
HOGENOMi HOG000253916.
HOVERGENi HBG052103.
InParanoidi Q9HB29.
KOi K05172.
OMAi FTEQSQC.
OrthoDBi EOG7H1JK3.
PhylomeDBi Q9HB29.
TreeFami TF325519.

Miscellaneous databases

GeneWikii IL1RL2.
GenomeRNAii 8808.
NextBioi 33040.
PROi Q9HB29.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HB29.
Bgeei Q9HB29.
CleanExi HS_IL1RL2.
Genevestigatori Q9HB29.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
    Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
    J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)."
    Lovenberg T.W., Crowe P.D., Liu C., Chalmers D.T., Liu X.-J., Liaw C., Clevenger W., Oltersdorf T., De Souza E.B., Maki R.A.
    J. Neuroimmunol. 70:113-122(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. SeattleSNPs variation discovery resource
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-352 AND PRO-550.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
    Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
    J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS RECEPTOR FOR IL36G.

Entry informationi

Entry nameiILRL2_HUMAN
AccessioniPrimary (citable) accession number: Q9HB29
Secondary accession number(s): Q13525
, Q45H74, Q53TU8, Q587I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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