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Q9HB29

- ILRL2_HUMAN

UniProt

Q9HB29 - ILRL2_HUMAN

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Protein

Interleukin-1 receptor-like 2

Gene

IL1RL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways By similarity. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.By similarity1 Publication

GO - Molecular functioni

  1. interleukin-1, Type I, activating receptor activity Source: InterPro
  2. interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. cytokine-mediated signaling pathway Source: GOC
  3. positive regulation of interleukin-6 production Source: Ensembl
  4. positive regulation of T cell differentiation Source: Ensembl
  5. regulation of inflammatory response Source: Ensembl
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Short name:
IL-36R
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:IL1RL2
Synonyms:IL1RRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5999. IL1RL2.

Subcellular locationi

Membrane; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 575556Interleukin-1 receptor-like 2PRO_0000015445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi42 ↔ 95PROSITE-ProRule annotation
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 195PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 316PROSITE-ProRule annotation
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB29.
PRIDEiQ9HB29.

PTM databases

PhosphoSiteiQ9HB29.

Expressioni

Tissue specificityi

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.2 Publications

Gene expression databases

BgeeiQ9HB29.
CleanExiHS_IL1RL2.
ExpressionAtlasiQ9HB29. baseline and differential.
GenevestigatoriQ9HB29.

Organism-specific databases

HPAiHPA015485.

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN By similarity.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000264257.

Structurei

3D structure databases

ProteinModelPortaliQ9HB29.
SMRiQ9HB29. Positions 53-330, 381-537.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 335316ExtracellularSequence AnalysisAdd
BLAST
Topological domaini357 – 575219CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like C2-type 1Add
BLAST
Domaini126 – 21186Ig-like C2-type 2Add
BLAST
Domaini222 – 31897Ig-like C2-type 3Add
BLAST
Domaini381 – 539159TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40914.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiQ9HB29.
KOiK05172.
OMAiFTEQSQC.
OrthoDBiEOG7H1JK3.
PhylomeDBiQ9HB29.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HB29-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG
60 70 80 90 100
EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR
110 120 130 140 150
DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF
160 170 180 190 200
PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT
210 220 230 240 250
HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN
260 270 280 290 300
VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI
310 320 330 340 350
TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV
360 370 380 390 400
SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA
410 420 430 440 450
VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV
460 470 480 490 500
IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES
510 520 530 540 550
IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL
560 570
QHTPCYRTAG PELGSRRKKC TLTTG
Length:575
Mass (Da):65,405
Last modified:February 7, 2006 - v2
Checksum:i7AC0FCAB43A2A6CD
GO
Isoform 2 (identifier: Q9HB29-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MWSLLLCGLS...PFAFNCTFPP → MTGLVSLSYF...PSPFHCLSQQ
     47-163: Missing.
     217-218: TE → K

Note: No experimental confirmation available.

Show »
Length:457
Mass (Da):51,658
Checksum:i573004E5D66E67BE
GO

Sequence cautioni

The sequence AAB53237.1 differs from that shown. Reason: Frameshift at position 556.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861I → V in AAG21368. (PubMed:10882729)Curated
Sequence conflicti545 – 55612PPVQL…HTPCY → LRSTCRSTHLCTA(PubMed:8898719)CuratedAdd
BLAST
Sequence conflicti556 – 5561Y → C in AAG21368. (PubMed:10882729)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371I → T.
Corresponds to variant rs13405631 [ dbSNP | Ensembl ].
VAR_053378
Natural varianti352 – 3521V → I.1 Publication
Corresponds to variant rs33946385 [ dbSNP | Ensembl ].
VAR_025259
Natural varianti550 – 5501L → P.1 Publication
Corresponds to variant rs2302612 [ dbSNP | Ensembl ].
VAR_025260

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646MWSLL…CTFPP → MTGLVSLSYFPLSTRSCALQ SCSPVWGCGPCCSAGCPSPF HCLSQQ in isoform 2. 1 PublicationVSP_056292Add
BLAST
Alternative sequencei47 – 163117Missing in isoform 2. 1 PublicationVSP_056293Add
BLAST
Alternative sequencei217 – 2182TE → K in isoform 2. 1 PublicationVSP_056294

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284434 mRNA. Translation: AAG21368.1.
U49065 mRNA. Translation: AAB53237.1. Frameshift.
DQ131903 Genomic DNA. Translation: AAZ38712.1.
AC007271 Genomic DNA. Translation: AAX81989.1.
AC007248 Genomic DNA. Translation: AAY15046.1.
BC107064 mRNA. Translation: AAI07065.1.
CCDSiCCDS2056.1. [Q9HB29-1]
PIRiG02426.
RefSeqiNP_003845.2. NM_003854.2.
XP_005264093.1. XM_005264036.1.
UniGeneiHs.659863.

Genome annotation databases

EnsembliENST00000264257; ENSP00000264257; ENSG00000115598. [Q9HB29-1]
ENST00000441515; ENSP00000413348; ENSG00000115598. [Q9HB29-2]
GeneIDi8808.
KEGGihsa:8808.
UCSCiuc002tbs.3. human. [Q9HB29-1]

Polymorphism databases

DMDMi90110768.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF284434 mRNA. Translation: AAG21368.1 .
U49065 mRNA. Translation: AAB53237.1 . Frameshift.
DQ131903 Genomic DNA. Translation: AAZ38712.1 .
AC007271 Genomic DNA. Translation: AAX81989.1 .
AC007248 Genomic DNA. Translation: AAY15046.1 .
BC107064 mRNA. Translation: AAI07065.1 .
CCDSi CCDS2056.1. [Q9HB29-1 ]
PIRi G02426.
RefSeqi NP_003845.2. NM_003854.2.
XP_005264093.1. XM_005264036.1.
UniGenei Hs.659863.

3D structure databases

ProteinModelPortali Q9HB29.
SMRi Q9HB29. Positions 53-330, 381-537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000264257.

PTM databases

PhosphoSitei Q9HB29.

Polymorphism databases

DMDMi 90110768.

Proteomic databases

PaxDbi Q9HB29.
PRIDEi Q9HB29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264257 ; ENSP00000264257 ; ENSG00000115598 . [Q9HB29-1 ]
ENST00000441515 ; ENSP00000413348 ; ENSG00000115598 . [Q9HB29-2 ]
GeneIDi 8808.
KEGGi hsa:8808.
UCSCi uc002tbs.3. human. [Q9HB29-1 ]

Organism-specific databases

CTDi 8808.
GeneCardsi GC02P102803.
H-InvDB HIX0029839.
HGNCi HGNC:5999. IL1RL2.
HPAi HPA015485.
MIMi 604512. gene.
neXtProti NX_Q9HB29.
PharmGKBi PA29815.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40914.
GeneTreei ENSGT00760000119071.
HOGENOMi HOG000253916.
HOVERGENi HBG052103.
InParanoidi Q9HB29.
KOi K05172.
OMAi FTEQSQC.
OrthoDBi EOG7H1JK3.
PhylomeDBi Q9HB29.
TreeFami TF325519.

Miscellaneous databases

GeneWikii IL1RL2.
GenomeRNAii 8808.
NextBioi 33040.
PROi Q9HB29.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB29.
CleanExi HS_IL1RL2.
ExpressionAtlasi Q9HB29. baseline and differential.
Genevestigatori Q9HB29.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."
    Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., Sims J.E.
    J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)."
    Lovenberg T.W., Crowe P.D., Liu C., Chalmers D.T., Liu X.-J., Liaw C., Clevenger W., Oltersdorf T., De Souza E.B., Maki R.A.
    J. Neuroimmunol. 70:113-122(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. SeattleSNPs variation discovery resource
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-352 AND PRO-550.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
    Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
    J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS RECEPTOR FOR IL36G.
  7. "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."
    Magne D., Palmer G., Barton J.L., Mezin F., Talabot-Ayer D., Bas S., Duffy T., Noger M., Guerne P.A., Nicklin M.J., Gabay C.
    Arthritis Res. Ther. 8:R80-R80(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."
    Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W., Gudjonsson J.E., Ward N.L., Johnston A.
    J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiILRL2_HUMAN
AccessioniPrimary (citable) accession number: Q9HB29
Secondary accession number(s): A4FU63
, Q13525, Q45H74, Q53TU8, Q587I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3