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Protein

Pleckstrin homology domain-containing family A member 3

Gene

PLEKHA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).1 Publication

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: Ensembl
  • phospholipid binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116095-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 3
Short name:
PH domain-containing family A member 3
Alternative name(s):
Phosphatidylinositol-four-phosphate adapter protein 1
Short name:
FAPP-1
Short name:
Phosphoinositol 4-phosphate adapter protein 1
Gene namesi
Name:PLEKHA3
Synonyms:FAPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14338. PLEKHA3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116095.
PharmGKBiPA33403.

Polymorphism and mutation databases

BioMutaiPLEKHA3.
DMDMi48474646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538781 – 300Pleckstrin homology domain-containing family A member 3Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HB20.
MaxQBiQ9HB20.
PaxDbiQ9HB20.
PeptideAtlasiQ9HB20.
PRIDEiQ9HB20.

PTM databases

iPTMnetiQ9HB20.
PhosphoSitePlusiQ9HB20.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000116095.
CleanExiHS_PLEKHA3.
ExpressionAtlasiQ9HB20. baseline and differential.
GenevisibleiQ9HB20. HS.

Organism-specific databases

HPAiHPA034496.
HPA034497.

Interactioni

Subunit structurei

Interacts with GTP-bound ARF1.1 Publication

Protein-protein interaction databases

BioGridi122427. 4 interactors.
IntActiQ9HB20. 2 interactors.
STRINGi9606.ENSP00000234453.

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Turni11 – 13Combined sources3
Beta strandi15 – 23Combined sources9
Beta strandi26 – 32Combined sources7
Helixi33 – 38Combined sources6
Beta strandi43 – 45Combined sources3
Helixi46 – 48Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi58 – 65Combined sources8
Turni66 – 68Combined sources3
Beta strandi69 – 74Combined sources6
Helixi78 – 89Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KCJNMR-A1-100[»]
2MDXNMR-A1-100[»]
3RCPX-ray1.90A1-99[»]
ProteinModelPortaliQ9HB20.
SMRiQ9HB20.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HB20.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 93PHPROSITE-ProRule annotationAdd BLAST93

Domaini

The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN).By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3221. Eukaryota.
ENOG410YFEA. LUCA.
GeneTreeiENSGT00650000093230.
HOGENOMiHOG000231911.
HOVERGENiHBG053613.
InParanoidiQ9HB20.
KOiK20313.
OMAiRPVHCSR.
OrthoDBiEOG091G0IIT.
PhylomeDBiQ9HB20.
TreeFamiTF317467.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVLYKWTN YLTGWQPRWF VLDNGILSYY DSQDDVCKGS KGSIKMAVCE
60 70 80 90 100
IKVHSADNTR MELIIPGEQH FYMKAVNAAE RQRWLVALGS SKACLTDTRT
110 120 130 140 150
KKEKEISETS ESLKTKMSEL RLYCDLLMQQ VHTIQEFVHH DENHSSPSAE
160 170 180 190 200
NMNEASSLLS ATCNTFITTL EECVKIANAK FKPEMFQLHH PDPLVSPVSP
210 220 230 240 250
SPVQMMKRSV SHPGSCSSER SSHSIKEPVS TLHRLSQRRR RTYSDTDSCS
260 270 280 290 300
DIPLEDPDRP VHCSKNTLNG DLASATIPEE SRLMAKKQSE SEDTLPSFSS
Length:300
Mass (Da):33,861
Last modified:March 29, 2004 - v2
Checksum:i0B6EF45C7D17E82C
GO

Sequence cautioni

The sequence BAA90927 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284M → T in AAG15199 (PubMed:11001876).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286162 mRNA. Translation: AAG15199.1.
AK000074 mRNA. Translation: BAA90927.1. Different initiation.
AK314459 mRNA. Translation: BAG37067.1.
AC009948 Genomic DNA. Translation: AAX88884.1.
CH471058 Genomic DNA. Translation: EAX11026.1.
BC044567 mRNA. Translation: AAH44567.1.
CCDSiCCDS33336.1.
RefSeqiNP_061964.3. NM_019091.3.
UniGeneiHs.41086.

Genome annotation databases

EnsembliENST00000234453; ENSP00000234453; ENSG00000116095.
GeneIDi65977.
KEGGihsa:65977.
UCSCiuc002umn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286162 mRNA. Translation: AAG15199.1.
AK000074 mRNA. Translation: BAA90927.1. Different initiation.
AK314459 mRNA. Translation: BAG37067.1.
AC009948 Genomic DNA. Translation: AAX88884.1.
CH471058 Genomic DNA. Translation: EAX11026.1.
BC044567 mRNA. Translation: AAH44567.1.
CCDSiCCDS33336.1.
RefSeqiNP_061964.3. NM_019091.3.
UniGeneiHs.41086.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KCJNMR-A1-100[»]
2MDXNMR-A1-100[»]
3RCPX-ray1.90A1-99[»]
ProteinModelPortaliQ9HB20.
SMRiQ9HB20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122427. 4 interactors.
IntActiQ9HB20. 2 interactors.
STRINGi9606.ENSP00000234453.

PTM databases

iPTMnetiQ9HB20.
PhosphoSitePlusiQ9HB20.

Polymorphism and mutation databases

BioMutaiPLEKHA3.
DMDMi48474646.

Proteomic databases

EPDiQ9HB20.
MaxQBiQ9HB20.
PaxDbiQ9HB20.
PeptideAtlasiQ9HB20.
PRIDEiQ9HB20.

Protocols and materials databases

DNASUi65977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234453; ENSP00000234453; ENSG00000116095.
GeneIDi65977.
KEGGihsa:65977.
UCSCiuc002umn.4. human.

Organism-specific databases

CTDi65977.
GeneCardsiPLEKHA3.
HGNCiHGNC:14338. PLEKHA3.
HPAiHPA034496.
HPA034497.
MIMi607774. gene.
neXtProtiNX_Q9HB20.
OpenTargetsiENSG00000116095.
PharmGKBiPA33403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3221. Eukaryota.
ENOG410YFEA. LUCA.
GeneTreeiENSGT00650000093230.
HOGENOMiHOG000231911.
HOVERGENiHBG053613.
InParanoidiQ9HB20.
KOiK20313.
OMAiRPVHCSR.
OrthoDBiEOG091G0IIT.
PhylomeDBiQ9HB20.
TreeFamiTF317467.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116095-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

EvolutionaryTraceiQ9HB20.
GenomeRNAii65977.
PROiQ9HB20.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116095.
CleanExiHS_PLEKHA3.
ExpressionAtlasiQ9HB20. baseline and differential.
GenevisibleiQ9HB20. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHA3_HUMAN
AccessioniPrimary (citable) accession number: Q9HB20
Secondary accession number(s): Q4ZG69, Q86TQ1, Q9NXT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.