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Q9HB19

- PKHA2_HUMAN

UniProt

Q9HB19 - PKHA2_HUMAN

Protein

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane By similarity.By similarity

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: Ensembl
    2. fibronectin binding Source: UniProtKB
    3. laminin binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of cell-matrix adhesion Source: UniProtKB

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pleckstrin homology domain-containing family A member 2
    Short name:
    PH domain-containing family A member 2
    Alternative name(s):
    Tandem PH domain-containing protein 2
    Short name:
    TAPP-2
    Gene namesi
    Name:PLEKHA2
    Synonyms:TAPP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14336. PLEKHA2.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Nucleus By similarity
    Note: Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. membrane Source: UniProtKB
    3. nucleus Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell
    5. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33402.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Pleckstrin homology domain-containing family A member 2PRO_0000053876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841Phosphoserine1 Publication
    Modified residuei349 – 3491Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9HB19.
    PaxDbiQ9HB19.
    PRIDEiQ9HB19.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.

    Gene expression databases

    ArrayExpressiQ9HB19.
    BgeeiQ9HB19.
    CleanExiHS_PLEKHA2.
    GenevestigatoriQ9HB19.

    Organism-specific databases

    HPAiHPA004706.

    Interactioni

    Subunit structurei

    Binds MPDZ and PTPN13.By similarity

    Protein-protein interaction databases

    BioGridi121881. 3 interactions.
    MINTiMINT-275130.
    STRINGi9606.ENSP00000393860.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB19.
    SMRiQ9HB19. Positions 1-113, 199-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 113107PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 298101PH 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG45745.
    HOGENOMiHOG000116175.
    HOVERGENiHBG053612.
    InParanoidiQ9HB19.
    PhylomeDBiQ9HB19.
    TreeFamiTF329516.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 2 hits.
    [Graphical view]
    SMARTiSM00233. PH. 2 hits.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HB19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA    50
    MGAGAVGALQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD 100
    MKDWVEALNQ ASKITVPKGG GLPMTTEVLK SLAAPPALEK KPQVAYKTEI 150
    IGGVVVHTPI SQNGGDGQEG SEPGSHTILR RSQSYIPTSG CRASTGPPLI 200
    KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIFLKDVLKT 250
    HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL 300
    KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV 350
    ASSWQPWTPV PQAGEKLLPP GDTSEDSLFT PRPGEGAPPG VLPSSRIRHR 400
    SEPQHPKEKP FMFNLDDENI RTSDV 425
    Length:425
    Mass (Da):47,255
    Last modified:December 20, 2005 - v2
    Checksum:i145BBE9CE9E64B4E
    GO

    Sequence cautioni

    The sequence AAG15201.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441L → F in AAG15201. (PubMed:11001876)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861I → N.
    Corresponds to variant rs59439576 [ dbSNP | Ensembl ].
    VAR_061516

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067817 Genomic DNA. No translation available.
    AC108863 Genomic DNA. No translation available.
    AF286164 mRNA. Translation: AAG15201.1. Different initiation.
    RefSeqiNP_067636.1. NM_021623.1.
    UniGeneiHs.369123.

    Genome annotation databases

    EnsembliENST00000420274; ENSP00000393860; ENSG00000169499.
    GeneIDi59339.
    KEGGihsa:59339.

    Polymorphism databases

    DMDMi84028237.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067817 Genomic DNA. No translation available.
    AC108863 Genomic DNA. No translation available.
    AF286164 mRNA. Translation: AAG15201.1 . Different initiation.
    RefSeqi NP_067636.1. NM_021623.1.
    UniGenei Hs.369123.

    3D structure databases

    ProteinModelPortali Q9HB19.
    SMRi Q9HB19. Positions 1-113, 199-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121881. 3 interactions.
    MINTi MINT-275130.
    STRINGi 9606.ENSP00000393860.

    Polymorphism databases

    DMDMi 84028237.

    Proteomic databases

    MaxQBi Q9HB19.
    PaxDbi Q9HB19.
    PRIDEi Q9HB19.

    Protocols and materials databases

    DNASUi 59339.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000420274 ; ENSP00000393860 ; ENSG00000169499 .
    GeneIDi 59339.
    KEGGi hsa:59339.

    Organism-specific databases

    CTDi 59339.
    GeneCardsi GC08P038776.
    H-InvDB HIX0007463.
    HGNCi HGNC:14336. PLEKHA2.
    HPAi HPA004706.
    MIMi 607773. gene.
    neXtProti NX_Q9HB19.
    PharmGKBi PA33402.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45745.
    HOGENOMi HOG000116175.
    HOVERGENi HBG053612.
    InParanoidi Q9HB19.
    PhylomeDBi Q9HB19.
    TreeFami TF329516.

    Miscellaneous databases

    ChiTaRSi PLEKHA2. human.
    GenomeRNAii 59339.
    NextBioi 65216.
    PROi Q9HB19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HB19.
    Bgeei Q9HB19.
    CleanExi HS_PLEKHA2.
    Genevestigatori Q9HB19.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 2 hits.
    [Graphical view ]
    SMARTi SM00233. PH. 2 hits.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities."
      Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R.
      Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304.
    3. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPKHA2_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3