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Protein

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).By similarity

GO - Molecular functioni

  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • PDZ domain binding Source: GO_Central
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: Reactome
  • positive regulation of cell-matrix adhesion Source: UniProtKB

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 2
Short name:
PH domain-containing family A member 2
Alternative name(s):
Tandem PH domain-containing protein 2
Short name:
TAPP-2
Gene namesi
Name:PLEKHA2
Synonyms:TAPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14336. PLEKHA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi59339.
PharmGKBiPA33402.

Polymorphism and mutation databases

BioMutaiPLEKHA2.
DMDMi84028237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538761 – 425Pleckstrin homology domain-containing family A member 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei184PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HB19.
MaxQBiQ9HB19.
PaxDbiQ9HB19.
PeptideAtlasiQ9HB19.
PRIDEiQ9HB19.

PTM databases

iPTMnetiQ9HB19.
PhosphoSitePlusiQ9HB19.

Expressioni

Tissue specificityi

Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.

Gene expression databases

CleanExiHS_PLEKHA2.

Organism-specific databases

HPAiHPA004706.

Interactioni

Subunit structurei

Binds MPDZ and PTPN13.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • PDZ domain binding Source: GO_Central

Protein-protein interaction databases

BioGridi121881. 3 interactors.
IntActiQ9HB19. 13 interactors.
MINTiMINT-275130.
STRINGi9606.ENSP00000393860.

Structurei

3D structure databases

ProteinModelPortaliQ9HB19.
SMRiQ9HB19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 113PH 1PROSITE-ProRule annotationAdd BLAST107
Domaini198 – 298PH 2PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF2M. Eukaryota.
ENOG410ZQEQ. LUCA.
HOGENOMiHOG000116175.
HOVERGENiHBG053612.
InParanoidiQ9HB19.
PhylomeDBiQ9HB19.
TreeFamiTF329516.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00169. PH. 2 hits.
SMARTiView protein in SMART
SM00233. PH. 2 hits.
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9HB19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
MGAGAVGALQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
MKDWVEALNQ ASKITVPKGG GLPMTTEVLK SLAAPPALEK KPQVAYKTEI
160 170 180 190 200
IGGVVVHTPI SQNGGDGQEG SEPGSHTILR RSQSYIPTSG CRASTGPPLI
210 220 230 240 250
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIFLKDVLKT
260 270 280 290 300
HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
310 320 330 340 350
KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV
360 370 380 390 400
ASSWQPWTPV PQAGEKLLPP GDTSEDSLFT PRPGEGAPPG VLPSSRIRHR
410 420
SEPQHPKEKP FMFNLDDENI RTSDV
Length:425
Mass (Da):47,255
Last modified:December 20, 2005 - v2
Checksum:i145BBE9CE9E64B4E
GO

Sequence cautioni

The sequence AAG15201 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244L → F in AAG15201 (PubMed:11001876).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061516186I → N. Corresponds to variant dbSNP:rs59439576Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
AF286164 mRNA. Translation: AAG15201.1. Different initiation.
CCDSiCCDS75732.1.
RefSeqiNP_067636.1. NM_021623.1.
UniGeneiHs.369123.

Genome annotation databases

EnsembliENST00000420274; ENSP00000393860; ENSG00000169499.
GeneIDi59339.
KEGGihsa:59339.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKHA2_HUMAN
AccessioniPrimary (citable) accession number: Q9HB19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 20, 2005
Last modified: November 22, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot