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Q9HB19 (PKHA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pleckstrin homology domain-containing family A member 2

Short name=PH domain-containing family A member 2
Alternative name(s):
Tandem PH domain-containing protein 2
Short name=TAPP-2
Gene names
Name:PLEKHA2
Synonyms:TAPP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane By similarity.

Subunit structure

Binds MPDZ and PTPN13 By similarity.

Subcellular location

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein By similarity. Nucleus By similarity. Note: Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2 By similarity.

Tissue specificity

Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.

Sequence similarities

Contains 2 PH domains.

Sequence caution

The sequence AAG15201.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Pleckstrin homology domain-containing family A member 2
PRO_0000053876

Regions

Domain7 – 113107PH 1
Domain198 – 298101PH 2

Amino acid modifications

Modified residue1841Phosphoserine Ref.4
Modified residue3491Phosphoserine Ref.3

Natural variations

Natural variant1861I → N.
Corresponds to variant rs59439576 [ dbSNP | Ensembl ].
VAR_061516

Experimental info

Sequence conflict2441L → F in AAG15201. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9HB19 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 145BBE9CE9E64B4E

FASTA42547,255
        10         20         30         40         50         60 
MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA MGAGAVGALQ 

        70         80         90        100        110        120 
LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD MKDWVEALNQ ASKITVPKGG 

       130        140        150        160        170        180 
GLPMTTEVLK SLAAPPALEK KPQVAYKTEI IGGVVVHTPI SQNGGDGQEG SEPGSHTILR 

       190        200        210        220        230        240 
RSQSYIPTSG CRASTGPPLI KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR 

       250        260        270        280        290        300 
TIFLKDVLKT HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL 

       310        320        330        340        350        360 
KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV ASSWQPWTPV 

       370        380        390        400        410        420 
PQAGEKLLPP GDTSEDSLFT PRPGEGAPPG VLPSSRIRHR SEPQHPKEKP FMFNLDDENI 


RTSDV 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities."
Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R.
Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304.
[3]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
AF286164 mRNA. Translation: AAG15201.1. Different initiation.
RefSeqNP_067636.1. NM_021623.1.
UniGeneHs.369123.

3D structure databases

ProteinModelPortalQ9HB19.
SMRQ9HB19. Positions 1-113, 199-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121881. 3 interactions.
MINTMINT-275130.
STRING9606.ENSP00000393860.

Polymorphism databases

DMDM84028237.

Proteomic databases

PaxDbQ9HB19.
PRIDEQ9HB19.

Protocols and materials databases

DNASU59339.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000420274; ENSP00000393860; ENSG00000169499.
GeneID59339.
KEGGhsa:59339.

Organism-specific databases

CTD59339.
GeneCardsGC08P038776.
H-InvDBHIX0007463.
HGNCHGNC:14336. PLEKHA2.
HPAHPA004706.
MIM607773. gene.
neXtProtNX_Q9HB19.
PharmGKBPA33402.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45745.
HOGENOMHOG000116175.
HOVERGENHBG053612.
InParanoidQ9HB19.
PhylomeDBQ9HB19.
TreeFamTF329516.

Gene expression databases

ArrayExpressQ9HB19.
BgeeQ9HB19.
CleanExHS_PLEKHA2.
GenevestigatorQ9HB19.

Family and domain databases

Gene3D2.30.29.30. 2 hits.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF00169. PH. 2 hits.
[Graphical view]
SMARTSM00233. PH. 2 hits.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPLEKHA2. human.
GenomeRNAi59339.
NextBio65216.
PROQ9HB19.
SOURCESearch...

Entry information

Entry namePKHA2_HUMAN
AccessionPrimary (citable) accession number: Q9HB19
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM