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Protein

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).By similarity

GO - Molecular functioni

  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • PDZ domain binding Source: GO_Central
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

  • positive regulation of cell-matrix adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169499-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 2
Short name:
PH domain-containing family A member 2
Alternative name(s):
Tandem PH domain-containing protein 2
Short name:
TAPP-2
Gene namesi
Name:PLEKHA2
Synonyms:TAPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14336. PLEKHA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi59339.
PharmGKBiPA33402.

Polymorphism and mutation databases

BioMutaiPLEKHA2.
DMDMi84028237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538761 – 425Pleckstrin homology domain-containing family A member 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei184PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HB19.
MaxQBiQ9HB19.
PaxDbiQ9HB19.
PeptideAtlasiQ9HB19.
PRIDEiQ9HB19.

PTM databases

iPTMnetiQ9HB19.
PhosphoSitePlusiQ9HB19.

Expressioni

Tissue specificityi

Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.

Gene expression databases

BgeeiENSG00000169499.
CleanExiHS_PLEKHA2.

Organism-specific databases

HPAiHPA004706.

Interactioni

Subunit structurei

Binds MPDZ and PTPN13.By similarity

GO - Molecular functioni

  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • PDZ domain binding Source: GO_Central

Protein-protein interaction databases

BioGridi121881. 2 interactors.
MINTiMINT-275130.
STRINGi9606.ENSP00000393860.

Structurei

3D structure databases

ProteinModelPortaliQ9HB19.
SMRiQ9HB19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 113PH 1PROSITE-ProRule annotationAdd BLAST107
Domaini198 – 298PH 2PROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF2M. Eukaryota.
ENOG410ZQEQ. LUCA.
HOGENOMiHOG000116175.
HOVERGENiHBG053612.
InParanoidiQ9HB19.
PhylomeDBiQ9HB19.
TreeFamiTF329516.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
MGAGAVGALQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
MKDWVEALNQ ASKITVPKGG GLPMTTEVLK SLAAPPALEK KPQVAYKTEI
160 170 180 190 200
IGGVVVHTPI SQNGGDGQEG SEPGSHTILR RSQSYIPTSG CRASTGPPLI
210 220 230 240 250
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIFLKDVLKT
260 270 280 290 300
HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
310 320 330 340 350
KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV
360 370 380 390 400
ASSWQPWTPV PQAGEKLLPP GDTSEDSLFT PRPGEGAPPG VLPSSRIRHR
410 420
SEPQHPKEKP FMFNLDDENI RTSDV
Length:425
Mass (Da):47,255
Last modified:December 20, 2005 - v2
Checksum:i145BBE9CE9E64B4E
GO

Sequence cautioni

The sequence AAG15201 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244L → F in AAG15201 (PubMed:11001876).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061516186I → N.Corresponds to variant rs59439576dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
AF286164 mRNA. Translation: AAG15201.1. Different initiation.
CCDSiCCDS75732.1.
RefSeqiNP_067636.1. NM_021623.1.
UniGeneiHs.369123.

Genome annotation databases

EnsembliENST00000420274; ENSP00000393860; ENSG00000169499.
GeneIDi59339.
KEGGihsa:59339.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067817 Genomic DNA. No translation available.
AC108863 Genomic DNA. No translation available.
AF286164 mRNA. Translation: AAG15201.1. Different initiation.
CCDSiCCDS75732.1.
RefSeqiNP_067636.1. NM_021623.1.
UniGeneiHs.369123.

3D structure databases

ProteinModelPortaliQ9HB19.
SMRiQ9HB19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121881. 2 interactors.
MINTiMINT-275130.
STRINGi9606.ENSP00000393860.

PTM databases

iPTMnetiQ9HB19.
PhosphoSitePlusiQ9HB19.

Polymorphism and mutation databases

BioMutaiPLEKHA2.
DMDMi84028237.

Proteomic databases

EPDiQ9HB19.
MaxQBiQ9HB19.
PaxDbiQ9HB19.
PeptideAtlasiQ9HB19.
PRIDEiQ9HB19.

Protocols and materials databases

DNASUi59339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420274; ENSP00000393860; ENSG00000169499.
GeneIDi59339.
KEGGihsa:59339.

Organism-specific databases

CTDi59339.
DisGeNETi59339.
GeneCardsiPLEKHA2.
H-InvDBHIX0007463.
HGNCiHGNC:14336. PLEKHA2.
HPAiHPA004706.
MIMi607773. gene.
neXtProtiNX_Q9HB19.
PharmGKBiPA33402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2M. Eukaryota.
ENOG410ZQEQ. LUCA.
HOGENOMiHOG000116175.
HOVERGENiHBG053612.
InParanoidiQ9HB19.
PhylomeDBiQ9HB19.
TreeFamiTF329516.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169499-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

ChiTaRSiPLEKHA2. human.
GenomeRNAii59339.
PROiQ9HB19.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169499.
CleanExiHS_PLEKHA2.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHA2_HUMAN
AccessioniPrimary (citable) accession number: Q9HB19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.