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Q9HB15

- KCNKC_HUMAN

UniProt

Q9HB15 - KCNKC_HUMAN

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Protein

Potassium channel subfamily K member 12

Gene

KCNK12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).By similarity

GO - Molecular functioni

  1. potassium channel activity Source: UniProtKB-KW
  2. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 12
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name:
THIK-2
Gene namesi
Name:KCNK12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6274. KCNK12.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Potassium channel subfamily K member 12PRO_0000101760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HB15.
PRIDEiQ9HB15.

PTM databases

PhosphoSiteiQ9HB15.

Expressioni

Gene expression databases

BgeeiQ9HB15.
CleanExiHS_KCNK12.
GenevestigatoriQ9HB15.

Interactioni

Subunit structurei

Heterodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9HB15.
SMRiQ9HB15. Positions 49-298.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 21247CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini303 – 430128CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei114 – 13421Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Intramembranei243 – 26321Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260772.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB15.
KOiK04921.
OMAiHVMLILG.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9HB15.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9HB15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA
360 370 380 390 400
DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,889
Last modified:March 1, 2001 - v1
Checksum:i7D6DC7C3788277FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF287302 mRNA. Translation: AAG32313.1.
BC047749 mRNA. Translation: AAH47749.1.
CCDSiCCDS1835.1.
RefSeqiNP_071338.1. NM_022055.1.
UniGeneiHs.591586.

Genome annotation databases

EnsembliENST00000327876; ENSP00000327611; ENSG00000184261.
GeneIDi56660.
KEGGihsa:56660.
UCSCiuc002rwb.3. human.

Polymorphism databases

DMDMi24636285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF287302 mRNA. Translation: AAG32313.1 .
BC047749 mRNA. Translation: AAH47749.1 .
CCDSi CCDS1835.1.
RefSeqi NP_071338.1. NM_022055.1.
UniGenei Hs.591586.

3D structure databases

ProteinModelPortali Q9HB15.
SMRi Q9HB15. Positions 49-298.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 522.

PTM databases

PhosphoSitei Q9HB15.

Polymorphism databases

DMDMi 24636285.

Proteomic databases

PaxDbi Q9HB15.
PRIDEi Q9HB15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327876 ; ENSP00000327611 ; ENSG00000184261 .
GeneIDi 56660.
KEGGi hsa:56660.
UCSCi uc002rwb.3. human.

Organism-specific databases

CTDi 56660.
GeneCardsi GC02M047747.
HGNCi HGNC:6274. KCNK12.
MIMi 607366. gene.
neXtProti NX_Q9HB15.
PharmGKBi PA30054.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260772.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000013227.
HOVERGENi HBG052238.
InParanoidi Q9HB15.
KOi K04921.
OMAi HVMLILG.
OrthoDBi EOG7DC24D.
PhylomeDBi Q9HB15.
TreeFami TF313947.

Miscellaneous databases

GeneWikii KCNK12.
GenomeRNAii 56660.
NextBioi 62139.
PROi Q9HB15.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB15.
CleanExi HS_KCNK12.
Genevestigatori Q9HB15.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PRINTSi PR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.

Entry informationi

Entry nameiKCNKC_HUMAN
AccessioniPrimary (citable) accession number: Q9HB15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3