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Protein

Potassium channel subfamily K member 12

Gene

KCNK12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 12
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name:
THIK-2
Gene namesi
Name:KCNK12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6274. KCNK12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Intramembranei114 – 13421Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 21247CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Intramembranei243 – 26321Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST
Topological domaini303 – 430128CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30054.

Polymorphism and mutation databases

BioMutaiKCNK12.
DMDMi24636285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Potassium channel subfamily K member 12PRO_0000101760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HB15.
PRIDEiQ9HB15.

PTM databases

PhosphoSiteiQ9HB15.

Expressioni

Gene expression databases

BgeeiQ9HB15.
CleanExiHS_KCNK12.
GenevestigatoriQ9HB15.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

IntActiQ9HB15. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9HB15.
SMRiQ9HB15. Positions 45-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260772.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB15.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9HB15.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9HB15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL
60 70 80 90 100
VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA
110 120 130 140 150
LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG
160 170 180 190 200
LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL
210 220 230 240 250
SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG WDYVDSLYFC
260 270 280 290 300
FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
310 320 330 340 350
LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA
360 370 380 390 400
DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV
410 420 430
CVNTRQNGFS GGVGALGIMN NRLAETSASR
Length:430
Mass (Da):46,889
Last modified:March 1, 2001 - v1
Checksum:i7D6DC7C3788277FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287302 mRNA. Translation: AAG32313.1.
BC047749 mRNA. Translation: AAH47749.1.
CCDSiCCDS1835.1.
RefSeqiNP_071338.1. NM_022055.1.
UniGeneiHs.591586.

Genome annotation databases

EnsembliENST00000327876; ENSP00000327611; ENSG00000184261.
GeneIDi56660.
KEGGihsa:56660.
UCSCiuc002rwb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287302 mRNA. Translation: AAG32313.1.
BC047749 mRNA. Translation: AAH47749.1.
CCDSiCCDS1835.1.
RefSeqiNP_071338.1. NM_022055.1.
UniGeneiHs.591586.

3D structure databases

ProteinModelPortaliQ9HB15.
SMRiQ9HB15. Positions 45-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HB15. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi522.

PTM databases

PhosphoSiteiQ9HB15.

Polymorphism and mutation databases

BioMutaiKCNK12.
DMDMi24636285.

Proteomic databases

PaxDbiQ9HB15.
PRIDEiQ9HB15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327876; ENSP00000327611; ENSG00000184261.
GeneIDi56660.
KEGGihsa:56660.
UCSCiuc002rwb.3. human.

Organism-specific databases

CTDi56660.
GeneCardsiGC02M047747.
HGNCiHGNC:6274. KCNK12.
MIMi607366. gene.
neXtProtiNX_Q9HB15.
PharmGKBiPA30054.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG260772.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB15.
KOiK04921.
OMAiMISMRDL.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9HB15.
TreeFamiTF313947.

Miscellaneous databases

GeneWikiiKCNK12.
GenomeRNAii56660.
NextBioi62139.
PROiQ9HB15.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HB15.
CleanExiHS_KCNK12.
GenevestigatoriQ9HB15.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.

Entry informationi

Entry nameiKCNKC_HUMAN
AccessioniPrimary (citable) accession number: Q9HB15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.