Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HB15

- KCNKC_HUMAN

UniProt

Q9HB15 - KCNKC_HUMAN

Protein

Potassium channel subfamily K member 12

Gene

KCNK12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel By similarity.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB-KW
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 12
    Alternative name(s):
    Tandem pore domain halothane-inhibited potassium channel 2
    Short name:
    THIK-2
    Gene namesi
    Name:KCNK12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6274. KCNK12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30054.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Potassium channel subfamily K member 12PRO_0000101760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9HB15.
    PRIDEiQ9HB15.

    PTM databases

    PhosphoSiteiQ9HB15.

    Expressioni

    Gene expression databases

    BgeeiQ9HB15.
    CleanExiHS_KCNK12.
    GenevestigatoriQ9HB15.

    Interactioni

    Subunit structurei

    Heterodimer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB15.
    SMRiQ9HB15. Positions 49-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 21247CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini303 – 430128CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei114 – 13421Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei243 – 26321Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 276Poly-Cys

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260772.
    HOGENOMiHOG000013227.
    HOVERGENiHBG052238.
    InParanoidiQ9HB15.
    KOiK04921.
    OMAiHVMLILG.
    OrthoDBiEOG7DC24D.
    PhylomeDBiQ9HB15.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR005410. 2pore_dom_K_chnl_THIK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PRINTSiPR01333. 2POREKCHANEL.
    PR01588. THIKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9HB15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL    50
    VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA 100
    LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG 150
    LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL 200
    SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG WDYVDSLYFC 250
    FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI 300
    LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA 350
    DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV 400
    CVNTRQNGFS GGVGALGIMN NRLAETSASR 430
    Length:430
    Mass (Da):46,889
    Last modified:March 1, 2001 - v1
    Checksum:i7D6DC7C3788277FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287302 mRNA. Translation: AAG32313.1.
    BC047749 mRNA. Translation: AAH47749.1.
    CCDSiCCDS1835.1.
    RefSeqiNP_071338.1. NM_022055.1.
    UniGeneiHs.591586.

    Genome annotation databases

    EnsembliENST00000327876; ENSP00000327611; ENSG00000184261.
    GeneIDi56660.
    KEGGihsa:56660.
    UCSCiuc002rwb.3. human.

    Polymorphism databases

    DMDMi24636285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287302 mRNA. Translation: AAG32313.1 .
    BC047749 mRNA. Translation: AAH47749.1 .
    CCDSi CCDS1835.1.
    RefSeqi NP_071338.1. NM_022055.1.
    UniGenei Hs.591586.

    3D structure databases

    ProteinModelPortali Q9HB15.
    SMRi Q9HB15. Positions 49-298.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 522.

    PTM databases

    PhosphoSitei Q9HB15.

    Polymorphism databases

    DMDMi 24636285.

    Proteomic databases

    PaxDbi Q9HB15.
    PRIDEi Q9HB15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327876 ; ENSP00000327611 ; ENSG00000184261 .
    GeneIDi 56660.
    KEGGi hsa:56660.
    UCSCi uc002rwb.3. human.

    Organism-specific databases

    CTDi 56660.
    GeneCardsi GC02M047747.
    HGNCi HGNC:6274. KCNK12.
    MIMi 607366. gene.
    neXtProti NX_Q9HB15.
    PharmGKBi PA30054.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260772.
    HOGENOMi HOG000013227.
    HOVERGENi HBG052238.
    InParanoidi Q9HB15.
    KOi K04921.
    OMAi HVMLILG.
    OrthoDBi EOG7DC24D.
    PhylomeDBi Q9HB15.
    TreeFami TF313947.

    Miscellaneous databases

    GeneWikii KCNK12.
    GenomeRNAii 56660.
    NextBioi 62139.
    PROi Q9HB15.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HB15.
    CleanExi HS_KCNK12.
    Genevestigatori Q9HB15.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR005410. 2pore_dom_K_chnl_THIK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01333. 2POREKCHANEL.
    PR01588. THIKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.

    Entry informationi

    Entry nameiKCNKC_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3