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Q9HB15 (KCNKC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 12
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name=THIK-2
Gene names
Name:KCNK12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel By similarity.

Subunit structure

Heterodimer Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Potassium channel subfamily K member 12
PRO_0000101760

Regions

Topological domain1 – 3838Cytoplasmic Potential
Transmembrane39 – 5921Helical; Potential
Intramembrane114 – 13421Pore-forming; Name=Pore-forming 1; Potential
Transmembrane145 – 16521Helical; Potential
Topological domain166 – 21247Cytoplasmic Potential
Transmembrane213 – 23321Helical; Potential
Intramembrane243 – 26321Pore-forming; Name=Pore-forming 2; Potential
Transmembrane282 – 30221Helical; Potential
Topological domain303 – 430128Cytoplasmic Potential
Compositional bias22 – 276Poly-Cys

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9HB15 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7D6DC7C3788277FF

FASTA43046,889
        10         20         30         40         50         60 
MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL VAGATVFSAL 

        70         80         90        100        110        120 
ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA LAAGVRADAL RPRWDFPGAF 

       130        140        150        160        170        180 
YFVGTVVSTI GFGMTTPATV GGKAFLIAYG LFGCAGTILF FNLFLERIIS LLAFIMRACR 

       190        200        210        220        230        240 
ERQLRRSGLL PATFRRGSAL SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG 

       250        260        270        280        290        300 
WDYVDSLYFC FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI 

       310        320        330        340        350        360 
LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA DPAARDSDAE 

       370        380        390        400        410        420 
GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV CVNTRQNGFS GGVGALGIMN 

       430 
NRLAETSASR 

« Hide

References

« Hide 'large scale' references
[1]"THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels."
Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H., Daut J., Karschin A., Derst C.
J. Biol. Chem. 276:7302-7311(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF287302 mRNA. Translation: AAG32313.1.
BC047749 mRNA. Translation: AAH47749.1.
CCDSCCDS1835.1.
RefSeqNP_071338.1. NM_022055.1.
UniGeneHs.591586.

3D structure databases

ProteinModelPortalQ9HB15.
SMRQ9HB15. Positions 49-298.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY522.

PTM databases

PhosphoSiteQ9HB15.

Polymorphism databases

DMDM24636285.

Proteomic databases

PaxDbQ9HB15.
PRIDEQ9HB15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327876; ENSP00000327611; ENSG00000184261.
GeneID56660.
KEGGhsa:56660.
UCSCuc002rwb.3. human.

Organism-specific databases

CTD56660.
GeneCardsGC02M047747.
HGNCHGNC:6274. KCNK12.
MIM607366. gene.
neXtProtNX_Q9HB15.
PharmGKBPA30054.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260772.
HOGENOMHOG000013227.
HOVERGENHBG052238.
InParanoidQ9HB15.
KOK04921.
OMAHVMLILG.
OrthoDBEOG7DC24D.
PhylomeDBQ9HB15.
TreeFamTF313947.

Gene expression databases

BgeeQ9HB15.
CleanExHS_KCNK12.
GenevestigatorQ9HB15.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetSearch...

Other

GeneWikiKCNK12.
GenomeRNAi56660.
NextBio62139.
PROQ9HB15.
SOURCESearch...

Entry information

Entry nameKCNKC_HUMAN
AccessionPrimary (citable) accession number: Q9HB15
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM