Q9HB15 (KCNKC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel subfamily K member 12

Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 2
Short name=THIK-2

Gene names

Name:

KCNK12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel By similarity.
Subunit structure	Heterodimer Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	potassium channel activity Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	Potassium channel subfamily K member 12		PRO_0000101760
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Intramembrane	114 – 134	21	Pore-forming; Name=Pore-forming 1; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Topological domain	166 – 212	47	Cytoplasmic Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Intramembrane	243 – 263	21	Pore-forming; Name=Pore-forming 2; Potential
	Transmembrane	282 – 302	21	Helical; Potential
	Topological domain	303 – 430	128	Cytoplasmic Potential
	Compositional bias	22 – 27	6	Poly-Cys
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9HB15 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7D6DC7C3788277FF	FASTA	430	46,889
	10 20 30 40 50 60 MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL VAGATVFSAL 70 80 90 100 110 120 ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA LAAGVRADAL RPRWDFPGAF 130 140 150 160 170 180 YFVGTVVSTI GFGMTTPATV GGKAFLIAYG LFGCAGTILF FNLFLERIIS LLAFIMRACR 190 200 210 220 230 240 ERQLRRSGLL PATFRRGSAL SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG 250 260 270 280 290 300 WDYVDSLYFC FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI 310 320 330 340 350 360 LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA DPAARDSDAE 370 380 390 400 410 420 GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV CVNTRQNGFS GGVGALGIMN 430 NRLAETSASR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels." Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H., Daut J., Karschin A., Derst C. J. Biol. Chem. 276:7302-7311(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF287302 mRNA. Translation: AAG32313.1. BC047749 mRNA. Translation: AAH47749.1.
IPI	IPI00004933.
RefSeq	NP_071338.1. NM_022055.1.
UniGene	Hs.591586.
3D structure databases
ProteinModelPortal	Q9HB15.
ModBase	Search...
PTM databases
PhosphoSite	Q9HB15.
Polymorphism databases
DMDM	24636285.
Proteomic databases
PaxDb	Q9HB15.
PRIDE	Q9HB15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327876; ENSP00000327611; ENSG00000184261.
GeneID	56660.
KEGG	hsa:56660.
UCSC	uc002rwb.3. human.
Organism-specific databases
CTD	56660.
GeneCards	GC02M047747.
HGNC	HGNC:6274. KCNK12.
MIM	607366. gene.
neXtProt	NX_Q9HB15.
PharmGKB	PA30054.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260772.
HOGENOM	HOG000013227.
HOVERGEN	HBG052238.
InParanoid	Q9HB15.
KO	K04921.
OMA	HVMLILG.
OrthoDB	EOG47WNNV.
PhylomeDB	Q9HB15.
Gene expression databases
Bgee	Q9HB15.
CleanEx	HS_KCNK12.
Genevestigator	Q9HB15.
GermOnline	ENSG00000184261. Homo sapiens.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR005410. 2pore_dom_K_chnl_THIK. IPR013099. Ion_trans_2. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PRINTS	PR01333. 2POREKCHANEL. PR01588. THIKCHANNEL.
ProtoNet	Search...
Other
GenomeRNAi	56660.
NextBio	62139.
SOURCE	Search...

Entry information

Entry name

KCNKC_HUMAN

Accession

Primary (citable) accession number: Q9HB15

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.