Q9HB14 (KCNKD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel subfamily K member 13

Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name=THIK-1

Gene names

Name:

KCNK13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel displaying weak inward rectification in symmetrical K+ solution By similarity.
Subunit structure	Homodimer Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	The current is enhanced by arachidonic acid and inhibited by halothane By similarity.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	potassium channel activity Traceable author statement. Source: Reactome voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Potassium channel subfamily K member 13		PRO_0000101762
Regions
	Topological domain	1 – 19	19	Cytoplasmic Potential
	Transmembrane	20 – 40	21	Helical; Potential
	Intramembrane	95 – 115	21	Pore-forming; Name=Pore-forming 1; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Topological domain	146 – 193	48	Cytoplasmic Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Intramembrane	224 – 244	21	Pore-forming; Name=Pore-forming 2; Potential
	Transmembrane	263 – 283	21	Helical; Potential
	Topological domain	284 – 408	125	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	305	1	G → R. Corresponds to variant rs3814848 [ dbSNP | Ensembl ].		VAR_052429
	Natural variant	389	1	G → A. Corresponds to variant rs35909577 [ dbSNP | Ensembl ].		VAR_034052
Experimental info
	Sequence conflict	288	1	N → D in AAG32314. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HB14 [UniParc]. Last modified November 1, 2002. Version 2. Checksum: B303C01AFD59EE19	FASTA	408	45,391
	10 20 30 40 50 60 MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK QRWEERLANF 70 80 90 100 110 120 SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA FYFVGTVVST IGFGMTTPAT 130 140 150 160 170 180 VGGKIFLIFY GLVGCSSTIL FFNLFLERLI TIIAYIMKSC HQRQLRRRGA LPQESLKDAG 190 200 210 220 230 240 QCEVDSLAGW KPSVYYVMLI LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF 250 260 270 280 290 300 GDLVSSQNAH YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP 310 320 330 340 350 360 QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK DLLAANKASL 370 380 390 400 AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR LAETSGDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels." Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H., Daut J., Karschin A., Derst C. J. Biol. Chem. 276:7302-7311(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF287303 mRNA. Translation: AAG32314.1. BC012779 mRNA. Translation: AAH12779.1.
IPI	IPI00171921.
RefSeq	NP_071337.2. NM_022054.2.
UniGene	Hs.510191.
3D structure databases
ProteinModelPortal	Q9HB14.
ModBase	Search...
PTM databases
PhosphoSite	Q9HB14.
Polymorphism databases
DMDM	24636284.
Proteomic databases
PaxDb	Q9HB14.
PRIDE	Q9HB14.
Protocols and materials databases
DNASU	56659.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282146; ENSP00000282146; ENSG00000152315.
GeneID	56659.
KEGG	hsa:56659.
UCSC	uc001xye.1. human.
Organism-specific databases
CTD	56659.
GeneCards	GC14P090528.
HGNC	HGNC:6275. KCNK13.
HPA	HPA003514.
MIM	607367. gene.
neXtProt	NX_Q9HB14.
PharmGKB	PA30055.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260772.
HOGENOM	HOG000013227.
HOVERGEN	HBG052238.
InParanoid	Q9HB14.
KO	K04922.
OMA	IAYIMKS.
OrthoDB	EOG47WNNV.
PhylomeDB	Q9HB14.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q9HB14.
Bgee	Q9HB14.
CleanEx	HS_KCNK13.
Genevestigator	Q9HB14.
GermOnline	ENSG00000152315. Homo sapiens.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR005410. 2pore_dom_K_chnl_THIK. IPR013099. Ion_trans_2. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PRINTS	PR01333. 2POREKCHANEL. PR01588. THIKCHANNEL.
ProtoNet	Search...
Other
GenomeRNAi	56659.
NextBio	62135.
SOURCE	Search...

Entry information

Entry name

KCNKD_HUMAN

Accession

Primary (citable) accession number: Q9HB14
Secondary accession number(s): Q96E79

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	November 1, 2002
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.