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Protein

Potassium channel subfamily K member 13

Gene

KCNK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel displaying weak inward rectification in symmetrical K+ solution.By similarity

Miscellaneous

The current is enhanced by arachidonic acid and inhibited by halothane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299287. Tandem pore domain halothane-inhibited K+ channel (THIK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name:
THIK-1
Gene namesi
Name:KCNK13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:6275. KCNK13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Intramembranei95 – 115Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 193CytoplasmicSequence analysisAdd BLAST48
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Intramembranei224 – 244Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 408CytoplasmicSequence analysisAdd BLAST125

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56659.
OpenTargetsiENSG00000152315.
PharmGKBiPA30055.

Polymorphism and mutation databases

BioMutaiKCNK13.
DMDMi24636284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017621 – 408Potassium channel subfamily K member 13Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9HB14.
MaxQBiQ9HB14.
PaxDbiQ9HB14.
PeptideAtlasiQ9HB14.
PRIDEiQ9HB14.

PTM databases

iPTMnetiQ9HB14.
PhosphoSitePlusiQ9HB14.

Expressioni

Gene expression databases

BgeeiENSG00000152315.
CleanExiHS_KCNK13.
GenevisibleiQ9HB14. HS.

Organism-specific databases

HPAiHPA003514.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000282146.

Structurei

3D structure databases

ProteinModelPortaliQ9HB14.
SMRiQ9HB14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00860000133807.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB14.
KOiK04922.
OMAiVNWILRK.
OrthoDBiEOG091G06SB.
PhylomeDBiQ9HB14.
TreeFamiTF313947.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9HB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK
60 70 80 90 100
QRWEERLANF SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA
110 120 130 140 150
FYFVGTVVST IGFGMTTPAT VGGKIFLIFY GLVGCSSTIL FFNLFLERLI
160 170 180 190 200
TIIAYIMKSC HQRQLRRRGA LPQESLKDAG QCEVDSLAGW KPSVYYVMLI
210 220 230 240 250
LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF GDLVSSQNAH
260 270 280 290 300
YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP
310 320 330 340 350
QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK
360 370 380 390 400
DLLAANKASL AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR

LAETSGDR
Length:408
Mass (Da):45,391
Last modified:November 1, 2002 - v2
Checksum:iB303C01AFD59EE19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288N → D in AAG32314 (PubMed:11060316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052429305G → R. Corresponds to variant dbSNP:rs3814848Ensembl.1
Natural variantiVAR_034052389G → A. Corresponds to variant dbSNP:rs35909577Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287303 mRNA. Translation: AAG32314.1.
EU978942 mRNA. Translation: ACH86101.1.
CH471061 Genomic DNA. Translation: EAW81417.1.
BC012779 mRNA. Translation: AAH12779.1.
CCDSiCCDS9889.1.
RefSeqiNP_071337.2. NM_022054.3.
UniGeneiHs.510191.

Genome annotation databases

EnsembliENST00000282146; ENSP00000282146; ENSG00000152315.
GeneIDi56659.
KEGGihsa:56659.
UCSCiuc001xye.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCNKD_HUMAN
AccessioniPrimary (citable) accession number: Q9HB14
Secondary accession number(s): B5TJL8, Q96E79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: July 5, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families