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Protein

Potassium channel subfamily K member 13

Gene

KCNK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel displaying weak inward rectification in symmetrical K+ solution.By similarity

Miscellaneous

The current is enhanced by arachidonic acid and inhibited by halothane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK)
R-HSA-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name:
THIK-1
Gene namesi
Name:KCNK13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000152315.4
HGNCiHGNC:6275 KCNK13
MIMi607367 gene
neXtProtiNX_Q9HB14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Intramembranei95 – 115Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 193CytoplasmicSequence analysisAdd BLAST48
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Intramembranei224 – 244Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 408CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56659
OpenTargetsiENSG00000152315
PharmGKBiPA30055

Polymorphism and mutation databases

BioMutaiKCNK13
DMDMi24636284

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017621 – 408Potassium channel subfamily K member 13Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HB14
PaxDbiQ9HB14
PeptideAtlasiQ9HB14
PRIDEiQ9HB14

PTM databases

iPTMnetiQ9HB14
PhosphoSitePlusiQ9HB14

Expressioni

Gene expression databases

BgeeiENSG00000152315
CleanExiHS_KCNK13
GenevisibleiQ9HB14 HS

Organism-specific databases

HPAiHPA003514

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi121171, 1 interactor
STRINGi9606.ENSP00000282146

Structurei

3D structure databases

ProteinModelPortaliQ9HB14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00860000133807
HOGENOMiHOG000013227
HOVERGENiHBG052238
InParanoidiQ9HB14
KOiK04922
OMAiVNWILRK
OrthoDBiEOG091G06SB
PhylomeDBiQ9HB14
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR005410 2pore_dom_K_chnl_THIK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01588 THIKCHANNEL

Sequencei

Sequence statusi: Complete.

Q9HB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK
60 70 80 90 100
QRWEERLANF SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA
110 120 130 140 150
FYFVGTVVST IGFGMTTPAT VGGKIFLIFY GLVGCSSTIL FFNLFLERLI
160 170 180 190 200
TIIAYIMKSC HQRQLRRRGA LPQESLKDAG QCEVDSLAGW KPSVYYVMLI
210 220 230 240 250
LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF GDLVSSQNAH
260 270 280 290 300
YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP
310 320 330 340 350
QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK
360 370 380 390 400
DLLAANKASL AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR

LAETSGDR
Length:408
Mass (Da):45,391
Last modified:November 1, 2002 - v2
Checksum:iB303C01AFD59EE19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288N → D in AAG32314 (PubMed:11060316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052429305G → R. Corresponds to variant dbSNP:rs3814848Ensembl.1
Natural variantiVAR_034052389G → A. Corresponds to variant dbSNP:rs35909577Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287303 mRNA Translation: AAG32314.1
EU978942 mRNA Translation: ACH86101.1
CH471061 Genomic DNA Translation: EAW81417.1
BC012779 mRNA Translation: AAH12779.1
CCDSiCCDS9889.1
RefSeqiNP_071337.2, NM_022054.3
UniGeneiHs.510191

Genome annotation databases

EnsembliENST00000282146; ENSP00000282146; ENSG00000152315
GeneIDi56659
KEGGihsa:56659
UCSCiuc001xye.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCNKD_HUMAN
AccessioniPrimary (citable) accession number: Q9HB14
Secondary accession number(s): B5TJL8, Q96E79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: April 25, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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