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Q9HB14 (KCNKD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name=THIK-1
Gene names
Name:KCNK13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel displaying weak inward rectification in symmetrical K+ solution By similarity.

Subunit structure

Homodimer Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

The current is enhanced by arachidonic acid and inhibited by halothane By similarity.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsynaptic transmission

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpotassium channel activity

Traceable author statement. Source: Reactome

voltage-gated ion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Potassium channel subfamily K member 13
PRO_0000101762

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Intramembrane95 – 11521Pore-forming; Name=Pore-forming 1; Potential
Transmembrane125 – 14521Helical; Potential
Topological domain146 – 19348Cytoplasmic Potential
Transmembrane194 – 21421Helical; Potential
Intramembrane224 – 24421Pore-forming; Name=Pore-forming 2; Potential
Transmembrane263 – 28321Helical; Potential
Topological domain284 – 408125Cytoplasmic Potential

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation651N-linked (GlcNAc...) Potential

Natural variations

Natural variant3051G → R.
Corresponds to variant rs3814848 [ dbSNP | Ensembl ].
VAR_052429
Natural variant3891G → A.
Corresponds to variant rs35909577 [ dbSNP | Ensembl ].
VAR_034052

Experimental info

Sequence conflict2881N → D in AAG32314. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HB14 [UniParc].

Last modified November 1, 2002. Version 2.
Checksum: B303C01AFD59EE19

FASTA40845,391
        10         20         30         40         50         60 
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK QRWEERLANF 

        70         80         90        100        110        120 
SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA FYFVGTVVST IGFGMTTPAT 

       130        140        150        160        170        180 
VGGKIFLIFY GLVGCSSTIL FFNLFLERLI TIIAYIMKSC HQRQLRRRGA LPQESLKDAG 

       190        200        210        220        230        240 
QCEVDSLAGW KPSVYYVMLI LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF 

       250        260        270        280        290        300 
GDLVSSQNAH YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP 

       310        320        330        340        350        360 
QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK DLLAANKASL 

       370        380        390        400 
AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR LAETSGDR 

« Hide

References

« Hide 'large scale' references
[1]"THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels."
Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H., Daut J., Karschin A., Derst C.
J. Biol. Chem. 276:7302-7311(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF287303 mRNA. Translation: AAG32314.1.
EU978942 mRNA. Translation: ACH86101.1.
CH471061 Genomic DNA. Translation: EAW81417.1.
BC012779 mRNA. Translation: AAH12779.1.
RefSeqNP_071337.2. NM_022054.3.
UniGeneHs.510191.

3D structure databases

ProteinModelPortalQ9HB14.
SMRQ9HB14. Positions 30-279.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY523.

PTM databases

PhosphoSiteQ9HB14.

Polymorphism databases

DMDM24636284.

Proteomic databases

PaxDbQ9HB14.
PRIDEQ9HB14.

Protocols and materials databases

DNASU56659.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282146; ENSP00000282146; ENSG00000152315.
GeneID56659.
KEGGhsa:56659.
UCSCuc001xye.1. human.

Organism-specific databases

CTD56659.
GeneCardsGC14P090528.
HGNCHGNC:6275. KCNK13.
HPAHPA003514.
MIM607367. gene.
neXtProtNX_Q9HB14.
PharmGKBPA30055.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260772.
HOGENOMHOG000013227.
HOVERGENHBG052238.
InParanoidQ9HB14.
KOK04922.
OMALISCCAS.
OrthoDBEOG7DC24D.
PhylomeDBQ9HB14.
TreeFamTF313947.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ9HB14.
CleanExHS_KCNK13.
GenevestigatorQ9HB14.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetSearch...

Other

GeneWikiKCNK13.
GenomeRNAi56659.
NextBio62135.
PROQ9HB14.
SOURCESearch...

Entry information

Entry nameKCNKD_HUMAN
AccessionPrimary (citable) accession number: Q9HB14
Secondary accession number(s): B5TJL8, Q96E79
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM