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Q9HB14

- KCNKD_HUMAN

UniProt

Q9HB14 - KCNKD_HUMAN

Protein

Potassium channel subfamily K member 13

Gene

KCNK13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Nov 2002)
      Previous versions | rss
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    Functioni

    Potassium channel displaying weak inward rectification in symmetrical K+ solution.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: Reactome
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75880. Tandem pore domain halothane-inhibited K+ channel (THIK).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 13
    Alternative name(s):
    Tandem pore domain halothane-inhibited potassium channel 1
    Short name:
    THIK-1
    Gene namesi
    Name:KCNK13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6275. KCNK13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Potassium channel subfamily K member 13PRO_0000101762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9HB14.
    PRIDEiQ9HB14.

    PTM databases

    PhosphoSiteiQ9HB14.

    Expressioni

    Gene expression databases

    BgeeiQ9HB14.
    CleanExiHS_KCNK13.
    GenevestigatoriQ9HB14.

    Organism-specific databases

    HPAiHPA003514.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB14.
    SMRiQ9HB14. Positions 30-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 19348CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 408125CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei95 – 11521Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei224 – 24421Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260772.
    HOGENOMiHOG000013227.
    HOVERGENiHBG052238.
    InParanoidiQ9HB14.
    KOiK04922.
    OMAiNFVFILM.
    OrthoDBiEOG7DC24D.
    PhylomeDBiQ9HB14.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR005410. 2pore_dom_K_chnl_THIK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PRINTSiPR01333. 2POREKCHANEL.
    PR01588. THIKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9HB14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK    50
    QRWEERLANF SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA 100
    FYFVGTVVST IGFGMTTPAT VGGKIFLIFY GLVGCSSTIL FFNLFLERLI 150
    TIIAYIMKSC HQRQLRRRGA LPQESLKDAG QCEVDSLAGW KPSVYYVMLI 200
    LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF GDLVSSQNAH 250
    YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP 300
    QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK 350
    DLLAANKASL AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR 400
    LAETSGDR 408
    Length:408
    Mass (Da):45,391
    Last modified:November 1, 2002 - v2
    Checksum:iB303C01AFD59EE19
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti288 – 2881N → D in AAG32314. (PubMed:11060316)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti305 – 3051G → R.
    Corresponds to variant rs3814848 [ dbSNP | Ensembl ].
    VAR_052429
    Natural varianti389 – 3891G → A.
    Corresponds to variant rs35909577 [ dbSNP | Ensembl ].
    VAR_034052

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287303 mRNA. Translation: AAG32314.1.
    EU978942 mRNA. Translation: ACH86101.1.
    CH471061 Genomic DNA. Translation: EAW81417.1.
    BC012779 mRNA. Translation: AAH12779.1.
    CCDSiCCDS9889.1.
    RefSeqiNP_071337.2. NM_022054.3.
    UniGeneiHs.510191.

    Genome annotation databases

    EnsembliENST00000282146; ENSP00000282146; ENSG00000152315.
    GeneIDi56659.
    KEGGihsa:56659.
    UCSCiuc001xye.1. human.

    Polymorphism databases

    DMDMi24636284.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287303 mRNA. Translation: AAG32314.1 .
    EU978942 mRNA. Translation: ACH86101.1 .
    CH471061 Genomic DNA. Translation: EAW81417.1 .
    BC012779 mRNA. Translation: AAH12779.1 .
    CCDSi CCDS9889.1.
    RefSeqi NP_071337.2. NM_022054.3.
    UniGenei Hs.510191.

    3D structure databases

    ProteinModelPortali Q9HB14.
    SMRi Q9HB14. Positions 30-290.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 523.

    PTM databases

    PhosphoSitei Q9HB14.

    Polymorphism databases

    DMDMi 24636284.

    Proteomic databases

    PaxDbi Q9HB14.
    PRIDEi Q9HB14.

    Protocols and materials databases

    DNASUi 56659.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282146 ; ENSP00000282146 ; ENSG00000152315 .
    GeneIDi 56659.
    KEGGi hsa:56659.
    UCSCi uc001xye.1. human.

    Organism-specific databases

    CTDi 56659.
    GeneCardsi GC14P090528.
    HGNCi HGNC:6275. KCNK13.
    HPAi HPA003514.
    MIMi 607367. gene.
    neXtProti NX_Q9HB14.
    PharmGKBi PA30055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260772.
    HOGENOMi HOG000013227.
    HOVERGENi HBG052238.
    InParanoidi Q9HB14.
    KOi K04922.
    OMAi NFVFILM.
    OrthoDBi EOG7DC24D.
    PhylomeDBi Q9HB14.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75880. Tandem pore domain halothane-inhibited K+ channel (THIK).

    Miscellaneous databases

    GeneWikii KCNK13.
    GenomeRNAii 56659.
    NextBioi 62135.
    PROi Q9HB14.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HB14.
    CleanExi HS_KCNK13.
    Genevestigatori Q9HB14.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR005410. 2pore_dom_K_chnl_THIK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01333. 2POREKCHANEL.
    PR01588. THIKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
      Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
      Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiKCNKD_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB14
    Secondary accession number(s): B5TJL8, Q96E79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: November 1, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The current is enhanced by arachidonic acid and inhibited by halothane.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3