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Protein

Potassium channel subfamily K member 13

Gene

KCNK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel displaying weak inward rectification in symmetrical K+ solution.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75880. Tandem pore domain halothane-inhibited K+ channel (THIK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name:
THIK-1
Gene namesi
Name:KCNK13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:6275. KCNK13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Intramembranei95 – 11521Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Topological domaini146 – 19348CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Intramembranei224 – 24421Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Topological domaini284 – 408125CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30055.

Polymorphism and mutation databases

BioMutaiKCNK13.
DMDMi24636284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Potassium channel subfamily K member 13PRO_0000101762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HB14.
PaxDbiQ9HB14.
PRIDEiQ9HB14.

PTM databases

PhosphoSiteiQ9HB14.

Expressioni

Gene expression databases

BgeeiQ9HB14.
CleanExiHS_KCNK13.
GenevisibleiQ9HB14. HS.

Organism-specific databases

HPAiHPA003514.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000282146.

Structurei

3D structure databases

ProteinModelPortaliQ9HB14.
SMRiQ9HB14. Positions 26-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260772.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB14.
KOiK04922.
OMAiVNWILRK.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9HB14.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9HB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK
60 70 80 90 100
QRWEERLANF SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA
110 120 130 140 150
FYFVGTVVST IGFGMTTPAT VGGKIFLIFY GLVGCSSTIL FFNLFLERLI
160 170 180 190 200
TIIAYIMKSC HQRQLRRRGA LPQESLKDAG QCEVDSLAGW KPSVYYVMLI
210 220 230 240 250
LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF GDLVSSQNAH
260 270 280 290 300
YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP
310 320 330 340 350
QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK
360 370 380 390 400
DLLAANKASL AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR

LAETSGDR
Length:408
Mass (Da):45,391
Last modified:November 1, 2002 - v2
Checksum:iB303C01AFD59EE19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881N → D in AAG32314 (PubMed:11060316).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti305 – 3051G → R.
Corresponds to variant rs3814848 [ dbSNP | Ensembl ].
VAR_052429
Natural varianti389 – 3891G → A.
Corresponds to variant rs35909577 [ dbSNP | Ensembl ].
VAR_034052

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287303 mRNA. Translation: AAG32314.1.
EU978942 mRNA. Translation: ACH86101.1.
CH471061 Genomic DNA. Translation: EAW81417.1.
BC012779 mRNA. Translation: AAH12779.1.
CCDSiCCDS9889.1.
RefSeqiNP_071337.2. NM_022054.3.
UniGeneiHs.510191.

Genome annotation databases

EnsembliENST00000282146; ENSP00000282146; ENSG00000152315.
GeneIDi56659.
KEGGihsa:56659.
UCSCiuc001xye.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287303 mRNA. Translation: AAG32314.1.
EU978942 mRNA. Translation: ACH86101.1.
CH471061 Genomic DNA. Translation: EAW81417.1.
BC012779 mRNA. Translation: AAH12779.1.
CCDSiCCDS9889.1.
RefSeqiNP_071337.2. NM_022054.3.
UniGeneiHs.510191.

3D structure databases

ProteinModelPortaliQ9HB14.
SMRiQ9HB14. Positions 26-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000282146.

Chemistry

GuidetoPHARMACOLOGYi523.

PTM databases

PhosphoSiteiQ9HB14.

Polymorphism and mutation databases

BioMutaiKCNK13.
DMDMi24636284.

Proteomic databases

MaxQBiQ9HB14.
PaxDbiQ9HB14.
PRIDEiQ9HB14.

Protocols and materials databases

DNASUi56659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282146; ENSP00000282146; ENSG00000152315.
GeneIDi56659.
KEGGihsa:56659.
UCSCiuc001xye.1. human.

Organism-specific databases

CTDi56659.
GeneCardsiGC14P090528.
HGNCiHGNC:6275. KCNK13.
HPAiHPA003514.
MIMi607367. gene.
neXtProtiNX_Q9HB14.
PharmGKBiPA30055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG260772.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ9HB14.
KOiK04922.
OMAiVNWILRK.
OrthoDBiEOG7DC24D.
PhylomeDBiQ9HB14.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiREACT_75880. Tandem pore domain halothane-inhibited K+ channel (THIK).

Miscellaneous databases

GeneWikiiKCNK13.
GenomeRNAii56659.
NextBioi62135.
PROiQ9HB14.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HB14.
CleanExiHS_KCNK13.
GenevisibleiQ9HB14. HS.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR005410. 2pore_dom_K_chnl_THIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
    Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
    Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiKCNKD_HUMAN
AccessioniPrimary (citable) accession number: Q9HB14
Secondary accession number(s): B5TJL8, Q96E79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: July 22, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The current is enhanced by arachidonic acid and inhibited by halothane.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.