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Q9HB09 (B2L12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bcl-2-like protein 12

Short name=Bcl2-L-12
Alternative name(s):
Bcl-2-related proline-rich protein
Gene names
Name:BCL2L12
Synonyms:BPR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.

Sequence similarities

Belongs to the Bcl-2 family.

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HB09-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HB09-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-176: SPAQEEPTDF...PGPATPDFYA → PSYSRLLCFG...GPAGGGGRSH
     177-334: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: Q9HB09-3)

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Bcl-2-like protein 12
PRO_0000143072

Regions

Motif311 – 32212BH2

Amino acid modifications

Modified residue1131Phosphoserine Ref.5
Modified residue1171Phosphothreonine Ref.5
Modified residue1211Phosphoserine Ref.5
Modified residue2421Phosphoserine Ref.5 Ref.7 Ref.8
Modified residue2431Phosphoserine Ref.8

Natural variations

Alternative sequence1201Missing in isoform 3.
VSP_043269
Alternative sequence121 – 17656SPAQE…PDFYA → PSYSRLLCFGGPAAGTAGPR AAEISAQPRITGSPIDREGS HTAEAGGPAGGGGRSH in isoform 2.
VSP_000522
Alternative sequence177 – 334158Missing in isoform 2.
VSP_000523
Natural variant471G → V.
Corresponds to variant rs2060263 [ dbSNP | Ensembl ].
VAR_048419

Experimental info

Sequence conflict2701P → S in AAH07724. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 5398E54C83E7CAB7

FASTA33436,821
        10         20         30         40         50         60 
MGRPAGLFPP LCPFLGFRPE ACWERHMQIE RAPSVPPFLR WAGYRPGPVR RRGKVELIKF 

        70         80         90        100        110        120 
VRVQWRRPQV EWRRRRWGPG PGASMAGSEE LGLREDTLRV LAAFLRRGEA AGSPVPTPPR 

       130        140        150        160        170        180 
SPAQEEPTDF LSRLRRCLPC SLGRGAAPSE SPRPCSLPIR PCYGLEPGPA TPDFYALVAQ 

       190        200        210        220        230        240 
RLEQLVQEQL KSPPSPELQG PPSTEKEAIL RRLVALLEEE AEVINQKLAS DPALRSKLVR 

       250        260        270        280        290        300 
LSSDSFARLV ELFCSRDDSS RPSRACPGPP PPSPEPLARL ALAMELSRRV AGLGGTLAGL 

       310        320        330 
SVEHVHSFTP WIQAHGGWEG ILAVSPVDLN LPLD 

« Hide

Isoform 2 [UniParc].

Checksum: DC503A642100CAE4
Show »

FASTA17619,133
Isoform 3 [UniParc].

Checksum: AC8C106CC9D01518
Show »

FASTA33336,665

References

« Hide 'large scale' references
[1]"Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family."
Scorilas A., Kyriakopoulou L., Yousef G.M., Ashworth L.K., Kwamie A., Diamandis E.P.
Genomics 72:217-221(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Uterus.
[4]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; THR-117; SER-121 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242 AND SER-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289220 Genomic DNA. Translation: AAG29495.1.
AF289220 Genomic DNA. Translation: AAG29496.1.
AC011495 Genomic DNA. No translation available.
BC007724 mRNA. Translation: AAH07724.2.
BC104004 mRNA. Translation: AAI04005.1.
BC104005 mRNA. Translation: AAI04006.1.
BC104006 mRNA. Translation: AAI04007.1.
RefSeqNP_001035758.1. NM_001040668.1.
NP_001269445.1. NM_001282516.1.
NP_001269446.1. NM_001282517.1.
NP_001269448.1. NM_001282519.1.
NP_001269449.1. NM_001282520.1.
NP_001269450.1. NM_001282521.1.
NP_619580.1. NM_138639.1.
UniGeneHs.289052.

3D structure databases

ProteinModelPortalQ9HB09.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123692. 4 interactions.
IntActQ9HB09. 3 interactions.
STRING9606.ENSP00000246785.

PTM databases

PhosphoSiteQ9HB09.

Polymorphism databases

DMDM23396468.

Proteomic databases

PaxDbQ9HB09.
PRIDEQ9HB09.

Protocols and materials databases

DNASU83596.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246784; ENSP00000246784; ENSG00000126453. [Q9HB09-2]
ENST00000246785; ENSP00000246785; ENSG00000126453. [Q9HB09-1]
ENST00000441864; ENSP00000393803; ENSG00000126453. [Q9HB09-3]
GeneID83596.
KEGGhsa:83596.
UCSCuc002ppa.3. human. [Q9HB09-1]
uc002ppb.3. human. [Q9HB09-3]

Organism-specific databases

CTD83596.
GeneCardsGC19P050168.
HGNCHGNC:13787. BCL2L12.
HPAHPA020856.
MIM610837. gene.
neXtProtNX_Q9HB09.
PharmGKBPA25306.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41154.
HOGENOMHOG000294149.
HOVERGENHBG050647.
InParanoidQ9HB09.
OMAQEEPTDF.
OrthoDBEOG7XM2ZJ.
PhylomeDBQ9HB09.
TreeFamTF338350.

Gene expression databases

ArrayExpressQ9HB09.
BgeeQ9HB09.
CleanExHS_BCL2L12.
GenevestigatorQ9HB09.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSBCL2L12. human.
GeneWikiBCL2L12.
GenomeRNAi83596.
NextBio72533.
PROQ9HB09.
SOURCESearch...

Entry information

Entry nameB2L12_HUMAN
AccessionPrimary (citable) accession number: Q9HB09
Secondary accession number(s): Q3SY11 expand/collapse secondary AC list , Q3SY13, Q96I96, Q9HB08
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM