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Q9HB07

- MYG1_HUMAN

UniProt

Q9HB07 - MYG1_HUMAN

Protein

UPF0160 protein MYG1, mitochondrial

Gene

C12orf10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. locomotory exploration behavior Source: Ensembl
    2. pigmentation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0160 protein MYG1, mitochondrial
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17590. C12orf10.

    Subcellular locationi

    Nucleus 1 Publication. Mitochondrion 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrion Source: MGI
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4747MitochondrionSequence AnalysisAdd
    BLAST
    Chaini48 – 376329UPF0160 protein MYG1, mitochondrialPRO_0000213483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-acetyllysine1 Publication
    Modified residuei273 – 2731N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9HB07.
    PaxDbiQ9HB07.
    PRIDEiQ9HB07.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00029444.

    PTM databases

    PhosphoSiteiQ9HB07.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9HB07.
    BgeeiQ9HB07.
    CleanExiHS_C12orf10.
    GenevestigatoriQ9HB07.

    Organism-specific databases

    HPAiHPA038626.
    HPA038627.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9HB07. 1 interaction.
    MINTiMINT-1490123.
    STRINGi9606.ENSP00000267103.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HB07.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0160 (MYG1) family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG4286.
    HOGENOMiHOG000208845.
    HOVERGENiHBG009879.
    InParanoidiQ9HB07.
    OMAiCVFVHAA.
    OrthoDBiEOG7D59NQ.
    PhylomeDBiQ9HB07.
    TreeFamiTF313313.

    Family and domain databases

    InterProiIPR003226. Met-dep_prot_hydro.
    [Graphical view]
    PANTHERiPTHR11215. PTHR11215. 1 hit.
    PfamiPF03690. UPF0160. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HB07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHQFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH    50
    NGTFHCDEAL ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP 100
    RRHRYDHHQR SFTETMSSLS PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT 150
    SEEDSMVGTL YDKMYENFVE EVDAVDNGIS QWAEGEPRYA LTTTLSARVA 200
    RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL PARALVEEAL 250
    AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ 300
    WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG 350
    GHHTREGALS MARATLAQRS YLPQIS 376
    Length:376
    Mass (Da):42,449
    Last modified:May 18, 2010 - v2
    Checksum:iCC045005FF3C29CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41Q → R in AAG17847. 1 PublicationCurated
    Sequence conflicti150 – 1501T → P in AAG17847. 1 PublicationCurated
    Sequence conflicti353 – 3531H → P in AAG17847. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti349 – 3491T → I.1 Publication
    Corresponds to variant rs1534282 [ dbSNP | Ensembl ].
    VAR_059854

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289485 mRNA. Translation: AAG17847.1.
    AC073611 Genomic DNA. No translation available.
    CCDSiCCDS31810.1.
    UniGeneiHs.655988.

    Genome annotation databases

    EnsembliENST00000267103; ENSP00000267103; ENSG00000139637.
    UCSCiuc001scp.4. human.

    Polymorphism databases

    DMDMi296439232.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289485 mRNA. Translation: AAG17847.1 .
    AC073611 Genomic DNA. No translation available.
    CCDSi CCDS31810.1.
    UniGenei Hs.655988.

    3D structure databases

    ProteinModelPortali Q9HB07.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9HB07. 1 interaction.
    MINTi MINT-1490123.
    STRINGi 9606.ENSP00000267103.

    PTM databases

    PhosphoSitei Q9HB07.

    Polymorphism databases

    DMDMi 296439232.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00029444.

    Proteomic databases

    MaxQBi Q9HB07.
    PaxDbi Q9HB07.
    PRIDEi Q9HB07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267103 ; ENSP00000267103 ; ENSG00000139637 .
    UCSCi uc001scp.4. human.

    Organism-specific databases

    GeneCardsi GC12P053693.
    HGNCi HGNC:17590. C12orf10.
    HPAi HPA038626.
    HPA038627.
    MIMi 611366. gene.
    neXtProti NX_Q9HB07.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4286.
    HOGENOMi HOG000208845.
    HOVERGENi HBG009879.
    InParanoidi Q9HB07.
    OMAi CVFVHAA.
    OrthoDBi EOG7D59NQ.
    PhylomeDBi Q9HB07.
    TreeFami TF313313.

    Miscellaneous databases

    ChiTaRSi C12orf10. human.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HB07.
    Bgeei Q9HB07.
    CleanExi HS_C12orf10.
    Genevestigatori Q9HB07.

    Family and domain databases

    InterProi IPR003226. Met-dep_prot_hydro.
    [Graphical view ]
    PANTHERi PTHR11215. PTHR11215. 1 hit.
    Pfami PF03690. UPF0160. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human homologue of MYG1 the highly conserved gene from autonomously proliferating mouse melanocytes."
      Smicun Y.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-349.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Characterization of MYG1 gene and protein: subcellular distribution and function."
      Philips M.-A., Vikesaa J., Luuk H., Joenson L., Lillevaeli K., Rehfeld J.F., Vasar E., Koks S., Nielsen F.C.
      Biol. Cell 101:361-373(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HB07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3