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Q9HB07

- MYG1_HUMAN

UniProt

Q9HB07 - MYG1_HUMAN

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Protein

UPF0160 protein MYG1, mitochondrial

Gene

C12orf10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. locomotory exploration behavior Source: Ensembl
  2. pigmentation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0160 protein MYG1, mitochondrial
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17590. C12orf10.

Subcellular locationi

Nucleus 1 Publication. Mitochondrion 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrion Source: MGI
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4747MitochondrionSequence AnalysisAdd
BLAST
Chaini48 – 376329UPF0160 protein MYG1, mitochondrialPRO_0000213483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-acetyllysine1 Publication
Modified residuei273 – 2731N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9HB07.
PaxDbiQ9HB07.
PRIDEiQ9HB07.

2D gel databases

REPRODUCTION-2DPAGEIPI00029444.

PTM databases

PhosphoSiteiQ9HB07.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testis.1 Publication

Gene expression databases

BgeeiQ9HB07.
CleanExiHS_C12orf10.
ExpressionAtlasiQ9HB07. baseline and differential.
GenevestigatoriQ9HB07.

Organism-specific databases

HPAiHPA038626.
HPA038627.

Interactioni

Protein-protein interaction databases

IntActiQ9HB07. 2 interactions.
MINTiMINT-1490123.
STRINGi9606.ENSP00000267103.

Structurei

3D structure databases

ProteinModelPortaliQ9HB07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0160 (MYG1) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG4286.
GeneTreeiENSGT00390000010265.
HOGENOMiHOG000208845.
HOVERGENiHBG009879.
InParanoidiQ9HB07.
OMAiCVFVHAA.
OrthoDBiEOG7D59NQ.
PhylomeDBiQ9HB07.
TreeFamiTF313313.

Family and domain databases

InterProiIPR003226. Met-dep_prot_hydro.
[Graphical view]
PANTHERiPTHR11215. PTHR11215. 1 hit.
PfamiPF03690. UPF0160. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HB07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHQFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH
60 70 80 90 100
NGTFHCDEAL ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP
110 120 130 140 150
RRHRYDHHQR SFTETMSSLS PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT
160 170 180 190 200
SEEDSMVGTL YDKMYENFVE EVDAVDNGIS QWAEGEPRYA LTTTLSARVA
210 220 230 240 250
RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL PARALVEEAL
260 270 280 290 300
AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ
310 320 330 340 350
WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG
360 370
GHHTREGALS MARATLAQRS YLPQIS
Length:376
Mass (Da):42,449
Last modified:May 18, 2010 - v2
Checksum:iCC045005FF3C29CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41Q → R in AAG17847. 1 PublicationCurated
Sequence conflicti150 – 1501T → P in AAG17847. 1 PublicationCurated
Sequence conflicti353 – 3531H → P in AAG17847. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491T → I.1 Publication
Corresponds to variant rs1534282 [ dbSNP | Ensembl ].
VAR_059854

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289485 mRNA. Translation: AAG17847.1.
AC073611 Genomic DNA. No translation available.
CCDSiCCDS31810.1.
UniGeneiHs.655988.

Genome annotation databases

EnsembliENST00000267103; ENSP00000267103; ENSG00000139637.
UCSCiuc001scp.4. human.

Polymorphism databases

DMDMi296439232.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289485 mRNA. Translation: AAG17847.1 .
AC073611 Genomic DNA. No translation available.
CCDSi CCDS31810.1.
UniGenei Hs.655988.

3D structure databases

ProteinModelPortali Q9HB07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9HB07. 2 interactions.
MINTi MINT-1490123.
STRINGi 9606.ENSP00000267103.

PTM databases

PhosphoSitei Q9HB07.

Polymorphism databases

DMDMi 296439232.

2D gel databases

REPRODUCTION-2DPAGE IPI00029444.

Proteomic databases

MaxQBi Q9HB07.
PaxDbi Q9HB07.
PRIDEi Q9HB07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267103 ; ENSP00000267103 ; ENSG00000139637 .
UCSCi uc001scp.4. human.

Organism-specific databases

GeneCardsi GC12P053693.
HGNCi HGNC:17590. C12orf10.
HPAi HPA038626.
HPA038627.
MIMi 611366. gene.
neXtProti NX_Q9HB07.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4286.
GeneTreei ENSGT00390000010265.
HOGENOMi HOG000208845.
HOVERGENi HBG009879.
InParanoidi Q9HB07.
OMAi CVFVHAA.
OrthoDBi EOG7D59NQ.
PhylomeDBi Q9HB07.
TreeFami TF313313.

Miscellaneous databases

ChiTaRSi C12orf10. human.
SOURCEi Search...

Gene expression databases

Bgeei Q9HB07.
CleanExi HS_C12orf10.
ExpressionAtlasi Q9HB07. baseline and differential.
Genevestigatori Q9HB07.

Family and domain databases

InterProi IPR003226. Met-dep_prot_hydro.
[Graphical view ]
PANTHERi PTHR11215. PTHR11215. 1 hit.
Pfami PF03690. UPF0160. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of MYG1 the highly conserved gene from autonomously proliferating mouse melanocytes."
    Smicun Y.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-349.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of MYG1 gene and protein: subcellular distribution and function."
    Philips M.-A., Vikesaa J., Luuk H., Joenson L., Lillevaeli K., Rehfeld J.F., Vasar E., Koks S., Nielsen F.C.
    Biol. Cell 101:361-373(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYG1_HUMAN
AccessioniPrimary (citable) accession number: Q9HB07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3