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Protein

UPF0160 protein MYG1, mitochondrial

Gene

C12orf10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • locomotory exploration behavior Source: Ensembl
  • pigmentation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139637-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0160 protein MYG1, mitochondrial
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17590. C12orf10.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: MGI
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi60314.
OpenTargetsiENSG00000139637.

Polymorphism and mutation databases

DMDMi296439232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 47MitochondrionSequence analysisAdd BLAST47
ChainiPRO_000021348348 – 376UPF0160 protein MYG1, mitochondrialAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineCombined sources1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei273N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HB07.
MaxQBiQ9HB07.
PaxDbiQ9HB07.
PeptideAtlasiQ9HB07.
PRIDEiQ9HB07.

2D gel databases

REPRODUCTION-2DPAGEIPI00029444.

PTM databases

iPTMnetiQ9HB07.
PhosphoSitePlusiQ9HB07.
SwissPalmiQ9HB07.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000139637.
CleanExiHS_C12orf10.
ExpressionAtlasiQ9HB07. baseline and differential.
GenevisibleiQ9HB07. HS.

Organism-specific databases

HPAiHPA038626.
HPA038627.

Interactioni

Protein-protein interaction databases

IntActiQ9HB07. 5 interactors.
MINTiMINT-1490123.
STRINGi9606.ENSP00000267103.

Structurei

3D structure databases

ProteinModelPortaliQ9HB07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0160 (MYG1) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2948. Eukaryota.
COG4286. LUCA.
GeneTreeiENSGT00390000010265.
HOGENOMiHOG000208845.
HOVERGENiHBG009879.
InParanoidiQ9HB07.
OMAiLETCHTV.
OrthoDBiEOG091G0IQD.
PhylomeDBiQ9HB07.
TreeFamiTF313313.

Family and domain databases

InterProiIPR003226. Met-dep_prot_hydro.
[Graphical view]
PANTHERiPTHR11215. PTHR11215. 1 hit.
PfamiPF03690. UPF0160. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HB07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHQFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH
60 70 80 90 100
NGTFHCDEAL ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP
110 120 130 140 150
RRHRYDHHQR SFTETMSSLS PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT
160 170 180 190 200
SEEDSMVGTL YDKMYENFVE EVDAVDNGIS QWAEGEPRYA LTTTLSARVA
210 220 230 240 250
RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL PARALVEEAL
260 270 280 290 300
AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ
310 320 330 340 350
WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG
360 370
GHHTREGALS MARATLAQRS YLPQIS
Length:376
Mass (Da):42,449
Last modified:May 18, 2010 - v2
Checksum:iCC045005FF3C29CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4Q → R in AAG17847 (Ref. 1) Curated1
Sequence conflicti150T → P in AAG17847 (Ref. 1) Curated1
Sequence conflicti353H → P in AAG17847 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059854349T → I.1 PublicationCorresponds to variant rs1534282dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289485 mRNA. Translation: AAG17847.1.
AC073611 Genomic DNA. No translation available.
CCDSiCCDS31810.1.
UniGeneiHs.655988.

Genome annotation databases

EnsembliENST00000267103; ENSP00000267103; ENSG00000139637.
UCSCiuc001scp.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289485 mRNA. Translation: AAG17847.1.
AC073611 Genomic DNA. No translation available.
CCDSiCCDS31810.1.
UniGeneiHs.655988.

3D structure databases

ProteinModelPortaliQ9HB07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HB07. 5 interactors.
MINTiMINT-1490123.
STRINGi9606.ENSP00000267103.

PTM databases

iPTMnetiQ9HB07.
PhosphoSitePlusiQ9HB07.
SwissPalmiQ9HB07.

Polymorphism and mutation databases

DMDMi296439232.

2D gel databases

REPRODUCTION-2DPAGEIPI00029444.

Proteomic databases

EPDiQ9HB07.
MaxQBiQ9HB07.
PaxDbiQ9HB07.
PeptideAtlasiQ9HB07.
PRIDEiQ9HB07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267103; ENSP00000267103; ENSG00000139637.
UCSCiuc001scp.5. human.

Organism-specific databases

DisGeNETi60314.
GeneCardsiC12orf10.
HGNCiHGNC:17590. C12orf10.
HPAiHPA038626.
HPA038627.
MIMi611366. gene.
neXtProtiNX_Q9HB07.
OpenTargetsiENSG00000139637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2948. Eukaryota.
COG4286. LUCA.
GeneTreeiENSGT00390000010265.
HOGENOMiHOG000208845.
HOVERGENiHBG009879.
InParanoidiQ9HB07.
OMAiLETCHTV.
OrthoDBiEOG091G0IQD.
PhylomeDBiQ9HB07.
TreeFamiTF313313.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139637-MONOMER.

Miscellaneous databases

ChiTaRSiC12orf10. human.
PROiQ9HB07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139637.
CleanExiHS_C12orf10.
ExpressionAtlasiQ9HB07. baseline and differential.
GenevisibleiQ9HB07. HS.

Family and domain databases

InterProiIPR003226. Met-dep_prot_hydro.
[Graphical view]
PANTHERiPTHR11215. PTHR11215. 1 hit.
PfamiPF03690. UPF0160. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYG1_HUMAN
AccessioniPrimary (citable) accession number: Q9HB07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.