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Q9HB07 (MYG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UPF0160 protein MYG1, mitochondrial
Gene names
Name:C12orf10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus. Mitochondrion Ref.3.

Tissue specificity

Ubiquitously expressed, with highest levels in testis. Ref.3

Sequence similarities

Belongs to the UPF0160 (MYG1) family.

Ontologies

Keywords
   Cellular componentMitochondrion
Nucleus
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlocomotory exploration behavior

Inferred from electronic annotation. Source: Ensembl

pigmentation

Non-traceable author statement PubMed 16996721. Source: UniProtKB

   Cellular_componentmitochondrion

Inferred from direct assay Ref.3. Source: MGI

nucleus

Inferred from direct assay. Source: HPA

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4747Mitochondrion Potential
Chain48 – 376329UPF0160 protein MYG1, mitochondrial
PRO_0000213483

Amino acid modifications

Modified residue2671N6-acetyllysine Ref.4
Modified residue2731N6-acetyllysine By similarity

Natural variations

Natural variant3491T → I. Ref.1
Corresponds to variant rs1534282 [ dbSNP | Ensembl ].
VAR_059854

Experimental info

Sequence conflict41Q → R in AAG17847. Ref.1
Sequence conflict1501T → P in AAG17847. Ref.1
Sequence conflict3531H → P in AAG17847. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HB07 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: CC045005FF3C29CD

FASTA37642,449
        10         20         30         40         50         60 
MGHQFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH NGTFHCDEAL 

        70         80         90        100        110        120 
ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP RRHRYDHHQR SFTETMSSLS 

       130        140        150        160        170        180 
PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT SEEDSMVGTL YDKMYENFVE EVDAVDNGIS 

       190        200        210        220        230        240 
QWAEGEPRYA LTTTLSARVA RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL 

       250        260        270        280        290        300 
PARALVEEAL AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ 

       310        320        330        340        350        360 
WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG GHHTREGALS 

       370 
MARATLAQRS YLPQIS 

« Hide

References

« Hide 'large scale' references
[1]"The human homologue of MYG1 the highly conserved gene from autonomously proliferating mouse melanocytes."
Smicun Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-349.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Characterization of MYG1 gene and protein: subcellular distribution and function."
Philips M.-A., Vikesaa J., Luuk H., Joenson L., Lillevaeli K., Rehfeld J.F., Vasar E., Koks S., Nielsen F.C.
Biol. Cell 101:361-373(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[4]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289485 mRNA. Translation: AAG17847.1.
AC073611 Genomic DNA. No translation available.
CCDSCCDS31810.1.
UniGeneHs.655988.

3D structure databases

ProteinModelPortalQ9HB07.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9HB07. 1 interaction.
MINTMINT-1490123.
STRING9606.ENSP00000267103.

PTM databases

PhosphoSiteQ9HB07.

Polymorphism databases

DMDM296439232.

2D gel databases

REPRODUCTION-2DPAGEIPI00029444.

Proteomic databases

MaxQBQ9HB07.
PaxDbQ9HB07.
PRIDEQ9HB07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267103; ENSP00000267103; ENSG00000139637.
UCSCuc001scp.4. human.

Organism-specific databases

GeneCardsGC12P053693.
HGNCHGNC:17590. C12orf10.
HPAHPA038626.
HPA038627.
MIM611366. gene.
neXtProtNX_Q9HB07.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4286.
HOGENOMHOG000208845.
HOVERGENHBG009879.
InParanoidQ9HB07.
OMACVFVHAA.
OrthoDBEOG7D59NQ.
PhylomeDBQ9HB07.
TreeFamTF313313.

Gene expression databases

ArrayExpressQ9HB07.
BgeeQ9HB07.
CleanExHS_C12orf10.
GenevestigatorQ9HB07.

Family and domain databases

InterProIPR003226. Met-dep_prot_hydro.
[Graphical view]
PANTHERPTHR11215. PTHR11215. 1 hit.
PfamPF03690. UPF0160. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC12orf10. human.
SOURCESearch...

Entry information

Entry nameMYG1_HUMAN
AccessionPrimary (citable) accession number: Q9HB07
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM