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Protein

Elongation of very long chain fatty acids protein 3

Gene

ELOVL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation1 Publication

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation1 Publication

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000119915-MONOMER.
ZFISH:ENSG00000119915-MONOMER.
BRENDAi2.3.1.119. 2681.
ReactomeiR-HSA-2046105. Linoleic acid (LA) metabolism.
R-HSA-2046106. alpha-linolenic acid (ALA) metabolism.
R-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.
UniPathwayiUPA00658.

Chemistry databases

SwissLipidsiSLP:000000248.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 3UniRule annotationCurated (EC:2.3.1.199UniRule annotation1 Publication)
Alternative name(s):
3-keto acyl-CoA synthase ELOVL3UniRule annotation
Cold-inducible glycoprotein of 30 kDa
ELOVL fatty acid elongase 3UniRule annotation
Short name:
ELOVL FA elongase 3UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 3UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 3UniRule annotation
Gene namesi
Name:ELOVL3UniRule annotation
Synonyms:CIG30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18047. ELOVL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei63 – 83HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119915.
PharmGKBiPA27762.

Chemistry databases

ChEMBLiCHEMBL5791.

Polymorphism and mutation databases

BioMutaiELOVL3.
DMDMi26006738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075401 – 270Elongation of very long chain fatty acids protein 3Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)UniRule annotation1
Glycosylationi110N-linked (GlcNAc...)UniRule annotation1

Post-translational modificationi

N-Glycosylated.UniRule annotation1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HB03.
PRIDEiQ9HB03.

PTM databases

iPTMnetiQ9HB03.
PhosphoSitePlusiQ9HB03.

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSG00000119915.
CleanExiHS_ELOVL3.
GenevisibleiQ9HB03. HS.

Organism-specific databases

HPAiHPA036236.

Interactioni

Protein-protein interaction databases

BioGridi123637. 2 interactors.
IntActiQ9HB03. 1 interactor.
STRINGi9606.ENSP00000359022.

Chemistry databases

BindingDBiQ9HB03.

Structurei

3D structure databases

ProteinModelPortaliQ9HB03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 270Di-lysine motifUniRule annotation5

Domaini

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.UniRule annotation

Sequence similaritiesi

Belongs to the ELO family. ELOVL3 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ9HB03.
KOiK10248.
OMAiCHTTTEQ.
OrthoDBiEOG091G0EKU.
PhylomeDBiQ9HB03.
TreeFamiTF106467.

Family and domain databases

HAMAPiMF_03203. VLCF_elongase_3. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033679. ELOVL3.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HB03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTAMNVSHE VNQLFQPYNF ELSKDMRPFF EEYWATSFPI ALIYLVLIAV
60 70 80 90 100
GQNYMKERKG FNLQGPLILW SFCLAIFSIL GAVRMWGIMG TVLLTGGLKQ
110 120 130 140 150
TVCFINFIDN STVKFWSWVF LLSKVIELGD TAFIILRKRP LIFIHWYHHS
160 170 180 190 200
TVLVYTSFGY KNKVPAGGWF VTMNFGVHAI MYTYYTLKAA NVKPPKMLPM
210 220 230 240 250
LITSLQILQM FVGAIVSILT YIWRQDQGCH TTMEHLFWSF ILYMTYFILF
260 270
AHFFCQTYIR PKVKAKTKSQ
Length:270
Mass (Da):31,500
Last modified:November 28, 2002 - v2
Checksum:i0C6C8F1E7B5DE8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160011 Genomic DNA. Translation: CAH71623.1.
CH471066 Genomic DNA. Translation: EAW49711.1.
BC034344 mRNA. Translation: AAH34344.1.
AF292387 Genomic DNA. Translation: AAG17875.1.
CCDSiCCDS7531.1.
RefSeqiNP_689523.1. NM_152310.2.
XP_011538547.1. XM_011540245.2.
UniGeneiHs.302130.

Genome annotation databases

EnsembliENST00000370005; ENSP00000359022; ENSG00000119915.
GeneIDi83401.
KEGGihsa:83401.
UCSCiuc001kut.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160011 Genomic DNA. Translation: CAH71623.1.
CH471066 Genomic DNA. Translation: EAW49711.1.
BC034344 mRNA. Translation: AAH34344.1.
AF292387 Genomic DNA. Translation: AAG17875.1.
CCDSiCCDS7531.1.
RefSeqiNP_689523.1. NM_152310.2.
XP_011538547.1. XM_011540245.2.
UniGeneiHs.302130.

3D structure databases

ProteinModelPortaliQ9HB03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123637. 2 interactors.
IntActiQ9HB03. 1 interactor.
STRINGi9606.ENSP00000359022.

Chemistry databases

BindingDBiQ9HB03.
ChEMBLiCHEMBL5791.
SwissLipidsiSLP:000000248.

PTM databases

iPTMnetiQ9HB03.
PhosphoSitePlusiQ9HB03.

Polymorphism and mutation databases

BioMutaiELOVL3.
DMDMi26006738.

Proteomic databases

PaxDbiQ9HB03.
PRIDEiQ9HB03.

Protocols and materials databases

DNASUi83401.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370005; ENSP00000359022; ENSG00000119915.
GeneIDi83401.
KEGGihsa:83401.
UCSCiuc001kut.5. human.

Organism-specific databases

CTDi83401.
GeneCardsiELOVL3.
HGNCiHGNC:18047. ELOVL3.
HPAiHPA036236.
MIMi611815. gene.
neXtProtiNX_Q9HB03.
OpenTargetsiENSG00000119915.
PharmGKBiPA27762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ9HB03.
KOiK10248.
OMAiCHTTTEQ.
OrthoDBiEOG091G0EKU.
PhylomeDBiQ9HB03.
TreeFamiTF106467.

Enzyme and pathway databases

UniPathwayiUPA00658.
BioCyciMetaCyc:ENSG00000119915-MONOMER.
ZFISH:ENSG00000119915-MONOMER.
BRENDAi2.3.1.119. 2681.
ReactomeiR-HSA-2046105. Linoleic acid (LA) metabolism.
R-HSA-2046106. alpha-linolenic acid (ALA) metabolism.
R-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

GenomeRNAii83401.
PROiQ9HB03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119915.
CleanExiHS_ELOVL3.
GenevisibleiQ9HB03. HS.

Family and domain databases

HAMAPiMF_03203. VLCF_elongase_3. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033679. ELOVL3.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOV3_HUMAN
AccessioniPrimary (citable) accession number: Q9HB03
Secondary accession number(s): Q5VZL3, Q8N180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 28, 2002
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.