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Reviewed, UniProtKB/Swiss-Prot Q9HAZ2 (PRD16_HUMAN)

Last modified November 3, 2009. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    PR domain zinc finger protein 16
Alternative name(s):
    PR domain-containing protein 16
    Transcription factor MEL1
      Short name=MDS1/EVI1-like gene 1
Gene names
Name: PRDM16
Synonyms: KIAA1675, MEL1, PFM13
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation. Ref.7 Ref.9 Ref.10

Subunit structure

Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct. Interacts with PPARG and PPARA; controls brown adipocytes differentiation. Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes. Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific gene. Interacts with SMAD3 By similarity. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.

Subcellular location

Nucleus. Ref.10

Tissue specificity

Expressed in uterus and kidney. Ref.7 Ref.1

Involvement in disease

Defects in PRDM16 are found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Ref.9 Ref.1 Ref.8

Sequence similarities

Contains 10 C2H2-type zinc fingers.

Contains 1 SET domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative promoter usage
Alternative splicing
Chromosomal rearrangement
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Repressor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbrown fat cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of granulocyte differentiation

Inferred from direct assay. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter Ref.10

Inferred from direct assay. Source: UniProtKB

negative regulation of transforming growth factor beta receptor signaling pathway Ref.9 Ref.10

Inferred from direct assay. Source: UniProtKB

positive regulation of transcription, DNA-dependent

Inferred from direct assay. Source: UniProtKB

regulation of cellular respiration

Inferred from sequence or structural similarity. Source: UniProtKB

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componenttranscriptional repressor complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionsequence-specific DNA binding Ref.7

Inferred from direct assay. Source: UniProtKB

transcription coactivator activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription repressor activity

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HAZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HAZ2-2)

Also known as: MEL1L;

The sequence of this isoform differs from the canonical sequence as follows:
     1233-1251: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9HAZ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     191-191: Q → QV
     868-868: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9HAZ2-4)

Also known as: MEL1S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
Note: Produced by alternative promoter usage.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12761276PR domain zinc finger protein 16
PRO_0000047773

Regions

Domain83 – 215133SET
Zinc finger230 – 25324C2H2-type 1; atypical
Zinc finger281 – 30323C2H2-type 2
Zinc finger309 – 33123C2H2-type 3
Zinc finger337 – 36024C2H2-type 4
Zinc finger366 – 38823C2H2-type 5
Zinc finger394 – 41623C2H2-type 6
Zinc finger423 – 44523C2H2-type 7; atypical
Zinc finger951 – 97323C2H2-type 8
Zinc finger979 – 100224C2H2-type 9
Zinc finger1008 – 103225C2H2-type 10
Region679 – 1038360Interaction with CTBP1 and CTBP2 By similarity
Region739 – 1276538Mediates interaction with SKI and regulation of TGF-beta signaling
Compositional bias459 – 55799Pro-rich

Natural variations

Alternative sequence1 – 184184Missing in isoform 4.
VSP_038063
Alternative sequence1911Q → QV in isoform 3.
VSP_038064
Alternative sequence8681Missing in isoform 3.
VSP_038065
Alternative sequence1233 – 125119Missing in isoform 2.
VSP_006932
Natural variant5331S → P: dbSNP rs870124. Ref.1 Ref.3 Ref.6
VAR_031433
Natural variant6331P → L: dbSNP rs2493292.
VAR_031434

Experimental info

Sequence conflict50 – 523PPS → SPP in AAG33382. Ref.2
Sequence conflict3241L → F in AAG33382. Ref.2
Sequence conflict4911S → Y in AAG33382. Ref.2
Sequence conflict10221N → K in BAB84297. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 22, 2009. Version 3.
Checksum: AD16C5C0EE89A528

FASTA1,276140,251
        10         20         30         40         50         60 
MRSKARARKL AKSDGDVVNN MYEPNRDLLA SHSAEDEAED SAMSPIPVGP PSPFPTSEDF 

        70         80         90        100        110        120 
TPKEGSPYEA PVYIPEDIPI PADFELRESS IPGAGLGVWA KRKMEAGERL GPCVVVPRAA 

       130        140        150        160        170        180 
AKETDFGWEQ ILTDVEVSPQ EGCITKISED LGSEKFCVDA NQAGAGSWLK YIRVACSCDD 

       190        200        210        220        230        240 
QNLTMCQISE QIYYKVIKDI EPGEELLVHV KEGVYPLGTV PPGLDEEPTF RCDECDELFQ 

       250        260        270        280        290        300 
SKLDLRRHKK YTCGSVGAAL YEGLAEELKP EGLGGGSGQA HECKDCERMF PNKYSLEQHM 

       310        320        330        340        350        360 
VIHTEEREYK CDQCPKAFNW KSNLIRHQMS HDSGKRFECE NCVKVFTDPS NLQRHIRSQH 

       370        380        390        400        410        420 
VGARAHACPD CGKTFATSSG LKQHKHIHST VKPFICEVCH KSYTQFSNLC RHKRMHADCR 

       430        440        450        460        470        480 
TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH YTPGGIFAPG LPLTPSPMMD KAKPSPSLNH 

       490        500        510        520        530        540 
ASLGFNEYFP SRPHPGSLPF STAPPTFPAL TPGFPGIFPP SLYPRPPLLP PTSLLKSPLN 

       550        560        570        580        590        600 
HTQDAKLPSP LGNPALPLVS AVSNSSQGTT AAAGPEEKFE SRLEDSCVEK LKTRSSDMSD 

       610        620        630        640        650        660 
GSDFEDVNTT TGTDLDTTTG TGSDLDSDVD SDPDKDKGKG KSAEGQPKFG GGLAPPGAPN 

       670        680        690        700        710        720 
SVAEVPVFYS QHSFFPPPDE QLLTATGAAG DSIKAIASIA EKYFGPGFMG MQEKKLGSLP 

       730        740        750        760        770        780 
YHSAFPFQFL PNFPHSLYPF TDRALAHNLL VKAEPKSPRD ALKVGGPSAE CPFDLTTKPK 

       790        800        810        820        830        840 
DVKPILPMPK GPSAPASGEE QPLDLSIGSR ARASQNGGGR EPRKNHVYGE RKLGAGEGLP 

       850        860        870        880        890        900 
QVCPARMPQQ PPLHYAKPSP FFMDPIYSRV EKRKVTDPVG ALKEKYLRPS PLLFHPQMSA 

       910        920        930        940        950        960 
IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER YTCRYCGKIF 

       970        980        990       1000       1010       1020 
PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN IHNKEKPFKC HLCNRCFGQQ 

      1030       1040       1050       1060       1070       1080 
TNLDRHLKKH EHENAPVSQH PGVLTNHLGT SASSPTSESD NHALLDEKED SYFSEIRNFI 

      1090       1100       1110       1120       1130       1140 
ANSEMNQAST RTEKRADMQI VDGSAQCPGL ASEKQEDVEE EDDDDLEEDD EDSLAGKSQD 

      1150       1160       1170       1180       1190       1200 
DTVSPAPEPQ AAYEDEEDEE PAASLAVGFD HTRRCAEDHE GGLLALEPMP TFGKGLDLRR 

      1210       1220       1230       1240       1250       1260 
AAEEAFEVKD VLNSTLDSEA LKHTLCRQAK NQAYAMMLSL SEDTPLHTPS QGSLDAWLKV 

      1270 
TGATSESGAF HPINHL 

« Hide

Isoform 2 (MEL1L).

Checksum: 1CB045F5BBFE9D20
Show »

FASTA1,257138,177
Isoform 3.

Checksum: A5A073C5C5F26306
Show »

FASTA1,276140,263
Isoform 4 (MEL1S).

Checksum: 7A24088D0A73B54F
Show »

FASTA1,092120,338

References

« Hide 'large scale' references
[1]"A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells."
Mochizuki N., Shimizu S., Nagasawa T., Tanaka H., Taniwaki M., Yokota J., Morishita K.
Blood 96:3209-3214(2000) [PubMed: 11050005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-533, CHROMOSOMAL TRANSLOCATION, DISEASE, TISSUE SPECIFICITY.
[2]"A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
Fang W., Yang X.-H., Huang S.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-533.
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-533.
[7]"A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation."
Nishikata I., Sasaki H., Iga M., Tateno Y., Imayoshi S., Asou N., Nakamura T., Morishita K.
Blood 102:3323-3332(2003) [PubMed: 12816872] [Abstract]
Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4), TISSUE SPECIFICITY.
Tissue: Placenta.
[8]"Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1."
Xinh P.T., Tri N.K., Nagao H., Nakazato H., Taketazu F., Fujisawa S., Yagasaki F., Chen Y.Z., Hayashi Y., Toyoda A., Hattori M., Sakaki Y., Tokunaga K., Sato Y.
Genes Chromosomes Cancer 36:313-316(2003) [PubMed: 12557231] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION, DISEASE.
[9]"Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells."
Yoshida M., Nosaka K., Yasunaga J., Nishikata I., Morishita K., Matsuoka M.
Blood 103:2753-2760(2004) [PubMed: 14656887] [Abstract]
Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORM 4), DISEASE.
[10]"SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells."
Takahata M., Inoue Y., Tsuda H., Imoto I., Koinuma D., Hayashi M., Ichikura T., Yamori T., Nagasaki K., Yoshida M., Matsuoka M., Morishita K., Yuki K., Hanyu A., Miyazawa K., Inazawa J., Miyazono K., Imamura T.
J. Biol. Chem. 284:3334-3344(2009) [PubMed: 19049980] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HDAC1; SKI; SMAD2 AND SMAD3.
+Additional computationally mapped references.

Cross-references

Sequence databases

AB078876 mRNA. Translation: BAB84297.1.
AF294278 mRNA. Translation: AAG33382.1.
AB051462 mRNA. Translation: BAB21766.2. Different initiation.
AL512383 expand/collapse EMBL AC list , AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71132.1.
AL512383 expand/collapse EMBL AC list , AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71133.1.
AL512383 expand/collapse EMBL AC list , AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71134.1.
AL590438 expand/collapse EMBL AC list , AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71529.1.
AL590438 expand/collapse EMBL AC list , AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71530.1.
AL590438 expand/collapse EMBL AC list , AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71531.1.
AL008733 expand/collapse EMBL AC list , AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19629.1.
AL008733 expand/collapse EMBL AC list , AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19630.1.
AL008733 expand/collapse EMBL AC list , AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19631.1.
AL354743 expand/collapse EMBL AC list , AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22788.1.
AL354743 expand/collapse EMBL AC list , AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22789.1.
AL354743 expand/collapse EMBL AC list , AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22790.1.
BC161614 mRNA. Translation: AAI61614.1.
IPIIPI00289654.
IPI00642532.
IPI00914925.
IPI00940111.
RefSeqNP_071397.2.
NP_955533.1.
UniGeneHs.99500

3D structure databases

HSSPHSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9HAZ2.

Proteomic databases

PRIDEQ9HAZ2.

Genome annotation databases

EnsemblENST00000270722; ENSP00000270722; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000378389; ENSP00000367640; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000378391; ENSP00000367643; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000378398; ENSP00000367651; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000408992; ENSP00000386140; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000441472; ENSP00000407968; ENSG00000142611; Homo sapiens. [Genome view]
ENST00000442529; ENSP00000405253; ENSG00000142611; Homo sapiens. [Genome view]
GeneID63976.
KEGGhsa:63976.
UCSCuc001akc.1. human.
uc001akd.1. human.
uc001ake.1. human.
uc001akf.1. human.

Organism-specific databases

CTD63976.
GeneCardsGC01P003008.
HGNCHGNC:14000. PRDM16.
MIM605557. gene.
PharmGKBPA33714.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9HAZ2.

Gene expression databases

ArrayExpressQ9HAZ2.
BgeeQ9HAZ2.
CleanExHS_PRDM16.
GenevestigatorQ9HAZ2.
GermOnlineENSG00000142611. Homo sapiens.

Family and domain databases

InterProIPR001214. SET.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
PfamPF00096. zf-C2H2. 10 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 4 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio65776.
SOURCESearch...

Entry information

Entry namePRD16_HUMAN
AccessionPrimary (citable) accession number: Q9HAZ2
Secondary accession number(s): A6NHQ8 expand/collapse secondary AC list , B1AJP7, B1AJP8, B1AJP9, B1WB48, Q8WYJ9, Q9C0I8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: September 22, 2009
Last modified: November 3, 2009
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents