Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PR domain zinc finger protein 16

Gene

PRDM16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 253C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri281 – 303C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri951 – 973C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri979 – 1002C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1008 – 1032C2H2-type 10PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142611-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.
SIGNORiQ9HAZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 16Curated
Alternative name(s):
PR domain-containing protein 16Curated
Transcription factor MEL1Curated
Short name:
MDS1/EVI1-like gene 11 Publication
Gene namesi
Name:PRDM16Imported
Synonyms:KIAA1675Imported, MEL11 Publication, PFM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14000. PRDM16.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • nucleus Source: UniProtKB
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Left ventricular non-compaction 8 (LVNC8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies.
See also OMIM:615373
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070214816N → S in LVNC8. 1 PublicationCorresponds to variant rs397514743dbSNPEnsembl.1
Cardiomyopathy, dilated 1LL (CMD1LL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:615373
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070212271E → K in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs200052869dbSNPEnsembl.1
Natural variantiVAR_070213291P → L in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs397514744dbSNPEnsembl.1
Natural variantiVAR_070215887L → P in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs202115331dbSNPEnsembl.1

A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia.

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi63976.
MalaCardsiPRDM16.
MIMi615373. phenotype.
OpenTargetsiENSG00000142611.
Orphaneti1606. 1p36 deletion syndrome.
154. Familial isolated dilated cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA33714.

Polymorphism and mutation databases

BioMutaiPRDM16.
DMDMi259016328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477731 – 1276PR domain zinc finger protein 16Add BLAST1276

Proteomic databases

MaxQBiQ9HAZ2.
PaxDbiQ9HAZ2.
PeptideAtlasiQ9HAZ2.
PRIDEiQ9HAZ2.

PTM databases

iPTMnetiQ9HAZ2.
PhosphoSitePlusiQ9HAZ2.

Expressioni

Tissue specificityi

Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.3 Publications

Gene expression databases

BgeeiENSG00000142611.
CleanExiHS_PRDM16.
ExpressionAtlasiQ9HAZ2. baseline and differential.
GenevisibleiQ9HAZ2. HS.

Organism-specific databases

HPAiCAB008670.

Interactioni

Subunit structurei

Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct. Interacts with PPARG and PPARA; controls brown adipocytes differentiation. Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes. Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific gene (By similarity). Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (PubMed:19049980). Interacts with ZNF516; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific gene (PubMed:25578880).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctbp2P565462EBI-4566658,EBI-1384883From a different organism.

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122023. 7 interactors.
IntActiQ9HAZ2. 2 interactors.
STRINGi9606.ENSP00000270722.

Structurei

Secondary structure

11276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi84 – 91Combined sources8
Turni92 – 94Combined sources3
Beta strandi95 – 102Combined sources8
Beta strandi126 – 129Combined sources4
Turni140 – 142Combined sources3
Turni153 – 155Combined sources3
Beta strandi161 – 163Combined sources3
Helixi167 – 170Combined sources4
Helixi178 – 180Combined sources3
Beta strandi183 – 188Combined sources6
Beta strandi191 – 198Combined sources8
Beta strandi212 – 215Combined sources4
Helixi216 – 219Combined sources4
Turni222 – 225Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N1INMR-A54-226[»]
ProteinModelPortaliQ9HAZ2.
SMRiQ9HAZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 211SETPROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni679 – 1038Interaction with CTBP1, CTBP2 and ZNF516By similarityAdd BLAST360
Regioni739 – 1276Mediates interaction with SKI and regulation of TGF-beta signaling1 PublicationAdd BLAST538

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi459 – 557Pro-richAdd BLAST99

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 253C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri281 – 303C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri951 – 973C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri979 – 1002C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1008 – 1032C2H2-type 10PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063676.
HOVERGENiHBG005619.
InParanoidiQ9HAZ2.
OMAiMMDKSKP.
OrthoDBiEOG091G0BYE.
PhylomeDBiQ9HAZ2.
TreeFamiTF315309.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSKARARKL AKSDGDVVNN MYEPNRDLLA SHSAEDEAED SAMSPIPVGP
60 70 80 90 100
PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PADFELRESS IPGAGLGVWA
110 120 130 140 150
KRKMEAGERL GPCVVVPRAA AKETDFGWEQ ILTDVEVSPQ EGCITKISED
160 170 180 190 200
LGSEKFCVDA NQAGAGSWLK YIRVACSCDD QNLTMCQISE QIYYKVIKDI
210 220 230 240 250
EPGEELLVHV KEGVYPLGTV PPGLDEEPTF RCDECDELFQ SKLDLRRHKK
260 270 280 290 300
YTCGSVGAAL YEGLAEELKP EGLGGGSGQA HECKDCERMF PNKYSLEQHM
310 320 330 340 350
VIHTEEREYK CDQCPKAFNW KSNLIRHQMS HDSGKRFECE NCVKVFTDPS
360 370 380 390 400
NLQRHIRSQH VGARAHACPD CGKTFATSSG LKQHKHIHST VKPFICEVCH
410 420 430 440 450
KSYTQFSNLC RHKRMHADCR TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH
460 470 480 490 500
YTPGGIFAPG LPLTPSPMMD KAKPSPSLNH ASLGFNEYFP SRPHPGSLPF
510 520 530 540 550
STAPPTFPAL TPGFPGIFPP SLYPRPPLLP PTSLLKSPLN HTQDAKLPSP
560 570 580 590 600
LGNPALPLVS AVSNSSQGTT AAAGPEEKFE SRLEDSCVEK LKTRSSDMSD
610 620 630 640 650
GSDFEDVNTT TGTDLDTTTG TGSDLDSDVD SDPDKDKGKG KSAEGQPKFG
660 670 680 690 700
GGLAPPGAPN SVAEVPVFYS QHSFFPPPDE QLLTATGAAG DSIKAIASIA
710 720 730 740 750
EKYFGPGFMG MQEKKLGSLP YHSAFPFQFL PNFPHSLYPF TDRALAHNLL
760 770 780 790 800
VKAEPKSPRD ALKVGGPSAE CPFDLTTKPK DVKPILPMPK GPSAPASGEE
810 820 830 840 850
QPLDLSIGSR ARASQNGGGR EPRKNHVYGE RKLGAGEGLP QVCPARMPQQ
860 870 880 890 900
PPLHYAKPSP FFMDPIYSRV EKRKVTDPVG ALKEKYLRPS PLLFHPQMSA
910 920 930 940 950
IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER
960 970 980 990 1000
YTCRYCGKIF PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN
1010 1020 1030 1040 1050
IHNKEKPFKC HLCNRCFGQQ TNLDRHLKKH EHENAPVSQH PGVLTNHLGT
1060 1070 1080 1090 1100
SASSPTSESD NHALLDEKED SYFSEIRNFI ANSEMNQAST RTEKRADMQI
1110 1120 1130 1140 1150
VDGSAQCPGL ASEKQEDVEE EDDDDLEEDD EDSLAGKSQD DTVSPAPEPQ
1160 1170 1180 1190 1200
AAYEDEEDEE PAASLAVGFD HTRRCAEDHE GGLLALEPMP TFGKGLDLRR
1210 1220 1230 1240 1250
AAEEAFEVKD VLNSTLDSEA LKHTLCRQAK NQAYAMMLSL SEDTPLHTPS
1260 1270
QGSLDAWLKV TGATSESGAF HPINHL
Length:1,276
Mass (Da):140,251
Last modified:September 22, 2009 - v3
Checksum:iAD16C5C0EE89A528
GO
Isoform 2 (identifier: Q9HAZ2-2) [UniParc]FASTAAdd to basket
Also known as: MEL1L

The sequence of this isoform differs from the canonical sequence as follows:
     1233-1251: Missing.

Note: No experimental confirmation available.
Show »
Length:1,257
Mass (Da):138,177
Checksum:i1CB045F5BBFE9D20
GO
Isoform 3 (identifier: Q9HAZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-191: Q → QV
     868-868: Missing.

Note: No experimental confirmation available.
Show »
Length:1,276
Mass (Da):140,263
Checksum:iA5A073C5C5F26306
GO
Isoform 4 (identifier: Q9HAZ2-4) [UniParc]FASTAAdd to basket
Also known as: MEL1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,092
Mass (Da):120,338
Checksum:i7A24088D0A73B54F
GO

Sequence cautioni

The sequence BAB21766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50 – 52PPS → SPP in AAG33382 (Ref. 2) Curated3
Sequence conflicti324L → F in AAG33382 (Ref. 2) Curated1
Sequence conflicti491S → Y in AAG33382 (Ref. 2) Curated1
Sequence conflicti1022N → K in BAB84297 (PubMed:11050005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070212271E → K in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs200052869dbSNPEnsembl.1
Natural variantiVAR_070213291P → L in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs397514744dbSNPEnsembl.1
Natural variantiVAR_031433533S → P.3 PublicationsCorresponds to variant rs870124dbSNPEnsembl.1
Natural variantiVAR_031434633P → L.Corresponds to variant rs2493292dbSNPEnsembl.1
Natural variantiVAR_070214816N → S in LVNC8. 1 PublicationCorresponds to variant rs397514743dbSNPEnsembl.1
Natural variantiVAR_070215887L → P in CMD1LL; unknown pathological significance. 1 PublicationCorresponds to variant rs202115331dbSNPEnsembl.1
Natural variantiVAR_0702161101V → M.1 PublicationCorresponds to variant rs201654872dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380631 – 184Missing in isoform 4. CuratedAdd BLAST184
Alternative sequenceiVSP_038064191Q → QV in isoform 3. 1 Publication1
Alternative sequenceiVSP_038065868Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_0069321233 – 1251Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078876 mRNA. Translation: BAB84297.1.
AF294278 mRNA. Translation: AAG33382.1.
AB051462 mRNA. Translation: BAB21766.2. Different initiation.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71132.1.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71133.1.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71134.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71529.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71530.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71531.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19629.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19630.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19631.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22788.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22789.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22790.1.
BC161614 mRNA. Translation: AAI61614.1.
CCDSiCCDS41236.2. [Q9HAZ2-1]
CCDS44048.2. [Q9HAZ2-2]
RefSeqiNP_071397.3. NM_022114.3. [Q9HAZ2-1]
NP_955533.2. NM_199454.2. [Q9HAZ2-2]
XP_011540247.1. XM_011541945.2. [Q9HAZ2-4]
UniGeneiHs.99500.

Genome annotation databases

EnsembliENST00000270722; ENSP00000270722; ENSG00000142611. [Q9HAZ2-1]
ENST00000378391; ENSP00000367643; ENSG00000142611. [Q9HAZ2-2]
GeneIDi63976.
KEGGihsa:63976.
UCSCiuc001ake.4. human. [Q9HAZ2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078876 mRNA. Translation: BAB84297.1.
AF294278 mRNA. Translation: AAG33382.1.
AB051462 mRNA. Translation: BAB21766.2. Different initiation.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71132.1.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71133.1.
AL512383
, AL008733, AL354743, AL590438 Genomic DNA. Translation: CAH71134.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71529.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71530.1.
AL590438
, AL008733, AL354743, AL512383 Genomic DNA. Translation: CAH71531.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19629.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19630.1.
AL008733
, AL354743, AL512383, AL590438 Genomic DNA. Translation: CAI19631.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22788.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22789.1.
AL354743
, AL008733, AL512383, AL590438 Genomic DNA. Translation: CAI22790.1.
BC161614 mRNA. Translation: AAI61614.1.
CCDSiCCDS41236.2. [Q9HAZ2-1]
CCDS44048.2. [Q9HAZ2-2]
RefSeqiNP_071397.3. NM_022114.3. [Q9HAZ2-1]
NP_955533.2. NM_199454.2. [Q9HAZ2-2]
XP_011540247.1. XM_011541945.2. [Q9HAZ2-4]
UniGeneiHs.99500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N1INMR-A54-226[»]
ProteinModelPortaliQ9HAZ2.
SMRiQ9HAZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122023. 7 interactors.
IntActiQ9HAZ2. 2 interactors.
STRINGi9606.ENSP00000270722.

PTM databases

iPTMnetiQ9HAZ2.
PhosphoSitePlusiQ9HAZ2.

Polymorphism and mutation databases

BioMutaiPRDM16.
DMDMi259016328.

Proteomic databases

MaxQBiQ9HAZ2.
PaxDbiQ9HAZ2.
PeptideAtlasiQ9HAZ2.
PRIDEiQ9HAZ2.

Protocols and materials databases

DNASUi63976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270722; ENSP00000270722; ENSG00000142611. [Q9HAZ2-1]
ENST00000378391; ENSP00000367643; ENSG00000142611. [Q9HAZ2-2]
GeneIDi63976.
KEGGihsa:63976.
UCSCiuc001ake.4. human. [Q9HAZ2-1]

Organism-specific databases

CTDi63976.
DisGeNETi63976.
GeneCardsiPRDM16.
HGNCiHGNC:14000. PRDM16.
HPAiCAB008670.
MalaCardsiPRDM16.
MIMi605557. gene.
615373. phenotype.
neXtProtiNX_Q9HAZ2.
OpenTargetsiENSG00000142611.
Orphaneti1606. 1p36 deletion syndrome.
154. Familial isolated dilated cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA33714.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063676.
HOVERGENiHBG005619.
InParanoidiQ9HAZ2.
OMAiMMDKSKP.
OrthoDBiEOG091G0BYE.
PhylomeDBiQ9HAZ2.
TreeFamiTF315309.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142611-MONOMER.
ReactomeiR-HSA-3214841. PKMTs methylate histone lysines.
SIGNORiQ9HAZ2.

Miscellaneous databases

ChiTaRSiPRDM16. human.
GeneWikiiPRDM16.
GenomeRNAii63976.
PROiQ9HAZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142611.
CleanExiHS_PRDM16.
ExpressionAtlasiQ9HAZ2. baseline and differential.
GenevisibleiQ9HAZ2. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR030413. Evi1/Prdm16.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24393. PTHR24393. 1 hit.
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRD16_HUMAN
AccessioniPrimary (citable) accession number: Q9HAZ2
Secondary accession number(s): A6NHQ8
, B1AJP7, B1AJP8, B1AJP9, B1WB48, Q8WYJ9, Q9C0I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.