Q9HAY2 (MAGF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen F1

Alternative name(s):
MAGE-F1 antigen

Gene names

Name:

MAGEF1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitous.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Melanoma-associated antigen F1		PRO_0000156732
Regions
	Domain	76 – 277	202	MAGE
Natural variations
	Natural variant	93	1	K → R. Corresponds to variant rs34540780 [ dbSNP | Ensembl ].		VAR_057651
Experimental info
	Sequence conflict	66	1	A → S in AAG30208. Ref.1
	Sequence conflict	66	1	A → S in AAG38606. Ref.2
	Sequence conflict	66	1	A → S in AAH10056. Ref.3
	Sequence conflict	158	1	E → EE in AAG30208. Ref.1
	Sequence conflict	158	1	E → EE in AAG38606. Ref.2
	Sequence conflict	158	1	E → EE in AAH10056. Ref.3
	Sequence conflict	236	1	E → A in AAG30208. Ref.1
	Sequence conflict	236	1	E → A in AAG38606. Ref.2
	Sequence conflict	236	1	E → A in AAH10056. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9HAY2 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: 8CB673B3FF7921EE	FASTA	307	35,222
	10 20 30 40 50 60 MLQTPESRGL PVPQAEGEKD GGHDGETRAP TASQERPKEE LGAGREEGAA EPALTRKGAR 70 80 90 100 110 120 ALAAKALARR RAYRRLNRTV AELVQFLLVK DKKKSPITRS EMVKYVIGDL KILFPDIIAR 130 140 150 160 170 180 AAEHLRYVFG FELKQFDRKH HTYILINKLK PLEEEEEEDL GGDGPRLGLL MMILGLIYMR 190 200 210 220 230 240 GNSAREAQVW EMLRRLGVQP SKYHFLFGYP KRLIMEDFVQ QRYLSYRRVP HTNPPEYEFS 250 260 270 280 290 300 WGPRSNLEIS KMEVLGFVAK LHKKEPQHWP VQYREALADE ADRARAKARA EASMRARASA RAGIHLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily." Stone B., Schummer M., Paley P.J., Crawford M., Ford M., Urban N., Nelson B.H. Gene 267:173-182(2001) [PubMed: 11313144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"An overview of the MAGE gene family with the identification of all human members of the family." Chomez P., De Backer O., Bertrand M., De Plaen E., Boon T., Lucas S. Cancer Res. 61:5544-5551(2001) [PubMed: 11454705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-283. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF295378 mRNA. Translation: AAG30208.1. AC107294 Genomic DNA. No translation available. BC010056 mRNA. Translation: AAH10056.1. AF320910 mRNA. Translation: AAG38606.1.
IPI	IPI00005529.
RefSeq	NP_071432.2. NM_022149.4.
UniGene	Hs.306123.
3D structure databases
ProteinModelPortal	Q9HAY2.
SMR	Q9HAY2. Positions 70-285.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HAY2.
PTM databases
PhosphoSite	Q9HAY2.
Polymorphism databases
DMDM	300669649.
Proteomic databases
PRIDE	Q9HAY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317897; ENSP00000315064; ENSG00000177383.
GeneID	64110.
KEGG	hsa:64110.
UCSC	uc003fpa.1. human.
Organism-specific databases
CTD	64110.
GeneCards	GC03M184428.
H-InvDB	HIX0003923.
HGNC	HGNC:29639. MAGEF1.
MIM	609267. gene.
neXtProt	NX_Q9HAY2.
PharmGKB	PA134920978.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13102.
GeneTree	ENSGT00560000076930.
HOGENOM	HBG507249.
HOVERGEN	HBG006315.
InParanoid	Q9HAY2.
OMA	GYPKRLI.
OrthoDB	EOG44J2JT.
PhylomeDB	Q9HAY2.
Gene expression databases
ArrayExpress	Q9HAY2.
Bgee	Q9HAY2.
CleanEx	HS_MAGEF1.
Genevestigator	Q9HAY2.
GermOnline	ENSG00000177383. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	65968.
SOURCE	Search...

Entry information

Entry name

MAGF1_HUMAN

Accession

Primary (citable) accession number: Q9HAY2
Secondary accession number(s): Q9H215

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	July 13, 2010
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.