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Protein

Melanoma-associated antigen F1

Gene

MAGEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen F1
Alternative name(s):
MAGE-F1 antigen
Gene namesi
Name:MAGEF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29639. MAGEF1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177383.
PharmGKBiPA134920978.

Polymorphism and mutation databases

BioMutaiMAGEF1.
DMDMi300669649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567321 – 307Melanoma-associated antigen F1Add BLAST307

Proteomic databases

EPDiQ9HAY2.
PaxDbiQ9HAY2.
PeptideAtlasiQ9HAY2.
PRIDEiQ9HAY2.

PTM databases

iPTMnetiQ9HAY2.
PhosphoSitePlusiQ9HAY2.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000177383.
CleanExiHS_MAGEF1.
GenevisibleiQ9HAY2. HS.

Organism-specific databases

HPAiHPA046899.
HPA054190.

Interactioni

Subunit structurei

Interacts with LNX1, TRIM27 and NSMCE1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-5525855,EBI-724076

Protein-protein interaction databases

BioGridi122067. 11 interactors.
IntActiQ9HAY2. 6 interactors.
STRINGi9606.ENSP00000315064.

Structurei

3D structure databases

ProteinModelPortaliQ9HAY2.
SMRiQ9HAY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 277MAGEPROSITE-ProRule annotationAdd BLAST202

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ9HAY2.
OMAiGYPKRLI.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ9HAY2.
TreeFamiTF328505.

Family and domain databases

InterProiView protein in InterPro
IPR002190. MHD_dom.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HAY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTPESRGL PVPQAEGEKD GGHDGETRAP TASQERPKEE LGAGREEGAA
60 70 80 90 100
EPALTRKGAR ALAAKALARR RAYRRLNRTV AELVQFLLVK DKKKSPITRS
110 120 130 140 150
EMVKYVIGDL KILFPDIIAR AAEHLRYVFG FELKQFDRKH HTYILINKLK
160 170 180 190 200
PLEEEEEEDL GGDGPRLGLL MMILGLIYMR GNSAREAQVW EMLRRLGVQP
210 220 230 240 250
SKYHFLFGYP KRLIMEDFVQ QRYLSYRRVP HTNPPEYEFS WGPRSNLEIS
260 270 280 290 300
KMEVLGFVAK LHKKEPQHWP VQYREALADE ADRARAKARA EASMRARASA

RAGIHLW
Length:307
Mass (Da):35,222
Last modified:July 13, 2010 - v2
Checksum:i8CB673B3FF7921EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66A → S in AAG30208 (PubMed:11313144).Curated1
Sequence conflicti66A → S in AAG38606 (PubMed:16641997).Curated1
Sequence conflicti66A → S in AAH10056 (PubMed:15489334).Curated1
Sequence conflicti158E → EE in AAG30208 (PubMed:11313144).Curated1
Sequence conflicti158E → EE in AAG38606 (PubMed:16641997).Curated1
Sequence conflicti158E → EE in AAH10056 (PubMed:15489334).Curated1
Sequence conflicti236E → A in AAG30208 (PubMed:11313144).Curated1
Sequence conflicti236E → A in AAG38606 (PubMed:16641997).Curated1
Sequence conflicti236E → A in AAH10056 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05765193K → R. Corresponds to variant dbSNP:rs34540780Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295378 mRNA. Translation: AAG30208.1.
AC107294 Genomic DNA. No translation available.
BC010056 mRNA. Translation: AAH10056.1.
AF320910 mRNA. Translation: AAG38606.1.
CCDSiCCDS3269.1.
RefSeqiNP_071432.2. NM_022149.4.
UniGeneiHs.306123.

Genome annotation databases

EnsembliENST00000317897; ENSP00000315064; ENSG00000177383.
GeneIDi64110.
KEGGihsa:64110.
UCSCiuc003fpa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMAGF1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAY2
Secondary accession number(s): Q9H215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 13, 2010
Last modified: March 15, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot