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Protein

UDP-glucuronosyltransferase 1-10

Gene

UGT1A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glucuronosyltransferase activity Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase C binding Source: BHF-UCL

GO - Biological processi

  • cellular glucuronidation Source: BHF-UCL
  • flavone metabolic process Source: BHF-UCL
  • flavonoid glucuronidation Source: GO_Central
  • negative regulation of cellular glucuronidation Source: BHF-UCL
  • negative regulation of fatty acid metabolic process Source: BHF-UCL
  • negative regulation of glucuronosyltransferase activity Source: BHF-UCL
  • xenobiotic glucuronidation Source: GO_Central

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
SABIO-RKiQ9HAW8
SIGNORiQ9HAW8

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001694

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-10 (EC:2.4.1.17)
Short name:
UDPGT 1-10
Short name:
UGT1*10
Short name:
UGT1-10
Short name:
UGT1.10
Alternative name(s):
UDP-glucuronosyltransferase 1-J
Short name:
UGT-1J
Short name:
UGT1J
UDP-glucuronosyltransferase 1A10
Gene namesi
Name:UGT1A10
Synonyms:GNT1, UGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000242515.5
HGNCiHGNC:12531 UGT1A10
MIMi191740 gene
606435 gene
neXtProtiNX_Q9HAW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54575
OpenTargetsiENSG00000242515
PharmGKBiPA37174

Chemistry databases

ChEMBLiCHEMBL1743320
DrugBankiDB00316 Acetaminophen
DB00749 Etodolac
DB00678 Losartan
DB00688 Mycophenolate mofetil
DB00197 Troglitazone
DB00313 Valproic Acid

Polymorphism and mutation databases

BioMutaiUGT1A10
DMDMi29839636

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003600926 – 530UDP-glucuronosyltransferase 1-10Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HAW8
PaxDbiQ9HAW8
PeptideAtlasiQ9HAW8
PRIDEiQ9HAW8

PTM databases

iPTMnetiQ9HAW8
PhosphoSitePlusiQ9HAW8

Expressioni

Tissue specificityi

Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212).2 Publications

Gene expression databases

BgeeiENSG00000242515
ExpressionAtlasiQ9HAW8 baseline and differential
GenevisibleiQ9HAW8 HS

Interactioni

Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120053, 21 interactors
IntActiQ9HAW8, 7 interactors
STRINGi9606.ENSP00000343838

Chemistry databases

BindingDBiQ9HAW8

Structurei

3D structure databases

ProteinModelPortaliQ9HAW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiQ9HAW8
KOiK00699
OMAiFSDQPGN
OrthoDBiEOG091G03YY
PhylomeDBiQ9HAW8
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAW8-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA
110 120 130 140 150
QAQSIFSLLM SSSSGFLDLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG AQCPAPLSYV PNDLLGFSDA
210 220 230 240 250
MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT AYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,810
Last modified:March 1, 2001 - v1
Checksum:i73774EEEC7FE37BA
GO
Isoform 2 (identifier: Q9HAW8-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A10s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,586
Checksum:i06D89D99B1C0300E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 23MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC (PubMed:9271343).CuratedAdd BLAST23
Sequence conflicti40T → A in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti175H → R in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti224F → L in AAB81537 (PubMed:9271343).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01835459M → I1 PublicationCorresponds to variant dbSNP:rs56935833Ensembl.1
Natural variantiVAR_052464139E → K. Corresponds to variant dbSNP:rs10187694Ensembl.1
Natural variantiVAR_018355202T → I1 PublicationCorresponds to variant dbSNP:rs58704432Ensembl.1
Natural variantiVAR_052465244L → I. Corresponds to variant dbSNP:rs28969685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053966432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89508 mRNA Translation: AAB81537.1
AF297093 Genomic DNA Translation: AAG30417.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC020971 mRNA Translation: AAH20971.1
BC053576 mRNA Translation: AAH53576.1
BC069210 mRNA Translation: AAH69210.2
CCDSiCCDS33403.1 [Q9HAW8-1]
PIRiJC5656
RefSeqiNP_061948.1, NM_019075.2 [Q9HAW8-1]
UniGeneiHs.554822

Genome annotation databases

EnsembliENST00000344644; ENSP00000343838; ENSG00000242515 [Q9HAW8-1]
ENST00000373445; ENSP00000362544; ENSG00000242515 [Q9HAW8-2]
GeneIDi54575
KEGGihsa:54575
UCSCiuc002vuq.4 human [Q9HAW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUD110_HUMAN
AccessioniPrimary (citable) accession number: Q9HAW8
Secondary accession number(s): O00474, Q6NT91, Q7Z6H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health