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Protein

UDP-glucuronosyltransferase 1-10

Gene

UGT1A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glucuronosyltransferase activity Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase C binding Source: BHF-UCL

GO - Biological processi

  • cellular glucuronidation Source: BHF-UCL
  • flavone metabolic process Source: BHF-UCL
  • flavonoid biosynthetic process Source: GO_Central
  • flavonoid glucuronidation Source: GO_Central
  • negative regulation of cellular glucuronidation Source: BHF-UCL
  • negative regulation of fatty acid metabolic process Source: BHF-UCL
  • negative regulation of glucuronosyltransferase activity Source: BHF-UCL
  • xenobiotic glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
SABIO-RKQ9HAW8.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-10 (EC:2.4.1.17)
Short name:
UDPGT 1-10
Short name:
UGT1*10
Short name:
UGT1-10
Short name:
UGT1.10
Alternative name(s):
UDP-glucuronosyltransferase 1-J
Short name:
UGT-1J
Short name:
UGT1J
UDP-glucuronosyltransferase 1A10
Gene namesi
Name:UGT1A10
Synonyms:GNT1, UGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12531. UGT1A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54575.
OpenTargetsiENSG00000242515.
PharmGKBiPA37174.

Chemistry databases

ChEMBLiCHEMBL1743320.
DrugBankiDB00316. Acetaminophen.
DB00749. Etodolac.
DB00678. Losartan.
DB00688. Mycophenolate mofetil.
DB00313. Valproic Acid.

Polymorphism and mutation databases

BioMutaiUGT1A10.
DMDMi29839636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003600926 – 530UDP-glucuronosyltransferase 1-10Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9HAW8.
PaxDbiQ9HAW8.
PeptideAtlasiQ9HAW8.
PRIDEiQ9HAW8.

PTM databases

iPTMnetiQ9HAW8.
PhosphoSitePlusiQ9HAW8.

Expressioni

Tissue specificityi

Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212).2 Publications

Gene expression databases

BgeeiENSG00000242515.
ExpressionAtlasiQ9HAW8. baseline and differential.
GenevisibleiQ9HAW8. HS.

Interactioni

Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120053. 20 interactors.
IntActiQ9HAW8. 7 interactors.
STRINGi9606.ENSP00000343838.

Chemistry databases

BindingDBiQ9HAW8.

Structurei

3D structure databases

ProteinModelPortaliQ9HAW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ9HAW8.
KOiK00699.
OMAiCHYLEDA.
OrthoDBiEOG091G03YY.
PhylomeDBiQ9HAW8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAW8-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA
110 120 130 140 150
QAQSIFSLLM SSSSGFLDLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG AQCPAPLSYV PNDLLGFSDA
210 220 230 240 250
MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT AYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,810
Last modified:March 1, 2001 - v1
Checksum:i73774EEEC7FE37BA
GO
Isoform 2 (identifier: Q9HAW8-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A10s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,586
Checksum:i06D89D99B1C0300E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 23MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC (PubMed:9271343).CuratedAdd BLAST23
Sequence conflicti40T → A in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti175H → R in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti224F → L in AAB81537 (PubMed:9271343).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01835459M → I.1 PublicationCorresponds to variant rs56935833dbSNPEnsembl.1
Natural variantiVAR_052464139E → K.Corresponds to variant rs10187694dbSNPEnsembl.1
Natural variantiVAR_018355202T → I.1 PublicationCorresponds to variant rs58704432dbSNPEnsembl.1
Natural variantiVAR_052465244L → I.Corresponds to variant rs28969685dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053966432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89508 mRNA. Translation: AAB81537.1.
AF297093 Genomic DNA. Translation: AAG30417.1.
AC006985 Genomic DNA. No translation available.
AC019072 Genomic DNA. No translation available.
BC020971 mRNA. Translation: AAH20971.1.
BC053576 mRNA. Translation: AAH53576.1.
BC069210 mRNA. Translation: AAH69210.2.
CCDSiCCDS33403.1. [Q9HAW8-1]
PIRiJC5656.
RefSeqiNP_061948.1. NM_019075.2. [Q9HAW8-1]
UniGeneiHs.554822.

Genome annotation databases

EnsembliENST00000344644; ENSP00000343838; ENSG00000242515. [Q9HAW8-1]
ENST00000373445; ENSP00000362544; ENSG00000242515. [Q9HAW8-2]
GeneIDi54575.
KEGGihsa:54575.
UCSCiuc002vuq.4. human. [Q9HAW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89508 mRNA. Translation: AAB81537.1.
AF297093 Genomic DNA. Translation: AAG30417.1.
AC006985 Genomic DNA. No translation available.
AC019072 Genomic DNA. No translation available.
BC020971 mRNA. Translation: AAH20971.1.
BC053576 mRNA. Translation: AAH53576.1.
BC069210 mRNA. Translation: AAH69210.2.
CCDSiCCDS33403.1. [Q9HAW8-1]
PIRiJC5656.
RefSeqiNP_061948.1. NM_019075.2. [Q9HAW8-1]
UniGeneiHs.554822.

3D structure databases

ProteinModelPortaliQ9HAW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120053. 20 interactors.
IntActiQ9HAW8. 7 interactors.
STRINGi9606.ENSP00000343838.

Chemistry databases

BindingDBiQ9HAW8.
ChEMBLiCHEMBL1743320.
DrugBankiDB00316. Acetaminophen.
DB00749. Etodolac.
DB00678. Losartan.
DB00688. Mycophenolate mofetil.
DB00313. Valproic Acid.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ9HAW8.
PhosphoSitePlusiQ9HAW8.

Polymorphism and mutation databases

BioMutaiUGT1A10.
DMDMi29839636.

Proteomic databases

MaxQBiQ9HAW8.
PaxDbiQ9HAW8.
PeptideAtlasiQ9HAW8.
PRIDEiQ9HAW8.

Protocols and materials databases

DNASUi54575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344644; ENSP00000343838; ENSG00000242515. [Q9HAW8-1]
ENST00000373445; ENSP00000362544; ENSG00000242515. [Q9HAW8-2]
GeneIDi54575.
KEGGihsa:54575.
UCSCiuc002vuq.4. human. [Q9HAW8-1]

Organism-specific databases

CTDi54575.
DisGeNETi54575.
GeneCardsiUGT1A10.
HGNCiHGNC:12531. UGT1A10.
MIMi191740. gene.
606435. gene.
neXtProtiNX_Q9HAW8.
OpenTargetsiENSG00000242515.
PharmGKBiPA37174.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ9HAW8.
KOiK00699.
OMAiCHYLEDA.
OrthoDBiEOG091G03YY.
PhylomeDBiQ9HAW8.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
SABIO-RKQ9HAW8.

Miscellaneous databases

GeneWikiiUGT1A10.
GenomeRNAii54575.
PROiQ9HAW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242515.
ExpressionAtlasiQ9HAW8. baseline and differential.
GenevisibleiQ9HAW8. HS.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD110_HUMAN
AccessioniPrimary (citable) accession number: Q9HAW8
Secondary accession number(s): O00474, Q6NT91, Q7Z6H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.