Q9HAW8 (UD110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 1-10
Short name=UDPGT 1-10
Short name=UGT1*10
Short name=UGT1-10
Short name=UGT1.10
EC=2.4.1.17

Alternative name(s):
UDP-glucuronosyltransferase 1-J
Short name=UGT-1J
Short name=UGT1J
UDP-glucuronosyltransferase 1A10

Gene names

Name:	UGT1A10
Synonyms:	GNT1, UGT1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Liver and colon. Ref.1
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular glucuronidation Inferred from direct assay. Source: BHF-UCL flavone metabolic process Inferred from direct assay. Source: BHF-UCL
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from direct assay. Source: BHF-UCL protein heterodimerization activity Inferred from physical interaction. Source: BHF-UCL protein homodimerization activity Inferred from physical interaction. Source: BHF-UCL protein kinase C binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q9HAW8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 530	505	UDP-glucuronosyltransferase 1-10		PRO_0000036009
Regions
	Transmembrane	488 – 504	17	Helical; Potential
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	292	1	N-linked (GlcNAc...) Potential
	Glycosylation	344	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	59	1	M → I. Ref.4 Corresponds to variant rs56935833 [ dbSNP | Ensembl ].		VAR_018354
	Natural variant	139	1	E → K. Corresponds to variant rs10187694 [ dbSNP | Ensembl ].		VAR_052464
	Natural variant	202	1	T → I. Ref.4 Corresponds to variant rs58704432 [ dbSNP | Ensembl ].		VAR_018355
	Natural variant	244	1	L → I. Corresponds to variant rs28969685 [ dbSNP | Ensembl ].		VAR_052465
Experimental info
	Sequence conflict	1 – 23	23	MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC Ref.1
	Sequence conflict	40	1	T → A in AAB81537. Ref.1
	Sequence conflict	175	1	H → R in AAB81537. Ref.1
	Sequence conflict	224	1	F → L in AAB81537. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 73774EEEC7FE37BA	FASTA	530	59,810
	10 20 30 40 50 60 MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP 70 80 90 100 110 120 EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA QAQSIFSLLM SSSSGFLDLF 130 140 150 160 170 180 FSHCRSLFND RKLVEYLKES SFDAVFLDPF DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG 190 200 210 220 230 240 AQCPAPLSYV PNDLLGFSDA MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT 250 260 270 280 290 300 AYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV 310 320 330 340 350 360 VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH 370 380 390 400 410 420 PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL 430 440 450 460 470 480 ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW 490 500 510 520 530 YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue." Strassburg C.P., Oldhafer K., Manns M.P., Tukey R.H. Mol. Pharmacol. 52:212-220(1997) [PubMed: 9271343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Three novel single nucleotide polymorphisms in UGT1A10." Saeki M., Ozawa S., Saito Y., Jinno H., Hamaguchi T., Nokihara H., Shimada Y., Kunitoh H., Yamamoto N., Ohe Y., Yamada Y., Shirao K., Muto M., Mera K., Goto K., Ohmatsu H., Kubota K., Niho S. , Kakinuma R., Minami H., Ohtsu A., Yoshida T., Saijo N., Sawada J. Drug Metab. Pharmacokinet. 17:488-490(2002) [PubMed: 15618702] [Abstract] Cited for: VARIANTS ILE-59 AND ILE-202.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U89508 mRNA. Translation: AAB81537.1. AF297093 Genomic DNA. Translation: AAG30417.1. BC020971 mRNA. Translation: AAH20971.1. BC069210 mRNA. Translation: AAH69210.2.
IPI	IPI00233885.
PIR	JC5656.
RefSeq	NP_061948.1. NM_019075.2.
UniGene	Hs.554822.
3D structure databases
ProteinModelPortal	Q9HAW8.
SMR	Q9HAW8. Positions 35-62, 278-446.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HAW8.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q9HAW8.
Polymorphism databases
DMDM	29839636.
Proteomic databases
PRIDE	Q9HAW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344644; ENSP00000343838; ENSG00000242515.
GeneID	54575.
KEGG	hsa:54575.
UCSC	uc002vur.1. human.
Organism-specific databases
CTD	54575.
GeneCards	GC02P234545.
HGNC	HGNC:12531. UGT1A10.
MIM	191740. gene. 606435. gene.
neXtProt	NX_Q9HAW8.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076681.
HOVERGEN	HBG004033.
OrthoDB	EOG45B1FF.
PhylomeDB	Q9HAW8.
Enzyme and pathway databases
BRENDA	2.4.1.17. 2681.
Gene expression databases
ArrayExpress	Q9HAW8.
Genevestigator	Q9HAW8.
GermOnline	ENSG00000167165. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
KO	K00699.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	57074.
SOURCE	Search...

Entry information

Entry name

UD110_HUMAN

Accession

Primary (citable) accession number: Q9HAW8
Secondary accession number(s): O00474, Q6NT91

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.