Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HAW8

- UD110_HUMAN

UniProt

Q9HAW8 - UD110_HUMAN

Protein

UDP-glucuronosyltransferase 1-10

Gene

UGT1A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. enzyme binding Source: BHF-UCL
    2. glucuronosyltransferase activity Source: BHF-UCL
    3. protein heterodimerization activity Source: UniProt
    4. protein homodimerization activity Source: UniProt
    5. protein kinase C binding Source: BHF-UCL

    GO - Biological processi

    1. cellular glucuronidation Source: BHF-UCL
    2. flavone metabolic process Source: BHF-UCL

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 2681.
    SABIO-RKQ9HAW8.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-10 (EC:2.4.1.17)
    Short name:
    UDPGT 1-10
    Short name:
    UGT1*10
    Short name:
    UGT1-10
    Short name:
    UGT1.10
    Alternative name(s):
    UDP-glucuronosyltransferase 1-J
    Short name:
    UGT-1J
    Short name:
    UGT1J
    UDP-glucuronosyltransferase 1A10
    Gene namesi
    Name:UGT1A10
    Synonyms:GNT1, UGT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:12531. UGT1A10.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: BHF-UCL
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37174.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 530505UDP-glucuronosyltransferase 1-10PRO_0000036009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9HAW8.
    PRIDEiQ9HAW8.

    PTM databases

    PhosphoSiteiQ9HAW8.

    Expressioni

    Tissue specificityi

    Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212).2 Publications

    Gene expression databases

    BgeeiQ9HAW8.
    GenevestigatoriQ9HAW8.

    Interactioni

    Subunit structurei

    Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9.1 Publication

    Protein-protein interaction databases

    BioGridi120053. 1 interaction.
    IntActiQ9HAW8. 7 interactions.
    STRINGi9606.ENSP00000343838.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HAW8.
    SMRiQ9HAW8. Positions 280-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei488 – 50417HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    KOiK00699.
    OMAiCHYLEDA.
    OrthoDBiEOG7353X5.
    PhylomeDBiQ9HAW8.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HAW8-1) [UniParc]FASTAAdd to Basket

    Also known as: i1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL    50
    RGHEVVVVMP EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA 100
    QAQSIFSLLM SSSSGFLDLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF 150
    DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG AQCPAPLSYV PNDLLGFSDA 200
    MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT AYDLYSHTSI 250
    WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV 300
    VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK 350
    WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR 400
    METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE 450
    PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA 500
    FITFKCCAYG YRKCLGKKGR VKKAHKSKTH 530
    Length:530
    Mass (Da):59,810
    Last modified:March 1, 2001 - v1
    Checksum:i73774EEEC7FE37BA
    GO
    Isoform 2 (identifier: Q9HAW8-2) [UniParc]FASTAAdd to Basket

    Also known as: i2, UGT1A10s

    The sequence of this isoform differs from the canonical sequence as follows:
         432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

    Show »
    Length:441
    Mass (Da):49,586
    Checksum:i06D89D99B1C0300E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 2323MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC(PubMed:9271343)CuratedAdd
    BLAST
    Sequence conflicti40 – 401T → A in AAB81537. (PubMed:9271343)Curated
    Sequence conflicti175 – 1751H → R in AAB81537. (PubMed:9271343)Curated
    Sequence conflicti224 – 2241F → L in AAB81537. (PubMed:9271343)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591M → I.1 Publication
    Corresponds to variant rs56935833 [ dbSNP | Ensembl ].
    VAR_018354
    Natural varianti139 – 1391E → K.
    Corresponds to variant rs10187694 [ dbSNP | Ensembl ].
    VAR_052464
    Natural varianti202 – 2021T → I.1 Publication
    Corresponds to variant rs58704432 [ dbSNP | Ensembl ].
    VAR_018355
    Natural varianti244 – 2441L → I.
    Corresponds to variant rs28969685 [ dbSNP | Ensembl ].
    VAR_052465

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei432 – 53099SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationVSP_053966Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89508 mRNA. Translation: AAB81537.1.
    AF297093 Genomic DNA. Translation: AAG30417.1.
    AC006985 Genomic DNA. No translation available.
    AC019072 Genomic DNA. No translation available.
    BC020971 mRNA. Translation: AAH20971.1.
    BC053576 mRNA. Translation: AAH53576.1.
    BC069210 mRNA. Translation: AAH69210.2.
    CCDSiCCDS33403.1. [Q9HAW8-1]
    PIRiJC5656.
    RefSeqiNP_061948.1. NM_019075.2. [Q9HAW8-1]
    UniGeneiHs.554822.

    Genome annotation databases

    EnsembliENST00000344644; ENSP00000343838; ENSG00000242515. [Q9HAW8-1]
    ENST00000373445; ENSP00000362544; ENSG00000242515. [Q9HAW8-2]
    GeneIDi54575.
    KEGGihsa:54575.
    UCSCiuc002vur.3. human. [Q9HAW8-1]

    Polymorphism databases

    DMDMi29839636.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89508 mRNA. Translation: AAB81537.1 .
    AF297093 Genomic DNA. Translation: AAG30417.1 .
    AC006985 Genomic DNA. No translation available.
    AC019072 Genomic DNA. No translation available.
    BC020971 mRNA. Translation: AAH20971.1 .
    BC053576 mRNA. Translation: AAH53576.1 .
    BC069210 mRNA. Translation: AAH69210.2 .
    CCDSi CCDS33403.1. [Q9HAW8-1 ]
    PIRi JC5656.
    RefSeqi NP_061948.1. NM_019075.2. [Q9HAW8-1 ]
    UniGenei Hs.554822.

    3D structure databases

    ProteinModelPortali Q9HAW8.
    SMRi Q9HAW8. Positions 280-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120053. 1 interaction.
    IntActi Q9HAW8. 7 interactions.
    STRINGi 9606.ENSP00000343838.

    Chemistry

    BindingDBi Q9HAW8.
    ChEMBLi CHEMBL1743320.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q9HAW8.

    Polymorphism databases

    DMDMi 29839636.

    Proteomic databases

    PaxDbi Q9HAW8.
    PRIDEi Q9HAW8.

    Protocols and materials databases

    DNASUi 54575.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344644 ; ENSP00000343838 ; ENSG00000242515 . [Q9HAW8-1 ]
    ENST00000373445 ; ENSP00000362544 ; ENSG00000242515 . [Q9HAW8-2 ]
    GeneIDi 54575.
    KEGGi hsa:54575.
    UCSCi uc002vur.3. human. [Q9HAW8-1 ]

    Organism-specific databases

    CTDi 54575.
    GeneCardsi GC02P234545.
    HGNCi HGNC:12531. UGT1A10.
    MIMi 191740. gene.
    606435. gene.
    neXtProti NX_Q9HAW8.
    PharmGKBi PA37174.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    KOi K00699.
    OMAi CHYLEDA.
    OrthoDBi EOG7353X5.
    PhylomeDBi Q9HAW8.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 2681.
    SABIO-RK Q9HAW8.

    Miscellaneous databases

    GeneWikii UGT1A10.
    GenomeRNAii 54575.
    NextBioi 57074.
    PROi Q9HAW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HAW8.
    Genevestigatori Q9HAW8.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue."
      Strassburg C.P., Oldhafer K., Manns M.P., Tukey R.H.
      Mol. Pharmacol. 52:212-220(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
      Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C.
      Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon and Kidney.
    5. "Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
      Girard H., Levesque E., Bellemare J., Journault K., Caillier B., Guillemette C.
      Pharmacogenet. Genomics 17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    6. "Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones."
      Tang L., Singh R., Liu Z., Hu M.
      Mol. Pharm. 6:1466-1482(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."
      Bellemare J., Rouleau M., Girard H., Harvey M., Guillemette C.
      Drug Metab. Dispos. 38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    8. Cited for: VARIANTS ILE-59 AND ILE-202.

    Entry informationi

    Entry nameiUD110_HUMAN
    AccessioniPrimary (citable) accession number: Q9HAW8
    Secondary accession number(s): O00474, Q6NT91, Q7Z6H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3