Reviewed,
UniProtKB/Swiss-Prot Q9HAW8 (UD110_HUMAN)
Last modified
July 7, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 1-10 Short name=UDPGT Short name=UGT1*10 Short name=UGT1-10 Short name=UGT1.10 EC=2.4.1.17 Alternative name(s): UGT-1J Short name=UGT1J | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 530 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. |
| Tissue specificity | Liver and colon. Ref.1 |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Non-traceable author statement. Source: UniProtKB |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW microsomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues. | ||||||
| Isoform 1 (identifier: Q9HAW8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 530 | 505 | UDP-glucuronosyltransferase 1-10 | PRO_0000036009 | |||||
Regions | |||||||||
| Transmembrane | 488 – 504 | 17 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 292 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 344 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 59 | 1 | M → I Ref.4 | VAR_018354 | |||||
| Natural variant | 139 | 1 | E → K: dbSNP rs10187694. | VAR_052464 | |||||
| Natural variant | 202 | 1 | T → I Ref.4 | VAR_018355 | |||||
| Natural variant | 244 | 1 | L → I: dbSNP rs28969685. | VAR_052465 | |||||
Experimental info | |||||||||
| Sequence conflict | 1 – 23 | 23 | MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC Ref.1 | ||||||
| Sequence conflict | 40 | 1 | T → A in AAB81537. Ref.1 | ||||||
| Sequence conflict | 175 | 1 | H → R in AAB81537. Ref.1 | ||||||
| Sequence conflict | 224 | 1 | F → L in AAB81537. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue." Strassburg C.P., Oldhafer K., Manns M.P., Tukey R.H. Mol. Pharmacol. 52:212-220(1997) [PubMed: 9271343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [4] | "Three novel single nucleotide polymorphisms in UGT1A10." Saeki M., Ozawa S., Saito Y., Jinno H., Hamaguchi T., Nokihara H., Shimada Y., Kunitoh H., Yamamoto N., Ohe Y., Yamada Y., Shirao K., Muto M., Mera K., Goto K., Ohmatsu H., Kubota K., Niho S. Sawada J.Drug Metab. Pharmacokinet. 17:488-490(2002) [PubMed: 15618702] [Abstract] Cited for: VARIANTS ILE-59 AND ILE-202. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U89508 mRNA. Translation: AAB81537.1. AF297093 Genomic DNA. Translation: AAG30417.1. BC020971 mRNA. Translation: AAH20971.1. BC069210 mRNA. Translation: AAH69210.2. | |
| IPI | IPI00233885. |
| PIR | JC5656. |
| RefSeq | NP_061948.1. |
| UniGene | Hs.554822 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
PTM databases | |
| PhosphoSite | Q9HAW8. |
Proteomic databases | |
| PRIDE | Q9HAW8. |
Genome annotation databases | |
| Ensembl | ENSG00000167165. Homo sapiens. [Contig view] |
| GeneID | 54575. |
| KEGG | hsa:54575. |
| UCSC | uc002vur.1. human. |
Organism-specific databases | |
| GeneCards | GC02P234211. |
| HGNC | HGNC:12531. UGT1A10. |
| MIM | 191740. gene. 606435. gene. |
| Orphanet | 205. Crigler-Najjar syndrome. 357. Gilbert syndrome. 2312. Hyperbilirubinemia transient familial neonatal. |
| PharmGKB | PA37174. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9HAW8. |
| OMA | Q9HAW8. HIVHLED. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.17. 247. |
Gene expression databases | |
| ArrayExpress | Q9HAW8. |
| Bgee | Q9HAW8. |
| GermOnline | ENSG00000167165. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57074. |
| SOURCE | Search... |
Entry information
| Entry name | UD110_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9HAW8 Secondary accession number(s): O00474, Q6NT91 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


