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Q9HAV7

- GRPE1_HUMAN

UniProt

Q9HAV7 - GRPE1_HUMAN

Protein

GrpE protein homolog 1, mitochondrial

Gene

GRPEL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro
    2. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein folding Source: InterPro
    3. protein targeting to mitochondrion Source: Reactome

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GrpE protein homolog 1, mitochondrial
    Alternative name(s):
    HMGE
    Mt-GrpE#1
    Gene namesi
    Name:GRPEL1
    Synonyms:GREPEL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:19696. GRPEL1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134918140.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionBy similarityAdd
    BLAST
    Chaini28 – 217190GrpE protein homolog 1, mitochondrialPRO_0000013049Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
    Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
    Modified residuei100 – 1001N6-acetyllysineBy similarity
    Modified residuei120 – 1201N6-succinyllysineBy similarity
    Modified residuei215 – 2151N6-acetyllysine; alternate1 Publication
    Modified residuei215 – 2151N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9HAV7.
    PaxDbiQ9HAV7.
    PeptideAtlasiQ9HAV7.
    PRIDEiQ9HAV7.

    PTM databases

    PhosphoSiteiQ9HAV7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HAV7.
    BgeeiQ9HAV7.
    CleanExiHS_GRPEL1.
    GenevestigatoriQ9HAV7.

    Organism-specific databases

    HPAiHPA036647.

    Interactioni

    Subunit structurei

    Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 By similarity. Binds to HSP70, HSC70 and HSJ1B.By similarity

    Protein-protein interaction databases

    BioGridi123210. 16 interactions.
    IntActiQ9HAV7. 8 interactions.
    MINTiMINT-3069714.
    STRINGi9606.ENSP00000264954.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HAV7.
    SMRiQ9HAV7. Positions 34-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0576.
    HOGENOMiHOG000252083.
    HOVERGENiHBG051846.
    InParanoidiQ9HAV7.
    KOiK03687.
    OMAiPMEGKEP.
    OrthoDBiEOG718KDB.
    PhylomeDBiQ9HAV7.
    TreeFamiTF105284.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HAV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQCVRLAR RSLPALALSL RPSPRLLCTA TKQKNSGQNL EEDMGQSEQK    50
    ADPPATEKTL LEEKVKLEEQ LKETVEKYKR ALADTENLRQ RSQKLVEEAK 100
    LYGIQAFCKD LLEVADVLEK ATQCVPKEEI KDDNPHLKNL YEGLVMTEVQ 150
    IQKVFTKHGL LKLNPVGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK 200
    LHGRTLRPAL VGVVKEA 217
    Length:217
    Mass (Da):24,279
    Last modified:July 11, 2001 - v2
    Checksum:i40499AA3FC7E689E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312882 mRNA. Translation: BAG35730.1.
    AF298592 mRNA. Translation: AAG31605.1.
    AF087896 mRNA. Translation: AAP97195.1.
    AL542571 mRNA. No translation available.
    CH471131 Genomic DNA. Translation: EAW82371.1.
    BC024242 mRNA. Translation: AAH24242.1.
    CCDSiCCDS3396.1.
    RefSeqiNP_079472.1. NM_025196.2.
    UniGeneiHs.443723.

    Genome annotation databases

    EnsembliENST00000264954; ENSP00000264954; ENSG00000109519.
    GeneIDi80273.
    KEGGihsa:80273.
    UCSCiuc003gjy.1. human.

    Polymorphism databases

    DMDMi18202951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312882 mRNA. Translation: BAG35730.1 .
    AF298592 mRNA. Translation: AAG31605.1 .
    AF087896 mRNA. Translation: AAP97195.1 .
    AL542571 mRNA. No translation available.
    CH471131 Genomic DNA. Translation: EAW82371.1 .
    BC024242 mRNA. Translation: AAH24242.1 .
    CCDSi CCDS3396.1.
    RefSeqi NP_079472.1. NM_025196.2.
    UniGenei Hs.443723.

    3D structure databases

    ProteinModelPortali Q9HAV7.
    SMRi Q9HAV7. Positions 34-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123210. 16 interactions.
    IntActi Q9HAV7. 8 interactions.
    MINTi MINT-3069714.
    STRINGi 9606.ENSP00000264954.

    PTM databases

    PhosphoSitei Q9HAV7.

    Polymorphism databases

    DMDMi 18202951.

    Proteomic databases

    MaxQBi Q9HAV7.
    PaxDbi Q9HAV7.
    PeptideAtlasi Q9HAV7.
    PRIDEi Q9HAV7.

    Protocols and materials databases

    DNASUi 80273.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264954 ; ENSP00000264954 ; ENSG00000109519 .
    GeneIDi 80273.
    KEGGi hsa:80273.
    UCSCi uc003gjy.1. human.

    Organism-specific databases

    CTDi 80273.
    GeneCardsi GC04M007060.
    HGNCi HGNC:19696. GRPEL1.
    HPAi HPA036647.
    MIMi 606173. gene.
    neXtProti NX_Q9HAV7.
    PharmGKBi PA134918140.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0576.
    HOGENOMi HOG000252083.
    HOVERGENi HBG051846.
    InParanoidi Q9HAV7.
    KOi K03687.
    OMAi PMEGKEP.
    OrthoDBi EOG718KDB.
    PhylomeDBi Q9HAV7.
    TreeFami TF105284.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.

    Miscellaneous databases

    GenomeRNAii 80273.
    NextBioi 70741.
    PROi Q9HAV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HAV7.
    Bgeei Q9HAV7.
    CleanExi HS_GRPEL1.
    Genevestigatori Q9HAV7.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    2. "Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE."
      Choglay A.A., Chapple J.P., Blatch G.L., Cheetham M.E.
      Gene 267:125-134(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-117, CHARACTERIZATION.
      Tissue: Brain.
    3. "Cloning and characterization of a novel human cDNA homology to R.norvegicus stress-inducible chaperone mt-GrpE#1 mRNA."
      Wan Y.Z., Yu L., Zhang H.L., Fu Q., Jiang J.X., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGRPE1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HAV7
    Secondary accession number(s): B2R783, Q549M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3