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Q9HAV7

- GRPE1_HUMAN

UniProt

Q9HAV7 - GRPE1_HUMAN

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Protein
GrpE protein homolog 1, mitochondrial
Gene
GRPEL1, GREPEL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro
  2. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. protein folding Source: InterPro
  3. protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
HMGE
Mt-GrpE#1
Gene namesi
Name:GRPEL1
Synonyms:GREPEL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:19696. GRPEL1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
  2. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion By similarity
Add
BLAST
Chaini28 – 217190GrpE protein homolog 1, mitochondrialUniRule annotation
PRO_0000013049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-acetyllysine; alternate By similarity
Modified residuei94 – 941N6-succinyllysine; alternate By similarity
Modified residuei100 – 1001N6-acetyllysine By similarity
Modified residuei120 – 1201N6-succinyllysine By similarity
Modified residuei215 – 2151N6-acetyllysine; alternate1 Publication
Modified residuei215 – 2151N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9HAV7.
PaxDbiQ9HAV7.
PeptideAtlasiQ9HAV7.
PRIDEiQ9HAV7.

PTM databases

PhosphoSiteiQ9HAV7.

Expressioni

Gene expression databases

ArrayExpressiQ9HAV7.
BgeeiQ9HAV7.
CleanExiHS_GRPEL1.
GenevestigatoriQ9HAV7.

Organism-specific databases

HPAiHPA036647.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 By similarity. Binds to HSP70, HSC70 and HSJ1B.

Protein-protein interaction databases

BioGridi123210. 16 interactions.
IntActiQ9HAV7. 8 interactions.
MINTiMINT-3069714.
STRINGi9606.ENSP00000264954.

Structurei

3D structure databases

ProteinModelPortaliQ9HAV7.
SMRiQ9HAV7. Positions 34-216.

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ9HAV7.
KOiK03687.
OMAiPMEGKEP.
OrthoDBiEOG718KDB.
PhylomeDBiQ9HAV7.
TreeFamiTF105284.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HAV7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQCVRLAR RSLPALALSL RPSPRLLCTA TKQKNSGQNL EEDMGQSEQK    50
ADPPATEKTL LEEKVKLEEQ LKETVEKYKR ALADTENLRQ RSQKLVEEAK 100
LYGIQAFCKD LLEVADVLEK ATQCVPKEEI KDDNPHLKNL YEGLVMTEVQ 150
IQKVFTKHGL LKLNPVGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK 200
LHGRTLRPAL VGVVKEA 217
Length:217
Mass (Da):24,279
Last modified:July 11, 2001 - v2
Checksum:i40499AA3FC7E689E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312882 mRNA. Translation: BAG35730.1.
AF298592 mRNA. Translation: AAG31605.1.
AF087896 mRNA. Translation: AAP97195.1.
AL542571 mRNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82371.1.
BC024242 mRNA. Translation: AAH24242.1.
CCDSiCCDS3396.1.
RefSeqiNP_079472.1. NM_025196.2.
UniGeneiHs.443723.

Genome annotation databases

EnsembliENST00000264954; ENSP00000264954; ENSG00000109519.
GeneIDi80273.
KEGGihsa:80273.
UCSCiuc003gjy.1. human.

Polymorphism databases

DMDMi18202951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312882 mRNA. Translation: BAG35730.1 .
AF298592 mRNA. Translation: AAG31605.1 .
AF087896 mRNA. Translation: AAP97195.1 .
AL542571 mRNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82371.1 .
BC024242 mRNA. Translation: AAH24242.1 .
CCDSi CCDS3396.1.
RefSeqi NP_079472.1. NM_025196.2.
UniGenei Hs.443723.

3D structure databases

ProteinModelPortali Q9HAV7.
SMRi Q9HAV7. Positions 34-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123210. 16 interactions.
IntActi Q9HAV7. 8 interactions.
MINTi MINT-3069714.
STRINGi 9606.ENSP00000264954.

PTM databases

PhosphoSitei Q9HAV7.

Polymorphism databases

DMDMi 18202951.

Proteomic databases

MaxQBi Q9HAV7.
PaxDbi Q9HAV7.
PeptideAtlasi Q9HAV7.
PRIDEi Q9HAV7.

Protocols and materials databases

DNASUi 80273.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264954 ; ENSP00000264954 ; ENSG00000109519 .
GeneIDi 80273.
KEGGi hsa:80273.
UCSCi uc003gjy.1. human.

Organism-specific databases

CTDi 80273.
GeneCardsi GC04M007060.
HGNCi HGNC:19696. GRPEL1.
HPAi HPA036647.
MIMi 606173. gene.
neXtProti NX_Q9HAV7.
PharmGKBi PA134918140.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0576.
HOGENOMi HOG000252083.
HOVERGENi HBG051846.
InParanoidi Q9HAV7.
KOi K03687.
OMAi PMEGKEP.
OrthoDBi EOG718KDB.
PhylomeDBi Q9HAV7.
TreeFami TF105284.

Enzyme and pathway databases

Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii 80273.
NextBioi 70741.
PROi Q9HAV7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HAV7.
Bgeei Q9HAV7.
CleanExi HS_GRPEL1.
Genevestigatori Q9HAV7.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. "Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE."
    Choglay A.A., Chapple J.P., Blatch G.L., Cheetham M.E.
    Gene 267:125-134(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-117, CHARACTERIZATION.
    Tissue: Brain.
  3. "Cloning and characterization of a novel human cDNA homology to R.norvegicus stress-inducible chaperone mt-GrpE#1 mRNA."
    Wan Y.Z., Yu L., Zhang H.L., Fu Q., Jiang J.X., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGRPE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAV7
Secondary accession number(s): B2R783, Q549M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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