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Protein

GrpE protein homolog 1, mitochondrial

Gene

GRPEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: GO_Central
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109519-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
HMGE
Mt-GrpE#1
Gene namesi
Name:GRPEL1
Synonyms:GREPEL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19696. GRPEL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi80273.
OpenTargetsiENSG00000109519.
PharmGKBiPA134918140.

Polymorphism and mutation databases

BioMutaiGRPEL1.
DMDMi18202951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000001304928 – 217GrpE protein homolog 1, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei120N6-succinyllysineBy similarity1
Modified residuei215N6-acetyllysine; alternateCombined sources1
Modified residuei215N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HAV7.
MaxQBiQ9HAV7.
PaxDbiQ9HAV7.
PeptideAtlasiQ9HAV7.
PRIDEiQ9HAV7.
TopDownProteomicsiQ9HAV7.

PTM databases

iPTMnetiQ9HAV7.
PhosphoSitePlusiQ9HAV7.
SwissPalmiQ9HAV7.

Expressioni

Gene expression databases

BgeeiENSG00000109519.
CleanExiHS_GRPEL1.
GenevisibleiQ9HAV7. HS.

Organism-specific databases

HPAiHPA036647.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123210. 48 interactors.
IntActiQ9HAV7. 13 interactors.
MINTiMINT-3069714.
STRINGi9606.ENSP00000264954.

Structurei

3D structure databases

ProteinModelPortaliQ9HAV7.
SMRiQ9HAV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ9HAV7.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG091G0O5D.
PhylomeDBiQ9HAV7.
TreeFamiTF105284.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HAV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQCVRLAR RSLPALALSL RPSPRLLCTA TKQKNSGQNL EEDMGQSEQK
60 70 80 90 100
ADPPATEKTL LEEKVKLEEQ LKETVEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQAFCKD LLEVADVLEK ATQCVPKEEI KDDNPHLKNL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LKLNPVGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKEA
Length:217
Mass (Da):24,279
Last modified:July 11, 2001 - v2
Checksum:i40499AA3FC7E689E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312882 mRNA. Translation: BAG35730.1.
AF298592 mRNA. Translation: AAG31605.1.
AF087896 mRNA. Translation: AAP97195.1.
AL542571 mRNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82371.1.
BC024242 mRNA. Translation: AAH24242.1.
CCDSiCCDS3396.1.
RefSeqiNP_079472.1. NM_025196.3.
UniGeneiHs.443723.

Genome annotation databases

EnsembliENST00000264954; ENSP00000264954; ENSG00000109519.
GeneIDi80273.
KEGGihsa:80273.
UCSCiuc003gjy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312882 mRNA. Translation: BAG35730.1.
AF298592 mRNA. Translation: AAG31605.1.
AF087896 mRNA. Translation: AAP97195.1.
AL542571 mRNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82371.1.
BC024242 mRNA. Translation: AAH24242.1.
CCDSiCCDS3396.1.
RefSeqiNP_079472.1. NM_025196.3.
UniGeneiHs.443723.

3D structure databases

ProteinModelPortaliQ9HAV7.
SMRiQ9HAV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123210. 48 interactors.
IntActiQ9HAV7. 13 interactors.
MINTiMINT-3069714.
STRINGi9606.ENSP00000264954.

PTM databases

iPTMnetiQ9HAV7.
PhosphoSitePlusiQ9HAV7.
SwissPalmiQ9HAV7.

Polymorphism and mutation databases

BioMutaiGRPEL1.
DMDMi18202951.

Proteomic databases

EPDiQ9HAV7.
MaxQBiQ9HAV7.
PaxDbiQ9HAV7.
PeptideAtlasiQ9HAV7.
PRIDEiQ9HAV7.
TopDownProteomicsiQ9HAV7.

Protocols and materials databases

DNASUi80273.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264954; ENSP00000264954; ENSG00000109519.
GeneIDi80273.
KEGGihsa:80273.
UCSCiuc003gjy.2. human.

Organism-specific databases

CTDi80273.
DisGeNETi80273.
GeneCardsiGRPEL1.
HGNCiHGNC:19696. GRPEL1.
HPAiHPA036647.
MIMi606173. gene.
neXtProtiNX_Q9HAV7.
OpenTargetsiENSG00000109519.
PharmGKBiPA134918140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiQ9HAV7.
KOiK03687.
OMAiDAKLYGI.
OrthoDBiEOG091G0O5D.
PhylomeDBiQ9HAV7.
TreeFamiTF105284.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109519-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii80273.
PROiQ9HAV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109519.
CleanExiHS_GRPEL1.
GenevisibleiQ9HAV7. HS.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAV7
Secondary accession number(s): B2R783, Q549M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.