##gff-version 3 Q9HAU5 UniProtKB Chain 1 1272 . . . ID=PRO_0000097248;Note=Regulator of nonsense transcripts 2 Q9HAU5 UniProtKB Domain 168 431 . . . Note=MIF4G 1 Q9HAU5 UniProtKB Domain 569 758 . . . Note=MIF4G 2 Q9HAU5 UniProtKB Domain 773 986 . . . Note=MIF4G 3 Q9HAU5 UniProtKB Region 1 126 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Region 94 133 . . . Note=Sufficient for interaction with UPF1 Q9HAU5 UniProtKB Region 370 389 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Region 423 445 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Region 490 517 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Region 711 928 . . . Note=Sufficient for interaction with UPF3A and UPF3B Q9HAU5 UniProtKB Region 757 1272 . . . Note=Sufficient for interaction with EIF4A1 and EIF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11073994;Dbxref=PMID:11073994 Q9HAU5 UniProtKB Region 839 859 . . . Note=Binds to UPF3B Q9HAU5 UniProtKB Region 1018 1098 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Region 1084 1272 . . . Note=Sufficient for interaction with UPF1 C-terminus Q9HAU5 UniProtKB Region 1105 1198 . . . Note=Necessary for interaction with UPF1 Q9HAU5 UniProtKB Region 1105 1129 . . . Note=Interaction with UPF1 Q9HAU5 UniProtKB Region 1167 1207 . . . Note=Interaction with UPF1 Q9HAU5 UniProtKB Region 1220 1272 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Coiled coil 54 134 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9HAU5 UniProtKB Coiled coil 487 559 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9HAU5 UniProtKB Compositional bias 1025 1078 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Compositional bias 1079 1097 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9HAU5 UniProtKB Modified residue 1088 1088 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Q9HAU5 UniProtKB Natural variant 496 496 . . . ID=VAR_024345;Note=N->S;Dbxref=dbSNP:rs7079388 Q9HAU5 UniProtKB Mutagenesis 796 797 . . . Note=Strongly impairs RNA-binding. RK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 847 847 . . . Note=Does not abolish interaction with UPF3B. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 851 852 . . . Note=Does not abolish interaction with UPF3B. Does not abolish interaction with UPF3B%3B when associated with D-854. ED->KR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 854 854 . . . Note=Does not abolish interaction with UPF3B%3B when associated with K-851 and R-852. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 858 858 . . . Note=Abolishes interaction with UPF3B and association with SMG1 and RBM8A%3B reduces phosphorylation of UPF1. E->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15004547,ECO:0000269|PubMed:16452507;Dbxref=PMID:15004547,PMID:16452507 Q9HAU5 UniProtKB Mutagenesis 894 894 . . . Note=Does not impair RNA-binding%3B when associated with A-932. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 932 932 . . . Note=Does not impair RNA-binding%3B when associated with A-894. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15004547;Dbxref=PMID:15004547 Q9HAU5 UniProtKB Mutagenesis 1113 1113 . . . Note=Abolishes interaction with UPF1. F->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1120 1120 . . . Note=Decreases interaction with UPF1%3B does not reduce NMD efficiency. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1121 1121 . . . Note=Decreases interaction with UPF1%3B does not reduce NMD efficiency. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1123 1123 . . . Note=Decreases interaction with UPF1. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1169 1169 . . . Note=Decreases interaction with UPF1. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1171 1171 . . . Note=Abolishes interaction with UPF1%3B reduces NMD efficiency. F->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1171 1171 . . . Note=Greatly reduces NMD efficiency%3B when associated with E-1173 and E-1174. F->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1173 1173 . . . Note=Abolishes interaction with UPF1. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1173 1173 . . . Note=Greatly reduces NMD efficiency%3B when associated with E-1171 and E-1174. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1174 1174 . . . Note=Abolishes interaction with UPF1%3B reduces NMD efficiency. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1174 1174 . . . Note=Greatly reduces NMD efficiency%3B when associated with E-1171 and E-1173. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Mutagenesis 1176 1176 . . . Note=Decreases interaction with UPF1. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556969;Dbxref=PMID:19556969 Q9HAU5 UniProtKB Sequence conflict 119 119 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9HAU5 UniProtKB Sequence conflict 338 338 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9HAU5 UniProtKB Sequence conflict 844 844 . . . Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9HAU5 UniProtKB Sequence conflict 969 969 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9HAU5 UniProtKB Helix 122 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 152 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 158 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 168 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 178 180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 186 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 202 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 216 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 219 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 236 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 259 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 280 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Beta strand 299 301 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 305 320 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 325 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 346 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Turn 376 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 383 386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Turn 387 389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Turn 395 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Helix 399 419 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEM Q9HAU5 UniProtKB Beta strand 460 462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 463 469 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 474 476 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 539 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 560 574 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 575 577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 581 594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 598 609 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 613 618 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 619 629 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Turn 630 632 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 635 653 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 660 675 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 681 693 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 697 716 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 718 737 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 742 755 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CEK Q9HAU5 UniProtKB Helix 770 780 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 782 785 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NWU Q9HAU5 UniProtKB Helix 788 796 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 803 814 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 816 818 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 821 823 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 824 834 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Turn 835 837 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 839 859 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 862 864 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 865 880 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 886 898 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Beta strand 909 911 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 917 929 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 930 932 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 936 957 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Beta strand 964 966 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 970 983 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 993 1011 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UW4 Q9HAU5 UniProtKB Helix 1108 1126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WJV Q9HAU5 UniProtKB Beta strand 1168 1174 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WJV Q9HAU5 UniProtKB Beta strand 1183 1192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WJV Q9HAU5 UniProtKB Helix 1193 1197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WJV