Q9HAU0 (PKHA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology domain-containing family A member 5
Short name=PH domain-containing family A member 5

Alternative name(s):
Phosphoinositol 3-phosphate-binding protein 2
Short name=PEPP-2

Gene names

Name:	PLEKHA5
Synonyms:	KIAA1686, PEPP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.2.
Tissue specificity	Highly expressed in heart and kidney. Ref.1
Domain	Specifically interacts with PI3P, PI4P, PI5P, and PI(3,5)P2. Ref.2
Sequence similarities	Contains 1 PH domain. Contains 2 WW domains.
Sequence caution	The sequence AAH70174.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA91742.1 differs from that shown. Reason: Frameshift at position 759. The sequence BAB14419.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB21777.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-phosphatidylinositol binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATN1	P54259	2	EBI-945934,EBI-945980
ATXN1	P54253	2	EBI-945934,EBI-930964
RBFOX1	Q9NWB1	2	EBI-945934,EBI-945906

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HAU0-1)

Also known as: S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HAU0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     615-615: T → TPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQ

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9HAU0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     616-650: LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVH → WGREKVATATGAAEAVASDTHLPRTGSSSPSLLCV
     651-1116: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9HAU0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     800-800: E → EEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHC

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9HAU0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     785-840: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9HAU0-6)

Also known as: L;

The sequence of this isoform differs from the canonical sequence as follows:
     275-275: K → KRITFNF
     615-615: T → TPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQ
     616-616: L → MKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCL
     800-800: E → EEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHC

Note: Specifically expresssed in brain.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1116

1116

Pleckstrin homology domain-containing family A member 5

PRO_0000053883

Regions

Domain

10 – 43

34

WW 1

Domain

56 – 89

34

WW 2

Domain

169 – 268

100

PH

Amino acid modifications

Modified residue

809

1

Phosphoserine Ref.14

Modified residue

855

1

Phosphoserine Ref.11 Ref.14

Modified residue

933

1

Phosphoserine Ref.9 Ref.10 Ref.11 Ref.12

Natural variations

Alternative sequence

275

1

K → KRITFNF in isoform 6.

VSP_044678

Alternative sequence

615

1

T → TPEELTLLLIKLRRQQAELS SIREHTLAQLMQLKLEAHSP KNEILSHHLQRNTIYLDHQ in isoform 2 and isoform 6.

VSP_009775

Alternative sequence

616 – 650

35

LSQDE…DKVVH → WGREKVATATGAAEAVASDT HLPRTGSSSPSLLCV in isoform 3.

VSP_009776

Alternative sequence

616

1

L → MKENEPIITMVHTMIENSAL RPQLYQQFLRQKSKISLYCL in isoform 6.

VSP_044679

Alternative sequence

651 – 1116

466

Missing in isoform 3.

VSP_014595

Alternative sequence

785 – 840

56

Missing in isoform 5.

VSP_009777

Alternative sequence

800

1

E → EEEEVVPPRPPLPRSYDFTE QPPIIPPLPSDSSSLLCYSR GPVHLPEEKKMYQVQGYPRN GSHC in isoform 4 and isoform 6.

VSP_009778

Experimental info

Sequence conflict

627

1

K → R in BAB14419. Ref.8

Sequence conflict

736

1

M → T in BAB14419. Ref.8

Sequence conflict

970

1

P → S in BAA91742. Ref.8

Secondary structure

1

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1116

Helix Strand Turn

Details...

Beta strand

172 – 179

8

Beta strand

182 – 184

3

Beta strand

187 – 195

9

Beta strand

198 – 204

7

Beta strand

209 – 214

6

Helix

216 – 218

3

Beta strand

219 – 223

5

Helix

226 – 228

3

Beta strand

234 – 239

6

Beta strand

241 – 243

3

Beta strand

246 – 249

4

Helix

253 – 267

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (S) [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 327F792F644B9D48	FASTA	1,116	127,464
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI 310 320 330 340 350 360 KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP 370 380 390 400 410 420 AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI 430 440 450 460 470 480 QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH 490 500 510 520 530 540 DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS 550 560 570 580 590 600 IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG 610 620 630 640 650 660 LTLQSVSPQS LQGKTLSQDE GRGTLYKYRP EEVDIDAKLS RLCEQDKVVH ALEEKLQQLH 670 680 690 700 710 720 KEKYTLEQAL LSASQEIEMH ADNPAAIQTV VLQRDDLQNG LLSTCRELSR ATAELERAWR 730 740 750 760 770 780 EYDKLEYDVT VTRNQMQEQL DHLGEVQTES AGIQRAQIQK ELWRIQDVME GLSKHKQQRG 790 800 810 820 830 840 TTEIGMIGSK PFSTVKYKNE GPDYRLYKSE PELTTVAEVD ESNGEEKSEP VSEIETSVVK 850 860 870 880 890 900 GSHFPVGVVP PRAKSPTPES STIASYVTLR KTKKMMDLRT ERPRSAVEQL CLAESTRPRM 910 920 930 940 950 960 TVEEQMERIR RHQQACLREK KKGLNVIGAS DQSPLQSPSN LRDNPFRTTQ TRRRDDKELD 970 980 990 1000 1010 1020 TAIRENDVKP DHETPATEIV QLKETEPQNV DFSKELKKTE NISYEMLFEP EPNGVNSVEM 1030 1040 1050 1060 1070 1080 MDKERNKDKM PEDVTFSPQD ETQTANHKPE EHPEENTKNS VDEQEETVIS YESTPEVSRG 1090 1100 1110 NQTMAVKSLS PSPESSASPV PSTQPQLTEG SHFMCV
	Isoform 2 [UniParc]. Checksum: B82D29C6F281D311	FASTA	1,174	134,323
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI 310 320 330 340 350 360 KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP 370 380 390 400 410 420 AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI 430 440 450 460 470 480 QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH 490 500 510 520 530 540 DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS 550 560 570 580 590 600 IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG 610 620 630 640 650 660 LTLQSVSPQS LQGKTPEELT LLLIKLRRQQ AELSSIREHT LAQLMQLKLE AHSPKNEILS 670 680 690 700 710 720 HHLQRNTIYL DHQLSQDEGR GTLYKYRPEE VDIDAKLSRL CEQDKVVHAL EEKLQQLHKE 730 740 750 760 770 780 KYTLEQALLS ASQEIEMHAD NPAAIQTVVL QRDDLQNGLL STCRELSRAT AELERAWREY 790 800 810 820 830 840 DKLEYDVTVT RNQMQEQLDH LGEVQTESAG IQRAQIQKEL WRIQDVMEGL SKHKQQRGTT 850 860 870 880 890 900 EIGMIGSKPF STVKYKNEGP DYRLYKSEPE LTTVAEVDES NGEEKSEPVS EIETSVVKGS 910 920 930 940 950 960 HFPVGVVPPR AKSPTPESST IASYVTLRKT KKMMDLRTER PRSAVEQLCL AESTRPRMTV 970 980 990 1000 1010 1020 EEQMERIRRH QQACLREKKK GLNVIGASDQ SPLQSPSNLR DNPFRTTQTR RRDDKELDTA 1030 1040 1050 1060 1070 1080 IRENDVKPDH ETPATEIVQL KETEPQNVDF SKELKKTENI SYEMLFEPEP NGVNSVEMMD 1090 1100 1110 1120 1130 1140 KERNKDKMPE DVTFSPQDET QTANHKPEEH PEENTKNSVD EQEETVISYE STPEVSRGNQ 1150 1160 1170 TMAVKSLSPS PESSASPVPS TQPQLTEGSH FMCV
	Isoform 3 [UniParc]. Checksum: 98FCFC6BD6243232	FASTA	650	73,909
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI 310 320 330 340 350 360 KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP 370 380 390 400 410 420 AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI 430 440 450 460 470 480 QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH 490 500 510 520 530 540 DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS 550 560 570 580 590 600 IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG 610 620 630 640 650 LTLQSVSPQS LQGKTWGREK VATATGAAEA VASDTHLPRT GSSSPSLLCV
	Isoform 4 [UniParc]. Checksum: A7E7827DDD2166DC	FASTA	1,179	134,593
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI 310 320 330 340 350 360 KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP 370 380 390 400 410 420 AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI 430 440 450 460 470 480 QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH 490 500 510 520 530 540 DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS 550 560 570 580 590 600 IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG 610 620 630 640 650 660 LTLQSVSPQS LQGKTLSQDE GRGTLYKYRP EEVDIDAKLS RLCEQDKVVH ALEEKLQQLH 670 680 690 700 710 720 KEKYTLEQAL LSASQEIEMH ADNPAAIQTV VLQRDDLQNG LLSTCRELSR ATAELERAWR 730 740 750 760 770 780 EYDKLEYDVT VTRNQMQEQL DHLGEVQTES AGIQRAQIQK ELWRIQDVME GLSKHKQQRG 790 800 810 820 830 840 TTEIGMIGSK PFSTVKYKNE EEEVVPPRPP LPRSYDFTEQ PPIIPPLPSD SSSLLCYSRG 850 860 870 880 890 900 PVHLPEEKKM YQVQGYPRNG SHCGPDYRLY KSEPELTTVA EVDESNGEEK SEPVSEIETS 910 920 930 940 950 960 VVKGSHFPVG VVPPRAKSPT PESSTIASYV TLRKTKKMMD LRTERPRSAV EQLCLAESTR 970 980 990 1000 1010 1020 PRMTVEEQME RIRRHQQACL REKKKGLNVI GASDQSPLQS PSNLRDNPFR TTQTRRRDDK 1030 1040 1050 1060 1070 1080 ELDTAIREND VKPDHETPAT EIVQLKETEP QNVDFSKELK KTENISYEML FEPEPNGVNS 1090 1100 1110 1120 1130 1140 VEMMDKERNK DKMPEDVTFS PQDETQTANH KPEEHPEENT KNSVDEQEET VISYESTPEV 1150 1160 1170 SRGNQTMAVK SLSPSPESSA SPVPSTQPQL TEGSHFMCV
	Isoform 5 [UniParc]. Checksum: EC6B2DC66DC64F6A	FASTA	1,060	121,272
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI 310 320 330 340 350 360 KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP 370 380 390 400 410 420 AQTVHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI 430 440 450 460 470 480 QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH 490 500 510 520 530 540 DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS 550 560 570 580 590 600 IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG 610 620 630 640 650 660 LTLQSVSPQS LQGKTLSQDE GRGTLYKYRP EEVDIDAKLS RLCEQDKVVH ALEEKLQQLH 670 680 690 700 710 720 KEKYTLEQAL LSASQEIEMH ADNPAAIQTV VLQRDDLQNG LLSTCRELSR ATAELERAWR 730 740 750 760 770 780 EYDKLEYDVT VTRNQMQEQL DHLGEVQTES AGIQRAQIQK ELWRIQDVME GLSKHKQQRG 790 800 810 820 830 840 TTEIGSHFPV GVVPPRAKSP TPESSTIASY VTLRKTKKMM DLRTERPRSA VEQLCLAEST 850 860 870 880 890 900 RPRMTVEEQM ERIRRHQQAC LREKKKGLNV IGASDQSPLQ SPSNLRDNPF RTTQTRRRDD 910 920 930 940 950 960 KELDTAIREN DVKPDHETPA TEIVQLKETE PQNVDFSKEL KKTENISYEM LFEPEPNGVN 970 980 990 1000 1010 1020 SVEMMDKERN KDKMPEDVTF SPQDETQTAN HKPEEHPEEN TKNSVDEQEE TVISYESTPE 1030 1040 1050 1060 VSRGNQTMAV KSLSPSPESS ASPVPSTQPQ LTEGSHFMCV
	Isoform 6 (L) [UniParc]. Checksum: 06D1168C576FF684	FASTA	1,282	146,896
	10 20 30 40 50 60 MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT 70 80 90 100 110 120 GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS 130 140 150 160 170 180 MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD 190 200 210 220 230 240 STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH 250 260 270 280 290 300 PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRITFN FRVDKITSEN APTKETNNIP 310 320 330 340 350 360 NHRVLIKPEI QNNQKNKEMS KIEEKKALEA EKYGFQKDGQ DRPLTKINSV KLNSLPSEYE 370 380 390 400 410 420 SGSACPAQTV HYRPINLSSS ENKIVNVSLA DLRGGNRPNT GPLYTEADRV IQRTNSMQQL 430 440 450 460 470 480 EQWIKIQKGR GHEEETRGVI SYQTLPRNMP SHRAQIMARY PEGYRTLPRN SKTRPESICS 490 500 510 520 530 540 VTPSTHDKTL GPGAEEKRRS MRDDTMWQLY EWQQRQFYNK QSTLPRHSTL SSPKTMVNIS 550 560 570 580 590 600 DQTMHSIPTS PSHGSIAAYQ GYSPQRTYRS EVSSPIQRGD VTIDRRHRAH HPKHVYVPDR 610 620 630 640 650 660 RSVPAGLTLQ SVSPQSLQGK TPEELTLLLI KLRRQQAELS SIREHTLAQL MQLKLEAHSP 670 680 690 700 710 720 KNEILSHHLQ RNTIYLDHQM KENEPIITMV HTMIENSALR PQLYQQFLRQ KSKISLYCLS 730 740 750 760 770 780 QDEGRGTLYK YRPEEVDIDA KLSRLCEQDK VVHALEEKLQ QLHKEKYTLE QALLSASQEI 790 800 810 820 830 840 EMHADNPAAI QTVVLQRDDL QNGLLSTCRE LSRATAELER AWREYDKLEY DVTVTRNQMQ 850 860 870 880 890 900 EQLDHLGEVQ TESAGIQRAQ IQKELWRIQD VMEGLSKHKQ QRGTTEIGMI GSKPFSTVKY 910 920 930 940 950 960 KNEEEEVVPP RPPLPRSYDF TEQPPIIPPL PSDSSSLLCY SRGPVHLPEE KKMYQVQGYP 970 980 990 1000 1010 1020 RNGSHCGPDY RLYKSEPELT TVAEVDESNG EEKSEPVSEI ETSVVKGSHF PVGVVPPRAK 1030 1040 1050 1060 1070 1080 SPTPESSTIA SYVTLRKTKK MMDLRTERPR SAVEQLCLAE STRPRMTVEE QMERIRRHQQ 1090 1100 1110 1120 1130 1140 ACLREKKKGL NVIGASDQSP LQSPSNLRDN PFRTTQTRRR DDKELDTAIR ENDVKPDHET 1150 1160 1170 1180 1190 1200 PATEIVQLKE TEPQNVDFSK ELKKTENISY EMLFEPEPNG VNSVEMMDKE RNKDKMPEDV 1210 1220 1230 1240 1250 1260 TFSPQDETQT ANHKPEEHPE ENTKNSVDEQ EETVISYEST PEVSRGNQTM AVKSLSPSPE 1270 1280 SSASPVPSTQ PQLTEGSHFM CV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities." Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R. Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development." Yamada K., Nomura N., Yamano A., Yamada Y., Wakamatsu N. Gene 492:270-275(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, PH DOMAIN, ALTERNATIVE SPLICING.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-1116 (ISOFORM 3). Tissue: Lung and Placenta.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 625-1116 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 664-1116 (ISOFORM 5). Tissue: Teratocarcinoma.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-933, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-933, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855 AND SER-933, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-933, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-809 AND SER-855, MASS SPECTROMETRY.
[15]	"Solution structure of the PH domain of pleckstrin homology domain-containing protein family A member 5 from human." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 156-271.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF302150 mRNA. Translation: AAG22817.1.
AB642244 mRNA. Translation: BAL45489.1.
AB051473 mRNA. Translation: BAB21777.2. Different initiation.
AL834259 mRNA. Translation: CAD38934.1.
AC024902 Genomic DNA. No translation available.
AC087314 Genomic DNA. No translation available.
AC091805 Genomic DNA. No translation available.
AC092828 Genomic DNA. No translation available.
BC000969 mRNA. Translation: AAH00969.1.
BC070174 mRNA. Translation: AAH70174.1. Sequence problems.
BC013133 mRNA. Translation: AAH13133.3.
BC127092 mRNA. Translation: AAI27093.1.
AK001529 mRNA. Translation: BAA91742.1. Frameshift.
AK023127 mRNA. Translation: BAB14419.1. Different initiation.

IPI

IPI00029515.
IPI00169401.
IPI00409581.
IPI00409582.
IPI00409583.
IPI00910030.

RefSeq

NP_001137293.2. NM_001143821.2.
NP_001243399.1. NM_001256470.1.
NP_001243716.1. NM_001256787.1.
NP_061885.2. NM_019012.5.

UniGene

Hs.188614.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DKP	NMR	-	A	157-271	[»]

ProteinModelPortal

Q9HAU0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HAU0. 29 interactions.

STRING

9606.ENSP00000299275.

PTM databases

PhosphoSite

Q9HAU0.

Polymorphism databases

DMDM

48474955.

Proteomic databases

PaxDb

Q9HAU0.

PRIDE

Q9HAU0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000299275; ENSP00000299275; ENSG00000052126.
ENST00000309364; ENSP00000311239; ENSG00000052126.
ENST00000317589; ENSP00000325155; ENSG00000052126.
ENST00000355397; ENSP00000347560; ENSG00000052126.
ENST00000359180; ENSP00000352104; ENSG00000052126.
ENST00000429027; ENSP00000404296; ENSG00000052126.
ENST00000538714; ENSP00000439673; ENSG00000052126.

GeneID

54477.

KEGG

hsa:54477.

UCSC

uc001rea.3. human.
uc001reb.3. human.
uc001rec.1. human.
uc010sih.1. human.

Organism-specific databases

CTD

54477.

GeneCards

GC12P019282.

H-InvDB

HIX0171628.

HGNC

HGNC:30036. PLEKHA5.

HPA

HPA035923.
HPA035924.

MIM

607770. gene.

neXtProt

NX_Q9HAU0.

PharmGKB

PA134949896.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG279863.

HOVERGEN

HBG053615.

OMA

QTMAVKS.

Enzyme and pathway databases

SignaLink

Q9HAU0.

Gene expression databases

ArrayExpress

Q9HAU0.

Bgee

Q9HAU0.

CleanEx

HS_PLEKHA5.

Genevestigator

Q9HAU0.

GermOnline

ENSG00000052126. Homo sapiens.

Family and domain databases

Gene3D

2.30.29.30. 1 hit.

InterPro

IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001202. WW_dom.
[Graphical view]

Pfam

PF00169. PH. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]

SUPFAM

SSF51045. WW_Rsp5_WWP. 1 hit.

PROSITE

PS50003. PH_DOMAIN. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9HAU0.

GenomeRNAi

54477.

NextBio

56792.

SOURCE

Search...

Entry information

Entry name

PKHA5_HUMAN

Accession

Primary (citable) accession number: Q9HAU0
Secondary accession number(s): A0JP03 , E9PHQ3, Q6NSF8, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.