Protein pellino homolog 2 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9HAT8 (PELI2_HUMAN)

Last modified November 24, 2009. Version 58. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Protein pellino homolog 2
Short name=Pellino-2

Gene names

Name:

PELI2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Scaffold protein which probably links Toll-like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK kinases and TRAF6. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Ref.3 Ref.4
Subunit structure	Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Ref.3 Ref.4
Post-translational modification	Phosphorylated by IRAK1 and IRAK4. Ref.4
Sequence similarities	Belongs to the pellino family.

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Ontologies

Keywords
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
IRAK1	P51617	2	EBI-448407,EBI-358664
IRAK4	Q9NWZ3	2	EBI-448407,EBI-448378

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 420

420

Protein pellino homolog 2

PRO_0000194174

Amino acid modifications

Modified residue

176

N6-acetyllysine Ref.5

Secondary structure

420

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9HAT8-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2FC5E661C13BC11A
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FASTA

420

46,435

        10         20         30         40         50         60 
MFSPGQEEHC APNKEPVKYG ELVVLGYNGA LPNGDRGRRK SRFALYKRPK ANGVKPSTVH 

        70         80         90        100        110        120 
VISTPQASKA ISCKGQHSIS YTLSRNQTVV VEYTHDKDTD MFQVGRSTES PIDFVVTDTI 

       130        140        150        160        170        180 
SGSQNTDEAQ ITQSTISRFA CRIVCDRNEP YTARIFAAGF DSSKNIFLGE KAAKWKNPDG 

       190        200        210        220        230        240 
HMDGLTTNGV LVMHPRGGFT EESQPGVWRE ISVCGDVYTL RETRSAQQRG KLVESETNVL 

       250        260        270        280        290        300 
QDGSLIDLCG ATLLWRTADG LFHTPTQKHI EALRQEINAA RPQCPVGLNT LAFPSINRKE 

       310        320        330        340        350        360 
VVEEKQPWAY LSCGHVHGYH NWGHRSDTEA NERECPMCRT VGPYVPLWLG CEAGFYVDAG 

       370        380        390        400        410        420 
PPTHAFTPCG HVCSEKSAKY WSQIPLPHGT HAFHAACPFC ATQLVGEQNC IKLIFQGPID

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping." Resch K., Jockusch H., Schmitt-John T. Cytogenet. Cell Genet. 92:172-174(2001) [PubMed: 11306823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Pellino2 activates the mitogen activated protein kinase pathway." Jensen L.E., Whitehead A.S. FEBS Lett. 545:199-202(2003) [PubMed: 12804775] [Abstract] Cited for: FUNCTION, INTERACTION WITH TRAF6 AND MAP3K7.
[4]	"Characterization of Pellino2, a substrate of IRAK1 and IRAK4." Strelow A., Kollewe C., Wesche H. FEBS Lett. 547:157-161(2003) [PubMed: 12860405] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH IRAK1 AND IRAK4.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-176, MASS SPECTROMETRY.

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Cross-references

Sequence databases

AF302502 mRNA. Translation: AAG15390.1.
BC009476 mRNA. Translation: AAH09476.1.

IPI

IPI00009753.

RefSeq

NP_067078.1.

UniGene

Hs.657926

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EGA	X-ray	1.80	A	15-275	[»]
3EGB	X-ray	3.25	A/B	7-289	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HAT8. 3 interactions.

STRING

Q9HAT8.

PTM databases

PhosphoSite

Q9HAT8.

Proteomic databases

PRIDE

Q9HAT8.

Genome annotation databases

Ensembl

ENST00000267460; ENSP00000267460; ENSG00000139946; Homo sapiens. [Genome view]

GeneID

57161.

KEGG

hsa:57161.

UCSC

uc001xch.1. human.

Organism-specific databases

CTD

57161.

GeneCards

GC14P055654.

H-InvDB

HIX0011690.

HGNC

HGNC:8828. PELI2.

PharmGKB

PA33173.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9HAT8.

HOVERGEN

Q9HAT8.

OMA

DGLFHAP

OrthoDB

EOG90ZTH5

Gene expression databases

ArrayExpress

Q9HAT8.

Bgee

Q9HAT8.

CleanEx

HS_PELI2.

Genevestigator

Q9HAT8.

GermOnline

ENSG00000139946. Homo sapiens.

Family and domain databases

InterPro

IPR006800. Pellino.
[Graphical view]

PANTHER

PTHR12098:SF2. Pellino. 1 hit.

Pfam

PF04710. Pellino. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

63165.

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Entry information

Entry name

PELI2_HUMAN

Accession

Primary (citable) accession number: Q9HAT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents