Reviewed,
UniProtKB/Swiss-Prot Q9HAT8 (PELI2_HUMAN)
Last modified
November 24, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein pellino homolog 2 Short name=Pellino-2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 420 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Scaffold protein which probably links Toll-like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK kinases and TRAF6. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Ref.3 Ref.4 |
| Subunit structure | |
| Post-translational modification | Phosphorylated by IRAK1 and IRAK4. Ref.4 |
| Sequence similarities | Belongs to the pellino family. |
Ontologies
| Keywords | |
|---|---|
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | protein binding Ref.4 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| IRAK1 | P51617 | 2 | EBI-448407,EBI-358664 | |
| IRAK4 | Q9NWZ3 | 2 | EBI-448407,EBI-448378 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 420 | 420 | Protein pellino homolog 2 | PRO_0000194174 | |||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||
| Modified residue | 176 | 1 | N6-acetyllysine Ref.5 | ||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||
| Beta strand | 22 – 24 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 41 – 43 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 55 – 63 | 9 | |||||||||||||||||||||||||||||||||
| Beta strand | 77 – 82 | 6 | |||||||||||||||||||||||||||||||||
| Beta strand | 84 – 94 | 11 | |||||||||||||||||||||||||||||||||
| Beta strand | 99 – 104 | 6 | |||||||||||||||||||||||||||||||||
| Beta strand | 138 – 148 | 11 | |||||||||||||||||||||||||||||||||
| Beta strand | 153 – 157 | 5 | |||||||||||||||||||||||||||||||||
| Beta strand | 164 – 168 | 5 | |||||||||||||||||||||||||||||||||
| Beta strand | 191 – 193 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 208 – 211 | 4 | |||||||||||||||||||||||||||||||||
| Beta strand | 245 – 247 | 3 | |||||||||||||||||||||||||||||||||
| Beta strand | 252 – 255 | 4 | |||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping." Resch K., Jockusch H., Schmitt-John T. Cytogenet. Cell Genet. 92:172-174(2001) [PubMed: 11306823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [3] | "Pellino2 activates the mitogen activated protein kinase pathway." Jensen L.E., Whitehead A.S. FEBS Lett. 545:199-202(2003) [PubMed: 12804775] [Abstract] Cited for: FUNCTION, INTERACTION WITH TRAF6 AND MAP3K7. |
| [4] | "Characterization of Pellino2, a substrate of IRAK1 and IRAK4." Strelow A., Kollewe C., Wesche H. FEBS Lett. 547:157-161(2003) [PubMed: 12860405] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH IRAK1 AND IRAK4. |
| [5] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-176, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF302502 mRNA. Translation: AAG15390.1. BC009476 mRNA. Translation: AAH09476.1. | |||||||||||||||||||
| IPI | IPI00009753. | ||||||||||||||||||
| RefSeq | NP_067078.1. | ||||||||||||||||||
| UniGene | Hs.657926 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| |||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | Q9HAT8. 3 interactions. | ||||||||||||||||||
| STRING | Q9HAT8. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q9HAT8. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q9HAT8. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000267460; ENSP00000267460; ENSG00000139946; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 57161. | ||||||||||||||||||
| KEGG | hsa:57161. | ||||||||||||||||||
| UCSC | uc001xch.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 57161. | ||||||||||||||||||
| GeneCards | GC14P055654. | ||||||||||||||||||
| H-InvDB | HIX0011690. | ||||||||||||||||||
| HGNC | HGNC:8828. PELI2. | ||||||||||||||||||
| PharmGKB | PA33173. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | Q9HAT8. | ||||||||||||||||||
| HOVERGEN | Q9HAT8. | ||||||||||||||||||
| OMA | DGLFHAP | ||||||||||||||||||
| OrthoDB | EOG90ZTH5 | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q9HAT8. | ||||||||||||||||||
| Bgee | Q9HAT8. | ||||||||||||||||||
| CleanEx | HS_PELI2. | ||||||||||||||||||
| Genevestigator | Q9HAT8. | ||||||||||||||||||
| GermOnline | ENSG00000139946. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR006800. Pellino. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR12098:SF2. Pellino. 1 hit. | ||||||||||||||||||
| Pfam | PF04710. Pellino. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 63165. | ||||||||||||||||||
Entry information
| Entry name | PELI2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9HAT8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


