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Protein

Protein ERGIC-53-like

Gene

LMAN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERGIC-53-like
Alternative name(s):
ERGIC53-like protein
Lectin mannose-binding 1-like
Short name:
LMAN1-like protein
Gene namesi
Name:LMAN1L
Synonyms:ERGL
ORF Names:UNQ2784/PRO7174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140506.16.
HGNCiHGNC:6632. LMAN1L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 462LumenalSequence analysisAdd BLAST437
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 526CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79748.
OpenTargetsiENSG00000140506.
PharmGKBiPA30400.

Polymorphism and mutation databases

BioMutaiLMAN1L.
DMDMi61252672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001766326 – 526Protein ERGIC-53-likeAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi176 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HAT1.
PeptideAtlasiQ9HAT1.
PRIDEiQ9HAT1.

PTM databases

iPTMnetiQ9HAT1.
PhosphoSitePlusiQ9HAT1.

Expressioni

Tissue specificityi

Highly expressed in normal and neoplastic prostate. Also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS.1 Publication

Gene expression databases

BgeeiENSG00000140506.
CleanExiHS_LMAN1L.
ExpressionAtlasiQ9HAT1. baseline and differential.
GenevisibleiQ9HAT1. HS.

Interactioni

Protein-protein interaction databases

IntActiQ9HAT1. 1 interactor.
STRINGi9606.ENSP00000310431.

Structurei

3D structure databases

ProteinModelPortaliQ9HAT1.
SMRiQ9HAT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 252L-type lectin-likePROSITE-ProRule annotationAdd BLAST222

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3838. Eukaryota.
ENOG410ZFRX. LUCA.
GeneTreeiENSGT00530000062977.
HOGENOMiHOG000017354.
HOVERGENiHBG099863.
InParanoidiQ9HAT1.
KOiK10081.
OMAiPFWSHHG.
OrthoDBiEOG091G08WZ.
PhylomeDBiQ9HAT1.
TreeFamiTF313311.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR005052. Lectin_leg.
PfamiView protein in Pfam
PF03388. Lectin_leg-like. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51328. L_LECTIN_LIKE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAVSGPGPL FCLLLLLLDP HSPETGCPPL RRFEYKLSFK GPRLALPGAG
60 70 80 90 100
IPFWSHHGDA ILGLEEVRLT PSMRNRSGAV WSRASVPFSA WEVEVQMRVT
110 120 130 140 150
GLGRRGAQGM AVWYTRGRGH VGSVLGGLAS WDGIGIFFDS PAEDTQDSPA
160 170 180 190 200
IRVLASDGHI PSEQPGDGAS QGLGSCHWDF RNRPHPFRAR ITYWGQRLRM
210 220 230 240 250
SLNSGLTPSD PGEFCVDVGP LLLVPGGFFG VSAATGTLAD DHDVLSFLTF
260 270 280 290 300
SLSEPSPEVP PQPFLEMQQL RLARQLEGLW ARLGLGTRED VTPKSDSEAQ
310 320 330 340 350
GEGERLFDLE ETLGRHRRIL QALRGLSKQL AQAERQWKKQ LGPPGQARPD
360 370 380 390 400
GGWALDASCQ IPSTPGRGGH LSMSLNKDSA KVGALLHGQW TLLQALQEMR
410 420 430 440 450
DAAVRMAAEA QVSYLPVGIE HHFLELDHIL GLLQEELRGP AKAAAKAPRP
460 470 480 490 500
PGQPPRASSC LQPGIFLFYL LIQTVGFFGY VHFRQELNKS LQECLSTGSL
510 520
PLGPAPHTPR ALGILRRQPL PASMPA
Length:526
Mass (Da):57,129
Last modified:March 15, 2005 - v2
Checksum:iB36B81827D219F9E
GO
Isoform 2 (identifier: Q9HAT1-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q9HAT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-258: DDHDVLSFLTFSLSEPSPE → GEDPTGQ

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):55,697
Checksum:i61255B279D2DBDD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → H in AAG30902 (PubMed:11255007).Curated1
Sequence conflicti186P → S in AAQ89086 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049771105R → Q. Corresponds to variant dbSNP:rs3803568Ensembl.1
Natural variantiVAR_049772517R → S. Corresponds to variant dbSNP:rs1060480Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013143240 – 258DDHDV…EPSPE → GEDPTGQ in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303398 mRNA. Translation: AAG30902.1.
AY358724 mRNA. Translation: AAQ89086.1.
CCDSiCCDS10270.1. [Q9HAT1-1]
RefSeqiNP_068591.2. NM_021819.2. [Q9HAT1-1]
UniGeneiHs.620644.

Genome annotation databases

EnsembliENST00000309664; ENSP00000310431; ENSG00000140506. [Q9HAT1-1]
ENST00000379709; ENSP00000369031; ENSG00000140506. [Q9HAT1-3]
GeneIDi79748.
KEGGihsa:79748.
UCSCiuc002ayt.2. human. [Q9HAT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLMA1L_HUMAN
AccessioniPrimary (citable) accession number: Q9HAT1
Secondary accession number(s): Q6UWN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 15, 2005
Last modified: November 22, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot