ID ROP1A_HUMAN Reviewed; 212 AA. AC Q9HAT0; D3DN99; Q9UF38; DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2001, sequence version 2. DT 27-MAR-2024, entry version 152. DE RecName: Full=Ropporin-1A; DE AltName: Full=Cancer/testis antigen 91; DE Short=CT91; DE AltName: Full=Rhophilin-associated protein 1A; GN Name=ROPN1; Synonyms=ROPN1A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Testis; RA Zhou Z.M., Li J.M., Sha J.H.; RT "Cloning of a human sperm-specific binding protein of rhophilin and RT function in spermatogenesis."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, RP AND IDENTIFICATION AS A CANCER/TESTIS ANTIGEN. RX PubMed=17551920; DOI=10.1002/ijc.22842; RA Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.; RT "A yeast two-hybrid system using Sp17 identified ropporin as a novel RT cancer-testis antigen in hematologic malignancies."; RL Int. J. Cancer 121:1507-1511(2007). CC -!- FUNCTION: Important for male fertility. With ROPN1L, involved in CC fibrous sheath integrity and sperm motility, plays a role in PKA- CC dependent signaling processes required for spermatozoa capacitation. CC {ECO:0000250|UniProtKB:Q9ESG2}. CC -!- SUBUNIT: Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May CC interact with SPA17 (PubMed:17551920). Interacts with FSCB; the CC interaction increases upon spermatozoa capacitation conditions (By CC similarity). Interacts with CFAP61 (By similarity). CC {ECO:0000250|UniProtKB:Q9BZX4, ECO:0000250|UniProtKB:Q9ESG2, CC ECO:0000269|PubMed:17551920}. CC -!- INTERACTION: CC Q9HAT0; P0CW23: AKAIN1; NbExp=3; IntAct=EBI-1378139, EBI-18397742; CC Q9HAT0; Q86UN6: AKAP14; NbExp=3; IntAct=EBI-1378139, EBI-2119626; CC Q9HAT0; P24588: AKAP5; NbExp=3; IntAct=EBI-1378139, EBI-703640; CC Q9HAT0; O43687-2: AKAP7; NbExp=9; IntAct=EBI-1378139, EBI-10185182; CC Q9HAT0; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-1378139, EBI-541426; CC Q9HAT0; Q32M84-2: BTBD16; NbExp=3; IntAct=EBI-1378139, EBI-11961432; CC Q9HAT0; Q16543: CDC37; NbExp=3; IntAct=EBI-1378139, EBI-295634; CC Q9HAT0; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-1378139, EBI-10181988; CC Q9HAT0; P61024: CKS1B; NbExp=6; IntAct=EBI-1378139, EBI-456371; CC Q9HAT0; Q6PJW8: CNST; NbExp=5; IntAct=EBI-1378139, EBI-750390; CC Q9HAT0; Q8NFT6-2: DBF4B; NbExp=6; IntAct=EBI-1378139, EBI-12205861; CC Q9HAT0; P19447: ERCC3; NbExp=3; IntAct=EBI-1378139, EBI-1183307; CC Q9HAT0; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-1378139, EBI-1752811; CC Q9HAT0; Q9UHL3: FAM153A; NbExp=3; IntAct=EBI-1378139, EBI-2834075; CC Q9HAT0; P0C7A2-2: FAM153B; NbExp=5; IntAct=EBI-1378139, EBI-12940382; CC Q9HAT0; Q3B820: FAM161A; NbExp=3; IntAct=EBI-1378139, EBI-719941; CC Q9HAT0; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1378139, EBI-6658203; CC Q9HAT0; Q9NVN8: GNL3L; NbExp=7; IntAct=EBI-1378139, EBI-746682; CC Q9HAT0; Q92917: GPKOW; NbExp=6; IntAct=EBI-1378139, EBI-746309; CC Q9HAT0; Q9BTB7: HNRPUL1; NbExp=3; IntAct=EBI-1378139, EBI-10298318; CC Q9HAT0; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-1378139, EBI-2805604; CC Q9HAT0; Q6PJI1: KIF9; NbExp=3; IntAct=EBI-1378139, EBI-10254090; CC Q9HAT0; Q96BZ8: LENG1; NbExp=8; IntAct=EBI-1378139, EBI-726510; CC Q9HAT0; P61968: LMO4; NbExp=3; IntAct=EBI-1378139, EBI-2798728; CC Q9HAT0; Q8TBB1: LNX1; NbExp=5; IntAct=EBI-1378139, EBI-739832; CC Q9HAT0; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-1378139, EBI-741158; CC Q9HAT0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1378139, EBI-79165; CC Q9HAT0; Q99959-2: PKP2; NbExp=3; IntAct=EBI-1378139, EBI-10987518; CC Q9HAT0; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-1378139, EBI-5452779; CC Q9HAT0; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-1378139, EBI-11320284; CC Q9HAT0; Q13131: PRKAA1; NbExp=4; IntAct=EBI-1378139, EBI-1181405; CC Q9HAT0; P25786: PSMA1; NbExp=6; IntAct=EBI-1378139, EBI-359352; CC Q9HAT0; Q9HAT0: ROPN1; NbExp=6; IntAct=EBI-1378139, EBI-1378139; CC Q9HAT0; Q14D33: RTP5; NbExp=6; IntAct=EBI-1378139, EBI-10217913; CC Q9HAT0; O00560: SDCBP; NbExp=6; IntAct=EBI-1378139, EBI-727004; CC Q9HAT0; Q53GC0: SERTAD1; NbExp=3; IntAct=EBI-1378139, EBI-2826300; CC Q9HAT0; O60504: SORBS3; NbExp=3; IntAct=EBI-1378139, EBI-741237; CC Q9HAT0; Q15506: SPA17; NbExp=9; IntAct=EBI-1378139, EBI-1377865; CC Q9HAT0; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-1378139, EBI-742688; CC Q9HAT0; Q96C24: SYTL4; NbExp=3; IntAct=EBI-1378139, EBI-747142; CC Q9HAT0; O75382: TRIM3; NbExp=3; IntAct=EBI-1378139, EBI-2129889; CC Q9HAT0; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1378139, EBI-10241197; CC Q9HAT0; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-1378139, EBI-9053916; CC Q9HAT0; O75386: TULP3; NbExp=3; IntAct=EBI-1378139, EBI-5357290; CC Q9HAT0; Q96B02: UBE2W; NbExp=3; IntAct=EBI-1378139, EBI-716589; CC Q9HAT0; Q96FI0: UBE2W; NbExp=3; IntAct=EBI-1378139, EBI-10285774; CC Q9HAT0; Q96AX1: VPS33A; NbExp=3; IntAct=EBI-1378139, EBI-2527283; CC Q9HAT0; B7ZMN2: XKR3; NbExp=3; IntAct=EBI-1378139, EBI-10176176; CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum CC {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the CC principal piece and in the cytoplasmic droplet located at the distal CC end of the midpiece. Inner surface of the fibrous sheath. CC {ECO:0000250|UniProtKB:Q9ESG2}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9HAT0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9HAT0-2; Sequence=VSP_028743, VSP_028744; CC -!- TISSUE SPECIFICITY: Testis specific in adult. Overexpressed in CC hematologic tumor cells. {ECO:0000269|PubMed:17551920}. CC -!- DEVELOPMENTAL STAGE: Expressed in fetal liver. CC {ECO:0000269|PubMed:17551920}. CC -!- DOMAIN: The RIIa domain mediates interaction with AKAP3. {ECO:0000250}. CC -!- PTM: Sumoylated, sumoylation decreases upon spermatozoa capacitation CC conditions. {ECO:0000250|UniProtKB:Q9ESG2}. CC -!- MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which CC means 'tail'. CC -!- SIMILARITY: Belongs to the ropporin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF303889; AAG27712.2; -; mRNA. DR EMBL; AL133624; CAB63750.2; -; mRNA. DR EMBL; CH471052; EAW79425.1; -; Genomic_DNA. DR EMBL; CH471052; EAW79426.1; -; Genomic_DNA. DR EMBL; CH471052; EAW79427.1; -; Genomic_DNA. DR EMBL; BC132744; AAI32745.1; -; mRNA. DR EMBL; BC132746; AAI32747.1; -; mRNA. DR CCDS; CCDS3026.1; -. [Q9HAT0-1] DR RefSeq; NP_001304703.1; NM_001317774.1. [Q9HAT0-1] DR RefSeq; NP_060048.2; NM_017578.3. [Q9HAT0-1] DR RefSeq; XP_011511235.1; XM_011512933.2. DR RefSeq; XP_011511236.1; XM_011512934.2. DR AlphaFoldDB; Q9HAT0; -. DR SMR; Q9HAT0; -. DR BioGRID; 120138; 62. DR IntAct; Q9HAT0; 56. DR MINT; Q9HAT0; -. DR STRING; 9606.ENSP00000184183; -. DR iPTMnet; Q9HAT0; -. DR PhosphoSitePlus; Q9HAT0; -. DR BioMuta; ROPN1; -. DR DMDM; 74718687; -. DR MassIVE; Q9HAT0; -. DR PaxDb; 9606-ENSP00000184183; -. DR PeptideAtlas; Q9HAT0; -. DR ProteomicsDB; 81425; -. [Q9HAT0-1] DR ProteomicsDB; 81426; -. [Q9HAT0-2] DR Antibodypedia; 32969; 61 antibodies from 15 providers. DR DNASU; 54763; -. DR Ensembl; ENST00000184183.8; ENSP00000184183.4; ENSG00000065371.18. [Q9HAT0-1] DR Ensembl; ENST00000405845.8; ENSP00000385919.3; ENSG00000065371.18. [Q9HAT0-1] DR Ensembl; ENST00000459660.5; ENSP00000420590.1; ENSG00000065371.18. [Q9HAT0-2] DR Ensembl; ENST00000479867.1; ENSP00000420567.1; ENSG00000065371.18. [Q9HAT0-2] DR Ensembl; ENST00000484329.1; ENSP00000419205.1; ENSG00000065371.18. [Q9HAT0-2] DR Ensembl; ENST00000495093.1; ENSP00000417379.1; ENSG00000065371.18. [Q9HAT0-2] DR Ensembl; ENST00000620893.4; ENSP00000483603.1; ENSG00000065371.18. [Q9HAT0-1] DR GeneID; 54763; -. DR KEGG; hsa:54763; -. DR MANE-Select; ENST00000405845.8; ENSP00000385919.3; NM_001317774.2; NP_001304703.1. DR UCSC; uc003eha.4; human. [Q9HAT0-1] DR AGR; HGNC:17692; -. DR CTD; 54763; -. DR DisGeNET; 54763; -. DR GeneCards; ROPN1; -. DR HGNC; HGNC:17692; ROPN1. DR HPA; ENSG00000065371; Tissue enriched (testis). DR neXtProt; NX_Q9HAT0; -. DR OpenTargets; ENSG00000065371; -. DR PharmGKB; PA134952827; -. DR VEuPathDB; HostDB:ENSG00000065371; -. DR eggNOG; ENOG502R2JI; Eukaryota. DR GeneTree; ENSGT00390000012731; -. DR HOGENOM; CLU_069829_1_0_1; -. DR InParanoid; Q9HAT0; -. DR OMA; TNKQICI; -. DR OrthoDB; 1332598at2759; -. DR PhylomeDB; Q9HAT0; -. DR TreeFam; TF105421; -. DR PathwayCommons; Q9HAT0; -. DR Reactome; R-HSA-5666185; RHO GTPases Activate Rhotekin and Rhophilins. DR SignaLink; Q9HAT0; -. DR BioGRID-ORCS; 54763; 18 hits in 1096 CRISPR screens. DR GenomeRNAi; 54763; -. DR Pharos; Q9HAT0; Tbio. DR PRO; PR:Q9HAT0; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q9HAT0; Protein. DR Bgee; ENSG00000065371; Expressed in sperm and 84 other cell types or tissues. DR ExpressionAtlas; Q9HAT0; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL. DR GO; GO:0031514; C:motile cilium; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; HDA:UniProtKB. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0044782; P:cilium organization; ISS:UniProtKB. DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB. DR GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB. DR GO; GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB. DR GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB. DR CDD; cd23019; DD_ROP; 1. DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1. DR InterPro; IPR047844; ROP_DD. DR PANTHER; PTHR14952; ROPPORIN-1-LIKE PROTEIN; 1. DR PANTHER; PTHR14952:SF18; ROPPORIN-1A; 1. DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1. DR Genevisible; Q9HAT0; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell projection; Cilium; Flagellum; Phosphoprotein; KW Reference proteome; Ubl conjugation. FT CHAIN 1..212 FT /note="Ropporin-1A" FT /id="PRO_0000307392" FT DOMAIN 12..49 FT /note="RIIa" FT REGION 209..212 FT /note="Interaction with RHPN1" FT /evidence="ECO:0000250" FT MOD_RES 56 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q4KLL5" FT VAR_SEQ 39..58 FT /note="DYFEALSRGETPPVRERSER -> EYVLLSRLHPLEDGRRQRVL (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_028743" FT VAR_SEQ 59..212 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_028744" SQ SEQUENCE 212 AA; 23893 MW; B50D2859B464F6CC CRC64; MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV NDFTQNPRVQ LE //