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Q9HAT0 (ROP1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ropporin-1A
Alternative name(s):
Cancer/testis antigen 91
Short name=CT91
Rhophilin-associated protein 1A
Gene names
Name:ROPN1
Synonyms:ROPN1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer. Interacts with AKAP3 and RHPN1 By similarity. May interact with SPA17. Ref.5

Subcellular location

Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath By similarity.

Tissue specificity

Testis specific in adult. Overexpressed in hematologic tumor cells. Ref.5

Developmental stage

Expressed in fetal liver. Ref.5

Domain

The RIIa domain mediates interaction with AKAP3 By similarity.

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

Sequence similarities

Belongs to the ropporin family.

Contains 1 RIIa domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay PubMed 18421703. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 21630459. Source: UniProt

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HAT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HAT0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Ropporin-1A
PRO_0000307392

Regions

Domain12 – 4938RIIa
Region209 – 2124Interaction with RHPN1 By similarity

Natural variations

Alternative sequence39 – 5820DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2.
VSP_028743
Alternative sequence59 – 212154Missing in isoform 2.
VSP_028744

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: B50D2859B464F6CC

FASTA21223,893
        10         20         30         40         50         60 
MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP PVRERSERVA 

        70         80         90        100        110        120 
LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP TDLFNSVMNV GRFTEEIEWL 

       130        140        150        160        170        180 
KFLALACSAL GVTITKTLKI VCEVLSCDHN GGSPRIPFST FQFLYTYIAK VDGEISASHV 

       190        200        210 
SRMLNYMEQE VIGPDGIITV NDFTQNPRVQ LE 

« Hide

Isoform 2 [UniParc].

Checksum: EC21C285B271B063
Show »

FASTA586,711

References

« Hide 'large scale' references
[1]"Cloning of a human sperm-specific binding protein of rhophilin and function in spermatogenesis."
Zhou Z.M., Li J.M., Sha J.H.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.
Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303889 mRNA. Translation: AAG27712.2.
AL133624 mRNA. Translation: CAB63750.2.
CH471052 Genomic DNA. Translation: EAW79425.1.
CH471052 Genomic DNA. Translation: EAW79426.1.
CH471052 Genomic DNA. Translation: EAW79427.1.
BC132744 mRNA. Translation: AAI32745.1.
BC132746 mRNA. Translation: AAI32747.1.
CCDSCCDS3026.1. [Q9HAT0-1]
RefSeqNP_060048.2. NM_017578.2. [Q9HAT0-1]
XP_005247606.1. XM_005247549.1. [Q9HAT0-1]
UniGeneHs.567516.
Hs.733553.

3D structure databases

ProteinModelPortalQ9HAT0.
SMRQ9HAT0. Positions 10-46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120138. 1 interaction.
IntActQ9HAT0. 1 interaction.
STRING9606.ENSP00000184183.

PTM databases

PhosphoSiteQ9HAT0.

Polymorphism databases

DMDM74718687.

Proteomic databases

PaxDbQ9HAT0.
PRIDEQ9HAT0.

Protocols and materials databases

DNASU54763.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000184183; ENSP00000184183; ENSG00000065371. [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371. [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371. [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371. [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371. [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371. [Q9HAT0-2]
GeneID54763.
KEGGhsa:54763.
UCSCuc003eha.3. human. [Q9HAT0-1]

Organism-specific databases

CTD54763.
GeneCardsGC03M123636.
HGNCHGNC:17692. ROPN1.
HPACAB014875.
HPA052530.
neXtProtNX_Q9HAT0.
PharmGKBPA134952827.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38881.
HOGENOMHOG000006862.
HOVERGENHBG060390.
InParanoidQ9HAT0.
OMALIICAEE.
OrthoDBEOG70ZZP6.
PhylomeDBQ9HAT0.
TreeFamTF105421.

Gene expression databases

ArrayExpressQ9HAT0.
BgeeQ9HAT0.
CleanExHS_ROPN1.
GenevestigatorQ9HAT0.

Family and domain databases

InterProIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMSSF47391. SSF47391. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi54763.
NextBio57401.
PROQ9HAT0.

Entry information

Entry nameROP1A_HUMAN
AccessionPrimary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM