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Q9HAT0

- ROP1A_HUMAN

UniProt

Q9HAT0 - ROP1A_HUMAN

Protein

Ropporin-1A

Gene

ROPN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ropporin-1A
    Alternative name(s):
    Cancer/testis antigen 91
    Short name:
    CT91
    Rhophilin-associated protein 1A
    Gene namesi
    Name:ROPN1
    Synonyms:ROPN1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17692. ROPN1.

    Subcellular locationi


    Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134952827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Ropporin-1APRO_0000307392Add
    BLAST

    Proteomic databases

    PaxDbiQ9HAT0.
    PRIDEiQ9HAT0.

    PTM databases

    PhosphoSiteiQ9HAT0.

    Expressioni

    Tissue specificityi

    Testis specific in adult. Overexpressed in hematologic tumor cells.1 Publication

    Developmental stagei

    Expressed in fetal liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9HAT0.
    BgeeiQ9HAT0.
    CleanExiHS_ROPN1.
    GenevestigatoriQ9HAT0.

    Organism-specific databases

    HPAiCAB014875.
    HPA052530.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with AKAP3 and RHPN1 By similarity. May interact with SPA17.By similarity

    Protein-protein interaction databases

    BioGridi120138. 1 interaction.
    IntActiQ9HAT0. 1 interaction.
    STRINGi9606.ENSP00000184183.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HAT0.
    SMRiQ9HAT0. Positions 10-46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4938RIIaAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni209 – 2124Interaction with RHPN1By similarity

    Domaini

    The RIIa domain mediates interaction with AKAP3.By similarity

    Sequence similaritiesi

    Belongs to the ropporin family.Curated
    Contains 1 RIIa domain.Curated

    Phylogenomic databases

    eggNOGiNOG38881.
    HOGENOMiHOG000006862.
    HOVERGENiHBG060390.
    InParanoidiQ9HAT0.
    OMAiLIICAEE.
    OrthoDBiEOG70ZZP6.
    PhylomeDBiQ9HAT0.
    TreeFamiTF105421.

    Family and domain databases

    InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
    [Graphical view]
    SUPFAMiSSF47391. SSF47391. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HAT0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP    50
    PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP 100
    TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN 150
    GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV 200
    NDFTQNPRVQ LE 212
    Length:212
    Mass (Da):23,893
    Last modified:October 1, 2001 - v2
    Checksum:iB50D2859B464F6CC
    GO
    Isoform 2 (identifier: Q9HAT0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
         59-212: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:58
    Mass (Da):6,711
    Checksum:iEC21C285B271B063
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 5820DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2. 1 PublicationVSP_028743Add
    BLAST
    Alternative sequencei59 – 212154Missing in isoform 2. 1 PublicationVSP_028744Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303889 mRNA. Translation: AAG27712.2.
    AL133624 mRNA. Translation: CAB63750.2.
    CH471052 Genomic DNA. Translation: EAW79425.1.
    CH471052 Genomic DNA. Translation: EAW79426.1.
    CH471052 Genomic DNA. Translation: EAW79427.1.
    BC132744 mRNA. Translation: AAI32745.1.
    BC132746 mRNA. Translation: AAI32747.1.
    CCDSiCCDS3026.1. [Q9HAT0-1]
    RefSeqiNP_060048.2. NM_017578.2. [Q9HAT0-1]
    XP_005247606.1. XM_005247549.1. [Q9HAT0-1]
    UniGeneiHs.567516.
    Hs.733553.

    Genome annotation databases

    EnsembliENST00000184183; ENSP00000184183; ENSG00000065371. [Q9HAT0-1]
    ENST00000405845; ENSP00000385919; ENSG00000065371. [Q9HAT0-1]
    ENST00000459660; ENSP00000420590; ENSG00000065371. [Q9HAT0-2]
    ENST00000479867; ENSP00000420567; ENSG00000065371. [Q9HAT0-2]
    ENST00000484329; ENSP00000419205; ENSG00000065371. [Q9HAT0-2]
    ENST00000495093; ENSP00000417379; ENSG00000065371. [Q9HAT0-2]
    GeneIDi54763.
    KEGGihsa:54763.
    UCSCiuc003eha.3. human. [Q9HAT0-1]

    Polymorphism databases

    DMDMi74718687.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303889 mRNA. Translation: AAG27712.2 .
    AL133624 mRNA. Translation: CAB63750.2 .
    CH471052 Genomic DNA. Translation: EAW79425.1 .
    CH471052 Genomic DNA. Translation: EAW79426.1 .
    CH471052 Genomic DNA. Translation: EAW79427.1 .
    BC132744 mRNA. Translation: AAI32745.1 .
    BC132746 mRNA. Translation: AAI32747.1 .
    CCDSi CCDS3026.1. [Q9HAT0-1 ]
    RefSeqi NP_060048.2. NM_017578.2. [Q9HAT0-1 ]
    XP_005247606.1. XM_005247549.1. [Q9HAT0-1 ]
    UniGenei Hs.567516.
    Hs.733553.

    3D structure databases

    ProteinModelPortali Q9HAT0.
    SMRi Q9HAT0. Positions 10-46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120138. 1 interaction.
    IntActi Q9HAT0. 1 interaction.
    STRINGi 9606.ENSP00000184183.

    PTM databases

    PhosphoSitei Q9HAT0.

    Polymorphism databases

    DMDMi 74718687.

    Proteomic databases

    PaxDbi Q9HAT0.
    PRIDEi Q9HAT0.

    Protocols and materials databases

    DNASUi 54763.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000184183 ; ENSP00000184183 ; ENSG00000065371 . [Q9HAT0-1 ]
    ENST00000405845 ; ENSP00000385919 ; ENSG00000065371 . [Q9HAT0-1 ]
    ENST00000459660 ; ENSP00000420590 ; ENSG00000065371 . [Q9HAT0-2 ]
    ENST00000479867 ; ENSP00000420567 ; ENSG00000065371 . [Q9HAT0-2 ]
    ENST00000484329 ; ENSP00000419205 ; ENSG00000065371 . [Q9HAT0-2 ]
    ENST00000495093 ; ENSP00000417379 ; ENSG00000065371 . [Q9HAT0-2 ]
    GeneIDi 54763.
    KEGGi hsa:54763.
    UCSCi uc003eha.3. human. [Q9HAT0-1 ]

    Organism-specific databases

    CTDi 54763.
    GeneCardsi GC03M123636.
    HGNCi HGNC:17692. ROPN1.
    HPAi CAB014875.
    HPA052530.
    neXtProti NX_Q9HAT0.
    PharmGKBi PA134952827.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38881.
    HOGENOMi HOG000006862.
    HOVERGENi HBG060390.
    InParanoidi Q9HAT0.
    OMAi LIICAEE.
    OrthoDBi EOG70ZZP6.
    PhylomeDBi Q9HAT0.
    TreeFami TF105421.

    Miscellaneous databases

    GenomeRNAii 54763.
    NextBioi 57401.
    PROi Q9HAT0.

    Gene expression databases

    ArrayExpressi Q9HAT0.
    Bgeei Q9HAT0.
    CleanExi HS_ROPN1.
    Genevestigatori Q9HAT0.

    Family and domain databases

    InterProi IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
    [Graphical view ]
    SUPFAMi SSF47391. SSF47391. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human sperm-specific binding protein of rhophilin and function in spermatogenesis."
      Zhou Z.M., Li J.M., Sha J.H.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
      Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.
      Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

    Entry informationi

    Entry nameiROP1A_HUMAN
    AccessioniPrimary (citable) accession number: Q9HAT0
    Secondary accession number(s): D3DN99, Q9UF38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3