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Protein

Ropporin-1A

Gene

ROPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_355021. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1A
Alternative name(s):
Cancer/testis antigen 91
Short name:
CT91
Rhophilin-associated protein 1A
Gene namesi
Name:ROPN1
Synonyms:ROPN1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17692. ROPN1.

Subcellular locationi


    Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952827.

Polymorphism and mutation databases

BioMutaiROPN1.
DMDMi74718687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ropporin-1APRO_0000307392Add
BLAST

Proteomic databases

PaxDbiQ9HAT0.
PRIDEiQ9HAT0.

PTM databases

PhosphoSiteiQ9HAT0.

Expressioni

Tissue specificityi

Testis specific in adult. Overexpressed in hematologic tumor cells.1 Publication

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiQ9HAT0.
CleanExiHS_ROPN1.
ExpressionAtlasiQ9HAT0. baseline and differential.
GenevisibleiQ9HAT0. HS.

Organism-specific databases

HPAiCAB014875.
HPA052530.

Interactioni

Subunit structurei

Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP7O43687-23EBI-1378139,EBI-10185182
CEP57L1Q8IYX8-23EBI-1378139,EBI-10181988
CKS1BP610243EBI-1378139,EBI-456371
CNSTQ6PJW83EBI-1378139,EBI-750390
GNL3LQ9NVN83EBI-1378139,EBI-746682
GPKOWQ929173EBI-1378139,EBI-746309
HNRPUL1Q9BTB73EBI-1378139,EBI-10298318
KIF9Q6PJI13EBI-1378139,EBI-10254090
LENG1Q96BZ83EBI-1378139,EBI-726510
LNX1Q8TBB13EBI-1378139,EBI-739832
POLR3CQ9BUI43EBI-1378139,EBI-5452779
PRKAA1Q131313EBI-1378139,EBI-1181405
PSMA1P257863EBI-1378139,EBI-359352
RTP5Q14D333EBI-1378139,EBI-10217913
SDCBPO005603EBI-1378139,EBI-727004
SERTAD1Q53GC03EBI-1378139,EBI-2826300
SPA17Q155066EBI-1378139,EBI-1377865
TULP3O753863EBI-1378139,EBI-5357290
UBE2WQ96B023EBI-1378139,EBI-716589
UBE2WQ96FI03EBI-1378139,EBI-10285774
XKR3B7ZMN23EBI-1378139,EBI-10176176

Protein-protein interaction databases

BioGridi120138. 22 interactions.
IntActiQ9HAT0. 21 interactions.
STRINGi9606.ENSP00000184183.

Structurei

3D structure databases

ProteinModelPortaliQ9HAT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4938RIIaAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2124Interaction with RHPN1By similarity

Domaini

The RIIa domain mediates interaction with AKAP3.By similarity

Sequence similaritiesi

Belongs to the ropporin family.Curated
Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiNOG38881.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9HAT0.
OMAiRLIICAE.
OrthoDBiEOG70ZZP6.
PhylomeDBiQ9HAT0.
TreeFamiTF105421.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV
210
NDFTQNPRVQ LE
Length:212
Mass (Da):23,893
Last modified:October 1, 2001 - v2
Checksum:iB50D2859B464F6CC
GO
Isoform 2 (identifier: Q9HAT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.

Note: No experimental confirmation available.
Show »
Length:58
Mass (Da):6,711
Checksum:iEC21C285B271B063
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 5820DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2. 1 PublicationVSP_028743Add
BLAST
Alternative sequencei59 – 212154Missing in isoform 2. 1 PublicationVSP_028744Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303889 mRNA. Translation: AAG27712.2.
AL133624 mRNA. Translation: CAB63750.2.
CH471052 Genomic DNA. Translation: EAW79425.1.
CH471052 Genomic DNA. Translation: EAW79426.1.
CH471052 Genomic DNA. Translation: EAW79427.1.
BC132744 mRNA. Translation: AAI32745.1.
BC132746 mRNA. Translation: AAI32747.1.
CCDSiCCDS3026.1. [Q9HAT0-1]
RefSeqiNP_060048.2. NM_017578.2. [Q9HAT0-1]
XP_005247606.1. XM_005247549.2. [Q9HAT0-1]
UniGeneiHs.567516.
Hs.733553.

Genome annotation databases

EnsembliENST00000184183; ENSP00000184183; ENSG00000065371. [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371. [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371. [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371. [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371. [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371. [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371. [Q9HAT0-1]
GeneIDi54763.
KEGGihsa:54763.
UCSCiuc003eha.3. human. [Q9HAT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303889 mRNA. Translation: AAG27712.2.
AL133624 mRNA. Translation: CAB63750.2.
CH471052 Genomic DNA. Translation: EAW79425.1.
CH471052 Genomic DNA. Translation: EAW79426.1.
CH471052 Genomic DNA. Translation: EAW79427.1.
BC132744 mRNA. Translation: AAI32745.1.
BC132746 mRNA. Translation: AAI32747.1.
CCDSiCCDS3026.1. [Q9HAT0-1]
RefSeqiNP_060048.2. NM_017578.2. [Q9HAT0-1]
XP_005247606.1. XM_005247549.2. [Q9HAT0-1]
UniGeneiHs.567516.
Hs.733553.

3D structure databases

ProteinModelPortaliQ9HAT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120138. 22 interactions.
IntActiQ9HAT0. 21 interactions.
STRINGi9606.ENSP00000184183.

PTM databases

PhosphoSiteiQ9HAT0.

Polymorphism and mutation databases

BioMutaiROPN1.
DMDMi74718687.

Proteomic databases

PaxDbiQ9HAT0.
PRIDEiQ9HAT0.

Protocols and materials databases

DNASUi54763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000184183; ENSP00000184183; ENSG00000065371. [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371. [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371. [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371. [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371. [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371. [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371. [Q9HAT0-1]
GeneIDi54763.
KEGGihsa:54763.
UCSCiuc003eha.3. human. [Q9HAT0-1]

Organism-specific databases

CTDi54763.
GeneCardsiGC03M123636.
HGNCiHGNC:17692. ROPN1.
HPAiCAB014875.
HPA052530.
neXtProtiNX_Q9HAT0.
PharmGKBiPA134952827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG38881.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9HAT0.
OMAiRLIICAE.
OrthoDBiEOG70ZZP6.
PhylomeDBiQ9HAT0.
TreeFamiTF105421.

Enzyme and pathway databases

ReactomeiREACT_355021. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

ChiTaRSiROPN1. human.
GenomeRNAii54763.
NextBioi57401.
PROiQ9HAT0.

Gene expression databases

BgeeiQ9HAT0.
CleanExiHS_ROPN1.
ExpressionAtlasiQ9HAT0. baseline and differential.
GenevisibleiQ9HAT0. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human sperm-specific binding protein of rhophilin and function in spermatogenesis."
    Zhou Z.M., Li J.M., Sha J.H.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
    Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.
    Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Entry informationi

Entry nameiROP1A_HUMAN
AccessioniPrimary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2001
Last modified: June 24, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.