Q9HAT0 (ROP1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ropporin-1A

Alternative name(s):
Cancer/testis antigen 91
Short name=CT91
Rhophilin-associated protein 1A

Gene names

Name:	ROPN1
Synonyms:	ROPN1A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer. Interacts with AKAP3 and RHPN1 By similarity. May interact with SPA17. Ref.5
Subcellular location	Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath By similarity.
Tissue specificity	Testis specific in adult. Overexpressed in hematologic tumor cells. Ref.5
Developmental stage	Expressed in fetal liver. Ref.5
Domain	The RIIa domain mediates interaction with AKAP3 By similarity.
Miscellaneous	'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.
Sequence similarities	Belongs to the ropporin family. Contains 1 RIIa domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	cAMP-dependent protein kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HAT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HAT0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Ropporin-1A		PRO_0000307392
Regions
	Domain	12 – 49	38	RIIa
	Region	209 – 212	4	Interaction with RHPN1 By similarity
Natural variations
	Alternative sequence	39 – 58	20	DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2.		VSP_028743
	Alternative sequence	59 – 212	154	Missing in isoform 2.		VSP_028744

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: B50D2859B464F6CC	FASTA	212	23,893
	10 20 30 40 50 60 MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP PVRERSERVA 70 80 90 100 110 120 LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP TDLFNSVMNV GRFTEEIEWL 130 140 150 160 170 180 KFLALACSAL GVTITKTLKI VCEVLSCDHN GGSPRIPFST FQFLYTYIAK VDGEISASHV 190 200 210 SRMLNYMEQE VIGPDGIITV NDFTQNPRVQ LE
	Isoform 2 [UniParc]. Checksum: EC21C285B271B063	FASTA	58	6,711
	10 20 30 40 50 MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAAEY VLLSRLHPLE DGRRQRVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a human sperm-specific binding protein of rhophilin and function in spermatogenesis." Zhou Z.M., Li J.M., Sha J.H. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies." Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H. Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303889 mRNA. Translation: AAG27712.2. AL133624 mRNA. Translation: CAB63750.2. CH471052 Genomic DNA. Translation: EAW79425.1. CH471052 Genomic DNA. Translation: EAW79426.1. CH471052 Genomic DNA. Translation: EAW79427.1. BC132744 mRNA. Translation: AAI32745.1. BC132746 mRNA. Translation: AAI32747.1.
IPI	IPI00029498. IPI00383801.
RefSeq	NP_060048.2. NM_017578.2.
UniGene	Hs.567516. Hs.733553.
3D structure databases
ProteinModelPortal	Q9HAT0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HAT0. 1 interaction.
STRING	9606.ENSP00000184183.
PTM databases
PhosphoSite	Q9HAT0.
Polymorphism databases
DMDM	74718687.
Proteomic databases
PaxDb	Q9HAT0.
PRIDE	Q9HAT0.
Protocols and materials databases
DNASU	54763.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000184183; ENSP00000184183; ENSG00000065371. ENST00000405845; ENSP00000385919; ENSG00000065371. ENST00000459660; ENSP00000420590; ENSG00000065371. ENST00000479867; ENSP00000420567; ENSG00000065371. ENST00000484329; ENSP00000419205; ENSG00000065371. ENST00000495093; ENSP00000417379; ENSG00000065371.
GeneID	54763.
KEGG	hsa:54763.
UCSC	uc003eha.3. human.
Organism-specific databases
CTD	54763.
GeneCards	GC03M123636.
HGNC	HGNC:17692. ROPN1.
HPA	CAB014875. HPA052530.
neXtProt	NX_Q9HAT0.
PharmGKB	PA134952827.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38881.
HOGENOM	HOG000006862.
HOVERGEN	HBG060390.
InParanoid	Q9HAT0.
OMA	LIICAEE.
OrthoDB	EOG4W3SNW.
PhylomeDB	Q9HAT0.
Gene expression databases
ArrayExpress	Q9HAT0.
Bgee	Q9HAT0.
CleanEx	HS_ROPN1.
Genevestigator	Q9HAT0.
Family and domain databases
InterPro	IPR003117. cAMP_dep_PK_reg_su_I/II_a/b. [Graphical view]
SUPFAM	SSF47391. cAMP-dep_prot_kin_reg_I/II_a/b. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	54763.
NextBio	57401.

Entry information

Entry name

ROP1A_HUMAN

Accession

Primary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.