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Q9HAT0

- ROP1A_HUMAN

UniProt

Q9HAT0 - ROP1A_HUMAN

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Protein

Ropporin-1A

Gene

ROPN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1A
Alternative name(s):
Cancer/testis antigen 91
Short name:
CT91
Rhophilin-associated protein 1A
Gene namesi
Name:ROPN1
Synonyms:ROPN1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:17692. ROPN1.

Subcellular locationi


Note: In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ropporin-1APRO_0000307392Add
BLAST

Proteomic databases

PaxDbiQ9HAT0.
PRIDEiQ9HAT0.

PTM databases

PhosphoSiteiQ9HAT0.

Expressioni

Tissue specificityi

Testis specific in adult. Overexpressed in hematologic tumor cells.1 Publication

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiQ9HAT0.
CleanExiHS_ROPN1.
ExpressionAtlasiQ9HAT0. baseline and differential.
GenevestigatoriQ9HAT0.

Organism-specific databases

HPAiCAB014875.
HPA052530.

Interactioni

Subunit structurei

Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.By similarity

Protein-protein interaction databases

BioGridi120138. 1 interaction.
IntActiQ9HAT0. 1 interaction.
STRINGi9606.ENSP00000184183.

Structurei

3D structure databases

ProteinModelPortaliQ9HAT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4938RIIaAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2124Interaction with RHPN1By similarity

Domaini

The RIIa domain mediates interaction with AKAP3.By similarity

Sequence similaritiesi

Belongs to the ropporin family.Curated
Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiNOG38881.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ9HAT0.
OMAiLIICAEE.
OrthoDBiEOG70ZZP6.
PhylomeDBiQ9HAT0.
TreeFamiTF105421.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HAT0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV
210
NDFTQNPRVQ LE
Length:212
Mass (Da):23,893
Last modified:October 1, 2001 - v2
Checksum:iB50D2859B464F6CC
GO
Isoform 2 (identifier: Q9HAT0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.

Note: No experimental confirmation available.

Show »
Length:58
Mass (Da):6,711
Checksum:iEC21C285B271B063
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 5820DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2. 1 PublicationVSP_028743Add
BLAST
Alternative sequencei59 – 212154Missing in isoform 2. 1 PublicationVSP_028744Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303889 mRNA. Translation: AAG27712.2.
AL133624 mRNA. Translation: CAB63750.2.
CH471052 Genomic DNA. Translation: EAW79425.1.
CH471052 Genomic DNA. Translation: EAW79426.1.
CH471052 Genomic DNA. Translation: EAW79427.1.
BC132744 mRNA. Translation: AAI32745.1.
BC132746 mRNA. Translation: AAI32747.1.
CCDSiCCDS3026.1. [Q9HAT0-1]
RefSeqiNP_060048.2. NM_017578.2. [Q9HAT0-1]
XP_005247606.1. XM_005247549.1. [Q9HAT0-1]
UniGeneiHs.567516.
Hs.733553.

Genome annotation databases

EnsembliENST00000184183; ENSP00000184183; ENSG00000065371. [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371. [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371. [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371. [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371. [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371. [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371. [Q9HAT0-1]
GeneIDi54763.
KEGGihsa:54763.
UCSCiuc003eha.3. human. [Q9HAT0-1]

Polymorphism databases

DMDMi74718687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303889 mRNA. Translation: AAG27712.2 .
AL133624 mRNA. Translation: CAB63750.2 .
CH471052 Genomic DNA. Translation: EAW79425.1 .
CH471052 Genomic DNA. Translation: EAW79426.1 .
CH471052 Genomic DNA. Translation: EAW79427.1 .
BC132744 mRNA. Translation: AAI32745.1 .
BC132746 mRNA. Translation: AAI32747.1 .
CCDSi CCDS3026.1. [Q9HAT0-1 ]
RefSeqi NP_060048.2. NM_017578.2. [Q9HAT0-1 ]
XP_005247606.1. XM_005247549.1. [Q9HAT0-1 ]
UniGenei Hs.567516.
Hs.733553.

3D structure databases

ProteinModelPortali Q9HAT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120138. 1 interaction.
IntActi Q9HAT0. 1 interaction.
STRINGi 9606.ENSP00000184183.

PTM databases

PhosphoSitei Q9HAT0.

Polymorphism databases

DMDMi 74718687.

Proteomic databases

PaxDbi Q9HAT0.
PRIDEi Q9HAT0.

Protocols and materials databases

DNASUi 54763.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000184183 ; ENSP00000184183 ; ENSG00000065371 . [Q9HAT0-1 ]
ENST00000405845 ; ENSP00000385919 ; ENSG00000065371 . [Q9HAT0-1 ]
ENST00000459660 ; ENSP00000420590 ; ENSG00000065371 . [Q9HAT0-2 ]
ENST00000479867 ; ENSP00000420567 ; ENSG00000065371 . [Q9HAT0-2 ]
ENST00000484329 ; ENSP00000419205 ; ENSG00000065371 . [Q9HAT0-2 ]
ENST00000495093 ; ENSP00000417379 ; ENSG00000065371 . [Q9HAT0-2 ]
ENST00000620893 ; ENSP00000483603 ; ENSG00000065371 . [Q9HAT0-1 ]
GeneIDi 54763.
KEGGi hsa:54763.
UCSCi uc003eha.3. human. [Q9HAT0-1 ]

Organism-specific databases

CTDi 54763.
GeneCardsi GC03M123636.
HGNCi HGNC:17692. ROPN1.
HPAi CAB014875.
HPA052530.
neXtProti NX_Q9HAT0.
PharmGKBi PA134952827.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38881.
GeneTreei ENSGT00390000012731.
HOGENOMi HOG000006862.
HOVERGENi HBG060390.
InParanoidi Q9HAT0.
OMAi LIICAEE.
OrthoDBi EOG70ZZP6.
PhylomeDBi Q9HAT0.
TreeFami TF105421.

Miscellaneous databases

GenomeRNAii 54763.
NextBioi 57401.
PROi Q9HAT0.

Gene expression databases

Bgeei Q9HAT0.
CleanExi HS_ROPN1.
ExpressionAtlasi Q9HAT0. baseline and differential.
Genevestigatori Q9HAT0.

Family and domain databases

InterProi IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view ]
SUPFAMi SSF47391. SSF47391. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human sperm-specific binding protein of rhophilin and function in spermatogenesis."
    Zhou Z.M., Li J.M., Sha J.H.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
    Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.
    Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH SPA17, DEVELOPMENTAL STAGE, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Entry informationi

Entry nameiROP1A_HUMAN
AccessioniPrimary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3