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Protein

Ropporin-1A

Gene

ROPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.By similarity

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

Caution

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1A
Alternative name(s):
Cancer/testis antigen 91
Short name:
CT91
Rhophilin-associated protein 1A
Gene namesi
Name:ROPN1
Synonyms:ROPN1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000065371.17
HGNCiHGNC:17692 ROPN1
neXtProtiNX_Q9HAT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

Pathology & Biotechi

Organism-specific databases

DisGeNETi54763
OpenTargetsiENSG00000065371
PharmGKBiPA134952827

Polymorphism and mutation databases

BioMutaiROPN1
DMDMi74718687

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073921 – 212Ropporin-1AAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9HAT0
PeptideAtlasiQ9HAT0
PRIDEiQ9HAT0

PTM databases

iPTMnetiQ9HAT0
PhosphoSitePlusiQ9HAT0

Expressioni

Tissue specificityi

Testis specific in adult. Overexpressed in hematologic tumor cells.1 Publication

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000065371
CleanExiHS_ROPN1
ExpressionAtlasiQ9HAT0 baseline and differential
GenevisibleiQ9HAT0 HS

Organism-specific databases

HPAiCAB014875
HPA052530

Interactioni

Subunit structurei

Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17 (PubMed:17551920). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi12013826 interactors.
IntActiQ9HAT0 49 interactors.
MINTiQ9HAT0
STRINGi9606.ENSP00000184183

Structurei

3D structure databases

ProteinModelPortaliQ9HAT0
SMRiQ9HAT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 212Interaction with RHPN1By similarity4

Domaini

The RIIa domain mediates interaction with AKAP3.By similarity

Sequence similaritiesi

Belongs to the ropporin family.Curated

Phylogenomic databases

eggNOGiENOG410IFDW Eukaryota
ENOG410ZIXI LUCA
GeneTreeiENSGT00390000012731
HOGENOMiHOG000006862
HOVERGENiHBG060390
InParanoidiQ9HAT0
OMAiIITVNDF
OrthoDBiEOG091G0LKF
PhylomeDBiQ9HAT0
TreeFamiTF105421

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV
210
NDFTQNPRVQ LE
Length:212
Mass (Da):23,893
Last modified:October 1, 2001 - v2
Checksum:iB50D2859B464F6CC
GO
Isoform 2 (identifier: Q9HAT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.

Note: No experimental confirmation available.
Show »
Length:58
Mass (Da):6,711
Checksum:iEC21C285B271B063
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02874339 – 58DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02874459 – 212Missing in isoform 2. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303889 mRNA Translation: AAG27712.2
AL133624 mRNA Translation: CAB63750.2
CH471052 Genomic DNA Translation: EAW79425.1
CH471052 Genomic DNA Translation: EAW79426.1
CH471052 Genomic DNA Translation: EAW79427.1
BC132744 mRNA Translation: AAI32745.1
BC132746 mRNA Translation: AAI32747.1
CCDSiCCDS3026.1 [Q9HAT0-1]
RefSeqiNP_001304703.1, NM_001317774.1 [Q9HAT0-1]
NP_060048.2, NM_017578.3 [Q9HAT0-1]
XP_011511235.1, XM_011512933.2 [Q9HAT0-1]
XP_011511236.1, XM_011512934.2 [Q9HAT0-1]
UniGeneiHs.567516
Hs.663128
Hs.733553

Genome annotation databases

EnsembliENST00000184183; ENSP00000184183; ENSG00000065371 [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371 [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371 [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371 [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371 [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371 [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371 [Q9HAT0-1]
GeneIDi54763
KEGGihsa:54763
UCSCiuc003eha.4 human [Q9HAT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROP1A_HUMAN
AccessioniPrimary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2001
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome