SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9HAS3

- S28A3_HUMAN

UniProt

Q9HAS3 - S28A3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier family 28 member 3

Gene
SLC28A3, CNT3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.3 Publications

Kineticsi

  1. KM=21.6 µM for uridine2 Publications
  2. KM=15.4 µM for cytidine
  3. KM=21.2 µM for thymidine
  4. KM=15.1 µM for adenosine
  5. KM=43 µM for guanosine
  6. KM=52.5 µM for inosine

Vmax=25.8 pmol/min/mg enzyme for uridine uptake

Vmax=32.8 pmol/min/mg enzyme for cytidine uptake

Vmax=24.2 pmol/min/mg enzyme for thymidine uptake

Vmax=30.4 pmol/min/mg enzyme for adenosine uptake

Vmax=51.4 pmol/min/mg enzyme for guanosine uptake

Vmax=44.8 pmol/min/mg enzyme for inosine uptake

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. purine-specific nucleoside:sodium symporter activity Source: Ensembl
  3. pyrimidine- and adenine-specific:sodium symporter activity Source: Ensembl

GO - Biological processi

  1. pyrimidine nucleoside transport Source: Ensembl
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.41.2.8. the concentrative nucleoside transporter (cnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 28 member 3
Alternative name(s):
Concentrative Na(+)-nucleoside cotransporter 3
Short name:
CNT 3
Short name:
hCNT3
Gene namesi
Name:SLC28A3
Synonyms:CNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16484. SLC28A3.

Subcellular locationi

Isoform 1 : Cell membrane; Multi-pass membrane protein 1 Publication
Isoform 2 : Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 102102Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Topological domaini124 – 1274Extracellular Reviewed prediction
Transmembranei128 – 14821Helical; Reviewed predictionAdd
BLAST
Topological domaini149 – 17022Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Topological domaini192 – 2009Extracellular Reviewed prediction
Transmembranei201 – 22121Helical; Reviewed predictionAdd
BLAST
Topological domaini222 – 2232Cytoplasmic Reviewed prediction
Transmembranei224 – 24421Helical; Reviewed predictionAdd
BLAST
Topological domaini245 – 28743Extracellular Reviewed predictionAdd
BLAST
Transmembranei288 – 30821Helical; Reviewed predictionAdd
BLAST
Topological domaini309 – 3146Cytoplasmic Reviewed prediction
Transmembranei315 – 33521Helical; Reviewed predictionAdd
BLAST
Topological domaini336 – 36126Extracellular Reviewed predictionAdd
BLAST
Transmembranei362 – 38221Helical; Reviewed predictionAdd
BLAST
Topological domaini383 – 3886Cytoplasmic Reviewed prediction
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST
Topological domaini410 – 44334Extracellular Reviewed predictionAdd
BLAST
Transmembranei444 – 46421Helical; Reviewed predictionAdd
BLAST
Topological domaini465 – 47915Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei480 – 50021Helical; Reviewed predictionAdd
BLAST
Topological domaini501 – 55353Extracellular Reviewed predictionAdd
BLAST
Transmembranei554 – 57421Helical; Reviewed predictionAdd
BLAST
Topological domaini575 – 59319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei594 – 61421Helical; Reviewed predictionAdd
BLAST
Topological domaini615 – 69177Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Solute carrier family 28 member 3PRO_0000324146Add
BLAST

Proteomic databases

PaxDbiQ9HAS3.
PRIDEiQ9HAS3.

PTM databases

PhosphoSiteiQ9HAS3.

Expressioni

Tissue specificityi

Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.1 Publication

Inductioni

Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.1 Publication

Gene expression databases

ArrayExpressiQ9HAS3.
BgeeiQ9HAS3.
CleanExiHS_SLC28A3.
GenevestigatoriQ9HAS3.

Organism-specific databases

HPAiHPA023311.
HPA024729.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365413.

Structurei

3D structure databases

ProteinModelPortaliQ9HAS3.
SMRiQ9HAS3. Positions 201-612.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1972.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiQ9HAS3.
KOiK11536.
OMAiTRVYWRP.
OrthoDBiEOG7RV9FR.
PhylomeDBiQ9HAS3.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HAS3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT    50
KQDEEQVTVE QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT 100
LRHIIWGILL AGYLVMVISA CVLNFHRALP LFVITVAAIF FVVWDHLMAK 150
YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS LVLAVIFWLA FDTAKLGQQQ 200
LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG LLILRTDPGF 250
IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS 300
MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP 350
YLPYITKSEL HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS 400
LAAAKLFWPE TEKPKITLKN AMKMESGDSG NLLEAATQGA SSSISLVANI 450
AVNLIAFLAL LSFMNSALSW FGNMFDYPQL SFELICSYIF MPFSFMMGVE 500
WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF VNGVQQYISI 550
RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV 600
ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS 650
TVAKGPGEVI PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F 691
Length:691
Mass (Da):76,930
Last modified:March 1, 2001 - v1
Checksum:i80FD14518A8BFA61
GO
Isoform 2 (identifier: Q9HAS3-2) [UniParc]FASTAAdd to Basket

Also known as: hCNT3ins

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway.

Show »
Length:622
Mass (Da):69,027
Checksum:i8C9CB6F47D0AC0C0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → K.1 Publication
Corresponds to variant rs11568401 [ dbSNP | Ensembl ].
VAR_039665
Natural varianti5 – 51S → N.2 Publications
Corresponds to variant rs11568403 [ dbSNP | Ensembl ].
VAR_039666
Natural varianti62 – 621D → H.1 Publication
Corresponds to variant rs45621433 [ dbSNP | Ensembl ].
VAR_039667
Natural varianti67 – 671R → K.1 Publication
Corresponds to variant rs11568411 [ dbSNP | Ensembl ].
VAR_039668
Natural varianti113 – 1131Y → C.2 Publications
Corresponds to variant rs10868138 [ dbSNP | Ensembl ].
VAR_039669
Natural varianti131 – 1311L → F.1 Publication
VAR_039670
Natural varianti221 – 2211P → Q.
Corresponds to variant rs11140503 [ dbSNP | Ensembl ].
VAR_039671
Natural varianti328 – 3281I → V.1 Publication
Corresponds to variant rs11568418 [ dbSNP | Ensembl ].
VAR_039672
Natural varianti349 – 3491R → Q.1 Publication
Corresponds to variant rs45525131 [ dbSNP | Ensembl ].
VAR_039673
Natural varianti366 – 3661A → T.1 Publication
Corresponds to variant rs140138960 [ dbSNP | Ensembl ].
VAR_070606
Natural varianti367 – 3671G → R Reduced transport of inosine and thymidine. 1 Publication
VAR_039674
Natural varianti418 – 4181L → I.1 Publication
Corresponds to variant rs11568405 [ dbSNP | Ensembl ].
VAR_039675
Natural varianti513 – 5131Y → F.2 Publications
Corresponds to variant rs56350726 [ dbSNP | Ensembl ].
VAR_039676
Natural varianti585 – 5851R → H.1 Publication
Corresponds to variant rs11568398 [ dbSNP | Ensembl ].
VAR_039677
Natural varianti602 – 6021C → R Lower concentrative capacity and altered sodium binding capacity. 1 Publication
VAR_039678

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. VSP_053848Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511I → V in BAG36748. 1 Publication
Sequence conflicti293 – 2931V → I in BAG36748. 1 Publication
Sequence conflicti505 – 5051F → L in BAG65240. 1 Publication
Sequence conflicti628 – 6281A → S in BAF85538. 1 Publication
Sequence conflicti639 – 6391K → E in BAG36748. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305210 mRNA. Translation: AAG22551.1.
AK292849 mRNA. Translation: BAF85538.1.
AK304406 mRNA. Translation: BAG65240.1.
AK314039 mRNA. Translation: BAG36748.1.
AL356134, AL353787 Genomic DNA. Translation: CAH73162.1.
AL353787, AL356134 Genomic DNA. Translation: CAI16332.1.
BC093821 mRNA. Translation: AAH93821.1.
BC093823 mRNA. Translation: AAH93823.1.
CH471089 Genomic DNA. Translation: EAW62686.1.
CCDSiCCDS6670.1. [Q9HAS3-1]
RefSeqiNP_001186562.1. NM_001199633.1. [Q9HAS3-1]
NP_071410.1. NM_022127.2. [Q9HAS3-1]
UniGeneiHs.535966.

Genome annotation databases

EnsembliENST00000376238; ENSP00000365413; ENSG00000197506.
ENST00000537648; ENSP00000446438; ENSG00000197506.
GeneIDi64078.
KEGGihsa:64078.
UCSCiuc004anu.2. human. [Q9HAS3-1]

Polymorphism databases

DMDMi74752767.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305210 mRNA. Translation: AAG22551.1 .
AK292849 mRNA. Translation: BAF85538.1 .
AK304406 mRNA. Translation: BAG65240.1 .
AK314039 mRNA. Translation: BAG36748.1 .
AL356134 , AL353787 Genomic DNA. Translation: CAH73162.1 .
AL353787 , AL356134 Genomic DNA. Translation: CAI16332.1 .
BC093821 mRNA. Translation: AAH93821.1 .
BC093823 mRNA. Translation: AAH93823.1 .
CH471089 Genomic DNA. Translation: EAW62686.1 .
CCDSi CCDS6670.1. [Q9HAS3-1 ]
RefSeqi NP_001186562.1. NM_001199633.1. [Q9HAS3-1 ]
NP_071410.1. NM_022127.2. [Q9HAS3-1 ]
UniGenei Hs.535966.

3D structure databases

ProteinModelPortali Q9HAS3.
SMRi Q9HAS3. Positions 201-612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000365413.

Chemistry

BindingDBi Q9HAS3.
ChEMBLi CHEMBL5707.

Protein family/group databases

TCDBi 2.A.41.2.8. the concentrative nucleoside transporter (cnt) family.

PTM databases

PhosphoSitei Q9HAS3.

Polymorphism databases

DMDMi 74752767.

Proteomic databases

PaxDbi Q9HAS3.
PRIDEi Q9HAS3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376238 ; ENSP00000365413 ; ENSG00000197506 .
ENST00000537648 ; ENSP00000446438 ; ENSG00000197506 .
GeneIDi 64078.
KEGGi hsa:64078.
UCSCi uc004anu.2. human. [Q9HAS3-1 ]

Organism-specific databases

CTDi 64078.
GeneCardsi GC09M086890.
HGNCi HGNC:16484. SLC28A3.
HPAi HPA023311.
HPA024729.
MIMi 608269. gene.
neXtProti NX_Q9HAS3.
PharmGKBi PA426.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1972.
HOGENOMi HOG000267658.
HOVERGENi HBG054073.
InParanoidi Q9HAS3.
KOi K11536.
OMAi TRVYWRP.
OrthoDBi EOG7RV9FR.
PhylomeDBi Q9HAS3.
TreeFami TF314131.

Enzyme and pathway databases

Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

GenomeRNAii 64078.
NextBioi 35477357.
PROi Q9HAS3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HAS3.
Bgeei Q9HAS3.
CleanExi HS_SLC28A3.
Genevestigatori Q9HAS3.

Family and domain databases

InterProi IPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view ]
PANTHERi PTHR10590. PTHR10590. 1 hit.
Pfami PF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00804. nupC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)."
    Ritzel M.W.L., Ng A.M.L., Yao S.Y.M., Graham K., Loewen S.K., Smith K.M., Ritzel R.G., Mowles D.A., Carpenter P., Chen X.-Z., Karpinski E., Hyde R.J., Baldwin S.A., Cass C.E., Young J.D.
    J. Biol. Chem. 276:2914-2927(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-113; THR-366 AND PHE-513.
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  6. "Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene."
    Damaraju S., Zhang J., Visser F., Tackaberry T., Dufour J., Smith K.M., Slugoski M., Ritzel M.W.L., Baldwin S.A., Young J.D., Cass C.E.
    Pharmacogenet. Genomics 15:173-182(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES, VARIANTS ASN-5; PHE-131 AND PHE-513.
  7. "Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)."
    Hu H., Endres C.J., Chang C., Umapathy N.S., Lee E.-W., Fei Y.-J., Itagaki S., Swaan P.W., Ganapathy V., Unadkat J.D.
    Mol. Pharmacol. 69:1542-1553(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters."
    Yamamoto T., Kuniki K., Takekuma Y., Hirano T., Iseki K., Sugawara M.
    Eur. J. Pharmacol. 557:1-8(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum."
    Errasti-Murugarren E., Molina-Arcas M., Casado F.J., Pastor-Anglada M.
    FASEB J. 23:172-182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
  10. "Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3)."
    Badagnani I., Chan W., Castro R.A., Brett C.M., Huang C.C., Stryke D., Kawamoto M., Johns S.J., Ferrin T.E., Carlson E.J., Burchard E.G., Giacomini K.M.
    Pharmacogenomics J. 5:157-165(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-4; ASN-5; HIS-62; LYS-67; CYS-113; VAL-328; GLN-349; ARG-367; ILE-418 AND HIS-585, CHARACTERIZATION OF VARIANT ARG-367.
  11. "Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity."
    Errasti-Murugarren E., Cano-Soldado P., Pastor-Anglada M., Casado F.J.
    Mol. Pharmacol. 73:379-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-602, CHARACTERIZATION OF VARIANT ARG-602.

Entry informationi

Entry nameiS28A3_HUMAN
AccessioniPrimary (citable) accession number: Q9HAS3
Secondary accession number(s): A8K9Y4
, B1AML0, B2RA51, B4E2S8, F5GYE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi