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Q9HAS3

- S28A3_HUMAN

UniProt

Q9HAS3 - S28A3_HUMAN

Protein

Solute carrier family 28 member 3

Gene

SLC28A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.3 Publications

    Kineticsi

    1. KM=21.6 µM for uridine2 Publications
    2. KM=15.4 µM for cytidine2 Publications
    3. KM=21.2 µM for thymidine2 Publications
    4. KM=15.1 µM for adenosine2 Publications
    5. KM=43 µM for guanosine2 Publications
    6. KM=52.5 µM for inosine2 Publications

    Vmax=25.8 pmol/min/mg enzyme for uridine uptake2 Publications

    Vmax=32.8 pmol/min/mg enzyme for cytidine uptake2 Publications

    Vmax=24.2 pmol/min/mg enzyme for thymidine uptake2 Publications

    Vmax=30.4 pmol/min/mg enzyme for adenosine uptake2 Publications

    Vmax=51.4 pmol/min/mg enzyme for guanosine uptake2 Publications

    Vmax=44.8 pmol/min/mg enzyme for inosine uptake2 Publications

    GO - Molecular functioni

    1. nucleoside binding Source: InterPro
    2. purine-specific nucleoside:sodium symporter activity Source: Ensembl
    3. pyrimidine- and adenine-specific:sodium symporter activity Source: Ensembl

    GO - Biological processi

    1. pyrimidine nucleoside transport Source: Ensembl
    2. transmembrane transport Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.41.2.8. the concentrative nucleoside transporter (cnt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 28 member 3
    Alternative name(s):
    Concentrative Na(+)-nucleoside cotransporter 3
    Short name:
    CNT 3
    Short name:
    hCNT3
    Gene namesi
    Name:SLC28A3
    Synonyms:CNT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16484. SLC28A3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA426.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Solute carrier family 28 member 3PRO_0000324146Add
    BLAST

    Proteomic databases

    PaxDbiQ9HAS3.
    PRIDEiQ9HAS3.

    PTM databases

    PhosphoSiteiQ9HAS3.

    Expressioni

    Tissue specificityi

    Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.1 Publication

    Inductioni

    Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9HAS3.
    BgeeiQ9HAS3.
    CleanExiHS_SLC28A3.
    GenevestigatoriQ9HAS3.

    Organism-specific databases

    HPAiHPA023311.
    HPA024729.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HAS3.
    SMRiQ9HAS3. Positions 201-612.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 102102CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 1274ExtracellularSequence Analysis
    Topological domaini149 – 17022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 2009ExtracellularSequence Analysis
    Topological domaini222 – 2232CytoplasmicSequence Analysis
    Topological domaini245 – 28743ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 3146CytoplasmicSequence Analysis
    Topological domaini336 – 36126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini383 – 3886CytoplasmicSequence Analysis
    Topological domaini410 – 44334ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini465 – 47915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini501 – 55353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini575 – 59319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini615 – 69177ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei554 – 57421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei594 – 61421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1972.
    HOGENOMiHOG000267658.
    HOVERGENiHBG054073.
    InParanoidiQ9HAS3.
    KOiK11536.
    OMAiTRVYWRP.
    OrthoDBiEOG7RV9FR.
    PhylomeDBiQ9HAS3.
    TreeFamiTF314131.

    Family and domain databases

    InterProiIPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view]
    PANTHERiPTHR10590. PTHR10590. 1 hit.
    PfamiPF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00804. nupC. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HAS3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT    50
    KQDEEQVTVE QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT 100
    LRHIIWGILL AGYLVMVISA CVLNFHRALP LFVITVAAIF FVVWDHLMAK 150
    YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS LVLAVIFWLA FDTAKLGQQQ 200
    LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG LLILRTDPGF 250
    IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS 300
    MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP 350
    YLPYITKSEL HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS 400
    LAAAKLFWPE TEKPKITLKN AMKMESGDSG NLLEAATQGA SSSISLVANI 450
    AVNLIAFLAL LSFMNSALSW FGNMFDYPQL SFELICSYIF MPFSFMMGVE 500
    WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF VNGVQQYISI 550
    RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV 600
    ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS 650
    TVAKGPGEVI PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F 691
    Length:691
    Mass (Da):76,930
    Last modified:March 1, 2001 - v1
    Checksum:i80FD14518A8BFA61
    GO
    Isoform 2 (identifier: Q9HAS3-2) [UniParc]FASTAAdd to Basket

    Also known as: hCNT3ins

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: Missing.

    Note: Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway.

    Show »
    Length:622
    Mass (Da):69,027
    Checksum:i8C9CB6F47D0AC0C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti251 – 2511I → V in BAG36748. (PubMed:14702039)Curated
    Sequence conflicti293 – 2931V → I in BAG36748. (PubMed:14702039)Curated
    Sequence conflicti505 – 5051F → L in BAG65240. (PubMed:14702039)Curated
    Sequence conflicti628 – 6281A → S in BAF85538. (PubMed:14702039)Curated
    Sequence conflicti639 – 6391K → E in BAG36748. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41R → K.1 Publication
    Corresponds to variant rs11568401 [ dbSNP | Ensembl ].
    VAR_039665
    Natural varianti5 – 51S → N.2 Publications
    Corresponds to variant rs11568403 [ dbSNP | Ensembl ].
    VAR_039666
    Natural varianti62 – 621D → H.1 Publication
    Corresponds to variant rs45621433 [ dbSNP | Ensembl ].
    VAR_039667
    Natural varianti67 – 671R → K.1 Publication
    Corresponds to variant rs11568411 [ dbSNP | Ensembl ].
    VAR_039668
    Natural varianti113 – 1131Y → C.2 Publications
    Corresponds to variant rs10868138 [ dbSNP | Ensembl ].
    VAR_039669
    Natural varianti131 – 1311L → F.1 Publication
    VAR_039670
    Natural varianti221 – 2211P → Q.
    Corresponds to variant rs11140503 [ dbSNP | Ensembl ].
    VAR_039671
    Natural varianti328 – 3281I → V.1 Publication
    Corresponds to variant rs11568418 [ dbSNP | Ensembl ].
    VAR_039672
    Natural varianti349 – 3491R → Q.1 Publication
    Corresponds to variant rs45525131 [ dbSNP | Ensembl ].
    VAR_039673
    Natural varianti366 – 3661A → T.1 Publication
    Corresponds to variant rs140138960 [ dbSNP | Ensembl ].
    VAR_070606
    Natural varianti367 – 3671G → R Reduced transport of inosine and thymidine. 1 Publication
    VAR_039674
    Natural varianti418 – 4181L → I.1 Publication
    Corresponds to variant rs11568405 [ dbSNP | Ensembl ].
    VAR_039675
    Natural varianti513 – 5131Y → F.2 Publications
    Corresponds to variant rs56350726 [ dbSNP | Ensembl ].
    VAR_039676
    Natural varianti585 – 5851R → H.1 Publication
    Corresponds to variant rs11568398 [ dbSNP | Ensembl ].
    VAR_039677
    Natural varianti602 – 6021C → R Lower concentrative capacity and altered sodium binding capacity. 1 Publication
    VAR_039678

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_053848Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305210 mRNA. Translation: AAG22551.1.
    AK292849 mRNA. Translation: BAF85538.1.
    AK304406 mRNA. Translation: BAG65240.1.
    AK314039 mRNA. Translation: BAG36748.1.
    AL356134, AL353787 Genomic DNA. Translation: CAH73162.1.
    AL353787, AL356134 Genomic DNA. Translation: CAI16332.1.
    BC093821 mRNA. Translation: AAH93821.1.
    BC093823 mRNA. Translation: AAH93823.1.
    CH471089 Genomic DNA. Translation: EAW62686.1.
    CCDSiCCDS6670.1. [Q9HAS3-1]
    RefSeqiNP_001186562.1. NM_001199633.1. [Q9HAS3-1]
    NP_071410.1. NM_022127.2. [Q9HAS3-1]
    UniGeneiHs.535966.

    Genome annotation databases

    EnsembliENST00000376238; ENSP00000365413; ENSG00000197506. [Q9HAS3-1]
    GeneIDi64078.
    KEGGihsa:64078.
    UCSCiuc004anu.2. human. [Q9HAS3-1]

    Polymorphism databases

    DMDMi74752767.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305210 mRNA. Translation: AAG22551.1 .
    AK292849 mRNA. Translation: BAF85538.1 .
    AK304406 mRNA. Translation: BAG65240.1 .
    AK314039 mRNA. Translation: BAG36748.1 .
    AL356134 , AL353787 Genomic DNA. Translation: CAH73162.1 .
    AL353787 , AL356134 Genomic DNA. Translation: CAI16332.1 .
    BC093821 mRNA. Translation: AAH93821.1 .
    BC093823 mRNA. Translation: AAH93823.1 .
    CH471089 Genomic DNA. Translation: EAW62686.1 .
    CCDSi CCDS6670.1. [Q9HAS3-1 ]
    RefSeqi NP_001186562.1. NM_001199633.1. [Q9HAS3-1 ]
    NP_071410.1. NM_022127.2. [Q9HAS3-1 ]
    UniGenei Hs.535966.

    3D structure databases

    ProteinModelPortali Q9HAS3.
    SMRi Q9HAS3. Positions 201-612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365413.

    Chemistry

    BindingDBi Q9HAS3.
    ChEMBLi CHEMBL5707.

    Protein family/group databases

    TCDBi 2.A.41.2.8. the concentrative nucleoside transporter (cnt) family.

    PTM databases

    PhosphoSitei Q9HAS3.

    Polymorphism databases

    DMDMi 74752767.

    Proteomic databases

    PaxDbi Q9HAS3.
    PRIDEi Q9HAS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376238 ; ENSP00000365413 ; ENSG00000197506 . [Q9HAS3-1 ]
    GeneIDi 64078.
    KEGGi hsa:64078.
    UCSCi uc004anu.2. human. [Q9HAS3-1 ]

    Organism-specific databases

    CTDi 64078.
    GeneCardsi GC09M086890.
    HGNCi HGNC:16484. SLC28A3.
    HPAi HPA023311.
    HPA024729.
    MIMi 608269. gene.
    neXtProti NX_Q9HAS3.
    PharmGKBi PA426.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1972.
    HOGENOMi HOG000267658.
    HOVERGENi HBG054073.
    InParanoidi Q9HAS3.
    KOi K11536.
    OMAi TRVYWRP.
    OrthoDBi EOG7RV9FR.
    PhylomeDBi Q9HAS3.
    TreeFami TF314131.

    Enzyme and pathway databases

    Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Miscellaneous databases

    GenomeRNAii 64078.
    NextBioi 35477357.
    PROi Q9HAS3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HAS3.
    Bgeei Q9HAS3.
    CleanExi HS_SLC28A3.
    Genevestigatori Q9HAS3.

    Family and domain databases

    InterProi IPR008276. C_nuclsd_transpt.
    IPR018270. C_nuclsd_transpt_met_bac.
    IPR011657. CNT_C_dom.
    IPR002668. CNT_N_dom.
    IPR011642. Nucleoside_recog_Gate.
    [Graphical view ]
    PANTHERi PTHR10590. PTHR10590. 1 hit.
    Pfami PF07670. Gate. 1 hit.
    PF07662. Nucleos_tra2_C. 1 hit.
    PF01773. Nucleos_tra2_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00804. nupC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)."
      Ritzel M.W.L., Ng A.M.L., Yao S.Y.M., Graham K., Loewen S.K., Smith K.M., Ritzel R.G., Mowles D.A., Carpenter P., Chen X.-Z., Karpinski E., Hyde R.J., Baldwin S.A., Cass C.E., Young J.D.
      J. Biol. Chem. 276:2914-2927(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-113; THR-366 AND PHE-513.
      Tissue: Trachea.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    6. "Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene."
      Damaraju S., Zhang J., Visser F., Tackaberry T., Dufour J., Smith K.M., Slugoski M., Ritzel M.W.L., Baldwin S.A., Young J.D., Cass C.E.
      Pharmacogenet. Genomics 15:173-182(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOPHYSICOCHEMICAL PROPERTIES, VARIANTS ASN-5; PHE-131 AND PHE-513.
    7. "Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)."
      Hu H., Endres C.J., Chang C., Umapathy N.S., Lee E.-W., Fei Y.-J., Itagaki S., Swaan P.W., Ganapathy V., Unadkat J.D.
      Mol. Pharmacol. 69:1542-1553(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters."
      Yamamoto T., Kuniki K., Takekuma Y., Hirano T., Iseki K., Sugawara M.
      Eur. J. Pharmacol. 557:1-8(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum."
      Errasti-Murugarren E., Molina-Arcas M., Casado F.J., Pastor-Anglada M.
      FASEB J. 23:172-182(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    10. "Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3)."
      Badagnani I., Chan W., Castro R.A., Brett C.M., Huang C.C., Stryke D., Kawamoto M., Johns S.J., Ferrin T.E., Carlson E.J., Burchard E.G., Giacomini K.M.
      Pharmacogenomics J. 5:157-165(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-4; ASN-5; HIS-62; LYS-67; CYS-113; VAL-328; GLN-349; ARG-367; ILE-418 AND HIS-585, CHARACTERIZATION OF VARIANT ARG-367.
    11. "Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity."
      Errasti-Murugarren E., Cano-Soldado P., Pastor-Anglada M., Casado F.J.
      Mol. Pharmacol. 73:379-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-602, CHARACTERIZATION OF VARIANT ARG-602.

    Entry informationi

    Entry nameiS28A3_HUMAN
    AccessioniPrimary (citable) accession number: Q9HAS3
    Secondary accession number(s): A8K9Y4
    , B1AML0, B2RA51, B4E2S8, F5GYE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3