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Protein

Kinesin-like protein KIF9

Gene

KIF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATP3
Nucleotide bindingi93 – 100ATP8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

  • extracellular matrix disassembly Source: UniProtKB
  • microtubule-based movement Source: GO_Central
  • organelle disassembly Source: UniProtKB
  • regulation of podosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088727-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF9
Gene namesi
Name:KIF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16666. KIF9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB
  • podosome Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi64147.
OpenTargetsiENSG00000088727.
PharmGKBiPA30110.

Chemistry databases

ChEMBLiCHEMBL2321637.

Polymorphism and mutation databases

BioMutaiKIF9.
DMDMi308153656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254421 – 790Kinesin-like protein KIF9Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei530PhosphothreonineCombined sources1
Modified residuei546PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HAQ2.
PaxDbiQ9HAQ2.
PeptideAtlasiQ9HAQ2.
PRIDEiQ9HAQ2.

PTM databases

iPTMnetiQ9HAQ2.
PhosphoSitePlusiQ9HAQ2.

Expressioni

Gene expression databases

BgeeiENSG00000088727.
CleanExiHS_KIF9.
ExpressionAtlasiQ9HAQ2. baseline and differential.
GenevisibleiQ9HAQ2. HS.

Organism-specific databases

HPAiHPA022031.
HPA022033.
HPA030429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA82EBI-8472129,EBI-912440

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122086. 14 interactors.
IntActiQ9HAQ2. 30 interactors.
MINTiMINT-8417679.
STRINGi9606.ENSP00000265529.

Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 13Combined sources7
Turni21 – 23Combined sources3
Beta strandi24 – 26Combined sources3
Beta strandi30 – 36Combined sources7
Helixi43 – 46Combined sources4
Beta strandi52 – 56Combined sources5
Beta strandi58 – 63Combined sources6
Helixi66 – 73Combined sources8
Helixi75 – 82Combined sources8
Beta strandi87 – 94Combined sources8
Helixi99 – 103Combined sources5
Helixi110 – 112Combined sources3
Helixi115 – 128Combined sources14
Beta strandi133 – 145Combined sources13
Beta strandi148 – 151Combined sources4
Beta strandi154 – 156Combined sources3
Turni161 – 163Combined sources3
Beta strandi167 – 171Combined sources5
Beta strandi174 – 178Combined sources5
Helixi188 – 209Combined sources22
Helixi213 – 215Combined sources3
Beta strandi217 – 227Combined sources11
Beta strandi237 – 245Combined sources9
Helixi271 – 283Combined sources13
Helixi292 – 294Combined sources3
Helixi296 – 300Combined sources5
Helixi302 – 305Combined sources4
Beta strandi306 – 317Combined sources12
Helixi321 – 323Combined sources3
Helixi324 – 334Combined sources11
Helixi335 – 339Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
ProteinModelPortaliQ9HAQ2.
SMRiQ9HAQ2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HAQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST335

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili342 – 380Sequence analysisAdd BLAST39
Coiled coili658 – 690Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133684.
HOGENOMiHOG000116164.
HOVERGENiHBG019045.
InParanoidiQ9HAQ2.
KOiK10397.
OMAiMGLQQAH.
OrthoDBiEOG091G06D4.
PhylomeDBiQ9HAQ2.
TreeFamiTF105229.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9HAQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGVVNNQQ
60 70 80 90 100
TDWSFKLDGV LHDASQDLVY ETVAKDVVSQ ALDGYNGTIM CYGQTGAGKT
110 120 130 140 150
YTMMGATENY KHRGILPRAL QQVFRMIEER PTHAITVRVS YLEIYNESLF
160 170 180 190 200
DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL SVHLTSQEED AFSLLFEGET
210 220 230 240 250
NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK INLVDLAGSE
260 270 280 290 300
RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PFRQCKLTHA
310 320 330 340 350
LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY
360 370 380 390 400
DAERMVKNLE KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR
410 420 430 440 450
RYLEGTLDEI DIISLRQIKE VFNQFRVVLS QQEQEVESTL RRKYTLIDRN
460 470 480 490 500
DFAAISAIQK AGLVDVDGHL VGEPEGQNFG LGVAPFSTKP GKKAKSKKTF
510 520 530 540 550
KEPLSSLARK EGASSPVNGK DLDYVSTSKT QLVPSSKDGD VKDMLSRDRE
560 570 580 590 600
TSSIEPLPSD SPKEELRPIR PDTPPSKPVA FEEFKNEQGS EINRIFKENK
610 620 630 640 650
SILNERRKRA SETTQHINAI KREIDVTKEA LNFQKSLREK QGKYENKGLM
660 670 680 690 700
IIDEEEFLLI LKLKDLKKQY RSEYQDLRDL RAEIQYCQHL VDQCRHRLLM
710 720 730 740 750
EFDIWYNESF VIPEDMQMAL KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL
760 770 780 790
QQRVLPEGPD SISFYNAKVK IEQKHNYLKT MMGLQQAHRK
Length:790
Mass (Da):89,986
Last modified:October 5, 2010 - v4
Checksum:iAD5CCEDFA64FA971
GO
Isoform 2 (identifier: Q9HAQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-569: Missing.

Show »
Length:725
Mass (Da):82,972
Checksum:iA1D28B310994F210
GO

Sequence cautioni

The sequence BAB14713 differs from that shown. Dubious isoform. Probable cloning artifact lacking polyadenylation evidence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02213978V → I.Corresponds to variant rs2270569dbSNPEnsembl.1
Natural variantiVAR_02044396G → A.Corresponds to variant rs3733092dbSNPEnsembl.1
Natural variantiVAR_024513638R → W.2 PublicationsCorresponds to variant rs2276853dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002868505 – 569Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA. Translation: AAG33849.1.
AC104447 Genomic DNA. No translation available.
BC030657 mRNA. Translation: AAH30657.1.
AK023894 mRNA. Translation: BAB14713.1. Sequence problems.
CCDSiCCDS2751.1. [Q9HAQ2-2]
CCDS2752.1. [Q9HAQ2-1]
RefSeqiNP_001128350.1. NM_001134878.1. [Q9HAQ2-1]
NP_071737.1. NM_022342.4. [Q9HAQ2-2]
NP_878905.2. NM_182902.3. [Q9HAQ2-1]
XP_011532306.1. XM_011534004.2. [Q9HAQ2-1]
XP_016862518.1. XM_017007029.1. [Q9HAQ2-1]
UniGeneiHs.373947.

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727. [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727. [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727. [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727. [Q9HAQ2-1]
GeneIDi64147.
KEGGihsa:64147.
UCSCiuc003cqx.3. human. [Q9HAQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA. Translation: AAG33849.1.
AC104447 Genomic DNA. No translation available.
BC030657 mRNA. Translation: AAH30657.1.
AK023894 mRNA. Translation: BAB14713.1. Sequence problems.
CCDSiCCDS2751.1. [Q9HAQ2-2]
CCDS2752.1. [Q9HAQ2-1]
RefSeqiNP_001128350.1. NM_001134878.1. [Q9HAQ2-1]
NP_071737.1. NM_022342.4. [Q9HAQ2-2]
NP_878905.2. NM_182902.3. [Q9HAQ2-1]
XP_011532306.1. XM_011534004.2. [Q9HAQ2-1]
XP_016862518.1. XM_017007029.1. [Q9HAQ2-1]
UniGeneiHs.373947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
ProteinModelPortaliQ9HAQ2.
SMRiQ9HAQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122086. 14 interactors.
IntActiQ9HAQ2. 30 interactors.
MINTiMINT-8417679.
STRINGi9606.ENSP00000265529.

Chemistry databases

ChEMBLiCHEMBL2321637.

PTM databases

iPTMnetiQ9HAQ2.
PhosphoSitePlusiQ9HAQ2.

Polymorphism and mutation databases

BioMutaiKIF9.
DMDMi308153656.

Proteomic databases

MaxQBiQ9HAQ2.
PaxDbiQ9HAQ2.
PeptideAtlasiQ9HAQ2.
PRIDEiQ9HAQ2.

Protocols and materials databases

DNASUi64147.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727. [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727. [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727. [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727. [Q9HAQ2-1]
GeneIDi64147.
KEGGihsa:64147.
UCSCiuc003cqx.3. human. [Q9HAQ2-1]

Organism-specific databases

CTDi64147.
DisGeNETi64147.
GeneCardsiKIF9.
H-InvDBHIX0003269.
HIX0003270.
HGNCiHGNC:16666. KIF9.
HPAiHPA022031.
HPA022033.
HPA030429.
MIMi607910. gene.
neXtProtiNX_Q9HAQ2.
OpenTargetsiENSG00000088727.
PharmGKBiPA30110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133684.
HOGENOMiHOG000116164.
HOVERGENiHBG019045.
InParanoidiQ9HAQ2.
KOiK10397.
OMAiMGLQQAH.
OrthoDBiEOG091G06D4.
PhylomeDBiQ9HAQ2.
TreeFamiTF105229.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088727-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF9. human.
EvolutionaryTraceiQ9HAQ2.
GenomeRNAii64147.
PROiQ9HAQ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088727.
CleanExiHS_KIF9.
ExpressionAtlasiQ9HAQ2. baseline and differential.
GenevisibleiQ9HAQ2. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF9_HUMAN
AccessioniPrimary (citable) accession number: Q9HAQ2
Secondary accession number(s): Q86Z28, Q9H8A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.