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Protein

Kinesin-like protein KIF9

Gene

KIF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143ATP
Nucleotide bindingi93 – 1008ATP

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

  • extracellular matrix disassembly Source: UniProtKB
  • microtubule-based movement Source: GO_Central
  • organelle disassembly Source: UniProtKB
  • regulation of podosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF9
Gene namesi
Name:KIF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16666. KIF9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB
  • podosome Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30110.

Chemistry

ChEMBLiCHEMBL2321637.

Polymorphism and mutation databases

BioMutaiKIF9.
DMDMi308153656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Kinesin-like protein KIF9PRO_0000125442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei530 – 5301PhosphothreonineCombined sources
Modified residuei546 – 5461PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HAQ2.
PaxDbiQ9HAQ2.
PeptideAtlasiQ9HAQ2.
PRIDEiQ9HAQ2.

PTM databases

iPTMnetiQ9HAQ2.
PhosphoSiteiQ9HAQ2.

Expressioni

Gene expression databases

BgeeiQ9HAQ2.
CleanExiHS_KIF9.
ExpressionAtlasiQ9HAQ2. baseline and differential.
GenevisibleiQ9HAQ2. HS.

Organism-specific databases

HPAiHPA022031.
HPA022033.
HPA030429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA82EBI-8472129,EBI-912440

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122086. 14 interactions.
IntActiQ9HAQ2. 2 interactions.
MINTiMINT-8417679.
STRINGi9606.ENSP00000265529.

Structurei

Secondary structure

1
790
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 137Combined sources
Turni21 – 233Combined sources
Beta strandi24 – 263Combined sources
Beta strandi30 – 367Combined sources
Helixi43 – 464Combined sources
Beta strandi52 – 565Combined sources
Beta strandi58 – 636Combined sources
Helixi66 – 738Combined sources
Helixi75 – 828Combined sources
Beta strandi87 – 948Combined sources
Helixi99 – 1035Combined sources
Helixi110 – 1123Combined sources
Helixi115 – 12814Combined sources
Beta strandi133 – 14513Combined sources
Beta strandi148 – 1514Combined sources
Beta strandi154 – 1563Combined sources
Turni161 – 1633Combined sources
Beta strandi167 – 1715Combined sources
Beta strandi174 – 1785Combined sources
Helixi188 – 20922Combined sources
Helixi213 – 2153Combined sources
Beta strandi217 – 22711Combined sources
Beta strandi237 – 2459Combined sources
Helixi271 – 28313Combined sources
Helixi292 – 2943Combined sources
Helixi296 – 3005Combined sources
Helixi302 – 3054Combined sources
Beta strandi306 – 31712Combined sources
Helixi321 – 3233Combined sources
Helixi324 – 33411Combined sources
Helixi335 – 3395Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
ProteinModelPortaliQ9HAQ2.
SMRiQ9HAQ2. Positions 5-391.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HAQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 340335Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili342 – 38039Sequence analysisAdd
BLAST
Coiled coili658 – 69033Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00810000125470.
HOGENOMiHOG000116164.
HOVERGENiHBG019045.
InParanoidiQ9HAQ2.
KOiK10397.
OMAiMGLQQAH.
OrthoDBiEOG75J0MF.
PhylomeDBiQ9HAQ2.
TreeFamiTF105229.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9HAQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGVVNNQQ
60 70 80 90 100
TDWSFKLDGV LHDASQDLVY ETVAKDVVSQ ALDGYNGTIM CYGQTGAGKT
110 120 130 140 150
YTMMGATENY KHRGILPRAL QQVFRMIEER PTHAITVRVS YLEIYNESLF
160 170 180 190 200
DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL SVHLTSQEED AFSLLFEGET
210 220 230 240 250
NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK INLVDLAGSE
260 270 280 290 300
RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PFRQCKLTHA
310 320 330 340 350
LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY
360 370 380 390 400
DAERMVKNLE KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR
410 420 430 440 450
RYLEGTLDEI DIISLRQIKE VFNQFRVVLS QQEQEVESTL RRKYTLIDRN
460 470 480 490 500
DFAAISAIQK AGLVDVDGHL VGEPEGQNFG LGVAPFSTKP GKKAKSKKTF
510 520 530 540 550
KEPLSSLARK EGASSPVNGK DLDYVSTSKT QLVPSSKDGD VKDMLSRDRE
560 570 580 590 600
TSSIEPLPSD SPKEELRPIR PDTPPSKPVA FEEFKNEQGS EINRIFKENK
610 620 630 640 650
SILNERRKRA SETTQHINAI KREIDVTKEA LNFQKSLREK QGKYENKGLM
660 670 680 690 700
IIDEEEFLLI LKLKDLKKQY RSEYQDLRDL RAEIQYCQHL VDQCRHRLLM
710 720 730 740 750
EFDIWYNESF VIPEDMQMAL KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL
760 770 780 790
QQRVLPEGPD SISFYNAKVK IEQKHNYLKT MMGLQQAHRK
Length:790
Mass (Da):89,986
Last modified:October 5, 2010 - v4
Checksum:iAD5CCEDFA64FA971
GO
Isoform 2 (identifier: Q9HAQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-569: Missing.

Show »
Length:725
Mass (Da):82,972
Checksum:iA1D28B310994F210
GO

Sequence cautioni

The sequence BAB14713.1 differs from that shown.Dubious isoform. Probable cloning artifact lacking polyadenylation evidence.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781V → I.
Corresponds to variant rs2270569 [ dbSNP | Ensembl ].
VAR_022139
Natural varianti96 – 961G → A.
Corresponds to variant rs3733092 [ dbSNP | Ensembl ].
VAR_020443
Natural varianti638 – 6381R → W.2 Publications
Corresponds to variant rs2276853 [ dbSNP | Ensembl ].
VAR_024513

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei505 – 56965Missing in isoform 2. 1 PublicationVSP_002868Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA. Translation: AAG33849.1.
AC104447 Genomic DNA. No translation available.
BC030657 mRNA. Translation: AAH30657.1.
AK023894 mRNA. Translation: BAB14713.1. Sequence problems.
CCDSiCCDS2751.1. [Q9HAQ2-2]
CCDS2752.1. [Q9HAQ2-1]
RefSeqiNP_001128350.1. NM_001134878.1. [Q9HAQ2-1]
NP_071737.1. NM_022342.4. [Q9HAQ2-2]
NP_878905.2. NM_182902.3. [Q9HAQ2-1]
XP_011532306.1. XM_011534004.1. [Q9HAQ2-1]
UniGeneiHs.373947.

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727. [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727. [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727. [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727. [Q9HAQ2-1]
GeneIDi64147.
KEGGihsa:64147.
UCSCiuc003cqx.3. human. [Q9HAQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA. Translation: AAG33849.1.
AC104447 Genomic DNA. No translation available.
BC030657 mRNA. Translation: AAH30657.1.
AK023894 mRNA. Translation: BAB14713.1. Sequence problems.
CCDSiCCDS2751.1. [Q9HAQ2-2]
CCDS2752.1. [Q9HAQ2-1]
RefSeqiNP_001128350.1. NM_001134878.1. [Q9HAQ2-1]
NP_071737.1. NM_022342.4. [Q9HAQ2-2]
NP_878905.2. NM_182902.3. [Q9HAQ2-1]
XP_011532306.1. XM_011534004.1. [Q9HAQ2-1]
UniGeneiHs.373947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
ProteinModelPortaliQ9HAQ2.
SMRiQ9HAQ2. Positions 5-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122086. 14 interactions.
IntActiQ9HAQ2. 2 interactions.
MINTiMINT-8417679.
STRINGi9606.ENSP00000265529.

Chemistry

ChEMBLiCHEMBL2321637.

PTM databases

iPTMnetiQ9HAQ2.
PhosphoSiteiQ9HAQ2.

Polymorphism and mutation databases

BioMutaiKIF9.
DMDMi308153656.

Proteomic databases

MaxQBiQ9HAQ2.
PaxDbiQ9HAQ2.
PeptideAtlasiQ9HAQ2.
PRIDEiQ9HAQ2.

Protocols and materials databases

DNASUi64147.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727. [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727. [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727. [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727. [Q9HAQ2-1]
GeneIDi64147.
KEGGihsa:64147.
UCSCiuc003cqx.3. human. [Q9HAQ2-1]

Organism-specific databases

CTDi64147.
GeneCardsiKIF9.
H-InvDBHIX0003269.
HIX0003270.
HGNCiHGNC:16666. KIF9.
HPAiHPA022031.
HPA022033.
HPA030429.
MIMi607910. gene.
neXtProtiNX_Q9HAQ2.
PharmGKBiPA30110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00810000125470.
HOGENOMiHOG000116164.
HOVERGENiHBG019045.
InParanoidiQ9HAQ2.
KOiK10397.
OMAiMGLQQAH.
OrthoDBiEOG75J0MF.
PhylomeDBiQ9HAQ2.
TreeFamiTF105229.

Enzyme and pathway databases

ReactomeiR-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF9. human.
EvolutionaryTraceiQ9HAQ2.
GenomeRNAii64147.
PROiQ9HAQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HAQ2.
CleanExiHS_KIF9.
ExpressionAtlasiQ9HAQ2. baseline and differential.
GenevisibleiQ9HAQ2. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human kinesin protein 9, highly similar to Mus musculus mRNA for kinesin like protein 9."
    Li J.M., Sha J.H., Zhou Z.M.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TRP-638.
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-641 (ISOFORM 1), VARIANT TRP-638.
    Tissue: Thyroid.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-530 AND SER-546, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Crystal structure of the human KIF9 motor domain in complex with ADP."
    Structural genomics consortium (SGC)
    Submitted (NOV-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-340 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiKIF9_HUMAN
AccessioniPrimary (citable) accession number: Q9HAQ2
Secondary accession number(s): Q86Z28, Q9H8A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 5, 2010
Last modified: July 6, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.