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Protein

MLX-interacting protein

Gene

MLXIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter Source: GO_Central

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MLX-interacting protein
Alternative name(s):
Class E basic helix-loop-helix protein 36
Short name:
bHLHe36
Transcriptional activator MondoA
Gene namesi
Name:MLXIPImported
Synonyms:BHLHE36, KIAA0867, MIRImported, MONDOA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175727.13
HGNCiHGNC:17055 MLXIP
MIMi608090 gene
neXtProtiNX_Q9HAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22877
OpenTargetsiENSG00000175727
PharmGKBiPA128394590

Polymorphism and mutation databases

BioMutaiMLXIP
DMDMi156632588

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002987632 – 919MLX-interacting proteinAdd BLAST918

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei39PhosphoserineBy similarity1
Modified residuei669PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HAP2
MaxQBiQ9HAP2
PaxDbiQ9HAP2
PeptideAtlasiQ9HAP2
PRIDEiQ9HAP2

PTM databases

iPTMnetiQ9HAP2
PhosphoSitePlusiQ9HAP2

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Most abundant in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000175727
CleanExiHS_MLXIP
ExpressionAtlasiQ9HAP2 baseline and differential
GenevisibleiQ9HAP2 HS

Organism-specific databases

HPAiHPA023084

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116544, 5 interactors
IntActiQ9HAP2, 6 interactors
STRINGi9606.ENSP00000312834

Structurei

3D structure databases

ProteinModelPortaliQ9HAP2
SMRiQ9HAP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini719 – 769bHLHPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 327Required for cytoplasmic localization1 PublicationAdd BLAST255
Regioni322 – 445Transactivation domain1 PublicationAdd BLAST124
Regioni769 – 790Leucine-zipperAdd BLAST22
Regioni832 – 881Mediates heterotypic interactions between MLXIP and MLX and is required for cytoplasmic localization1 PublicationAdd BLAST50

Phylogenomic databases

eggNOGiKOG3582 Eukaryota
ENOG410XTA5 LUCA
GeneTreeiENSGT00530000063219
HOVERGENiHBG062003
InParanoidiQ9HAP2
KOiK09113
OMAiAQPTLHQ
OrthoDBiEOG091G02A1
PhylomeDBiQ9HAP2
TreeFamiTF324749

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032648 MLXIP
PANTHERiPTHR15741:SF23 PTHR15741:SF23, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9HAP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA
60 70 80 90 100
RAHASAAPPP PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD
110 120 130 140 150
TVNKQTCQTY SFGKTSSCHL SIDASLTKLF ECMTLAYSGK LVSPKWKNFK
160 170 180 190 200
GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN PVCHFVTPLD GSVDVDEHRR
210 220 230 240 250
PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED LSSLVQDDDM
260 270 280 290 300
LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
310 320 330 340 350
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS
360 370 380 390 400
ASAPVPDPNN PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE
410 420 430 440 450
HTSRTEDPFI QPTDFGPSEP PLSVPQPFLP VFTMPLLSPS PAPPPISPVL
460 470 480 490 500
PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA PSVITHTASA TLTHDAPATT
510 520 530 540 550
FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH PKPVSLTGGR
560 570 580 590 600
PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
610 620 630 640 650
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP
660 670 680 690 700
STAQDPLGKG EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS
710 720 730 740 750
PQNNCSGKSD PKNVAALKNR QMKHISAEQK RRFNIKMCFD MLNSLISNNS
760 770 780 790 800
KLTSHAITLQ KTVEYITKLQ QERGQMQEEA RRLREEIEEL NATIISCQQL
810 820 830 840 850
LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII IKPLFESFKG
860 870 880 890 900
MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
910
LPEQASKAVT RIGKRLGES
Length:919
Mass (Da):101,185
Last modified:August 21, 2007 - v2
Checksum:i47375FCC4333E0C2
GO
Isoform 21 Publication (identifier: Q9HAP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.

Show »
Length:526
Mass (Da):56,822
Checksum:i0C3ADBD852823E60
GO
Isoform 31 Publication (identifier: Q9HAP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-628: AAFSGQPQAV...APGVPEFHSS → GEPGGETQCG...HIHLNETKVS
     629-919: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:628
Mass (Da):69,091
Checksum:i30A3DE477411D863
GO
Isoform 41 Publication (identifier: Q9HAP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.
     770-772: QQE → LLS
     773-919: Missing.

Show »
Length:379
Mass (Da):39,808
Checksum:i6EC02D23459161A5
GO
Isoform 51 Publication (identifier: Q9HAP2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.
     426-443: Missing.
     578-628: AAFSGQPQAV...APGVPEFHSS → GEPGGETQCG...HIHLNETKVS
     629-919: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:217
Mass (Da):22,806
Checksum:iCD8533894CB00AB3
GO

Sequence cautioni

The sequence BAA74890 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059344396E → G2 PublicationsCorresponds to variant dbSNP:rs7978353Ensembl.1
Natural variantiVAR_059345539V → L. Corresponds to variant dbSNP:rs34702867Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524991 – 393Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST393
Alternative sequenceiVSP_052500426 – 443Missing in isoform 5. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_052501578 – 628AAFSG…EFHSS → GEPGGETQCGAPPDPEGCFP IPKAFKLVTTTTTLVCTCMR THIHLNETKVS in isoform 3 and isoform 5. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_052502629 – 919Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_052503770 – 772QQE → LLS in isoform 4. 1 Publication3
Alternative sequenceiVSP_052504773 – 919Missing in isoform 4. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312918 mRNA Translation: AAG34121.1
AF245480 mRNA Translation: AAL55689.1
AF245481 mRNA Translation: AAL55690.1
AB020674 mRNA Translation: BAA74890.2 Different initiation.
BC017656 mRNA Translation: AAH17656.1
BC028309 mRNA Translation: AAH28309.1
BC039704 mRNA Translation: AAH39704.1
BC151841 mRNA Translation: AAI51842.1
CCDSiCCDS73540.1 [Q9HAP2-1]
RefSeqiNP_055753.3, NM_014938.5 [Q9HAP2-1]
UniGeneiHs.437153
Hs.721711
Hs.731847

Genome annotation databases

EnsembliENST00000319080; ENSP00000312834; ENSG00000175727 [Q9HAP2-1]
ENST00000377037; ENSP00000366236; ENSG00000175727 [Q9HAP2-5]
ENST00000538698; ENSP00000440769; ENSG00000175727 [Q9HAP2-2]
ENST00000625732; ENSP00000486569; ENSG00000281178 [Q9HAP2-2]
ENST00000628109; ENSP00000486016; ENSG00000281178 [Q9HAP2-5]
ENST00000629738; ENSP00000487003; ENSG00000281178 [Q9HAP2-1]
GeneIDi22877
KEGGihsa:22877
UCSCiuc001ubq.4 human [Q9HAP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMLXIP_HUMAN
AccessioniPrimary (citable) accession number: Q9HAP2
Secondary accession number(s): A7MBN0
, O94945, Q7LC47, Q8IXP1, Q8TAH9, Q8WVQ0, Q8WYA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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