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Protein

Transcription factor COE2

Gene

EBF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 169C5-typeSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE2
Alternative name(s):
Early B-cell factor 2
Short name:
EBF-2
Gene namesi
Name:EBF2
Synonyms:COE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000221818.8.
HGNCiHGNC:19090. EBF2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64641.
OpenTargetsiENSG00000221818.
PharmGKBiPA38794.

Polymorphism and mutation databases

BioMutaiEBF2.
DMDMi119370337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078281 – 575Transcription factor COE2Add BLAST575

Proteomic databases

MaxQBiQ9HAK2.
PaxDbiQ9HAK2.
PeptideAtlasiQ9HAK2.
PRIDEiQ9HAK2.

PTM databases

iPTMnetiQ9HAK2.
PhosphoSitePlusiQ9HAK2.
SwissPalmiQ9HAK2.

Expressioni

Gene expression databases

BgeeiENSG00000221818.
CleanExiHS_EBF2.
ExpressionAtlasiQ9HAK2. baseline and differential.
GenevisibleiQ9HAK2. HS.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Interaction with DNABy similarity1
Sitei171Interaction with DNABy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF1Q130774EBI-12267154,EBI-359224

Protein-protein interaction databases

BioGridi122221. 1 interactor.
IntActiQ9HAK2. 2 interactors.
STRINGi9606.ENSP00000430241.

Structurei

3D structure databases

ProteinModelPortaliQ9HAK2.
SMRiQ9HAK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 336IPT/TIGAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 65Interaction with DNABy similarity4
Regioni196 – 203Interaction with DNABy similarity8
Regioni235 – 238Interaction with DNABy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi453 – 534Pro/Ser/Thr-richAdd BLAST82

Sequence similaritiesi

Belongs to the COE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 169C5-typeSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ9HAK2.
KOiK09103.
OMAiEYATPCI.
OrthoDBiEOG091G0A9D.
PhylomeDBiQ9HAK2.
TreeFamiTF313391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiView protein in Pfam
PF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
SMARTiView protein in SMART
SM00429. IPT. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS01345. COE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGIQDTLGR GPTLKEKSLG AEMDSVRSWV RNVGVVDANV AAQSGVALSR
60 70 80 90 100
AHFEKQPPSN LRKSNFFHFV LALYDRQGQP VEIERTAFVD FVENDKEQGN
110 120 130 140 150
EKTNNGTHYK LQLLYSNGVR TEQDLYVRLI DSVTKQPIAY EGQNKNPEMC
160 170 180 190 200
RVLLTHEVMC SRCCEKKSCG NRNETPSDPV IIDRFFLKFF LKCNQNCLKT
210 220 230 240 250
AGNPRDMRRF QVVLSTTVNV DGHVLAVSDN MFVHNNSKHG RRARRLDPSE
260 270 280 290 300
ATPCIKAISP SEGWTTGGAM VIIIGDNFFD GLQVVFGTML VWSELITPHA
310 320 330 340 350
IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFIYTALNE PTIDYGFQRL
360 370 380 390 400
QKVIPRHPGD PERLAKEMLL KRAADLVEAL YGTPHNNQDI ILKRAADIAE
410 420 430 440 450
ALYSVPRNPS QLPALSSSPA HSGMMGINSY GSQLGVSISE STQGNNQGYI
460 470 480 490 500
RNTSSISPRG YSSSSTPQQS NYSTSSNSMN GYSNVPMANL GVPGSPGFLN
510 520 530 540 550
GSPTGSPYGI MSSSPTVGSS STSSILPFSS SVFPAVKQKS AFAPVIRPQG
560 570
SPSPACSSGN GNGFRAMTGL VVPPM
Length:575
Mass (Da):62,650
Last modified:December 12, 2006 - v4
Checksum:i05FCDBC9CB81EC89
GO
Isoform 2 (identifier: Q9HAK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.
     510-575: IMSSSPTVGS...AMTGLVVPPM → TGLWLTWLLKAFWGKKRIETIPFL

Show »
Length:264
Mass (Da):28,748
Checksum:i7B5424D298D36159
GO

Sequence cautioni

The sequence BAB13843 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti483S → G in AAU10086 (Ref. 1) Curated1
Sequence conflicti513S → L in BAB13843 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048754559G → S. Corresponds to variant dbSNP:rs17054477Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555301 – 269Missing in isoform 2. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_055531510 – 575IMSSS…VVPPM → TGLWLTWLLKAFWGKKRIET IPFL in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY700779 mRNA. Translation: AAU10086.1.
AC023566 Genomic DNA. No translation available.
AC090103 Genomic DNA. No translation available.
AK021562 mRNA. Translation: BAB13843.1. Different initiation.
BC069665 mRNA. Translation: AAH69665.1.
BC069726 mRNA. Translation: AAH69726.1.
BC069747 mRNA. Translation: AAH69747.1.
BC069768 mRNA. Translation: AAH69768.1.
BC074794 mRNA. Translation: AAH74794.2.
BC113478 mRNA. Translation: AAI13479.1.
BC113504 mRNA. Translation: AAI13505.1.
CCDSiCCDS43726.1. [Q9HAK2-1]
RefSeqiNP_073150.2. NM_022659.3. [Q9HAK2-1]
UniGeneiHs.491292.

Genome annotation databases

EnsembliENST00000520164; ENSP00000430241; ENSG00000221818. [Q9HAK2-1]
ENST00000535548; ENSP00000437909; ENSG00000221818. [Q9HAK2-2]
GeneIDi64641.
KEGGihsa:64641.
UCSCiuc003xes.3. human. [Q9HAK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOE2_HUMAN
AccessioniPrimary (citable) accession number: Q9HAK2
Secondary accession number(s): A0PJM4
, A6NMF7, F5H645, Q66VZ3, Q6DK36, Q6IS86, Q6ISA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 12, 2006
Last modified: September 27, 2017
This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families