Q9HAJ7 (SP30L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase complex subunit SAP30L

Alternative name(s):
HCV non-structural protein 4A-transactivated protein 2
Sin3 corepressor complex subunit SAP30L
Sin3-associated protein p30-like

Gene names

Name:	SAP30L
Synonyms:	NS4ATP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Ref.7
Subunit structure	Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2. Interacts with FEZ1. Ref.6 Ref.7
Subcellular location	Nucleus › nucleolus Ref.1 Ref.7.
Tissue specificity	Expressed in all tissues tested with highest levels in testis.
Induction	Up-regulated by TGFB1. Ref.1
Sequence similarities	Belongs to the SAP30 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Histone deacetylase complex subunit SAP30L		PRO_0000309500
Regions
	Zinc finger	29 – 77	49	Atypical
Amino acid modifications
	Modified residue	92	1	Phosphothreonine Ref.8
	Modified residue	93	1	Phosphoserine By similarity
	Modified residue	99	1	Phosphoserine Ref.8
	Modified residue	104	1	Phosphothreonine Ref.9
Experimental info
	Mutagenesis	88 – 89	2	RK → KS: Impairs nuclear localization. Ref.1
	Mutagenesis	120 – 127	8	RRYKRHYK → AAAAAAAA: Abolishes nucleolar localization. Ref.1 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9HAJ7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: EB19E448C6A1FA45	FASTA	183	20,877
	10 20 30 40 50 60 MNGFSTEEDS REGPPAAPAA AAPGYGQSCC LIEDGERCVR PAGNASFSKR VQKSISQKKL 70 80 90 100 110 120 KLDIDKSVRH LYICDFHKNF IQSVRNKRKR KTSDDGGDSP EHDTDIPEVD LFQLQVNTLR 130 140 150 160 170 180 RYKRHYKLQT RPGFNKAQLA ETVSRHFRNI PVNEKETLAY FIYMVKSNKS RLDQKSEGGK QLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TGF-beta induces the expression of SAP30L, a novel nuclear protein." Lindfors K., Viiri K.M., Niittynen M., Heinonen T.Y., Maki M., Kainulainen H. BMC Genomics 4:53-53(2003) [PubMed: 14680513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, MUTAGENESIS OF 88-ARG-LYS-89, INDUCTION. Tissue: Heart.
[2]	"Homo sapiens gene 2 transactivated by nonstructural protein 4A of hepatitis C virus (NS4ATP2) mRNA." Liu Y., Yang Y., Cheng J., Ji D., Li L., Zhang L., Chen J. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region." Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J. J. Biol. Chem. 281:9869-9881(2006) [PubMed: 16484223] [Abstract] Cited for: INTERACTION WITH FEZ1.
[7]	"SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus." Viiri K.M., Korkeamaeki H., Kukkonen M.K., Nieminen L.K., Lindfors K., Peterson P., Maeki M., Kainulainen H., Lohi O. Nucleic Acids Res. 34:3288-3298(2006) [PubMed: 16820529] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SIN3A; HDAC1 AND HDAC2, MUTAGENESIS OF 120-ARG--LYS-127.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-99, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY341060 mRNA. Translation: AAQ16562.1. AY846876 mRNA. Translation: AAX54477.1. AK021588 mRNA. Translation: BAB13848.1. CH471062 Genomic DNA. Translation: EAW61637.1. BC009829 mRNA. Translation: AAH09829.1.
IPI	IPI00002831.
RefSeq	NP_001124534.1. NM_001131062.1. NP_001124535.1. NM_001131063.1. NP_078908.1. NM_024632.5.
UniGene	Hs.592566.
3D structure databases
ProteinModelPortal	Q9HAJ7.
SMR	Q9HAJ7. Positions 26-179.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HAJ7. 3 interactions.
STRING	Q9HAJ7.
PTM databases
PhosphoSite	Q9HAJ7.
Polymorphism databases
DMDM	74734226.
Proteomic databases
PRIDE	Q9HAJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297109; ENSP00000297109; ENSG00000164576.
GeneID	79685.
KEGG	hsa:79685.
UCSC	uc003lvk.1. human.
Organism-specific databases
CTD	79685.
GeneCards	GC05P153805.
H-InvDB	HIX0200723.
HGNC	HGNC:25663. SAP30L.
MIM	610398. gene.
neXtProt	NX_Q9HAJ7.
PharmGKB	PA144596386.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18913.
GeneTree	ENSGT00390000006633.
HOGENOM	HBG279868.
HOVERGEN	HBG057907.
InParanoid	Q9HAJ7.
OMA	FKTIPIK.
OrthoDB	EOG48PMMK.
PhylomeDB	Q9HAJ7.
Gene expression databases
ArrayExpress	Q9HAJ7.
Bgee	Q9HAJ7.
CleanEx	HS_SAP30L.
Genevestigator	Q9HAJ7.
Family and domain databases
InterPro	IPR024145. His_deAcase_SAP30/SAP30L. [Graphical view]
PANTHER	PTHR13286. PTHR13286. 1 hit.
ProtoNet	Search...
Other
NextBio	68948.
SOURCE	Search...

Entry information

Entry name

SP30L_HUMAN

Accession

Primary (citable) accession number: Q9HAJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.