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Protein

Probable fibrosin-1

Gene

FBRS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fibrosin-1
Gene namesi
Name:FBRS
Synonyms:FBS, FBS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:20442. FBRS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi64319.
OpenTargetsiENSG00000156860.
PharmGKBiPA162388128.

Polymorphism and mutation databases

BioMutaiFBRS.
DMDMi332278207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872061 – 460Probable fibrosin-1Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Asymmetric dimethylarginineCombined sources1
Modified residuei239Asymmetric dimethylarginineCombined sources1
Modified residuei281PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9HAH7.
PaxDbiQ9HAH7.
PeptideAtlasiQ9HAH7.
PRIDEiQ9HAH7.

PTM databases

iPTMnetiQ9HAH7.
PhosphoSitePlusiQ9HAH7.

Expressioni

Gene expression databases

BgeeiENSG00000156860.
CleanExiHS_FBRS.
ExpressionAtlasiQ9HAH7. baseline and differential.
GenevisibleiQ9HAH7. HS.

Organism-specific databases

HPAiHPA044117.

Interactioni

Protein-protein interaction databases

BioGridi122132. 23 interactors.
DIPiDIP-61357N.
IntActiQ9HAH7. 16 interactors.
STRINGi9606.ENSP00000348489.

Structurei

3D structure databases

ProteinModelPortaliQ9HAH7.
SMRiQ9HAH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 329Ala-richAdd BLAST19
Compositional biasi342 – 422Pro-richAdd BLAST81

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000035095.
HOVERGENiHBG051563.
InParanoidiQ9HAH7.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9HAH7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFEKYPGKME GLFRHNPYTA FPPAVPGLPP GLPPAVSFGS LQGAFQPKST
60 70 80 90 100
NPELPPRLGP VPSGLSQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH
110 120 130 140 150
QEKMKGDSHK LDFRNDLLPC LPGPYGALPP GQELSHPASL FTATGAVHAA
160 170 180 190 200
ANPFTAAPGA HGPFLSPSTH IDPFGRPTSF ASLAALSNGA FGGLGSPTFN
210 220 230 240 250
SGAVFAQKES PGAPPAFASP PDPWGRLHRS PLTFPAWVRP PEAARTPGSD
260 270 280 290 300
KERPVERREP SITKEEKDRD LPFSRPQLRV SPATPKARAG EEGPRPTKES
310 320 330 340 350
VRVKEERKEE AAAAAAAAAA AAAAAAAAAT GPQGLHLLFE RPRPPPFLGP
360 370 380 390 400
SPPDRCAGFL EPTWLAAPPR LARPPRFYEA GEELTGPGAV AAARLYGLEP
410 420 430 440 450
AHPLLYSRLA PPPPPAAAPG TPHLLSKTPP GALLGAPPPL VPAPRPSSPP
460
RGPGPARADR
Length:460
Mass (Da):48,388
Last modified:May 3, 2011 - v3
Checksum:iB99B5624ACD7848B
GO
Isoform 1 (identifier: Q9HAH7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-460: PPGALLGAPPPLVPAPRPSSPPRGPGPARADR → FCTFLQGCPS...SPWEGGASRR

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):51,839
Checksum:i03E1D281919FF547
GO

Sequence cautioni

The sequence BAB13872 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14094 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168S → G in BAG60498 (PubMed:14702039).Curated1
Sequence conflicti255V → A in BAB13872 (PubMed:14702039).Curated1
Sequence conflicti283A → V in BAG60498 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010991429 – 460PPGAL…ARADR → FCTFLQGCPSQQFPSWLIKP SDWCCVPSLWPLCGERGLQG EEPGRDSQASPWEGGASRR in isoform 1. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021680 mRNA. Translation: BAB13872.1. Different initiation.
AK022551 mRNA. Translation: BAB14094.1. Different initiation.
AK298229 mRNA. Translation: BAG60498.1.
AC093249 Genomic DNA. No translation available.
RefSeqiNP_001098549.2. NM_001105079.2.
UniGeneiHs.247186.
Hs.728926.

Genome annotation databases

EnsembliENST00000287468; ENSP00000287468; ENSG00000156860. [Q9HAH7-2]
GeneIDi64319.
KEGGihsa:64319.
UCSCiuc002dzd.4. human. [Q9HAH7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021680 mRNA. Translation: BAB13872.1. Different initiation.
AK022551 mRNA. Translation: BAB14094.1. Different initiation.
AK298229 mRNA. Translation: BAG60498.1.
AC093249 Genomic DNA. No translation available.
RefSeqiNP_001098549.2. NM_001105079.2.
UniGeneiHs.247186.
Hs.728926.

3D structure databases

ProteinModelPortaliQ9HAH7.
SMRiQ9HAH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122132. 23 interactors.
DIPiDIP-61357N.
IntActiQ9HAH7. 16 interactors.
STRINGi9606.ENSP00000348489.

PTM databases

iPTMnetiQ9HAH7.
PhosphoSitePlusiQ9HAH7.

Polymorphism and mutation databases

BioMutaiFBRS.
DMDMi332278207.

Proteomic databases

EPDiQ9HAH7.
PaxDbiQ9HAH7.
PeptideAtlasiQ9HAH7.
PRIDEiQ9HAH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287468; ENSP00000287468; ENSG00000156860. [Q9HAH7-2]
GeneIDi64319.
KEGGihsa:64319.
UCSCiuc002dzd.4. human. [Q9HAH7-2]

Organism-specific databases

CTDi64319.
DisGeNETi64319.
GeneCardsiFBRS.
HGNCiHGNC:20442. FBRS.
HPAiHPA044117.
MIMi608601. gene.
neXtProtiNX_Q9HAH7.
OpenTargetsiENSG00000156860.
PharmGKBiPA162388128.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000035095.
HOVERGENiHBG051563.
InParanoidiQ9HAH7.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156860-MONOMER.

Miscellaneous databases

ChiTaRSiFBRS. human.
GeneWikiiFBRS.
GenomeRNAii64319.
PROiQ9HAH7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156860.
CleanExiHS_FBRS.
ExpressionAtlasiQ9HAH7. baseline and differential.
GenevisibleiQ9HAH7. HS.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.
ProtoNetiSearch...

Entry informationi

Entry nameiFBRS_HUMAN
AccessioniPrimary (citable) accession number: Q9HAH7
Secondary accession number(s): B4DP86, Q96CI9, Q9H9X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 3, 2011
Last modified: November 30, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Prakash et al. cloned a cDNA corresponding to the 3'UTR of the last exon of the gene (PubMed:9809749). They have shown that a synthetic peptide derived from this sequence could stimulate fibroblasts growth in vitro, and that this protein could be a fibrogenic lymphokine, that could stimulate several biological activities related to scarring. It would be expressed in placenta, skeletal muscle, pancreas, thymus, testis, and leukocytes. However, it was not confirmed by in vivo data.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.