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Protein

Probable fibrosin-1

Gene

FBRS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fibrosin-1
Gene namesi
Name:FBRS
Synonyms:FBS, FBS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:20442. FBRS.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388128.

Polymorphism and mutation databases

BioMutaiFBRS.
DMDMi332278207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Probable fibrosin-1PRO_0000087206Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HAH7.
MaxQBiQ9HAH7.
PaxDbiQ9HAH7.
PeptideAtlasiQ9HAH7.
PRIDEiQ9HAH7.

PTM databases

iPTMnetiQ9HAH7.
PhosphoSiteiQ9HAH7.

Expressioni

Gene expression databases

BgeeiQ9HAH7.
CleanExiHS_FBRS.
ExpressionAtlasiQ9HAH7. baseline and differential.
GenevisibleiQ9HAH7. HS.

Organism-specific databases

HPAiHPA044117.

Interactioni

Protein-protein interaction databases

BioGridi122132. 23 interactions.
DIPiDIP-61357N.
IntActiQ9HAH7. 6 interactions.
STRINGi9606.ENSP00000348489.

Structurei

3D structure databases

ProteinModelPortaliQ9HAH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 32919Ala-richAdd
BLAST
Compositional biasi342 – 42281Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000035095.
HOVERGENiHBG051563.
InParanoidiQ9HAH7.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9HAH7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFEKYPGKME GLFRHNPYTA FPPAVPGLPP GLPPAVSFGS LQGAFQPKST
60 70 80 90 100
NPELPPRLGP VPSGLSQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH
110 120 130 140 150
QEKMKGDSHK LDFRNDLLPC LPGPYGALPP GQELSHPASL FTATGAVHAA
160 170 180 190 200
ANPFTAAPGA HGPFLSPSTH IDPFGRPTSF ASLAALSNGA FGGLGSPTFN
210 220 230 240 250
SGAVFAQKES PGAPPAFASP PDPWGRLHRS PLTFPAWVRP PEAARTPGSD
260 270 280 290 300
KERPVERREP SITKEEKDRD LPFSRPQLRV SPATPKARAG EEGPRPTKES
310 320 330 340 350
VRVKEERKEE AAAAAAAAAA AAAAAAAAAT GPQGLHLLFE RPRPPPFLGP
360 370 380 390 400
SPPDRCAGFL EPTWLAAPPR LARPPRFYEA GEELTGPGAV AAARLYGLEP
410 420 430 440 450
AHPLLYSRLA PPPPPAAAPG TPHLLSKTPP GALLGAPPPL VPAPRPSSPP
460
RGPGPARADR
Length:460
Mass (Da):48,388
Last modified:May 3, 2011 - v3
Checksum:iB99B5624ACD7848B
GO
Isoform 1 (identifier: Q9HAH7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-460: PPGALLGAPPPLVPAPRPSSPPRGPGPARADR → FCTFLQGCPS...SPWEGGASRR

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):51,839
Checksum:i03E1D281919FF547
GO

Sequence cautioni

The sequence BAB13872.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14094.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681S → G in BAG60498 (PubMed:14702039).Curated
Sequence conflicti255 – 2551V → A in BAB13872 (PubMed:14702039).Curated
Sequence conflicti283 – 2831A → V in BAG60498 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei429 – 46032PPGAL…ARADR → FCTFLQGCPSQQFPSWLIKP SDWCCVPSLWPLCGERGLQG EEPGRDSQASPWEGGASRR in isoform 1. 1 PublicationVSP_010991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021680 mRNA. Translation: BAB13872.1. Different initiation.
AK022551 mRNA. Translation: BAB14094.1. Different initiation.
AK298229 mRNA. Translation: BAG60498.1.
AC093249 Genomic DNA. No translation available.
RefSeqiNP_001098549.2. NM_001105079.2.
UniGeneiHs.247186.
Hs.728926.

Genome annotation databases

EnsembliENST00000287468; ENSP00000287468; ENSG00000156860. [Q9HAH7-2]
GeneIDi64319.
KEGGihsa:64319.
UCSCiuc002dzd.4. human. [Q9HAH7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021680 mRNA. Translation: BAB13872.1. Different initiation.
AK022551 mRNA. Translation: BAB14094.1. Different initiation.
AK298229 mRNA. Translation: BAG60498.1.
AC093249 Genomic DNA. No translation available.
RefSeqiNP_001098549.2. NM_001105079.2.
UniGeneiHs.247186.
Hs.728926.

3D structure databases

ProteinModelPortaliQ9HAH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122132. 23 interactions.
DIPiDIP-61357N.
IntActiQ9HAH7. 6 interactions.
STRINGi9606.ENSP00000348489.

PTM databases

iPTMnetiQ9HAH7.
PhosphoSiteiQ9HAH7.

Polymorphism and mutation databases

BioMutaiFBRS.
DMDMi332278207.

Proteomic databases

EPDiQ9HAH7.
MaxQBiQ9HAH7.
PaxDbiQ9HAH7.
PeptideAtlasiQ9HAH7.
PRIDEiQ9HAH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287468; ENSP00000287468; ENSG00000156860. [Q9HAH7-2]
GeneIDi64319.
KEGGihsa:64319.
UCSCiuc002dzd.4. human. [Q9HAH7-2]

Organism-specific databases

CTDi64319.
GeneCardsiFBRS.
HGNCiHGNC:20442. FBRS.
HPAiHPA044117.
MIMi608601. gene.
neXtProtiNX_Q9HAH7.
PharmGKBiPA162388128.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000035095.
HOVERGENiHBG051563.
InParanoidiQ9HAH7.

Miscellaneous databases

ChiTaRSiFBRS. human.
GeneWikiiFBRS.
GenomeRNAii64319.
PROiQ9HAH7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HAH7.
CleanExiHS_FBRS.
ExpressionAtlasiQ9HAH7. baseline and differential.
GenevisibleiQ9HAH7. HS.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-460 (ISOFORM 1).
    Tissue: Embryo and Teratocarcinoma.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine."
    Prakash S., Robbins P.W.
    DNA Cell Biol. 17:879-884(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF 3'-UTR.
    Tissue: Placenta and T-cell.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiFBRS_HUMAN
AccessioniPrimary (citable) accession number: Q9HAH7
Secondary accession number(s): B4DP86, Q96CI9, Q9H9X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 3, 2011
Last modified: July 6, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Prakash et al. cloned a cDNA corresponding to the 3'UTR of the last exon of the gene (PubMed:9809749). They have shown that a synthetic peptide derived from this sequence could stimulate fibroblasts growth in vitro, and that this protein could be a fibrogenic lymphokine, that could stimulate several biological activities related to scarring. It would be expressed in placenta, skeletal muscle, pancreas, thymus, testis, and leukocytes. However, it was not confirmed by in vivo data.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.