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Protein

Zinc finger protein 556

Gene

ZNF556

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172000-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 556
Gene namesi
Name:ZNF556
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25669. ZNF556.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172000.
PharmGKBiPA134949188.

Polymorphism and mutation databases

BioMutaiZNF556.
DMDMi74762747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748761 – 456Zinc finger protein 556Add BLAST456

Proteomic databases

MaxQBiQ9HAH1.
PaxDbiQ9HAH1.
PeptideAtlasiQ9HAH1.
PRIDEiQ9HAH1.

PTM databases

iPTMnetiQ9HAH1.
PhosphoSitePlusiQ9HAH1.

Expressioni

Gene expression databases

BgeeiENSG00000172000.
CleanExiHS_ZNF556.
ExpressionAtlasiQ9HAH1. baseline and differential.
GenevisibleiQ9HAH1. HS.

Organism-specific databases

HPAiHPA067596.

Interactioni

Protein-protein interaction databases

BioGridi123082. 11 interactors.
STRINGi9606.ENSP00000302603.

Structurei

3D structure databases

ProteinModelPortaliQ9HAH1.
SMRiQ9HAH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 77KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HAH1.
KOiK09228.
OMAiCGKAYCW.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9HAH1.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HAH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTVVFEDVV VDFTLEEWAL LNPAQRKLYR DVMLETFKHL ASVDNEAQLK
60 70 80 90 100
ASGSISQQDT SGEKLSLKQK IEKFTRKNIW ASLLGKNWEE HSVKDKHNTK
110 120 130 140 150
ERHLSRNPRV ERPCKSSKGN KRGRTFRKTR NCNRHLRKNC CTSVRRYECS
160 170 180 190 200
QCGKLFTHSS SLIRHKRAHS GQKLYKCKEC GKAFSRPSYL QTHEKTHSGE
210 220 230 240 250
KPYACQSCGK TFLRSHSLTE HVRTHTGEKP YECGQCGKGF SCPKSFRAHV
260 270 280 290 300
MMHAGGRPYE CKHCGKAFRC QKSFRVHMIM HAGGRPYECK QCGKAYCWAT
310 320 330 340 350
SFQRHVRIHN GEKPYKCGKC GKAFGWPSSL HKHARTHAKK KPVSGGSVGK
360 370 380 390 400
SSARPRPSTD VKSQTREKVY KCETCGKTYG WSSSLHKHER KHTGEKPVNA
410 420 430 440 450
ASVGKPSGGL CSSKNVRTQI GQKPSKCEKC GKAFSCPKAF QGHVRSHTGK

KSCTSK
Length:456
Mass (Da):51,581
Last modified:March 1, 2001 - v1
Checksum:i9C52FF6C12AA88EB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030355137R → C.Corresponds to variant rs10421121dbSNPEnsembl.1
Natural variantiVAR_052863146R → L.Corresponds to variant rs35499960dbSNPEnsembl.1
Natural variantiVAR_052864353A → T.Corresponds to variant rs35296337dbSNPEnsembl.1
Natural variantiVAR_052865428E → K.Corresponds to variant rs35494032dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021699 mRNA. Translation: BAB13878.1.
BC009374 mRNA. Translation: AAH09374.1.
CCDSiCCDS12097.1.
RefSeqiNP_001287772.1. NM_001300843.1.
NP_079243.1. NM_024967.2.
UniGeneiHs.287433.

Genome annotation databases

EnsembliENST00000307635; ENSP00000302603; ENSG00000172000.
GeneIDi80032.
KEGGihsa:80032.
UCSCiuc002lwp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021699 mRNA. Translation: BAB13878.1.
BC009374 mRNA. Translation: AAH09374.1.
CCDSiCCDS12097.1.
RefSeqiNP_001287772.1. NM_001300843.1.
NP_079243.1. NM_024967.2.
UniGeneiHs.287433.

3D structure databases

ProteinModelPortaliQ9HAH1.
SMRiQ9HAH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123082. 11 interactors.
STRINGi9606.ENSP00000302603.

PTM databases

iPTMnetiQ9HAH1.
PhosphoSitePlusiQ9HAH1.

Polymorphism and mutation databases

BioMutaiZNF556.
DMDMi74762747.

Proteomic databases

MaxQBiQ9HAH1.
PaxDbiQ9HAH1.
PeptideAtlasiQ9HAH1.
PRIDEiQ9HAH1.

Protocols and materials databases

DNASUi80032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307635; ENSP00000302603; ENSG00000172000.
GeneIDi80032.
KEGGihsa:80032.
UCSCiuc002lwp.2. human.

Organism-specific databases

CTDi80032.
GeneCardsiZNF556.
HGNCiHGNC:25669. ZNF556.
HPAiHPA067596.
neXtProtiNX_Q9HAH1.
OpenTargetsiENSG00000172000.
PharmGKBiPA134949188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HAH1.
KOiK09228.
OMAiCGKAYCW.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9HAH1.
TreeFamiTF338854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172000-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF556. human.
GenomeRNAii80032.
PROiQ9HAH1.

Gene expression databases

BgeeiENSG00000172000.
CleanExiHS_ZNF556.
ExpressionAtlasiQ9HAH1. baseline and differential.
GenevisibleiQ9HAH1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN556_HUMAN
AccessioniPrimary (citable) accession number: Q9HAH1
Secondary accession number(s): Q96GM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.