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Protein

Chromatin modification-related protein MEAF6

Gene

MEAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.3 Publications

GO - Biological processi

  • histone H2A acetylation Source: UniProtKB
  • histone H3-K14 acetylation Source: UniProtKB
  • histone H4-K12 acetylation Source: UniProtKB
  • histone H4-K5 acetylation Source: UniProtKB
  • histone H4-K8 acetylation Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163875-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein MEAF6
Short name:
MYST/Esa1-associated factor 6
Alternative name(s):
Esa1-associated factor 6 homolog
Short name:
Protein EAF6 homolog
Short name:
hEAF6
Sarcoma antigen NY-SAR-91
Gene namesi
Name:MEAF6Imported
Synonyms:C1orf149, CENP-28, EAF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25674. MEAF6.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: HPA
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • kinetochore Source: UniProtKB
  • MOZ/MORF histone acetyltransferase complex Source: UniProtKB
  • NuA4 histone acetyltransferase complex Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.

Organism-specific databases

DisGeNETi64769.
OpenTargetsiENSG00000163875.
PharmGKBiPA165751536.

Polymorphism and mutation databases

DMDMi74752760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002726092 – 191Chromatin modification-related protein MEAF6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysineCombined sources1
Modified residuei74N6-acetyllysineCombined sources1
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HAF1.
MaxQBiQ9HAF1.
PeptideAtlasiQ9HAF1.
PRIDEiQ9HAF1.

PTM databases

iPTMnetiQ9HAF1.
PhosphoSitePlusiQ9HAF1.

Expressioni

Gene expression databases

BgeeiENSG00000163875.
CleanExiHS_C1orf149.
ExpressionAtlasiQ9HAF1. baseline and differential.
GenevisibleiQ9HAF1. HS.

Organism-specific databases

HPAiHPA029599.
HPA029600.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FXR2P511163EBI-399266,EBI-740459
LDOC1O957513EBI-399266,EBI-740738
PLEKHF2Q9H8W45EBI-399266,EBI-742388
TRIM54Q9BYV23EBI-399266,EBI-2130429

Protein-protein interaction databases

BioGridi122280. 53 interactors.
IntActiQ9HAF1. 17 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9HAF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 47Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the EAF6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000015257.
HOGENOMiHOG000290166.
InParanoidiQ9HAF1.
KOiK11344.
OMAiYQKETEY.
OrthoDBiEOG091G126R.
PhylomeDBiQ9HAF1.
TreeFamiTF324130.

Family and domain databases

InterProiIPR015418. Eaf6.
[Graphical view]
PfamiPF09340. NuA4. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HAF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMHNKAAPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED
60 70 80 90 100
TQMYGNIIRG WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV
110 120 130 140 150
SALAGVQDQL IEKREPGSGT ESDTSPDFHN QENEPSQEDP EDLDGSVQGV
160 170 180 190
KPQKAASSTS SGSHHSSHKK RKNKNRHRID LKLNKKPRAD Y
Length:191
Mass (Da):21,635
Last modified:March 1, 2001 - v1
Checksum:iC0FBC7566BAAF1F7
GO
Isoform 2 (identifier: Q9HAF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-191: RIDLKLNKKPRADY → SPSGMFDYDFEYVY

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):21,625
Checksum:i4A46263CF13F3C99
GO
Isoform 3 (identifier: Q9HAF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: R → SPSGMFDYDFE

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,755
Checksum:iE30FC55A4AB5EBA0
GO
Isoform 4 (identifier: Q9HAF1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-191: IDLKLNKKPRADY → MNVSPKTGWHQLHL

Note: Gene prediction based on EST data.
Show »
Length:192
Mass (Da):21,709
Checksum:i3DC03438B928A5A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AM → RG in AAO65179 (PubMed:12601173).Curated2
Sequence conflicti4H → P in AAZ13760 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022450178 – 191RIDLK…PRADY → SPSGMFDYDFEYVY in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_022451178R → SPSGMFDYDFE in isoform 3. 1 Publication1
Alternative sequenceiVSP_047018179 – 191IDLKL…PRADY → MNVSPKTGWHQLHL in isoform 4. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538212 mRNA. Translation: CAD98071.1.
BX640719 mRNA. Translation: CAE45838.1.
AK021792 mRNA. Translation: BAB13898.1.
DQ099384 mRNA. Translation: AAZ13760.1.
AL034379 Genomic DNA. Translation: CAI20549.1.
AL034379 Genomic DNA. Translation: CAI20550.1.
BC056406 mRNA. Translation: AAH56406.1.
BC016328 mRNA. Translation: AAH16328.1.
AY211926 mRNA. Translation: AAO65179.1.
CCDSiCCDS418.1. [Q9HAF1-3]
CCDS59195.1. [Q9HAF1-4]
CCDS59196.1. [Q9HAF1-1]
RefSeqiNP_001257804.1. NM_001270875.1. [Q9HAF1-1]
NP_001257805.1. NM_001270876.1. [Q9HAF1-4]
NP_073593.2. NM_022756.5. [Q9HAF1-3]
UniGeneiHs.17118.

Genome annotation databases

EnsembliENST00000296214; ENSP00000296214; ENSG00000163875. [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875. [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875. [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875. [Q9HAF1-2]
GeneIDi64769.
KEGGihsa:64769.
UCSCiuc001cbe.4. human. [Q9HAF1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538212 mRNA. Translation: CAD98071.1.
BX640719 mRNA. Translation: CAE45838.1.
AK021792 mRNA. Translation: BAB13898.1.
DQ099384 mRNA. Translation: AAZ13760.1.
AL034379 Genomic DNA. Translation: CAI20549.1.
AL034379 Genomic DNA. Translation: CAI20550.1.
BC056406 mRNA. Translation: AAH56406.1.
BC016328 mRNA. Translation: AAH16328.1.
AY211926 mRNA. Translation: AAO65179.1.
CCDSiCCDS418.1. [Q9HAF1-3]
CCDS59195.1. [Q9HAF1-4]
CCDS59196.1. [Q9HAF1-1]
RefSeqiNP_001257804.1. NM_001270875.1. [Q9HAF1-1]
NP_001257805.1. NM_001270876.1. [Q9HAF1-4]
NP_073593.2. NM_022756.5. [Q9HAF1-3]
UniGeneiHs.17118.

3D structure databases

ProteinModelPortaliQ9HAF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122280. 53 interactors.
IntActiQ9HAF1. 17 interactors.

PTM databases

iPTMnetiQ9HAF1.
PhosphoSitePlusiQ9HAF1.

Polymorphism and mutation databases

DMDMi74752760.

Proteomic databases

EPDiQ9HAF1.
MaxQBiQ9HAF1.
PeptideAtlasiQ9HAF1.
PRIDEiQ9HAF1.

Protocols and materials databases

DNASUi64769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296214; ENSP00000296214; ENSG00000163875. [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875. [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875. [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875. [Q9HAF1-2]
GeneIDi64769.
KEGGihsa:64769.
UCSCiuc001cbe.4. human. [Q9HAF1-1]

Organism-specific databases

CTDi64769.
DisGeNETi64769.
GeneCardsiMEAF6.
HGNCiHGNC:25674. MEAF6.
HPAiHPA029599.
HPA029600.
MIMi611001. gene.
neXtProtiNX_Q9HAF1.
OpenTargetsiENSG00000163875.
PharmGKBiPA165751536.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000015257.
HOGENOMiHOG000290166.
InParanoidiQ9HAF1.
KOiK11344.
OMAiYQKETEY.
OrthoDBiEOG091G126R.
PhylomeDBiQ9HAF1.
TreeFamiTF324130.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163875-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Miscellaneous databases

GeneWikiiC1orf149.
GenomeRNAii64769.
PROiQ9HAF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163875.
CleanExiHS_C1orf149.
ExpressionAtlasiQ9HAF1. baseline and differential.
GenevisibleiQ9HAF1. HS.

Family and domain databases

InterProiIPR015418. Eaf6.
[Graphical view]
PfamiPF09340. NuA4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAF6_HUMAN
AccessioniPrimary (citable) accession number: Q9HAF1
Secondary accession number(s): B1AK64
, Q4F967, Q7Z311, Q86WE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.