Q9HAD4 (WDR41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 41

Gene names

Name:	WDR41
ORF Names:	MSTP048

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 6 WD repeats.
Sequence caution	The sequence AAO06948.1 differs from that shown. Reason: Frameshift at position 188.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	WD repeat-containing protein 41		PRO_0000051390
Regions
	Repeat	40 – 79	40	WD 1
	Repeat	82 – 128	47	WD 2
	Repeat	131 – 168	38	WD 3
	Repeat	220 – 258	39	WD 4
	Repeat	321 – 359	39	WD 5
	Repeat	403 – 441	39	WD 6
Natural variations
	Natural variant	61	1	G → D. Corresponds to variant rs389319 [ dbSNP | Ensembl ].		VAR_031215
	Natural variant	260	1	R → C. Corresponds to variant rs17751013 [ dbSNP | Ensembl ].		VAR_031216
	Natural variant	329	1	V → I. Ref.1 Ref.4 Corresponds to variant rs33204 [ dbSNP | Ensembl ].		VAR_023777
Experimental info
	Sequence conflict	365	1	G → D in BAB13915. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HAD4 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: AADC0725E29B5B84	FASTA	459	51,728
	10 20 30 40 50 60 MLRWLIGGGR EPQGLAEKSP LQTIGEEQTQ NPYTELLVLK AHHDIVRFLV QLDDYRFASA 70 80 90 100 110 120 GDDGIVVVWN AQTGEKLLEL NGHTQKITAI ITFPSLESCE EKNQLILTAS ADRTVIVWDG 130 140 150 160 170 180 DTTRQVQRIS CFQSTVKCLT VLQRLDVWLS GGNDLCVWNR KLDLLCKTSH LSDTGISALV 190 200 210 220 230 240 EIPKNCVVAA VGKELIIFRL VAPTEGSLEW DILEVKRLLD HQDNILSLIN VNDLSFVTGS 250 260 270 280 290 300 HVGELIIWDA LDWTMQAYER NFWDPSPQLD TQQEIKLCQK SNDISIHHFT CDEENVFAAV 310 320 330 340 350 360 GRGLYVYSLQ MKRVIACQKT AHDSNVLHVA RLPNRQLISC SEDGSVRIWE LREKQQLAAE 370 380 390 400 410 420 PVPTGFFNMW GFGRVSKQAS QPVKKQQENA TSCSLELIGD LIGHSSSVEM FLYFEDHGLV 430 440 450 TCSADHLIIL WKNGERESGL RSLRLFQKLE ENGDLYLAV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-329. Tissue: Embryo and Ovarian carcinoma.
[2]	Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Liu B., Ye J., Song L., Zhao Y., Cao H.Q., Zhao X.W., Gao Y., Liu L.S., Ding J.F., Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Aorta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-459, VARIANT ILE-329. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001766 mRNA. Translation: BAA91895.1. AK021855 mRNA. Translation: BAB13915.1. AK023977 mRNA. Translation: BAB14749.1. AF115511 mRNA. Translation: AAO06948.1. Frameshift. BC040241 mRNA. Translation: AAH40241.1. AL834138 mRNA. Translation: CAD38853.2.
IPI	IPI00306934.
RefSeq	NP_060738.2. NM_018268.2.
UniGene	Hs.482573.
3D structure databases
ProteinModelPortal	Q9HAD4.
SMR	Q9HAD4. Positions 37-201, 284-435.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HAD4. 3 interactions.
PTM databases
PhosphoSite	Q9HAD4.
Polymorphism databases
DMDM	134047969.
Proteomic databases
PRIDE	Q9HAD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296679; ENSP00000296679; ENSG00000164253.
GeneID	55255.
KEGG	hsa:55255.
UCSC	uc003kff.1. human.
Organism-specific databases
CTD	55255.
GeneCards	GC05M076721.
H-InvDB	HIX0004971.
HGNC	HGNC:25601. WDR41.
HPA	HPA043124.
neXtProt	NX_Q9HAD4.
PharmGKB	PA134906058.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07386.
GeneTree	ENSGT00390000017026.
HOGENOM	HBG282375.
HOVERGEN	HBG079768.
InParanoid	Q9HAD4.
OMA	FFNMWGF.
OrthoDB	EOG479F73.
PhylomeDB	Q9HAD4.
Gene expression databases
ArrayExpress	Q9HAD4.
Bgee	Q9HAD4.
CleanEx	HS_WDR41.
Genevestigator	Q9HAD4.
GermOnline	ENSG00000164253. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	59332.

Entry information

Entry name

WDR41_HUMAN

Accession

Primary (citable) accession number: Q9HAD4
Secondary accession number(s): Q7Z792 , Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.