Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin domain-containing protein 1

Gene

UBTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
Gene namesi
Name:UBTD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25683. UBTD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi80019.
OpenTargetsiENSG00000165886.
PharmGKBiPA134976337.

Polymorphism and mutation databases

BioMutaiUBTD1.
DMDMi74752759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426741 – 227Ubiquitin domain-containing protein 1Add BLAST227

Proteomic databases

EPDiQ9HAC8.
MaxQBiQ9HAC8.
PaxDbiQ9HAC8.
PeptideAtlasiQ9HAC8.
PRIDEiQ9HAC8.

PTM databases

iPTMnetiQ9HAC8.
PhosphoSitePlusiQ9HAC8.
SwissPalmiQ9HAC8.

Expressioni

Inductioni

Induced by cytotoxic agents, it is also increased during premature senescence. the induction seems to be mediated by TP53.1 Publication

Gene expression databases

BgeeiENSG00000165886.
CleanExiHS_UBTD1.
GenevisibleiQ9HAC8. HS.

Organism-specific databases

HPAiHPA034825.

Interactioni

Subunit structurei

Interacts with UBTD1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123073. 20 interactors.
IntActiQ9HAC8. 19 interactors.
MINTiMINT-1439968.
STRINGi9606.ENSP00000359698.

Structurei

3D structure databases

ProteinModelPortaliQ9HAC8.
SMRiQ9HAC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0013. Eukaryota.
ENOG410XRPV. LUCA.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ9HAC8.
OMAiLGDKMHI.
OrthoDBiEOG091G0FKF.
PhylomeDBiQ9HAC8.
TreeFamiTF323925.

Family and domain databases

InterProiView protein in InterPro
IPR032752. UBD.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF16455. UBD. 1 hit.
PF00240. ubiquitin. 1 hit.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PPPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLSASLPDT VGQLKRQLHA QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,938
Last modified:March 1, 2001 - v1
Checksum:i7D34DB6027797255
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133E → G in BAD96317 (Ref. 2) Curated1
Sequence conflicti173Q → L in BAD96317 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA. Translation: BAB13921.1.
AK222597 mRNA. Translation: BAD96317.1.
AL359388 Genomic DNA. Translation: CAI14191.1.
CH471066 Genomic DNA. Translation: EAW49918.1.
CH471066 Genomic DNA. Translation: EAW49919.1.
BC007331 mRNA. Translation: AAH07331.1.
CCDSiCCDS7465.1.
RefSeqiNP_079230.1. NM_024954.4.
UniGeneiHs.500724.

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886.
GeneIDi80019.
KEGGihsa:80019.
UCSCiuc001knv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA. Translation: BAB13921.1.
AK222597 mRNA. Translation: BAD96317.1.
AL359388 Genomic DNA. Translation: CAI14191.1.
CH471066 Genomic DNA. Translation: EAW49918.1.
CH471066 Genomic DNA. Translation: EAW49919.1.
BC007331 mRNA. Translation: AAH07331.1.
CCDSiCCDS7465.1.
RefSeqiNP_079230.1. NM_024954.4.
UniGeneiHs.500724.

3D structure databases

ProteinModelPortaliQ9HAC8.
SMRiQ9HAC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123073. 20 interactors.
IntActiQ9HAC8. 19 interactors.
MINTiMINT-1439968.
STRINGi9606.ENSP00000359698.

PTM databases

iPTMnetiQ9HAC8.
PhosphoSitePlusiQ9HAC8.
SwissPalmiQ9HAC8.

Polymorphism and mutation databases

BioMutaiUBTD1.
DMDMi74752759.

Proteomic databases

EPDiQ9HAC8.
MaxQBiQ9HAC8.
PaxDbiQ9HAC8.
PeptideAtlasiQ9HAC8.
PRIDEiQ9HAC8.

Protocols and materials databases

DNASUi80019.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886.
GeneIDi80019.
KEGGihsa:80019.
UCSCiuc001knv.2. human.

Organism-specific databases

CTDi80019.
DisGeNETi80019.
GeneCardsiUBTD1.
HGNCiHGNC:25683. UBTD1.
HPAiHPA034825.
MIMi616388. gene.
neXtProtiNX_Q9HAC8.
OpenTargetsiENSG00000165886.
PharmGKBiPA134976337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0013. Eukaryota.
ENOG410XRPV. LUCA.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ9HAC8.
OMAiLGDKMHI.
OrthoDBiEOG091G0FKF.
PhylomeDBiQ9HAC8.
TreeFamiTF323925.

Miscellaneous databases

ChiTaRSiUBTD1. human.
GenomeRNAii80019.
PROiPR:Q9HAC8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165886.
CleanExiHS_UBTD1.
GenevisibleiQ9HAC8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR032752. UBD.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF16455. UBD. 1 hit.
PF00240. ubiquitin. 1 hit.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAC8
Secondary accession number(s): D3DR57, Q53HI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.