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Protein

Ubiquitin domain-containing protein 1

Gene

UBTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
Gene namesi
Name:UBTD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165886.4
HGNCiHGNC:25683 UBTD1
MIMi616388 gene
neXtProtiNX_Q9HAC8

Pathology & Biotechi

Organism-specific databases

DisGeNETi80019
OpenTargetsiENSG00000165886
PharmGKBiPA134976337

Polymorphism and mutation databases

BioMutaiUBTD1
DMDMi74752759

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426741 – 227Ubiquitin domain-containing protein 1Add BLAST227

Proteomic databases

EPDiQ9HAC8
MaxQBiQ9HAC8
PaxDbiQ9HAC8
PeptideAtlasiQ9HAC8
PRIDEiQ9HAC8

PTM databases

iPTMnetiQ9HAC8
PhosphoSitePlusiQ9HAC8
SwissPalmiQ9HAC8

Expressioni

Inductioni

Induced by cytotoxic agents, it is also increased during premature senescence. the induction seems to be mediated by TP53.1 Publication

Gene expression databases

BgeeiENSG00000165886
CleanExiHS_UBTD1
GenevisibleiQ9HAC8 HS

Organism-specific databases

HPAiHPA034825

Interactioni

Subunit structurei

Interacts with UBTD1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123073, 25 interactors
IntActiQ9HAC8, 19 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9HAC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0013 Eukaryota
ENOG410XRPV LUCA
GeneTreeiENSGT00390000006816
HOGENOMiHOG000231205
HOVERGENiHBG080179
InParanoidiQ9HAC8
OMAiLGDKMHI
OrthoDBiEOG091G0FKF
PhylomeDBiQ9HAC8
TreeFamiTF323925

Family and domain databases

Gene3Di1.20.225.20, 1 hit
InterProiView protein in InterPro
IPR032752 UBD
IPR038169 UBD_sf
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PPPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLSASLPDT VGQLKRQLHA QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,938
Last modified:March 1, 2001 - v1
Checksum:i7D34DB6027797255
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133E → G in BAD96317 (Ref. 2) Curated1
Sequence conflicti173Q → L in BAD96317 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA Translation: BAB13921.1
AK222597 mRNA Translation: BAD96317.1
AL359388 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49918.1
CH471066 Genomic DNA Translation: EAW49919.1
BC007331 mRNA Translation: AAH07331.1
CCDSiCCDS7465.1
RefSeqiNP_079230.1, NM_024954.4
UniGeneiHs.500724

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886
GeneIDi80019
KEGGihsa:80019
UCSCiuc001knv.2 human

Similar proteinsi

Entry informationi

Entry nameiUBTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAC8
Secondary accession number(s): D3DR57, Q53HI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health