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Protein

Ubiquitin domain-containing protein 1

Gene

UBTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
Gene namesi
Name:UBTD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25683. UBTD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976337.

Polymorphism and mutation databases

BioMutaiUBTD1.
DMDMi74752759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ubiquitin domain-containing protein 1PRO_0000242674Add
BLAST

Proteomic databases

MaxQBiQ9HAC8.
PaxDbiQ9HAC8.
PeptideAtlasiQ9HAC8.
PRIDEiQ9HAC8.

PTM databases

PhosphoSiteiQ9HAC8.

Expressioni

Gene expression databases

BgeeiQ9HAC8.
CleanExiHS_UBTD1.
GenevestigatoriQ9HAC8.

Organism-specific databases

HPAiHPA034825.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MID1O153443EBI-745871,EBI-2340316
MID2Q9UJV3-23EBI-745871,EBI-10172526
MRFAP1L1Q96HT83EBI-745871,EBI-748896
TRIM39Q9HCM94EBI-745871,EBI-739510

Protein-protein interaction databases

BioGridi123073. 20 interactions.
IntActiQ9HAC8. 7 interactions.
MINTiMINT-1439968.
STRINGi9606.ENSP00000359698.

Structurei

3D structure databases

ProteinModelPortaliQ9HAC8.
SMRiQ9HAC8. Positions 24-137, 148-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 22476Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278278.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ9HAC8.
OMAiANDYIIN.
OrthoDBiEOG76HQ27.
PhylomeDBiQ9HAC8.
TreeFamiTF323925.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PPPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLSASLPDT VGQLKRQLHA QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,938
Last modified:March 1, 2001 - v1
Checksum:i7D34DB6027797255
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331E → G in BAD96317 (Ref. 2) Curated
Sequence conflicti173 – 1731Q → L in BAD96317 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA. Translation: BAB13921.1.
AK222597 mRNA. Translation: BAD96317.1.
AL359388 Genomic DNA. Translation: CAI14191.1.
CH471066 Genomic DNA. Translation: EAW49918.1.
CH471066 Genomic DNA. Translation: EAW49919.1.
BC007331 mRNA. Translation: AAH07331.1.
CCDSiCCDS7465.1.
RefSeqiNP_079230.1. NM_024954.4.
UniGeneiHs.500724.

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886.
GeneIDi80019.
KEGGihsa:80019.
UCSCiuc001knv.1. human.

Polymorphism and mutation databases

BioMutaiUBTD1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA. Translation: BAB13921.1.
AK222597 mRNA. Translation: BAD96317.1.
AL359388 Genomic DNA. Translation: CAI14191.1.
CH471066 Genomic DNA. Translation: EAW49918.1.
CH471066 Genomic DNA. Translation: EAW49919.1.
BC007331 mRNA. Translation: AAH07331.1.
CCDSiCCDS7465.1.
RefSeqiNP_079230.1. NM_024954.4.
UniGeneiHs.500724.

3D structure databases

ProteinModelPortaliQ9HAC8.
SMRiQ9HAC8. Positions 24-137, 148-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123073. 20 interactions.
IntActiQ9HAC8. 7 interactions.
MINTiMINT-1439968.
STRINGi9606.ENSP00000359698.

PTM databases

PhosphoSiteiQ9HAC8.

Polymorphism and mutation databases

BioMutaiUBTD1.
DMDMi74752759.

Proteomic databases

MaxQBiQ9HAC8.
PaxDbiQ9HAC8.
PeptideAtlasiQ9HAC8.
PRIDEiQ9HAC8.

Protocols and materials databases

DNASUi80019.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886.
GeneIDi80019.
KEGGihsa:80019.
UCSCiuc001knv.1. human.

Organism-specific databases

CTDi80019.
GeneCardsiGC10P099248.
HGNCiHGNC:25683. UBTD1.
HPAiHPA034825.
neXtProtiNX_Q9HAC8.
PharmGKBiPA134976337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278278.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ9HAC8.
OMAiANDYIIN.
OrthoDBiEOG76HQ27.
PhylomeDBiQ9HAC8.
TreeFamiTF323925.

Miscellaneous databases

ChiTaRSiUBTD1. human.
GenomeRNAii80019.
NextBioi70138.
PROiQ9HAC8.

Gene expression databases

BgeeiQ9HAC8.
CleanExiHS_UBTD1.
GenevestigatoriQ9HAC8.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Coronary artery.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiUBTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9HAC8
Secondary accession number(s): D3DR57, Q53HI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.