ID   LASS4_HUMAN             Reviewed;         394 AA.
AC   Q9HA82;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-NOV-2009, entry version 68.
DE   RecName: Full=LAG1 longevity assurance homolog 4;
GN   Name=LASS4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be either a bona fide (dihydro)ceramide synthase or
CC       a modulator of its activity. When overexpressed in cells is
CC       involved in the production of sphingolipids containing different
CC       fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20)
CC       ceramides) in a fumonisin B1-independent manner (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane
CC       protein (Potential). Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
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DR   EMBL; AK022151; BAB13972.1; -; mRNA.
DR   EMBL; BC009828; AAH09828.1; -; mRNA.
DR   IPI; IPI00002225; -.
DR   RefSeq; NP_078828.2; -.
DR   UniGene; Hs.515111; -.
DR   STRING; Q9HA82; -.
DR   PhosphoSite; Q9HA82; -.
DR   PRIDE; Q9HA82; -.
DR   Ensembl; ENST00000251363; ENSP00000251363; ENSG00000090661; Homo sapiens.
DR   GeneID; 79603; -.
DR   KEGG; hsa:79603; -.
DR   UCSC; uc002mjg.1; human.
DR   CTD; 79603; -.
DR   GeneCards; GC19P008180; -.
DR   HGNC; HGNC:23747; LASS4.
DR   PharmGKB; PA134915173; -.
DR   HOGENOM; Q9HA82; -.
DR   HOVERGEN; Q9HA82; -.
DR   Reactome; REACT_602; Metabolism of lipids and lipoproteins.
DR   NextBio; 68638; -.
DR   ArrayExpress; Q9HA82; -.
DR   Bgee; Q9HA82; -.
DR   CleanEx; HS_LASS4; -.
DR   Genevestigator; Q9HA82; -.
DR   GermOnline; ENSG00000090661; Homo sapiens.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR016439; Longevity_assurance_LAG1_LAC1.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005225; LAG1_LAC1; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; FALSE_NEG.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Endoplasmic reticulum; Homeobox;
KW   Lipid synthesis; Membrane; Nucleus; Phosphoprotein; Polymorphism;
KW   Transmembrane.
FT   CHAIN         1    394       LAG1 longevity assurance homolog 4.
FT                                /FTId=PRO_0000185512.
FT   TRANSMEM     32     52       Potential.
FT   TRANSMEM    140    160       Potential.
FT   TRANSMEM    179    199       Potential.
FT   TRANSMEM    209    229       Potential.
FT   TRANSMEM    260    280       Potential.
FT   TRANSMEM    304    324       Potential.
FT   DOMAIN      131    332       TLC.
FT   DNA_BIND     67    128       Homeobox.
FT   MOD_RES     349    349       Phosphoserine (By similarity).
FT   MOD_RES     350    350       Phosphoserine (By similarity).
FT   VARIANT     119    119       R -> Q (in dbSNP:rs17159388).
FT                                /FTId=VAR_034065.
FT   VARIANT     301    301       G -> S (in dbSNP:rs2288413).
FT                                /FTId=VAR_019556.
FT   VARIANT     353    353       V -> A (in dbSNP:rs17160348).
FT                                /FTId=VAR_060263.
FT   VARIANT     366    366       A -> T (in dbSNP:rs36259).
FT                                /FTId=VAR_019557.
FT   VARIANT     379    379       Q -> R (in dbSNP:rs17160349).
FT                                /FTId=VAR_060264.
SQ   SEQUENCE   394 AA;  46399 MW;  67228829BDED2801 CRC64;
     MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL AMRLAFERFI
     GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL SLLAAQCGLT LQQTQRWFRR
     RRNQDRPQLT KKFCEASWRF LFYLSSFVGG LSVLYHESWL WAPVMCWDRY PNQTLKPSLY
     WWYLLELGFY LSLLIRLPFD VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD
     SSDYLLEACK MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
     GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS EEVAAAQEPL
     QLKNGAAGGP RPAPTDGPQS RVAGRLTNRH TTAT
//