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Protein

Ceramide synthase 4

Gene

CERS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 128HomeoboxPROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090661-MONOMER.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.

Chemistry databases

SwissLipidsiSLP:000000699.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 4
Short name:
CerS4
Alternative name(s):
LAG1 longevity assurance homolog 4
Gene namesi
Name:CERS4
Synonyms:LASS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23747. CERS4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79603.
OpenTargetsiENSG00000090661.
PharmGKBiPA134915173.

Polymorphism and mutation databases

BioMutaiCERS4.
DMDMi296434561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855121 – 394Ceramide synthase 4Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HA82.
MaxQBiQ9HA82.
PaxDbiQ9HA82.
PeptideAtlasiQ9HA82.
PRIDEiQ9HA82.

PTM databases

iPTMnetiQ9HA82.
PhosphoSitePlusiQ9HA82.

Expressioni

Gene expression databases

BgeeiENSG00000090661.
CleanExiHS_LASS4.
ExpressionAtlasiQ9HA82. baseline and differential.
GenevisibleiQ9HA82. HS.

Organism-specific databases

HPAiCAB033734.
HPA054729.

Interactioni

Protein-protein interaction databases

BioGridi122740. 2 interactors.
IntActiQ9HA82. 1 interactor.
MINTiMINT-4650665.
STRINGi9606.ENSP00000251363.

Structurei

3D structure databases

ProteinModelPortaliQ9HA82.
SMRiQ9HA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOGENOMiHOG000231977.
HOVERGENiHBG052310.
InParanoidiQ9HA82.
KOiK04710.
OMAiPSLYWWY.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ9HA82.
TreeFamiTF314319.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL
60 70 80 90 100
AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL
110 120 130 140 150
SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG
160 170 180 190 200
LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD
210 220 230 240 250
VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK
260 270 280 290 300
MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
310 320 330 340 350
GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS
360 370 380 390
EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
Length:394
Mass (Da):46,399
Last modified:May 18, 2010 - v2
Checksum:iDAA12AA386ED2802
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034065119R → Q.Corresponds to variant rs17159388dbSNPEnsembl.1
Natural variantiVAR_019556301G → S.Corresponds to variant rs2288413dbSNPEnsembl.1
Natural variantiVAR_060263353A → V.2 PublicationsCorresponds to variant rs17160348dbSNPEnsembl.1
Natural variantiVAR_019557366A → T.1 PublicationCorresponds to variant rs36259dbSNPEnsembl.1
Natural variantiVAR_060264379R → Q.2 PublicationsCorresponds to variant rs17160349dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022151 mRNA. Translation: BAB13972.1.
AC022146 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68940.1.
CH471139 Genomic DNA. Translation: EAW68941.1.
CH471139 Genomic DNA. Translation: EAW68942.1.
CH471139 Genomic DNA. Translation: EAW68945.1.
BC009828 mRNA. Translation: AAH09828.1.
CCDSiCCDS12197.1.
RefSeqiNP_078828.2. NM_024552.2.
XP_011526592.1. XM_011528290.2.
XP_011526593.1. XM_011528291.2.
XP_011526594.1. XM_011528292.2.
XP_011526595.1. XM_011528293.2.
XP_011526596.1. XM_011528294.2.
XP_011526597.1. XM_011528295.2.
XP_016882792.1. XM_017027303.1.
XP_016882793.1. XM_017027304.1.
XP_016882794.1. XM_017027305.1.
UniGeneiHs.515111.

Genome annotation databases

EnsembliENST00000251363; ENSP00000251363; ENSG00000090661.
ENST00000559450; ENSP00000453509; ENSG00000090661.
GeneIDi79603.
KEGGihsa:79603.
UCSCiuc002mjg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022151 mRNA. Translation: BAB13972.1.
AC022146 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68940.1.
CH471139 Genomic DNA. Translation: EAW68941.1.
CH471139 Genomic DNA. Translation: EAW68942.1.
CH471139 Genomic DNA. Translation: EAW68945.1.
BC009828 mRNA. Translation: AAH09828.1.
CCDSiCCDS12197.1.
RefSeqiNP_078828.2. NM_024552.2.
XP_011526592.1. XM_011528290.2.
XP_011526593.1. XM_011528291.2.
XP_011526594.1. XM_011528292.2.
XP_011526595.1. XM_011528293.2.
XP_011526596.1. XM_011528294.2.
XP_011526597.1. XM_011528295.2.
XP_016882792.1. XM_017027303.1.
XP_016882793.1. XM_017027304.1.
XP_016882794.1. XM_017027305.1.
UniGeneiHs.515111.

3D structure databases

ProteinModelPortaliQ9HA82.
SMRiQ9HA82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122740. 2 interactors.
IntActiQ9HA82. 1 interactor.
MINTiMINT-4650665.
STRINGi9606.ENSP00000251363.

Chemistry databases

SwissLipidsiSLP:000000699.

PTM databases

iPTMnetiQ9HA82.
PhosphoSitePlusiQ9HA82.

Polymorphism and mutation databases

BioMutaiCERS4.
DMDMi296434561.

Proteomic databases

EPDiQ9HA82.
MaxQBiQ9HA82.
PaxDbiQ9HA82.
PeptideAtlasiQ9HA82.
PRIDEiQ9HA82.

Protocols and materials databases

DNASUi79603.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251363; ENSP00000251363; ENSG00000090661.
ENST00000559450; ENSP00000453509; ENSG00000090661.
GeneIDi79603.
KEGGihsa:79603.
UCSCiuc002mjg.4. human.

Organism-specific databases

CTDi79603.
DisGeNETi79603.
GeneCardsiCERS4.
HGNCiHGNC:23747. CERS4.
HPAiCAB033734.
HPA054729.
MIMi615334. gene.
neXtProtiNX_Q9HA82.
OpenTargetsiENSG00000090661.
PharmGKBiPA134915173.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOGENOMiHOG000231977.
HOVERGENiHBG052310.
InParanoidiQ9HA82.
KOiK04710.
OMAiPSLYWWY.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ9HA82.
TreeFamiTF314319.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090661-MONOMER.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

GenomeRNAii79603.
PROiQ9HA82.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090661.
CleanExiHS_LASS4.
ExpressionAtlasiQ9HA82. baseline and differential.
GenevisibleiQ9HA82. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERS4_HUMAN
AccessioniPrimary (citable) accession number: Q9HA82
Secondary accession number(s): D6W665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.