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Protein

Ceramide synthase 4

Gene

CERS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 128HomeoboxPROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsiSLP:000000699

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 4
Short name:
CerS4
Alternative name(s):
LAG1 longevity assurance homolog 4
Gene namesi
Name:CERS4
Synonyms:LASS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000090661.11
HGNCiHGNC:23747 CERS4
MIMi615334 gene
neXtProtiNX_Q9HA82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79603
OpenTargetsiENSG00000090661
PharmGKBiPA134915173

Polymorphism and mutation databases

BioMutaiCERS4
DMDMi296434561

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855121 – 394Ceramide synthase 4Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HA82
MaxQBiQ9HA82
PaxDbiQ9HA82
PeptideAtlasiQ9HA82
PRIDEiQ9HA82
ProteomicsDBi81384

PTM databases

iPTMnetiQ9HA82
PhosphoSitePlusiQ9HA82

Expressioni

Gene expression databases

BgeeiENSG00000090661
CleanExiHS_LASS4
ExpressionAtlasiQ9HA82 baseline and differential
GenevisibleiQ9HA82 HS

Organism-specific databases

HPAiCAB033734
HPA054729

Interactioni

Protein-protein interaction databases

BioGridi122740, 2 interactors
IntActiQ9HA82, 1 interactor
STRINGi9606.ENSP00000251363

Structurei

3D structure databases

ProteinModelPortaliQ9HA82
SMRiQ9HA82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607 Eukaryota
COG5058 LUCA
GeneTreeiENSGT00550000074401
HOGENOMiHOG000231977
HOVERGENiHBG052310
InParanoidiQ9HA82
KOiK04710
OMAiLYHESWL
OrthoDBiEOG091G0BWM
PhylomeDBiQ9HA82
TreeFamiTF314319

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR016439 Lag1/Lac1-like
IPR006634 TLC-dom
PANTHERiPTHR12560 PTHR12560, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005225 LAG1_LAC1, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS50922 TLC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL
60 70 80 90 100
AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL
110 120 130 140 150
SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG
160 170 180 190 200
LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD
210 220 230 240 250
VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK
260 270 280 290 300
MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
310 320 330 340 350
GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS
360 370 380 390
EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
Length:394
Mass (Da):46,399
Last modified:May 18, 2010 - v2
Checksum:iDAA12AA386ED2802
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034065119R → Q. Corresponds to variant dbSNP:rs17159388Ensembl.1
Natural variantiVAR_019556301G → S. Corresponds to variant dbSNP:rs2288413Ensembl.1
Natural variantiVAR_060263353A → V2 PublicationsCorresponds to variant dbSNP:rs17160348Ensembl.1
Natural variantiVAR_019557366A → T1 PublicationCorresponds to variant dbSNP:rs36259Ensembl.1
Natural variantiVAR_060264379R → Q2 PublicationsCorresponds to variant dbSNP:rs17160349Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022151 mRNA Translation: BAB13972.1
AC022146 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68940.1
CH471139 Genomic DNA Translation: EAW68941.1
CH471139 Genomic DNA Translation: EAW68942.1
CH471139 Genomic DNA Translation: EAW68945.1
BC009828 mRNA Translation: AAH09828.1
CCDSiCCDS12197.1
RefSeqiNP_078828.2, NM_024552.2
XP_011526592.1, XM_011528290.2
XP_011526593.1, XM_011528291.2
XP_011526594.1, XM_011528292.2
XP_011526595.1, XM_011528293.2
XP_011526596.1, XM_011528294.2
XP_011526597.1, XM_011528295.2
XP_016882792.1, XM_017027303.1
XP_016882793.1, XM_017027304.1
XP_016882794.1, XM_017027305.1
UniGeneiHs.515111

Genome annotation databases

EnsembliENST00000251363; ENSP00000251363; ENSG00000090661
ENST00000559450; ENSP00000453509; ENSG00000090661
GeneIDi79603
KEGGihsa:79603
UCSCiuc002mjg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCERS4_HUMAN
AccessioniPrimary (citable) accession number: Q9HA82
Secondary accession number(s): D6W665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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