ID   CAHM2_HUMAN             Reviewed;         323 AA.
AC   Q9HA72; D3DR94; O95893; Q6ZUV9;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Calcium homeostasis modulator protein 2;
DE   AltName: Full=Protein FAM26B;
GN   Name=CALHM2; Synonyms=FAM26B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RA   Mei G., Yu W., Gibbs R.A.;
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=18585350; DOI=10.1016/j.cell.2008.05.048;
RA   Dreses-Werringloer U., Lambert J.-C., Vingtdeux V., Zhao H., Vais H.,
RA   Siebert A., Jain A., Koppel J., Rovelet-Lecrux A., Hannequin D.,
RA   Pasquier F., Galimberti D., Scarpini E., Mann D., Lendon C., Campion D.,
RA   Amouyel P., Davies P., Foskett J.K., Campagne F., Marambaud P.;
RT   "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and
RT   Alzheimer's disease risk.";
RL   Cell 133:1149-1161(2008).
CC   -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC       {ECO:0000250|UniProtKB:Q8IU99}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9HA72-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9HA72-2; Sequence=VSP_013853, VSP_013854;
CC       Name=3;
CC         IsoId=Q9HA72-3; Sequence=VSP_013856, VSP_013855;
CC   -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR   EMBL; AK022195; BAB13983.1; -; mRNA.
DR   EMBL; AK125276; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AF131810; AAD20050.1; -; mRNA.
DR   EMBL; AL139339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471066; EAW49634.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49635.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49636.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49637.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49638.1; -; Genomic_DNA.
DR   EMBL; BC000039; AAH00039.1; -; mRNA.
DR   CCDS; CCDS7549.1; -. [Q9HA72-1]
DR   RefSeq; NP_057000.2; NM_015916.4. [Q9HA72-1]
DR   RefSeq; XP_006717943.1; XM_006717880.2. [Q9HA72-1]
DR   RefSeq; XP_006717946.1; XM_006717883.2. [Q9HA72-1]
DR   RefSeq; XP_006717947.1; XM_006717884.3. [Q9HA72-3]
DR   RefSeq; XP_011538150.1; XM_011539848.2. [Q9HA72-1]
DR   RefSeq; XP_016871795.1; XM_017016306.1. [Q9HA72-1]
DR   RefSeq; XP_016871796.1; XM_017016307.1. [Q9HA72-1]
DR   RefSeq; XP_016871797.1; XM_017016308.1. [Q9HA72-3]
DR   RefSeq; XP_016871798.1; XM_017016309.1. [Q9HA72-3]
DR   PDB; 6LMU; EM; 3.40 A; A/B/C/D/E/F/G/H/I/J/K=1-323.
DR   PDB; 6LMW; EM; 3.40 A; A/B/C/D/E/F/G/H=213-323.
DR   PDB; 6LMX; EM; 3.40 A; A/B/C/D/E/F/G/H/I=213-323.
DR   PDB; 6UIV; EM; 3.30 A; A/B/C/D/E/F/G/H/I/J/K=1-323.
DR   PDB; 6UIW; EM; 2.70 A; A/B/C/D/E/F/G/H/I/J/K=1-323.
DR   PDB; 6UIX; EM; 3.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=1-323.
DR   PDB; 6VAI; EM; 3.68 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=2-323.
DR   PDB; 6VAK; EM; 3.48 A; A/B/C/D/E/F/G/H/I/J/K=1-323.
DR   PDB; 6VAL; EM; 3.87 A; A/B/C/D/E/F/G/H/I/J/K=7-323.
DR   PDBsum; 6LMU; -.
DR   PDBsum; 6LMW; -.
DR   PDBsum; 6LMX; -.
DR   PDBsum; 6UIV; -.
DR   PDBsum; 6UIW; -.
DR   PDBsum; 6UIX; -.
DR   PDBsum; 6VAI; -.
DR   PDBsum; 6VAK; -.
DR   PDBsum; 6VAL; -.
DR   AlphaFoldDB; Q9HA72; -.
DR   EMDB; EMD-0920; -.
DR   EMDB; EMD-20788; -.
DR   EMDB; EMD-20789; -.
DR   EMDB; EMD-20790; -.
DR   EMDB; EMD-21140; -.
DR   EMDB; EMD-21141; -.
DR   SMR; Q9HA72; -.
DR   BioGRID; 119255; 4.
DR   STRING; 9606.ENSP00000260743; -.
DR   TCDB; 1.A.84.1.2; the calcium homeostasis modulator ca(2+) channel (calhm-c) family.
DR   PhosphoSitePlus; Q9HA72; -.
DR   SwissPalm; Q9HA72; -.
DR   BioMuta; CALHM2; -.
DR   DMDM; 67461081; -.
DR   jPOST; Q9HA72; -.
DR   MassIVE; Q9HA72; -.
DR   PaxDb; 9606-ENSP00000260743; -.
DR   PeptideAtlas; Q9HA72; -.
DR   ProteomicsDB; 81380; -. [Q9HA72-1]
DR   ProteomicsDB; 81381; -. [Q9HA72-2]
DR   ProteomicsDB; 81382; -. [Q9HA72-3]
DR   Pumba; Q9HA72; -.
DR   Antibodypedia; 18174; 26 antibodies from 12 providers.
DR   DNASU; 51063; -.
DR   Ensembl; ENST00000260743.10; ENSP00000260743.5; ENSG00000138172.11. [Q9HA72-1]
DR   Ensembl; ENST00000369788.7; ENSP00000358803.3; ENSG00000138172.11. [Q9HA72-1]
DR   GeneID; 51063; -.
DR   KEGG; hsa:51063; -.
DR   MANE-Select; ENST00000260743.10; ENSP00000260743.5; NM_015916.5; NP_057000.2.
DR   UCSC; uc001kxa.4; human. [Q9HA72-1]
DR   AGR; HGNC:23493; -.
DR   CTD; 51063; -.
DR   DisGeNET; 51063; -.
DR   GeneCards; CALHM2; -.
DR   HGNC; HGNC:23493; CALHM2.
DR   HPA; ENSG00000138172; Low tissue specificity.
DR   MIM; 612235; gene.
DR   neXtProt; NX_Q9HA72; -.
DR   OpenTargets; ENSG00000138172; -.
DR   PharmGKB; PA162380963; -.
DR   VEuPathDB; HostDB:ENSG00000138172; -.
DR   eggNOG; ENOG502QVU7; Eukaryota.
DR   GeneTree; ENSGT01030000234610; -.
DR   HOGENOM; CLU_069286_1_0_1; -.
DR   InParanoid; Q9HA72; -.
DR   OMA; FAFHCPC; -.
DR   OrthoDB; 2899675at2759; -.
DR   PhylomeDB; Q9HA72; -.
DR   TreeFam; TF329085; -.
DR   PathwayCommons; Q9HA72; -.
DR   BioGRID-ORCS; 51063; 32 hits in 1138 CRISPR screens.
DR   ChiTaRS; CALHM2; human.
DR   GenomeRNAi; 51063; -.
DR   Pharos; Q9HA72; Tdark.
DR   PRO; PR:Q9HA72; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9HA72; Protein.
DR   Bgee; ENSG00000138172; Expressed in granulocyte and 191 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR   InterPro; IPR029569; CALHM.
DR   PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR   PANTHER; PTHR32261:SF3; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 2; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
DR   Genevisible; Q9HA72; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..323
FT                   /note="Calcium homeostasis modulator protein 2"
FT                   /id="PRO_0000186720"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         181..196
FT                   /note="RYESQLFGWLLIGVVA -> SSLDGCSSAWWPSWCS (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_013856"
FT   VAR_SEQ         186..218
FT                   /note="LFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEA -> VRSCAKGSSSSLVVA
FT                   GERSGDGLVLKLGLVLRG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_013853"
FT   VAR_SEQ         197..323
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_013855"
FT   VAR_SEQ         219..323
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_013854"
FT   VARIANT         136
FT                   /note="V -> G (in dbSNP:rs2232660)"
FT                   /id="VAR_053084"
FT   VARIANT         194
FT                   /note="V -> M (in dbSNP:rs2232662)"
FT                   /id="VAR_033924"
FT   HELIX           14..19
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           24..41
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   TURN            50..52
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           53..75
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           77..88
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           89..91
FT                   /evidence="ECO:0007829|PDB:6LMU"
FT   HELIX           96..110
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           112..124
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           126..132
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           133..135
FT                   /evidence="ECO:0007829|PDB:6UIV"
FT   HELIX           138..140
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   STRAND          150..152
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           153..158
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           160..162
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           167..169
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           170..209
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           214..251
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           258..266
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   HELIX           275..280
FT                   /evidence="ECO:0007829|PDB:6UIW"
FT   STRAND          288..295
FT                   /evidence="ECO:0007829|PDB:6LMU"
FT   HELIX           298..305
FT                   /evidence="ECO:0007829|PDB:6UIW"
SQ   SEQUENCE   323 AA;  36175 MW;  20A4BC58F6763926 CRC64;
     MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLAA
     IGVPALVLFI IGIILNNHTW NLVAECQHRR TKNCSAAPTF LLLSSILGRA AVAPVTWSVI
     SLLRGEAYVC ALSEFVDPSS LTAREEHFPS AHATEILARF PCKENPDNLS DFREEVSRRL
     RYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRANEDQL FQRTAEVHSR
     VLAANNVRRF FGFVALNKDD EELIANFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH
     KWAQGLAGNG AAPDNVEMAL LPS
//