ID ZMAT3_HUMAN Reviewed; 289 AA. AC Q9HA38; B3KVA6; D3DNR1; Q96A21; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 24-JAN-2024, entry version 173. DE RecName: Full=Zinc finger matrin-type protein 3; DE AltName: Full=Zinc finger protein WIG-1; DE AltName: Full=p53-activated gene 608 protein; GN Name=ZMAT3 {ECO:0000312|EMBL:AAH02896.1}; GN Synonyms=PAG608 {ECO:0000312|EMBL:AAK83287.1}, WIG1 GN {ECO:0000312|EMBL:AAK83287.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK83287.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=11689294; DOI=10.1016/s0304-3835(01)00699-1; RA Varmeh-Ziaie S., Ichimura K., Yang F., Rabbits P., Collins V.P.; RT "Cloning and chromosomal localization of human WIG-1/PAG608 and RT demonstration of amplification with increased expression in primary RT squamous cell carcinoma of the lung."; RL Cancer Lett. 174:179-187(2001). RN [2] {ECO:0000305, ECO:0000312|EMBL:AAK71491.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, AND RP INDUCTION. RC TISSUE=Testis {ECO:0000312|EMBL:AAK71491.1}; RX PubMed=11571644; DOI=10.1038/sj.onc.1204722; RA Hellborg F., Qian W., Mendez-Vidal C., Asker C., Kost-Alimova M., RA Wilhelm M., Imreh S., Wiman K.G.; RT "Human wig-1, a p53 target gene that encodes a growth inhibitory zinc RT finger protein."; RL Oncogene 20:5466-5474(2001). RN [3] {ECO:0000312|EMBL:BAB14020.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Mammary gland {ECO:0000312|EMBL:BAB14020.1}; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000312|EMBL:AAH02896.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung carcinoma {ECO:0000312|EMBL:AAH02896.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] {ECO:0000305} RP SUBUNIT. RX PubMed=16844115; DOI=10.1016/j.febslet.2006.07.005; RA Mendez Vidal C., Prahl M., Wiman K.G.; RT "The p53-induced Wig-1 protein binds double-stranded RNAs with structural RT characteristics of siRNAs and miRNAs."; RL FEBS Lett. 580:4401-4408(2006). CC -!- FUNCTION: Acts as a bona fide target gene of p53/TP53. May play a role CC in the TP53-dependent growth regulatory pathway. May contribute to CC TP53-mediated apoptosis by regulation of TP53 expression and CC translocation to the nucleus and nucleolus. CC {ECO:0000269|PubMed:11571644}. CC -!- SUBUNIT: Interacts with dsRNA. {ECO:0000269|PubMed:16844115}. CC -!- INTERACTION: CC Q9HA38; Q9UKV8: AGO2; NbExp=5; IntAct=EBI-2548480, EBI-528269; CC Q9HA38; Q08211: DHX9; NbExp=3; IntAct=EBI-2548480, EBI-352022; CC Q9HA38; P22626: HNRNPA2B1; NbExp=3; IntAct=EBI-2548480, EBI-299649; CC Q9HA38; O75569: PRKRA; NbExp=3; IntAct=EBI-2548480, EBI-713955; CC Q9HA38; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-2548480, EBI-747107; CC Q9HA38; O95793: STAU1; NbExp=3; IntAct=EBI-2548480, EBI-358174; CC Q9HA38; Q15633: TARBP2; NbExp=3; IntAct=EBI-2548480, EBI-978581; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11571644}. Nucleus, CC nucleolus {ECO:0000269|PubMed:11571644}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9HA38-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9HA38-2; Sequence=VSP_040093; CC -!- TISSUE SPECIFICITY: Highly expressed in adult brain, and moderately in CC adult kidney and testis. Not detected in fetal brain, heart, pancreas, CC adrenal gland, liver or small intestine. {ECO:0000269|PubMed:11689294}. CC -!- INDUCTION: By DNA damage in a p53/TP53-dependent manner. Up-regulated CC following ionizing radiation in primary squamous cell carcinoma of the CC lung and in various colon cancer cell lines. CC {ECO:0000269|PubMed:11571644, ECO:0000269|PubMed:11689294}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF355465; AAK83287.1; -; mRNA. DR EMBL; AY037945; AAK71491.1; -; mRNA. DR EMBL; AK022358; BAB14020.1; -; mRNA. DR EMBL; AK122768; BAG53718.1; -; mRNA. DR EMBL; AC117456; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471052; EAW78424.1; -; Genomic_DNA. DR EMBL; CH471052; EAW78426.1; -; Genomic_DNA. DR EMBL; CH471052; EAW78425.1; -; Genomic_DNA. DR EMBL; BC002896; AAH02896.1; -; mRNA. DR CCDS; CCDS3224.1; -. [Q9HA38-1] DR CCDS; CCDS46962.1; -. [Q9HA38-2] DR RefSeq; NP_071915.1; NM_022470.3. [Q9HA38-1] DR RefSeq; NP_689426.1; NM_152240.2. [Q9HA38-2] DR RefSeq; XP_005247763.1; XM_005247706.2. DR RefSeq; XP_011511375.1; XM_011513073.1. [Q9HA38-1] DR AlphaFoldDB; Q9HA38; -. DR SMR; Q9HA38; -. DR BioGRID; 122151; 31. DR IntAct; Q9HA38; 22. DR MINT; Q9HA38; -. DR STRING; 9606.ENSP00000311221; -. DR iPTMnet; Q9HA38; -. DR PhosphoSitePlus; Q9HA38; -. DR BioMuta; ZMAT3; -. DR DMDM; 74734128; -. DR EPD; Q9HA38; -. DR MassIVE; Q9HA38; -. DR MaxQB; Q9HA38; -. DR PaxDb; 9606-ENSP00000311221; -. DR PeptideAtlas; Q9HA38; -. DR ProteomicsDB; 81372; -. [Q9HA38-1] DR ProteomicsDB; 81373; -. [Q9HA38-2] DR Pumba; Q9HA38; -. DR Antibodypedia; 18760; 226 antibodies from 32 providers. DR DNASU; 64393; -. DR Ensembl; ENST00000311417.7; ENSP00000311221.2; ENSG00000172667.11. [Q9HA38-1] DR Ensembl; ENST00000432729.5; ENSP00000396506.1; ENSG00000172667.11. [Q9HA38-2] DR GeneID; 64393; -. DR KEGG; hsa:64393; -. DR MANE-Select; ENST00000311417.7; ENSP00000311221.2; NM_022470.4; NP_071915.1. DR UCSC; uc003fjg.5; human. [Q9HA38-1] DR AGR; HGNC:29983; -. DR CTD; 64393; -. DR DisGeNET; 64393; -. DR GeneCards; ZMAT3; -. DR HGNC; HGNC:29983; ZMAT3. DR HPA; ENSG00000172667; Low tissue specificity. DR MIM; 606452; gene. DR neXtProt; NX_Q9HA38; -. DR OpenTargets; ENSG00000172667; -. DR PharmGKB; PA145147560; -. DR VEuPathDB; HostDB:ENSG00000172667; -. DR eggNOG; ENOG502QW4K; Eukaryota. DR GeneTree; ENSGT00730000111202; -. DR HOGENOM; CLU_051920_1_0_1; -. DR InParanoid; Q9HA38; -. DR OMA; QAHYRGK; -. DR OrthoDB; 3094294at2759; -. DR PhylomeDB; Q9HA38; -. DR TreeFam; TF350019; -. DR PathwayCommons; Q9HA38; -. DR SignaLink; Q9HA38; -. DR BioGRID-ORCS; 64393; 15 hits in 1167 CRISPR screens. DR ChiTaRS; ZMAT3; human. DR GenomeRNAi; 64393; -. DR Pharos; Q9HA38; Tbio. DR PRO; PR:Q9HA38; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q9HA38; Protein. DR Bgee; ENSG00000172667; Expressed in postcentral gyrus and 194 other cell types or tissues. DR ExpressionAtlas; Q9HA38; baseline and differential. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3. DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2. DR InterPro; IPR022755; Znf_C2H2_jaz. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR46786; ZINC FINGER MATRIN-TYPE PROTEIN 3; 1. DR PANTHER; PTHR46786:SF1; ZINC FINGER MATRIN-TYPE PROTEIN 3; 1. DR Pfam; PF12171; zf-C2H2_jaz; 1. DR Pfam; PF12874; zf-met; 2. DR SMART; SM00355; ZnF_C2H2; 3. DR SMART; SM00451; ZnF_U1; 3. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3. DR Genevisible; Q9HA38; HS. PE 1: Evidence at protein level; KW Alternative splicing; Apoptosis; DNA damage; Growth regulation; KW Metal-binding; Nucleus; Protein transport; Reference proteome; Repeat; KW RNA-binding; Translocation; Transport; Zinc; Zinc-finger. FT CHAIN 1..289 FT /note="Zinc finger matrin-type protein 3" FT /id="PRO_0000310779" FT ZN_FING 70..100 FT /note="Matrin-type 1" FT /evidence="ECO:0000255" FT ZN_FING 147..177 FT /note="Matrin-type 2" FT /evidence="ECO:0000255" FT ZN_FING 246..276 FT /note="Matrin-type 3" FT /evidence="ECO:0000255" FT REGION 1..42 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 180..201 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 20..37 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 220 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:11571644, FT ECO:0000303|PubMed:11689294, ECO:0000303|PubMed:14702039" FT /id="VSP_040093" SQ SEQUENCE 289 AA; 32059 MW; CF3CAB0AA51DDD29 CRC64; MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE EELSKGGEQD CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN YYAANSCPPP ARMSNVVEPA ATPVVPVPPQ MGSFKPGGRV ILATENDYCK LCDASFSSPA VAQAHYQGKN HAKRLRLAEA QSNSFSESSE LGQRRARKEG NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV TPSGQFYCSM CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV //